HRP20191569T1 - Metode za utvrđivanje bolesti bubrega - Google Patents
Metode za utvrđivanje bolesti bubrega Download PDFInfo
- Publication number
- HRP20191569T1 HRP20191569T1 HRP20191569T HRP20191569T1 HR P20191569 T1 HRP20191569 T1 HR P20191569T1 HR P20191569 T HRP20191569 T HR P20191569T HR P20191569 T1 HRP20191569 T1 HR P20191569T1
- Authority
- HR
- Croatia
- Prior art keywords
- sdma
- concentration
- free
- reactivity
- creatinine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 11
- 208000017169 kidney disease Diseases 0.000 title claims 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 12
- 229940109239 creatinine Drugs 0.000 claims 6
- 230000009257 reactivity Effects 0.000 claims 5
- YDGMGEXADBMOMJ-LURJTMIESA-N N(g)-dimethylarginine Chemical compound CN(C)C(\N)=N\CCC[C@H](N)C(O)=O YDGMGEXADBMOMJ-LURJTMIESA-N 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 230000024924 glomerular filtration Effects 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
- 229930064664 L-arginine Natural products 0.000 claims 1
- 235000014852 L-arginine Nutrition 0.000 claims 1
- NTWVQPHTOUKMDI-YFKPBYRVSA-N N-Methyl-arginine Chemical compound CN[C@H](C(O)=O)CCCN=C(N)N NTWVQPHTOUKMDI-YFKPBYRVSA-N 0.000 claims 1
- 206010062237 Renal impairment Diseases 0.000 claims 1
- YDGMGEXADBMOMJ-UHFFFAOYSA-N asymmetrical dimethylarginine Natural products CN(C)C(N)=NCCCC(N)C(O)=O YDGMGEXADBMOMJ-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000002596 correlated effect Effects 0.000 claims 1
- 230000009260 cross reactivity Effects 0.000 claims 1
- 230000005977 kidney dysfunction Effects 0.000 claims 1
- 230000003907 kidney function Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medical Informatics (AREA)
- Primary Health Care (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Data Mining & Analysis (AREA)
- Databases & Information Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Claims (10)
1. Postupak za procjenu brzine glomerularne filtracije (GFR) kod životinjskog subjekta koja uključuje:
mjerenje koncentracije slobodnog simetričnog dimetilaginina (SDMA) u uzorku krvi subjekta;
mjerenje koncentracije kreatinina u uzorku krvi subjekta; i
usporedbu vrijednosti koja proizlazi iz jednadžbe koja sadrži proizvod koncentracije kreatinina i koncentracije slobodnog SDMA na jednu ili više standardnih vrijednosti koje su u korelaciji sa brzinom glomerularne filtracije u životinjski subjekt.
2. Postupak sukladno zahtjevu 1, naznačen time što jednadžba sadrži inverziju produkta koncentracije kreatinina i koncentracija slobodnog SDMA.
3. Postupak sukladno zahtjevu 1, naznačen time što je najmanje jedna koncentracija kreatinina i koncentracija slobodnog SDMA u izračunu su ponderirani.
4. Postupak sukladno patentnom zahtjevu 3, naznačen time što se proizvod prve ponderirane vrijednosti temelji na koncentraciji kreatinina a druga ponderirana vrijednost koja se temelji na koncentraciji slobodnog SDMA predstavljena je formulom PROD =[CRE]P x [SDMA]Q gdje je PROD proizvod, [CRE] je koncentracija kreatinina, [SDMA] je koncentracija SDMA, P pruža težinu koju daje [CRE] u formuli, a Q je težina koju daje [SDMA] u formuli.
5. Metoda iz zahtjeva 4, naznačena time, da jedna ili više standardnih vrijednosti koreliraju s obratnim proizvodom.
6. Metoda iz zahtjeva 4, naznačena time, da je P između oko -5 i 0, ali ne uključuje 0.
7. Metoda iz zahtjeva 4, naznačena time, da Q iznosi između oko -2,5 i 0, ali ne uključuje 0.
8. Postupak sukladno zahtjevu 1 ili zahtjevu 2, naznačen time, da nadalje obuhvaća određivanje bubrežne funkcije, bolesti bubrega ili bubrega disfunkcija usporedbom GFR kod subjekta s GFR kod jednog ili više zdravih subjekata.
