HRP20190516T1 - Antibody molecules to pd-1 and uses thereof - Google Patents
Antibody molecules to pd-1 and uses thereofInfo
- Publication number
- HRP20190516T1 HRP20190516T1 HRP20190516TT HRP20190516T HRP20190516T1 HR P20190516 T1 HRP20190516 T1 HR P20190516T1 HR P20190516T T HRP20190516T T HR P20190516TT HR P20190516 T HRP20190516 T HR P20190516T HR P20190516 T1 HRP20190516 T1 HR P20190516T1
- Authority
- HR
- Croatia
- Prior art keywords
- antibody molecules
- antibody
- molecules
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461931512P | 2014-01-24 | 2014-01-24 | |
US201462059676P | 2014-10-03 | 2014-10-03 | |
US201462094834P | 2014-12-19 | 2014-12-19 | |
EP15703384.6A EP3097121B1 (en) | 2014-01-24 | 2015-01-23 | Antibody molecules to pd-1 and uses thereof |
PCT/US2015/012754 WO2015112900A1 (en) | 2014-01-24 | 2015-01-23 | Antibody molecules to pd-1 and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20190516T1 true HRP20190516T1 (en) | 2019-05-03 |
Family
ID=52463182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20190516TT HRP20190516T1 (en) | 2014-01-24 | 2019-03-15 | Antibody molecules to pd-1 and uses thereof |
Country Status (36)
Country | Link |
---|---|
US (4) | US9683048B2 (en) |
EP (2) | EP3097121B1 (en) |
JP (3) | JP6521986B2 (en) |
KR (1) | KR102357621B1 (en) |
CN (3) | CN111909270A (en) |
AU (2) | AU2015209145B2 (en) |
BR (1) | BR112016015677A2 (en) |
CA (1) | CA2935423C (en) |
CL (1) | CL2016001723A1 (en) |
CY (1) | CY1121542T1 (en) |
DK (1) | DK3097121T3 (en) |
EA (1) | EA201691488A1 (en) |
EC (1) | ECSP16068976A (en) |
ES (1) | ES2716685T3 (en) |
HK (1) | HK1225747B (en) |
HR (1) | HRP20190516T1 (en) |
HU (1) | HUE043363T2 (en) |
IL (2) | IL246382A0 (en) |
JO (2) | JOP20200094A1 (en) |
LT (1) | LT3097121T (en) |
ME (1) | ME03366B (en) |
MX (2) | MX2016009616A (en) |
MY (1) | MY184757A (en) |
NZ (1) | NZ721678A (en) |
PE (1) | PE20170255A1 (en) |
PH (1) | PH12016501456A1 (en) |
PL (1) | PL3097121T3 (en) |
PT (1) | PT3097121T (en) |
RS (1) | RS58535B1 (en) |
SG (2) | SG10201900002QA (en) |
SI (1) | SI3097121T1 (en) |
TN (1) | TN2016000272A1 (en) |
TW (3) | TW202237655A (en) |
UA (1) | UA122479C2 (en) |
UY (1) | UY35967A (en) |
WO (1) | WO2015112900A1 (en) |
Families Citing this family (533)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8709412B2 (en) * | 2001-06-29 | 2014-04-29 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of TIM receptor activity in combination with cytoreductive therapy |
EP3002296B1 (en) * | 2009-03-17 | 2020-04-29 | Université d'Aix-Marseille | Btla antibodies and uses thereof |
CA3154024C (en) | 2010-06-03 | 2024-02-27 | Pharmacyclics Llc | Use of inhibitors of bruton's tyrosine kinase (btk) in the treatment of relapsed or refractory follicular lymphoma |
CN106928362B (en) | 2011-04-29 | 2021-10-26 | 埃派斯进有限公司 | anti-CD 40 antibodies and methods of use thereof |
WO2012166899A2 (en) | 2011-06-03 | 2012-12-06 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
DK3409278T3 (en) | 2011-07-21 | 2020-11-09 | Sumitomo Dainippon Pharma Oncology Inc | Heterocyclic protein kinase inhibitors |
RS55542B1 (en) | 2011-11-29 | 2017-05-31 | Ono Pharmaceutical Co | Purinone derivative hydrochloride |
MX2015001081A (en) | 2012-07-24 | 2015-10-14 | Pharmacyclics Inc | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk). |
WO2014144847A2 (en) | 2013-03-15 | 2014-09-18 | G1 Therapeutics, Inc. | Hspc-sparing treatments for rb-positive abnormal cellular proliferation |
JP2016516772A (en) | 2013-04-09 | 2016-06-09 | リクスト・バイオテクノロジー,インコーポレイテッド | Formulation of oxacycloheptane and oxabicycloheptene |
LT2992017T (en) | 2013-05-02 | 2021-02-25 | Anaptysbio, Inc. | Antibodies directed against programmed death-1 (pd-1) |
ES2822665T3 (en) * | 2013-05-31 | 2021-05-04 | Merck Sharp & Dohme | Combination therapies for cancer |
RS58719B1 (en) | 2013-08-01 | 2019-06-28 | Five Prime Therapeutics Inc | Afucosylated anti-fgfr2iiib antibodies |
AR097306A1 (en) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | MODULATION OF TUMOR IMMUNITY |
