HRP20191989T1 - Farmaceutski pripravak za uporabu u povećanju trofizma sluznice nosa - Google Patents
Farmaceutski pripravak za uporabu u povećanju trofizma sluznice nosa Download PDFInfo
- Publication number
- HRP20191989T1 HRP20191989T1 HRP20191989TT HRP20191989T HRP20191989T1 HR P20191989 T1 HRP20191989 T1 HR P20191989T1 HR P20191989T T HRP20191989T T HR P20191989TT HR P20191989 T HRP20191989 T HR P20191989T HR P20191989 T1 HRP20191989 T1 HR P20191989T1
- Authority
- HR
- Croatia
- Prior art keywords
- alpha
- hydrogenated
- preparation
- oil
- tocopherol
- Prior art date
Links
- 210000002850 nasal mucosa Anatomy 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 8
- 239000003921 oil Substances 0.000 claims 7
- 235000019198 oils Nutrition 0.000 claims 7
- 229940087168 alpha tocopherol Drugs 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 6
- 229960000984 tocofersolan Drugs 0.000 claims 6
- 239000002076 α-tocopherol Substances 0.000 claims 6
- 235000004835 α-tocopherol Nutrition 0.000 claims 6
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims 5
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims 5
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 5
- 244000056974 Adansonia digitata Species 0.000 claims 4
- 235000003320 Adansonia digitata Nutrition 0.000 claims 4
- 244000060011 Cocos nucifera Species 0.000 claims 4
- 235000013162 Cocos nucifera Nutrition 0.000 claims 4
- 240000007817 Olea europaea Species 0.000 claims 4
- -1 alpha-tocopherol ester Chemical class 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 229920006007 hydrogenated polyisobutylene Polymers 0.000 claims 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 claims 4
- 229920000098 polyolefin Polymers 0.000 claims 4
- 235000003222 Helianthus annuus Nutrition 0.000 claims 3
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 2
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims 2
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims 2
- 244000020551 Helianthus annuus Species 0.000 claims 2
- 244000044822 Simmondsia californica Species 0.000 claims 2
- 235000004433 Simmondsia californica Nutrition 0.000 claims 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 150000001735 carboxylic acids Chemical class 0.000 claims 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-M decanoate Chemical compound CCCCCCCCCC([O-])=O GHVNFZFCNZKVNT-UHFFFAOYSA-M 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229940100554 isononyl isononanoate Drugs 0.000 claims 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims 2
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 claims 2
- 229940032094 squalane Drugs 0.000 claims 2
- 229940031439 squalene Drugs 0.000 claims 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 2
- 150000003626 triacylglycerols Chemical class 0.000 claims 2
- 239000008158 vegetable oil Substances 0.000 claims 2
- 201000008283 Atrophic Rhinitis Diseases 0.000 claims 1
- 241000208818 Helianthus Species 0.000 claims 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 1
- 206010039088 Rhinitis atrophic Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229940049918 linoleate Drugs 0.000 claims 1
- 210000001331 nose Anatomy 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 235000020238 sunflower seed Nutrition 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (9)
1. Pripravak za vanjsku primjenu, za uporabu u postizanju oporavka tkiva sluznice nosa poslije operacije nosa i sinusa, koja sadrži ester alfa-tokoferola s karboksilnom kiselinom formule R-COOH, u kojoj je R alkil radikal koji ima 1 do 19 atoma ugljika, ili alkenil ili alkinil radikal koji ima 2 do 19 atoma ugljika, i uljani nosač odabran iz grupe koja se sastoji od hidrogeniranog poliizobutena, hidrogeniranog polidecena i mješavina hidrogeniranog poliizobutena i/ili hidrogeniranog polidecena s hidrogeniranim poliolefinima, posebno hidrogeniranim C6-C14 poliolefinima, triglicerida kaprilne/kaprinske kiseline, biljnog ulja, ulja Adansonia digitata, ulja sjemena Adansonia digitata, kokosovog kaprilata/ kaprata, skvalana masline, skvalena masline, ulja sjemena suncokreta (Helianthus annus), ulja Simmondsia chinensis, kokosovog kaprilata, izononil izononanoata, ciklopentasiloksana, i njihovih smjesa.