9. Postupak sukladno bilo kojem od prethodnih zahtjeva, naznačen time da je mjerenje koncentracije slobodnog SDMA sadrži:
kontaktiranje uzorka s anti-SDMA antitijelom konjugiranim na etiketu i sa SDMA analogom; pri čemu anti-SDMA antitijelo je specifično za slobodnu SDMA i nema ili bitno nema unakrsnu reaktivnost s jednim ili više spojeva odabranih iz skupine koja se sastoji od asimetričnog dimetilarginina (ADMA), L-arginina, i N-metilarginina i
otkrivanje prisutnosti ili količine oznake povezane s SDMA analogom, te se na taj način određuje prisutnost ili količina SDMA u uzorku.
10. Metoda iz zahtjeva 9, naznačena time da anti-SDMA antitijelo ima reaktivnost za ADMA od
- manje od 25% njegove reaktivnosti za SDMA,
- manje od 10% njegove reaktivnosti za SDMA,
- manje od 5% njegove reaktivnosti za SDMA, ili
- manje od 1% njegove reaktivnosti za SDMA.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361874011P | 2013-09-05 | 2013-09-05 | |
| PCT/US2014/054278 WO2015035155A1 (en) | 2013-09-05 | 2014-09-05 | Methods for detecting renal disease |
| EP14842603.4A EP3041576B1 (en) | 2013-09-05 | 2014-09-05 | Methods for detecting renal disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191569T1 true HRP20191569T1 (hr) | 2019-11-29 |
Family
ID=52628954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191569 HRP20191569T1 (hr) | 2013-09-05 | 2019-08-30 | Metode za utvrđivanje bolesti bubrega |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11035861B2 (hr) |
| EP (3) | EP4295907A3 (hr) |
| JP (4) | JP6657096B2 (hr) |
| KR (2) | KR102412431B1 (hr) |
| CN (1) | CN105705202B (hr) |
| AU (2) | AU2014315063B2 (hr) |
| CA (2) | CA2923140C (hr) |
| CY (1) | CY1123179T1 (hr) |
| DK (1) | DK3041576T3 (hr) |
| ES (2) | ES2746008T3 (hr) |
| HR (1) | HRP20191569T1 (hr) |
| HU (1) | HUE045723T2 (hr) |
| LT (1) | LT3041576T (hr) |
| MX (2) | MX2016002922A (hr) |
| NZ (1) | NZ717554A (hr) |
| PL (1) | PL3041576T3 (hr) |
| PT (1) | PT3041576T (hr) |
| RS (1) | RS59287B1 (hr) |
| SI (1) | SI3041576T1 (hr) |
| WO (1) | WO2015035155A1 (hr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3041576T (pt) | 2013-09-05 | 2019-09-27 | Idexx Lab Inc | Métodos para detecção de uma doença renal |
| JP6896637B2 (ja) | 2015-02-20 | 2021-06-30 | アイデックス ラボラトリーズ インコーポレイテッドＩＤＥＸＸ Ｌａｂｏｒａｔｏｒｉｅｓ， Ｉｎｃ． | バックグラウンドシグナルを補正するホモジニアスなイムノアッセイ |
| JP6923449B2 (ja) * | 2015-04-30 | 2021-08-18 | アイデックス ラボラトリーズ インコーポレイテッドＩＤＥＸＸ Ｌａｂｏｒａｔｏｒｉｅｓ， Ｉｎｃ． | 腎疾患の検出方法 |
| PL3631472T3 (pl) | 2017-05-31 | 2022-10-17 | Mars, Incorporated | Sposoby diagnozowania i leczenia przewlekłej choroby nerek |
| EP3665705A1 (en) | 2017-08-08 | 2020-06-17 | Fresenius Medical Care Holdings, Inc. | Systems and methods for treating and estimating progression of chronic kidney disease |
| AU2018351349A1 (en) * | 2017-10-19 | 2020-04-23 | Idexx Laboratories, Inc. | Detection of symmetrical dimethylarginine |
| JP6868878B2 (ja) * | 2018-10-17 | 2021-05-12 | Kagami株式会社 | 糸球体濾過能力の決定方法 |
| CN109545377B (zh) * | 2018-10-22 | 2021-11-23 | 中南大学湘雅三医院 | 获取肾小球滤过率的模型的建立方法 |
| US10745492B1 (en) * | 2019-04-03 | 2020-08-18 | Ark Diagnostics, Inc. | Antibodies to symmetrically dimethylated arginine analytes and use thereof |
| WO2021046339A1 (en) * | 2019-09-05 | 2021-03-11 | The Regents Of The University Of California | Noninvasive method to quantify kidney function and functional decline |
| WO2021132658A1 (ja) * | 2019-12-27 | 2021-07-01 | Kagami株式会社 | 腎機能を推定する方法及びシステム |