CN112552401B (en) | 2013-09-13 | 2023-08-25 | 广州百济神州生物制药有限公司 | anti-PD 1 antibodies and their use as therapeutic and diagnostic agents |
EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
ME03527B (en) | 2013-12-12 | 2020-04-20 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
GB201322626D0 (en) | 2013-12-19 | 2014-02-05 | Immutep S A | Combined preparations for the treatment of cancer |
TWI681969B (en) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | Human antibodies to pd-1 |
TWI680138B (en) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | Human antibodies to pd-l1 |
JOP20200094A1 (en) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | Antibody molecules to pd-1 and uses thereof |
JOP20200096A1 (en) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | Antibody molecules to tim-3 and uses thereof |
US10570202B2 (en) | 2014-02-04 | 2020-02-25 | Pfizer Inc. | Combination of a PD-1 antagonist and a VEGFR inhibitor for treating cancer |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
US9394365B1 (en) * | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
WO2017042633A2 (en) * | 2015-09-10 | 2017-03-16 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns |
US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
KR20200029627A (en) | 2014-03-12 | 2020-03-18 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns |
US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
MX2016011993A (en) | 2014-03-14 | 2016-12-09 | Novartis Ag | Antibody molecules to lag-3 and uses thereof. |
CA2942528A1 (en) | 2014-03-20 | 2015-09-24 | Pharmacyclics Inc. | Phospholipase c gamma 2 and resistance associated mutations |
CA2943834A1 (en) | 2014-03-31 | 2015-10-08 | Genentech, Inc. | Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists |
EA037006B1 (en) | 2014-06-06 | 2021-01-26 | Бристол-Майерс Сквибб Компани | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof |
US10544225B2 (en) | 2014-07-03 | 2020-01-28 | Beigene, Ltd. | Anti-PD-L1 antibodies and their use as therapeutics and diagnostics |
US11186640B2 (en) * | 2014-07-31 | 2021-11-30 | The University Of Western Australia | Method for the identification of immunotherapy-drug combinations using a network approach |
CA2958200A1 (en) | 2014-08-14 | 2016-02-18 | Novartis Ag | Treatment of cancer using a gfr alpha-4 chimeric antigen receptor |
CN107108744B (en) | 2014-08-19 | 2020-09-25 | 诺华股份有限公司 | anti-CD 123 Chimeric Antigen Receptor (CAR) for cancer therapy |
EP4089076A1 (en) | 2014-08-28 | 2022-11-16 | Eisai R&D Management Co., Ltd. | High-purity quinoline derivative and method for manufacturing same |
WO2016040858A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
EP3925622A1 (en) | 2014-09-13 | 2021-12-22 | Novartis AG | Combination therapies |
BR112017005390A2 (en) | 2014-09-17 | 2017-12-12 | Novartis Ag | target cytotoxic cells with chimeric receptors for adoptive immunotherapy |
CN107106687A (en) * | 2014-10-03 | 2017-08-29 | 诺华股份有限公司 | Combined therapy |
JP6815992B2 (en) | 2014-10-08 | 2021-01-20 | ノバルティス アーゲー | Biomarkers predicting therapeutic response to chimeric antigen receptor therapy and their use |
MA41044A (en) | 2014-10-08 | 2017-08-15 | Novartis Ag | COMPOSITIONS AND METHODS OF USE FOR INCREASED IMMUNE RESPONSE AND CANCER TREATMENT |
EP4245376A3 (en) | 2014-10-14 | 2023-12-13 | Novartis AG | Antibody molecules to pd-l1 and uses thereof |
SG10201914022QA (en) | 2014-11-13 | 2020-03-30 | Univ Johns Hopkins | Checkpoint blockade and microsatellite instability |
WO2016090034A2 (en) | 2014-12-03 | 2016-06-09 | Novartis Ag | Methods for b cell preconditioning in car therapy |
TWI595006B (en) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | Anti-pd-1 antibodies and methods of use thereof |
GB201500374D0 (en) | 2015-01-09 | 2015-02-25 | Immutep S A | Combined preparations for the treatment of cancer |
MA41414A (en) * | 2015-01-28 | 2017-12-05 | Centre Nat Rech Scient | ICOS AGONIST BINDING PROTEINS |
WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