2. Pripravak za vanjsku primjenu, za uporabu u liječenju kroničnog atrofičnog rinitisa, koji sadrži ester alfa-tokoferola s karboksilnom kiselinom formule R-COOH, u kojoj je R alkil radikal koji ima 1 do 19 atoma ugljika, ili alkenil ili alkinil radikal koji ima 2 do 19 atoma ugljika, i uljani nosač odabran iz grupe koja se sastoji od hidrogeniranog poliizobutena, hidrogeniranog polidecena i mješavina hidrogeniranog poliizobutena i/ili hidrogeniranog polidecena s hidrogeniranim poliolefinima, posebno hidrogeniranim C6-C14 poliolefinima, triglicerida kaprilne/kaprinske kiseline, biljnog ulja, ulja Adansonia digitata, ulja sjemena Adansonia digitata, kokosovog kaprilata/kaprata, skvalana masline, skvalena masline, ulja sjemena suncokreta (Helianthus annus), ulja Simmondsia chinensis, kokosovog kaprilata, izononil izononanoata, ciklopentasiloksana, i njihovih smjesa.
3. Pripravak za uporabu u skladu s bilo kojim od patentnih zahtjeva 1 i 2, naznačen time što je navedeni ester alfa-tokoferola alfa-tokoferil acetat, n-propionat ili linoleat, poželjno alfa-tokoferil acetat.
4. Pripravak za uporabu u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačen time što navedeni pripravak sadrži 3% do 80% po težini navedenog estra alfa-tokoferola u odnosu na ukupnu težinu kompozicije.
5. Pripravak za uporabu u skladu s patentnim zahtjevom 4, naznačen time što navedeni pripravak sadrži 5% do 40%, poželjno 10% do 30%, po težini navedenog estra alfa-tokoferola u odnosu na ukupnu težinu kompozicije.
6. Pripravak za uporabu u skladu s bilo kojim od patentnih zahtjeva 1 do 5, naznačen time što se navedeni uljani nosač sastoji od hidrogeniranog polidecena.
7. Pripravak za uporabu u skladu s patentnim zahtjevom 6, naznačen time što je navedeni ester alfa-tokoferola alfa-tokoferil acetat.
8. Pripravak za uporabu u skladu s patentnim zahtjevom 7, koji se sastoji od alfa-tokoferil acetata i hidrogeniranog polidecena.
9. Pripravak za uporabu u skladu s patentnim zahtjevom 8, koji se sastoji od 10-30% alfa-tokoferil acetata i 70-90% hidrogeniranog polidecena.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI20141819 | 2014-10-22 | ||
| EP15783971.3A EP3209294B1 (en) | 2014-10-22 | 2015-10-02 | Pharmaceutical composition for use in increasing the trophism of nasal mucosa |
| PCT/EP2015/072796 WO2016062522A1 (en) | 2014-10-22 | 2015-10-02 | Pharmaceutical composition for use in increasing the trophism of nasal mucosa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191989T1 true HRP20191989T1 (hr) | 2020-02-07 |
Family
ID=51951918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191989TT HRP20191989T1 (hr) | 2014-10-22 | 2019-11-04 | Farmaceutski pripravak za uporabu u povećanju trofizma sluznice nosa |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10226444B2 (hr) |
| EP (1) | EP3209294B1 (hr) |
| CN (1) | CN107438429A (hr) |
| AU (1) | AU2015335204B2 (hr) |
| CA (1) | CA2965184A1 (hr) |
| CL (1) | CL2017000971A1 (hr) |
| CY (1) | CY1122289T1 (hr) |
| DK (1) | DK3209294T3 (hr) |
| EA (1) | EA033078B1 (hr) |
| ES (1) | ES2757349T3 (hr) |
| GE (1) | GEP20186863B (hr) |
| HR (1) | HRP20191989T1 (hr) |
| HU (1) | HUE047203T2 (hr) |
| LT (1) | LT3209294T (hr) |
| MX (1) | MX2017005195A (hr) |
| PL (1) | PL3209294T3 (hr) |
| PT (1) | PT3209294T (hr) |
| RS (1) | RS59496B1 (hr) |
| SI (1) | SI3209294T1 (hr) |
| WO (1) | WO2016062522A1 (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3026108A1 (en) | 2016-06-10 | 2017-12-14 | Clarity Cosmetics Inc. | Non-comedogenic hair and scalp care formulations and method for use |