| JP2021168837A (ja) * | 2020-04-17 | 2021-10-28 | 株式会社藤商事 | 遊技機 |
| CN112768073B (zh) * | 2021-01-15 | 2023-04-18 | 中山大学附属第三医院 | 一种肾小球滤过率估计模型的构建方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3134787A1 (de) * | 1981-09-02 | 1983-03-10 | Boehringer Mannheim Gmbh, 6800 Mannheim | Creatinin-antikoerper |
| US4818703A (en) | 1985-10-23 | 1989-04-04 | Pizzolante John M | Stabilized alkaline picrate reagent for jaffe creatinine determination |
| EP0356160A3 (en) | 1988-08-24 | 1991-09-11 | The Board Of Trustees Of The Leland Stanford Junior University | Capillary device |
| US5726010A (en) | 1991-07-31 | 1998-03-10 | Idexx Laboratories, Inc. | Reversible flow chromatographic binding assay |
| US6455288B1 (en) | 1993-04-08 | 2002-09-24 | Dade Behring Marburg Gmbh | Homogeneous immunoassays using mutant glucose-6-phosphate dehydrogenases |
| US5804452A (en) * | 1995-04-27 | 1998-09-08 | Quidel Corporation | One step urine creatinine assays |
| WO1998049199A1 (en) | 1997-05-01 | 1998-11-05 | Panorama Research, Inc. | Cardiovascular disease risk assessment |
| US6736957B1 (en) | 1997-10-16 | 2004-05-18 | Abbott Laboratories | Biosensor electrode mediators for regeneration of cofactors and process for using |
| US6358699B1 (en) | 1999-02-05 | 2002-03-19 | Cooke Pharma | Assay for asymmetrical NG, NG dimethyl-l-arginine |
| US6699673B2 (en) | 1999-12-22 | 2004-03-02 | The Research Foundation Of State University Of New York | Protein methylarginine-specific antibodies |
| EP1299398A1 (en) | 2000-07-06 | 2003-04-09 | Fal Diagnostics | Methods and kits for the detection of arginine compounds |
| US20040038296A1 (en) * | 2000-07-12 | 2004-02-26 | Werner Naser | Direct assessment of analyte to reference molecule ratios |
| DE10040904A1 (de) | 2000-08-18 | 2002-02-28 | Boeger Rainer H | Verfahren und Mittel zum Nachweis einer Wahrscheinlichkeit zukünftigen Fortschreitens von Gefässerkrankungen |
| US7241856B2 (en) | 2003-06-02 | 2007-07-10 | Pentron Clinical Technologies Llc | Dental resins, dental composite materials, and method of manufacture thereof |
| JP4214271B2 (ja) | 2002-10-15 | 2009-01-28 | アークレイ株式会社 | クレアチニン測定用試験片 |
| US7501053B2 (en) | 2002-10-23 | 2009-03-10 | Abbott Laboratories | Biosensor having improved hematocrit and oxygen biases |
| WO2004046314A2 (en) | 2002-11-15 | 2004-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for detecting asymmetric dimethylarginine in a biological sample |
| US20050148029A1 (en) * | 2003-09-29 | 2005-07-07 | Biosite, Inc. | Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes |
| DE602004020360D1 (de) | 2004-11-04 | 2009-05-14 | Germediq Forsch & Entw Ges Mbh | Methode zur Bestimmung von Arginin, methylierten Argininen und deren Derivate |
| US8725990B1 (en) | 2004-11-15 | 2014-05-13 | Nvidia Corporation | Configurable SIMD engine with high, low and mixed precision modes |
| US7879979B2 (en) | 2005-01-21 | 2011-02-01 | Alere International | Arginine analogs, and methods for their synthesis and use |
| JP2007176872A (ja) | 2005-12-28 | 2007-07-12 | Sentan Seimei Kagaku Kenkyusho:Kk | アシンメトリックジメチルアルギニンを認識する抗体及びその製造方法並びに翻訳後修飾アミノ酸含有タンパク質の検出方法 |
| FR2919063B1 (fr) * | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage du leucocyte elastase inhibitor pour le diagnostic in vitro du cancer colorectal. |
| CN101932722A (zh) * | 2007-12-05 | 2010-12-29 | 伦敦王室学院 | 方法和组合物 |
| DK2313364T3 (da) * | 2008-08-07 | 2020-11-02 | Idexx Lab Inc | Fremgangsmåder til detektering af symmetrisk demethylarginin |