MX2017010299A (en) * | 2015-02-09 | 2017-11-10 | Synta Pharmaceuticals Corp | Combination therapy of hsp90 inhibitors and pd-1 inhibitors for treating cancer. |
SI3258951T1 (en) | 2015-02-19 | 2020-07-31 | Compugen Ltd. | Anti-pvrig antibodies and methods of use |
RS65049B1 (en) | 2015-02-25 | 2024-02-29 | Eisai R&D Man Co Ltd | Method for suppressing bitterness of quinoline derivative |
SG10201810615VA (en) | 2015-02-26 | 2019-01-30 | Merck Patent Gmbh | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
CA2978311A1 (en) | 2015-03-04 | 2016-09-09 | Merck Sharp & Dohme Corp. | Combination of a pd-1 antagonist and eribulin for treating cancer |
CA2978226A1 (en) * | 2015-03-04 | 2016-09-09 | Merck Sharpe & Dohme Corp. | Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer |
BR112017018908A2 (en) | 2015-03-10 | 2018-04-17 | Aduro Biotech, Inc. | compositions and methods for activating interferon gene stimulator-dependent signaling |
EP3067062A1 (en) * | 2015-03-13 | 2016-09-14 | Ipsen Pharma S.A.S. | Combination of tasquinimod or a pharmaceutically acceptable salt thereof and a pd1 and/or pdl1 inhibitor, for use as a medicament |
EP3271483B1 (en) * | 2015-03-17 | 2021-07-21 | Mayo Foundation for Medical Education and Research | Methods and materials for assessing and treating cancer |
SG11201707583RA (en) * | 2015-03-17 | 2017-10-30 | Omniox Inc | MODULATION OF TUMOR IMMUNITY BY PROTEIN-MEDIATED 0<sb>2</sb> DELIVERY |
TWI703984B (en) * | 2015-04-03 | 2020-09-11 | 英商阿斯特克斯治療有限公司 | Fgfr/pd-1 combination therapy for the treatment of cancer |
US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
US20180140602A1 (en) | 2015-04-07 | 2018-05-24 | Novartis Ag | Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives |
EP4234685A3 (en) | 2015-04-17 | 2023-09-06 | Novartis AG | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
US10864180B2 (en) * | 2015-04-23 | 2020-12-15 | The Johns Hopkins University | Combination of immunotherapy with local chemotherapy for the treatment of malignancies |
US20160347836A1 (en) * | 2015-05-28 | 2016-12-01 | Bristol-Myers Squibb Company | Treatment of hodgkin's lymphoma using an anti-pd-1 antibody |
US20180237534A1 (en) | 2015-05-29 | 2018-08-23 | Bristol-Myers Squibb Company | Antibodies against ox40 and uses thereof |
KR20180038440A (en) * | 2015-06-09 | 2018-04-16 | 렉산 파마슈티컬스, 인코포레이티드 | Fluorocyclopentenylcytosine applications and methods of manufacture |
IL256245B (en) | 2015-06-16 | 2022-09-01 | Merck Patent Gmbh | Pd-l1 antagonist combination treatments |
ES2886107T3 (en) | 2015-06-16 | 2021-12-16 | Prism Biolab Co Ltd | Antineoplastic |
SG10201913303XA (en) | 2015-07-13 | 2020-03-30 | Cytomx Therapeutics Inc | Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof |
EP3858859A1 (en) * | 2015-07-14 | 2021-08-04 | Bristol-Myers Squibb Company | Method of treating cancer using immune checkpoint inhibitor; antibody that binds to programmed death-1 receptor (pd-1) or programmed death ligand 1 (pd-l1) |
KR20180036974A (en) | 2015-07-16 | 2018-04-10 | 바이오엑셀 테라퓨틱스 인코포레이티드 | A novel approach to the treatment of cancer using immunomodulation |
JP7146632B2 (en) | 2015-07-21 | 2022-10-04 | ノバルティス アーゲー | Methods of Improving Immune Cell Efficacy and Expansion |
WO2017019897A1 (en) | 2015-07-29 | 2017-02-02 | Novartis Ag | Combination therapies comprising antibody molecules to tim-3 |
CA2991857A1 (en) * | 2015-07-29 | 2017-02-02 | Novartis Ag | Novel combination for use in the treatment of cancer |
CN108235685A (en) * | 2015-07-29 | 2018-06-29 | 诺华股份有限公司 | The combination of PD-1 antagonists and EGFR inhibitor |
DK3317301T3 (en) * | 2015-07-29 | 2021-06-28 | Immutep Sas | COMBINATION THERAPIES INCLUDING ANTIBODY MOLECULES AGAINST LAYER-3 |
CN108025051B (en) * | 2015-07-29 | 2021-12-24 | 诺华股份有限公司 | Combination therapy comprising anti-PD-1 antibody molecules |
HRP20211645T1 (en) | 2015-07-30 | 2022-02-04 | Macrogenics, Inc. | Pd-1-binding molecules and methods of use thereof |