| IT201700047210A1 (it) | 2017-05-02 | 2018-11-02 | St Ganassini Spa Di Ricerche Biochimiche | Composizione cosmetica e/o dermatologica, e suoi usi in campo cosmetico e nel trattamento coadiuvante di patologie dermatologiche |
| IT201900003515A1 (it) * | 2019-03-11 | 2020-09-11 | Gilas Sas Di Carcano Maria Grazia E C | COMPOSIZIONE DERMO-COSMETICA PER USO TOPICO, A BASE DI VITAMINA E e/o SUOI ESTERI |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4364945A (en) | 1979-12-13 | 1982-12-21 | Whittle Barry J | Nasal composition for relieving nasal distress |
| US20100055152A1 (en) | 2008-08-26 | 2010-03-04 | Trutek Corporation | Antihistamine and antihistamine-like nasal application, products, and method |
| IT1282778B1 (it) | 1996-05-31 | 1998-03-31 | Giorgio Panin | Vitamina "e" acetato quale prodotto per applicazione topica |
| ITMI981586A1 (it) * | 1998-07-10 | 2000-01-10 | Giorgio Panin | Vitamina e e suoi esteri per l'uso nel trattamento topico di patologie delle mucose |
| IT1393056B1 (it) * | 2008-09-22 | 2012-04-11 | Bio Lo Ga Srl | Uso di vitamina e o suoi derivati per il controllo di artropodi |
| CN103717235A (zh) | 2011-06-24 | 2014-04-09 | 埃皮托吉尼西斯有限公司 | 作为抗原特异性免疫调节剂的包含选择的载体、维生素、单宁和类黄酮的组合的药物组合物 |
| FR2981273B1 (fr) | 2011-10-14 | 2013-12-20 | Gilles Andre Yves Bhat | Nouvelle composition pour les muqueuses: tocopherol, macerat huileux de fleurs de calendula dans de l'huile de rose musquee, palmitate de retinol, ubiquinone, ascorbyl palmitate et lactobacillus |
-
2015
- 2015-10-02 SI SI201530924T patent/SI3209294T1/sl unknown
- 2015-10-02 HU HUE15783971A patent/HUE047203T2/hu unknown
- 2015-10-02 EA EA201790447A patent/EA033078B1/ru not_active IP Right Cessation
- 2015-10-02 GE GEAP201514463A patent/GEP20186863B/en unknown
- 2015-10-02 CA CA2965184A patent/CA2965184A1/en not_active Abandoned
- 2015-10-02 DK DK15783971T patent/DK3209294T3/da active
- 2015-10-02 US US15/512,755 patent/US10226444B2/en active Active
- 2015-10-02 AU AU2015335204A patent/AU2015335204B2/en active Active
- 2015-10-02 WO PCT/EP2015/072796 patent/WO2016062522A1/en active Application Filing
- 2015-10-02 EP EP15783971.3A patent/EP3209294B1/en active Active
- 2015-10-02 RS RS20191407A patent/RS59496B1/sr unknown
- 2015-10-02 PT PT157839713T patent/PT3209294T/pt unknown
- 2015-10-02 PL PL15783971T patent/PL3209294T3/pl unknown
- 2015-10-02 CN CN201580055149.2A patent/CN107438429A/zh active Pending
- 2015-10-02 LT LT15783971T patent/LT3209294T/lt unknown
- 2015-10-02 ES ES15783971T patent/ES2757349T3/es active Active
- 2015-10-02 MX MX2017005195A patent/MX2017005195A/es active IP Right Grant
-
2017
- 2017-04-20 CL CL2017000971A patent/CL2017000971A1/es unknown
-
2019
- 2019-10-08 CY CY20191101053T patent/CY1122289T1/el unknown
- 2019-11-04 HR HRP20191989TT patent/HRP20191989T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US10226444B2 (en) | 2019-03-12 |
| AU2015335204B2 (en) | 2020-10-08 |
| ES2757349T3 (es) | 2020-04-29 |
| SI3209294T1 (sl) | 2019-12-31 |
| EA033078B1 (ru) | 2019-08-30 |
| EP3209294B1 (en) | 2019-08-21 |
| LT3209294T (lt) | 2019-10-25 |
| BR112017008070A2 (pt) | 2018-02-20 |
| EP3209294A1 (en) | 2017-08-30 |
| CY1122289T1 (el) | 2021-01-27 |
| HUE047203T2 (hu) | 2020-04-28 |
| DK3209294T3 (da) | 2019-10-28 |
| CA2965184A1 (en) | 2016-04-28 |
| AU2015335204A1 (en) | 2017-04-13 |
| RS59496B1 (sr) | 2019-12-31 |
| CN107438429A (zh) | 2017-12-05 |
| CL2017000971A1 (es) | 2018-01-12 |
| BR112017008070A8 (pt) | 2022-07-05 |
| MX2017005195A (es) | 2017-10-04 |
| EA201790447A1 (ru) | 2017-09-29 |
| PT3209294T (pt) | 2019-10-08 |
| US20170290799A1 (en) | 2017-10-12 |
| PL3209294T3 (pl) | 2020-01-31 |
| GEP20186863B (en) | 2018-06-11 |
| WO2016062522A1 (en) | 2016-04-28 |
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