| EP2438441B1 (en) | 2009-06-02 | 2014-05-21 | BIOCRATES Life Sciences AG | New biomarkers for assessing kidney diseases |
| CN101587118B (zh) * | 2009-07-03 | 2012-09-12 | 长春迪瑞医疗科技股份有限公司 | 肌酐尿液分析试纸及制备方法 |
| CN101598727B (zh) * | 2009-07-09 | 2012-10-10 | 上海科华生物工程股份有限公司 | 定量测定人体血液尿素含量的干化学试纸 |
| CN101865911A (zh) * | 2010-03-16 | 2010-10-20 | 苏州市玮琪生物科技有限公司 | 一种尿肌酐定量检测卡 |
| DE102011055265A1 (de) | 2010-11-17 | 2012-05-24 | Karl-Heinz Kellner | Automatenfähiger Immunoassay für biogene Amine |
| JP2012112785A (ja) | 2010-11-24 | 2012-06-14 | Tohoku Univ | 透析膜の評価方法 |
| JP5925026B2 (ja) * | 2011-04-28 | 2016-05-25 | アークレイ株式会社 | クレアチニン測定用乾式試験片及びクレアチニン測定法 |
| US20140038203A1 (en) * | 2012-07-09 | 2014-02-06 | Musc Foundation For Research Development | Methods for detecting or predicting kidney disease |
| PT3041576T (pt) | 2013-09-05 | 2019-09-27 | Idexx Lab Inc | Métodos para detecção de uma doença renal |
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2014
- 2014-09-05 PT PT14842603T patent/PT3041576T/pt unknown
- 2014-09-05 ES ES14842603T patent/ES2746008T3/es active Active
- 2014-09-05 CA CA2923140A patent/CA2923140C/en active Active
- 2014-09-05 JP JP2016540417A patent/JP6657096B2/ja active Active
- 2014-09-05 LT LT14842603T patent/LT3041576T/lt unknown
- 2014-09-05 PL PL14842603T patent/PL3041576T3/pl unknown
- 2014-09-05 MX MX2016002922A patent/MX2016002922A/es unknown
- 2014-09-05 KR KR1020217020124A patent/KR102412431B1/ko active IP Right Grant
- 2014-09-05 RS RSP20191171 patent/RS59287B1/sr unknown
- 2014-09-05 AU AU2014315063A patent/AU2014315063B2/en active Active
- 2014-09-05 CA CA3213810A patent/CA3213810A1/en active Pending
- 2014-09-05 ES ES18196516T patent/ES2969979T3/es active Active
- 2014-09-05 NZ NZ717554A patent/NZ717554A/en unknown
- 2014-09-05 HU HUE14842603A patent/HUE045723T2/hu unknown
- 2014-09-05 EP EP23207400.5A patent/EP4295907A3/en active Pending
- 2014-09-05 DK DK14842603.4T patent/DK3041576T3/da active
- 2014-09-05 EP EP18196516.1A patent/EP3480600B1/en active Active
- 2014-09-05 WO PCT/US2014/054278 patent/WO2015035155A1/en active Application Filing
- 2014-09-05 CN CN201480060296.4A patent/CN105705202B/zh active Active
- 2014-09-05 KR KR1020167009015A patent/KR102273028B1/ko active IP Right Grant
- 2014-09-05 SI SI201431344T patent/SI3041576T1/sl unknown
- 2014-09-05 EP EP14842603.4A patent/EP3041576B1/en active Active
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2016
- 2016-03-04 US US15/061,327 patent/US11035861B2/en active Active
- 2016-03-04 MX MX2021006716A patent/MX2021006716A/es unknown
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2019
- 2019-08-30 HR HRP20191569 patent/HRP20191569T1/hr unknown
- 2019-09-12 CY CY20191100954T patent/CY1123179T1/el unknown
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2020
- 2020-02-05 JP JP2020017580A patent/JP2020073927A/ja active Pending
- 2020-10-16 AU AU2020256440A patent/AU2020256440B2/en active Active
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2021
- 2021-06-09 US US17/343,369 patent/US20220137059A1/en active Pending
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2022
- 2022-02-02 JP JP2022014586A patent/JP2022070879A/ja active Pending
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2023
- 2023-11-14 JP JP2023193309A patent/JP2024020376A/ja active Pending
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