US20190010231A1 (en) * | 2015-08-07 | 2019-01-10 | Pieris Pharmaceuticals Gmbh | Novel fusion polypeptide specific for lag-3 and pd-1 |
AU2016306090B2 (en) | 2015-08-11 | 2019-05-02 | Novartis Ag | 5-bromo-2,6-di-(1H-pyrazol-l-yl)pyrimidin-4-amine for use in the treatment of cancer |
WO2017030956A1 (en) * | 2015-08-14 | 2017-02-23 | Agenus Inc. | Method of inducing a t-cell response to phosphopeptides using nucleic acids encoding phosphopeptide mimetics |
WO2017040660A1 (en) * | 2015-08-31 | 2017-03-09 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
PE20181322A1 (en) | 2015-09-01 | 2018-08-14 | Agenus Inc | ANTI-PD1 ANTIBODY AND ITS METHODS OF USE |
CN108780084B (en) | 2015-09-03 | 2022-07-22 | 诺华股份有限公司 | Biomarkers predictive of cytokine release syndrome |
US10894044B2 (en) * | 2015-09-16 | 2021-01-19 | Board Of Regents, The University Of Texas System | Combination of topoisomerase-I inhibitors with immunotherapy in the treatment of cancer |
EP3356416B1 (en) * | 2015-09-29 | 2021-03-24 | Shanghai Zhangjiang Biotechnology Co., Ltd | Pd-1 antibodies and uses thereof |
AU2016332725A1 (en) * | 2015-09-29 | 2018-03-22 | Celgene Corporation | PD-1 binding proteins and methods of use thereof |
CA3000564A1 (en) * | 2015-10-02 | 2017-04-06 | Symphogen A/S | Anti-pd-1 antibodies and compositions |
EP3356403A2 (en) | 2015-10-02 | 2018-08-08 | H. Hoffnabb-La Roche Ag | Bispecific antibodies specific for a costimulatory tnf receptor |
HUE055407T2 (en) | 2015-10-02 | 2021-11-29 | Hoffmann La Roche | Bispecific antibodies specific for pd1 and tim3 |
CN105175544B (en) * | 2015-10-20 | 2021-04-09 | 安徽瀚海博兴生物技术有限公司 | anti-PD-1 humanized monoclonal antibody and application thereof |
WO2017079303A1 (en) * | 2015-11-02 | 2017-05-11 | The Cleveland Clinic Foundation | Sequentially orchestrated immune checkpoint therapy for the treatment and prevention of cancer |
BR112018008904A2 (en) | 2015-11-03 | 2018-11-27 | Janssen Biotech Inc | antibodies specifically binding to tim-3 and their uses |
EP3973988A1 (en) * | 2015-11-04 | 2022-03-30 | Duke University | Combination therapy of immunotoxin and checkpoint inhibitor |
EP3371311B1 (en) | 2015-11-06 | 2021-07-21 | Orionis Biosciences BV | Bi-functional chimeric proteins and uses thereof |
CA3132021C (en) | 2015-11-18 | 2024-03-12 | Merck Sharp & Dohme Corp. | Pd1 and/or lag3 binders |
CN116327924A (en) * | 2015-11-23 | 2023-06-27 | 戊瑞治疗有限公司 | FGFR2 inhibitors alone or in combination with immunostimulants for cancer treatment |
MX2018007423A (en) * | 2015-12-17 | 2018-11-09 | Novartis Ag | Antibody molecules to pd-1 and uses thereof. |
US10392442B2 (en) | 2015-12-17 | 2019-08-27 | Bristol-Myers Squibb Company | Use of anti-PD-1 antibody in combination with anti-CD27 antibody in cancer treatment |
WO2017106810A2 (en) * | 2015-12-17 | 2017-06-22 | Novartis Ag | Combination of c-met inhibitor with antibody molecule to pd-1 and uses thereof |
UY37030A (en) | 2015-12-18 | 2017-07-31 | Novartis Ag | ANTIBODIES DIRECTED TO CD32B AND METHODS OF USE OF THE SAME |
WO2017112741A1 (en) | 2015-12-22 | 2017-06-29 | Novartis Ag | Mesothelin chimeric antigen receptor (car) and antibody against pd-l1 inhibitor for combined use in anticancer therapy |
EP3397962A1 (en) * | 2015-12-29 | 2018-11-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of patients suffering from a microsatellite unstable cancer |
KR20180100652A (en) | 2016-01-08 | 2018-09-11 | 유클리세스 파마슈티컬스 인코포레이티드 | A combination of a chromene compound and a second activator |
JP6993699B2 (en) | 2016-01-11 | 2022-02-03 | ウニヴェルズィテート・ツューリヒ | Immunostimulatory humanized monoclonal antibody against human interleukin-2 and its fusion protein |
US20210206854A1 (en) * | 2016-01-27 | 2021-07-08 | Bristol-Myers Squibb Company | Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent |
US10822415B2 (en) * | 2016-01-28 | 2020-11-03 | Inserm (Institut National De La Santéet De La Recherche Médicale) | Methods for enhancing the potency of the immune checkpoint inhibitors |
CN115850521A (en) | 2016-02-05 | 2023-03-28 | 奥里尼斯生物科学私人有限公司 | Targeted therapeutic agents and uses thereof |
BR112018015485A2 (en) | 2016-02-06 | 2018-12-18 | Epimab Biotherapeutics Inc | fabs-in-tandem immunoglobulin and its uses |
WO2017139470A1 (en) * | 2016-02-09 | 2017-08-17 | The General Hospital Corporation | Classification and treatment of gastric cancer |
JP2019512020A (en) | 2016-02-12 | 2019-05-09 | マディソン ヴァクシーンズ インコーポレイテッド | Cancer treatment |
MA44236A (en) | 2016-02-17 | 2018-12-26 | Novartis Ag | ANTI-TGFBETA ANTIBODY 2 |
CN109153714A (en) | 2016-03-04 | 2019-01-04 | 诺华股份有限公司 | Express the cell and application thereof of multiple Chimeric antigen receptor (CAR) molecule |
US10537633B2 (en) | 2016-03-04 | 2020-01-21 | Jn Biosciences Llc | Antibodies to TIGIT |
US10842743B2 (en) * | 2016-04-08 | 2020-11-24 | The Regents Of The University Of California | Modified hyaluronic acid hydrogels and proteins for the time-controlled release of biologic agents |
JP7128399B2 (en) * | 2016-04-14 | 2022-08-31 | クリエイティブ マイクロテック インコーポレーテッド | Methods of Using PD-L1 Expression in Treatment Decisions for Cancer Treatment |
TWI794171B (en) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Combination therapies of hdac inhibitors and pd-l1 inhibitors |
TWI808055B (en) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Combination therapies of hdac inhibitors and pd-1 inhibitors |
TWI822521B (en) | 2016-05-13 | 2023-11-11 | 美商再生元醫藥公司 | Methods of treating skin cancer by administering a pd-1 inhibitor |
EP3243832A1 (en) | 2016-05-13 | 2017-11-15 | F. Hoffmann-La Roche AG | Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety |
US11753463B2 (en) | 2016-05-13 | 2023-09-12 | Orionis Biosciences BV | Therapeutic targeting of non-cellular structures |
JP7105200B2 (en) | 2016-05-13 | 2022-07-22 | オリオニス バイオサイエンシズ ビーブイ | Targeted mutant interferon-beta and its uses |
US11414491B2 (en) | 2016-05-18 | 2022-08-16 | Mayo Foundation For Medical Education And Research | Targeting PD-L1 on tumor cells |
KR20230119265A (en) | 2016-06-02 | 2023-08-16 | 브리스톨-마이어스 스큅 컴퍼니 | Use of an anti-pd-1 antibody in combination with an anti-cd30 antibody in lymphoma treatment |
JP7175198B2 (en) | 2016-06-02 | 2022-11-18 | ブリストル-マイヤーズ スクイブ カンパニー | PD-1 Blockade with Nivolumab in Refractory Hodgkin Lymphoma |
CN109475634A (en) | 2016-06-03 | 2019-03-15 | 百时美施贵宝公司 | For treating the anti-PD-1 antibody of the method for relapsed small cell lung cancer |
KR20190015408A (en) | 2016-06-03 | 2019-02-13 | 브리스톨-마이어스 스큅 컴퍼니 | Anti-PD-1 antibody for use in methods of treating tumors |
EP3464373B1 (en) | 2016-06-03 | 2021-10-27 | Bristol-Myers Squibb Company | Use of anti-pd-1 antibody in the treatment of patients with colorectal cancer |
JP2019517549A (en) * | 2016-06-10 | 2019-06-24 | ノバルティス アーゲー | Therapeutic use of C-RAF inhibitors |
KR102523402B1 (en) * | 2016-06-14 | 2023-04-19 | 젠코어 인코포레이티드 | Bispecific Checkpoint Inhibitor Antibodies |
EP3471753A1 (en) | 2016-06-20 | 2019-04-24 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
KR20190031492A (en) | 2016-06-30 | 2019-03-26 | 난트 홀딩스 아이피, 엘엘씨 | NANT CANCER VACCINE |
EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
WO2018007885A1 (en) | 2016-07-05 | 2018-01-11 | Beigene, Ltd. | COMBINATION OF A PD-l ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER |
KR20190034588A (en) * | 2016-07-28 | 2019-04-02 | 노파르티스 아게 | Combination therapy of chimeric antigen receptor and PD-1 inhibitor |
WO2018027204A1 (en) | 2016-08-05 | 2018-02-08 | Genentech, Inc. | Multivalent and multiepitopic anitibodies having agonistic activity and methods of use |
CA3032949A1 (en) * | 2016-08-09 | 2018-02-15 | Angimmune, Llc | Treatment of cancer using a combination of immunomodulation and check point inhibitors |
US11858996B2 (en) | 2016-08-09 | 2024-01-02 | Kymab Limited | Anti-ICOS antibodies |
WO2018033135A1 (en) | 2016-08-19 | 2018-02-22 | Beigene, Ltd. | Use of a combination comprising a btk inhibitor for treating cancers |
WO2018049015A1 (en) | 2016-09-07 | 2018-03-15 | Trustees Of Tufts College | Combination therapies using immuno-dash inhibitors and pd-1 antagonists |
AU2017328309B2 (en) | 2016-09-14 | 2020-10-15 | Beijing Hanmi Pharm. Co., Ltd. | Antibody specifically binding to PD-1 and functional fragment thereof |
SI3512547T1 (en) * | 2016-09-14 | 2021-01-29 | Abbvie Biotherapeutics Inc. | Anti-pd-1 antibodies |
US10751414B2 (en) | 2016-09-19 | 2020-08-25 | Celgene Corporation | Methods of treating psoriasis using PD-1 binding antibodies |
CN106350488B (en) * | 2016-09-19 | 2019-09-27 | 大连大学 | PD-1 for treating tumour closes the preparation method of CIK |
US10766958B2 (en) | 2016-09-19 | 2020-09-08 | Celgene Corporation | Methods of treating vitiligo using PD-1 binding antibodies |
WO2018055503A1 (en) * | 2016-09-20 | 2018-03-29 | Novartis Ag | Combination comprising a pd-1 antagonist and an fgfr4 inhibitor |
MX2019003058A (en) * | 2016-09-21 | 2019-11-28 | Cstone Pharmaceuticals | The novel monoclonal antibodies to programmed death 1 (pd-1). |
EP4026849A1 (en) * | 2016-09-26 | 2022-07-13 | Ensemble Group Holdings | Methods of assessing and treating cancer in subjects having dysregulated lymphatic systems using a combination of vegfr-3 and pd-1 or pd-l1 inhibitors |
CN109790215B (en) | 2016-09-29 | 2023-06-30 | 北京韩美药品有限公司 | Heterodimeric immunoglobulin constructs and methods of making the same |
JP2019530704A (en) | 2016-10-06 | 2019-10-24 | ファイザー・インコーポレイテッド | Avelumab dosing regimen for the treatment of cancer |
CN110072540B (en) | 2016-10-12 | 2023-06-02 | 得克萨斯州大学系统董事会 | Methods and compositions for TUSC2 immunotherapy |
US11084859B2 (en) | 2016-10-24 | 2021-08-10 | Orionis Biosciences BV | Targeted mutant interferon-gamma and uses thereof |
WO2018081621A1 (en) | 2016-10-28 | 2018-05-03 | Bristol-Myers Squibb Company | Methods of treating urothelial carcinoma using an anti-pd-1 antibody |
KR20190101364A (en) | 2016-11-01 | 2019-08-30 | 테사로, 인코포레이티드 | Antibody Against Probable Death-1 (PD-1) |
ES2898025T3 (en) | 2016-11-02 | 2022-03-03 | Jounce Therapeutics Inc | Antibodies against PD-1 and their uses |
BR112019008426A2 (en) * | 2016-11-02 | 2019-09-03 | Engmab Sarl | bispecific antibody against bcma and cd3 and an immunological drug for combined use in the treatment of multiple myeloma |
KR20230141941A (en) | 2016-11-03 | 2023-10-10 | 브리스톨-마이어스 스큅 컴퍼니 | Activatable anti-ctla-4 antibodies and uses thereof |
US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
EP3534933A4 (en) | 2016-11-04 | 2020-06-24 | Aximmune, Inc. | Beta-alethine, immune modulators, and uses thereof |
WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
EP3541841A1 (en) * | 2016-11-18 | 2019-09-25 | Symphogen A/S | Anti-pd-1 antibodies and compositions |
TN2019000161A1 (en) | 2016-11-18 | 2020-10-05 | Beijing Hanmi Pharmaceutical Co Ltd | Anti-pd-1/anti-her2 natural antibody structure-like bispecific antibody of heterodimeric form and preparation thereof |
WO2018102786A1 (en) | 2016-12-03 | 2018-06-07 | Juno Therapeutics, Inc. | Methods for modulation of car-t cells |
BR112019011410A2 (en) | 2016-12-05 | 2019-10-22 | G1 Therapeutics Inc | methods for treating a patient having cancer, for increasing a proinflammatory immune effector cell population, for increasing the level of t-cell activation, for reducing the population of regulatory t-cells, for inhibiting the immunosuppressive function of regulatory t-cells, for the long-term enhancement of tumor-specific memory t-cell generation and to protect intratumoral immune cells from chemotherapy. |
JOP20190133A1 (en) | 2016-12-08 | 2019-06-02 | Innovent Biologics Suzhou Co Ltd | Anti-tim-3 antibodies for combination with anti-pd-1 antibodies |
CN108239083B (en) | 2016-12-26 | 2021-08-17 | 阿里根公司 | Aromatic hydrocarbon receptor modulators |
US11512134B2 (en) | 2017-08-01 | 2022-11-29 | Eli Lilly And Company | Anti-CD137 antibodies |
EA039433B1 (en) * | 2017-01-05 | 2022-01-27 | Нетрис Фарма | Combined treatment with netrin-1 interfering drugs and immune checkpoint inhibitors drugs |
JP7267921B2 (en) | 2017-01-06 | 2023-05-02 | クレシェンド・バイオロジックス・リミテッド | Single domain antibody against programmed cell death (PD-1) |
DK3565844T3 (en) | 2017-01-09 | 2023-05-01 | Tesaro Inc | Methods of treating cancer with anti-PD-1 antibodies |
US10350266B2 (en) * | 2017-01-10 | 2019-07-16 | Nodus Therapeutics, Inc. | Method of treating cancer with a multiple integrin binding Fc fusion protein |
CA3049656A1 (en) | 2017-01-10 | 2018-07-19 | Nodus Therapeutics | Combination tumor treatment with an integrin-binding-fc fusion protein and immune modulator |
CN117586401A (en) | 2017-01-20 | 2024-02-23 | 大有华夏生物医药集团有限公司 | anti-PD-1 antibodies and uses thereof |
WO2018134782A1 (en) | 2017-01-20 | 2018-07-26 | Novartis Ag | Combination therapy for the treatment of cancer |
TWI788321B (en) | 2017-01-20 | 2023-01-01 | 美商健臻公司 | Bone-targeting antibodies |
TWI787230B (en) | 2017-01-20 | 2022-12-21 | 法商賽諾菲公司 | Anti-tgf-beta antibodies and their use |
EA201991729A1 (en) | 2017-01-20 | 2019-12-30 | Санофи | ANTIBODIES TO TGF-BETA AND THEIR APPLICATION |
CN108341872B (en) | 2017-01-23 | 2020-05-19 | 科济生物医药(上海)有限公司 | Antibodies targeting BCMA and uses thereof |
CN108341871A (en) * | 2017-01-24 | 2018-07-31 | 三生国健药业(上海)股份有限公司 | Anti- PD-1 monoclonal antibodies and its preparation method and application |
EP3573989A4 (en) | 2017-01-25 | 2020-11-18 | Beigene, Ltd. | Crystalline forms of (s) -7- (1- (but-2-ynoyl) piperidin-4-yl) -2- (4-phenoxyphenyl) -4, 5, 6, 7-tetrahy dropyrazolo [1, 5-a]pyrimidine-3-carboxamide, preparation, and uses thereof |
US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
JOP20190187A1 (en) | 2017-02-03 | 2019-08-01 | Novartis Ag | Anti-ccr7 antibody drug conjugates |
EP3577133A1 (en) | 2017-02-06 | 2019-12-11 | Orionis Biosciences NV | Targeted chimeric proteins and uses thereof |
WO2018144999A1 (en) | 2017-02-06 | 2018-08-09 | Orionis Biosciences, Inc. | Targeted engineered interferon and uses thereof |
HUE057337T2 (en) | 2017-02-10 | 2022-05-28 | Novartis Ag | 1-(4-amino-5-bromo-6-(1 h-pyrazol-1-yl)pyrimidin-2-yl)-1 h-pyrazol-4-ol and use thereof in the treatment of cancer |
TWI674261B (en) | 2017-02-17 | 2019-10-11 | 美商英能腫瘤免疫股份有限公司 | Nlrp3 modulators |
KR20240011262A (en) | 2017-02-21 | 2024-01-25 | 리제너론 파아마슈티컬스, 인크. | Anti-pd-1 antibodies for treatment of lung cancer |
WO2018160540A1 (en) | 2017-02-28 | 2018-09-07 | Sanofi | Therapeutic rna |
US11161905B2 (en) | 2017-03-04 | 2021-11-02 | Xiangtan Tenghua Bioscience | Recombinant antibodies to programmed death 1 (PD-1) and uses thereof |
WO2018183928A1 (en) | 2017-03-31 | 2018-10-04 | Bristol-Myers Squibb Company | Methods of treating tumor |
WO2018178250A1 (en) | 2017-03-31 | 2018-10-04 | Boehringer Ingelheim International Gmbh | Anticancer combination therapy |
EA201992311A1 (en) | 2017-04-01 | 2020-05-15 | Бэйцзин Ханми Фарм. Ко., Лтд. | HETERODIMERIC BESPECIFIC ANTIBODY TO PD-L1 / PD-1 WITH A STRUCTURE SIMILAR TO NATURAL ANTIBODY AND ITS OBTAINING |
KR20200020662A (en) * | 2017-04-03 | 2020-02-26 | 온콜로지, 인크. | How to Treat Cancer Using PS-Targeted Antibodies with Immuno-Oncology Agent |
HUE059885T2 (en) * | 2017-04-03 | 2023-01-28 | Hoffmann La Roche | Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15 |
EA201992350A1 (en) | 2017-04-05 | 2020-03-23 | Симфоген А/С | COMBINED MEDICINES AIMED AT PD-1, TIM-3 AND LAG-3 |
BR112019021032A2 (en) | 2017-04-05 | 2020-05-05 | Boehringer Ingelheim Int | anticancer combination therapy |
TWI690538B (en) | 2017-04-05 | 2020-04-11 | 瑞士商赫孚孟拉羅股份公司 | Bispecific antibodies specifically binding to pd1 and lag3 |
US11603407B2 (en) | 2017-04-06 | 2023-03-14 | Regeneron Pharmaceuticals, Inc. | Stable antibody formulation |
US11559537B2 (en) | 2017-04-07 | 2023-01-24 | Trustees Of Tufts College | Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists |
TWI788340B (en) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | Anti-icos agonist antibodies and uses thereof |
EP3610022A1 (en) | 2017-04-14 | 2020-02-19 | Tollnine, Inc. | Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use |
CN106939049B (en) * | 2017-04-20 | 2019-10-01 | 苏州思坦维生物技术股份有限公司 | The monoclonal antibody and the preparation method and application thereof of antagonism inhibition people PD-1 antigen and its ligand binding |
WO2018231339A2 (en) * | 2017-04-20 | 2018-12-20 | Dana-Farber Cancer Institute, Inc. | Anti-phosphotyrosinylated pd-1 antibodies and uses thereof |
UY37695A (en) | 2017-04-28 | 2018-11-30 | Novartis Ag | BIS 2’-5’-RR- (3’F-A) (3’F-A) CYCLE DINUCLEOTIDE COMPOUND AND USES OF THE SAME |
AR111651A1 (en) | 2017-04-28 | 2019-08-07 | Novartis Ag | CONJUGATES OF ANTIBODIES THAT INCLUDE TOLL TYPE RECEIVER AGONISTS AND COMBINATION THERAPIES |
CN110621336A (en) | 2017-05-16 | 2019-12-27 | 戊瑞治疗有限公司 | Combination of an anti-FGFR 2 antibody with a chemotherapeutic agent in the treatment of cancer |
US11685787B2 (en) | 2017-05-16 | 2023-06-27 | Bristol-Myers Squibb Company | Treatment of cancer with anti-GITR agonist antibodies |
AR111760A1 (en) | 2017-05-19 | 2019-08-14 | Novartis Ag | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF SOLID TUMORS THROUGH INTRATUMORAL ADMINISTRATION |
CA3065304A1 (en) | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Compositions comprising an anti-lag-3 antibody or an anti-lag-3 antibody and an anti-pd-1 or anti-pd-l1 antibody |
WO2018222718A1 (en) | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Treatment of lag-3 positive tumors |
CA3060989A1 (en) | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Compositions comprising a combination of an anti-lag-3 antibody, a pd-1 pathway inhibitor, and an immunotherapeutic agent |
JOP20190279A1 (en) | 2017-05-31 | 2019-11-28 | Novartis Ag | Crystalline forms of 5-bromo-2,6-di(1 h-pyrazol-1-yl)pyrimidin-4-amine and new salts |
SG10202111336RA (en) | 2017-06-01 | 2021-11-29 | Compugen Ltd | Triple combination antibody therapies |
WO2018223004A1 (en) | 2017-06-01 | 2018-12-06 | Xencor, Inc. | Bispecific antibodies that bind cd20 and cd3 |
WO2018223040A1 (en) | 2017-06-01 | 2018-12-06 | Bristol-Myers Squibb Company | Methods of treating a tumor using an anti-pd-1 antibody |
EP3630839A1 (en) | 2017-06-01 | 2020-04-08 | Xencor, Inc. | Bispecific antibodies that bind cd 123 cd3 |
CN110691790A (en) | 2017-06-02 | 2020-01-14 | 勃林格殷格翰国际有限公司 | Anticancer combination therapy |
CA3065120A1 (en) | 2017-06-02 | 2018-12-06 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
EP3634995A4 (en) | 2017-06-05 | 2021-06-09 | Janssen Biotech, Inc. | Antibodies that specifically bind pd-1 and methods of use |
WO2018226336A1 (en) * | 2017-06-09 | 2018-12-13 | Providence Health & Services - Oregon | Utilization of cd39 and cd103 for identification of human tumor reactive cells for treatment of cancer |
WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
GB201709808D0 (en) | 2017-06-20 | 2017-08-02 | Kymab Ltd | Antibodies |
CA3061874A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Il-1beta binding antibodies for use in treating cancer |
AU2018290237A1 (en) | 2017-06-22 | 2020-01-16 | Novartis Ag | Antibody molecules to CD73 and uses thereof |
WO2018235056A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Il-1beta binding antibodies for use in treating cancer |
EP3642240A1 (en) | 2017-06-22 | 2020-04-29 | Novartis AG | Antibody molecules to cd73 and uses thereof |
WO2019005635A2 (en) * | 2017-06-25 | 2019-01-03 | Systimmune, Inc. | Anti-pd-1 antibodies and methods of making and using thereof |
AU2018290532A1 (en) | 2017-06-26 | 2019-11-21 | Beigene, Ltd. | Immunotherapy for hepatocellular carcinoma |
CA3066747A1 (en) | 2017-06-27 | 2019-01-03 | Novartis Ag | Dosage regimens for anti-tim-3 antibodies and uses thereof |
EP3421494A1 (en) | 2017-06-29 | 2019-01-02 | Sanofi | Use of isatuximab in combination with an anti-pd-1 antibody |
CN111050545A (en) | 2017-06-29 | 2020-04-21 | 朱诺治疗学股份有限公司 | Mouse model for evaluating toxicity associated with immunotherapy |
US11667714B2 (en) * | 2017-07-06 | 2023-06-06 | Merus N.V. | Binding molecules that modulate a biological activity expressed by a cell |
US20200283535A1 (en) * | 2017-07-06 | 2020-09-10 | Tusk Therapeutics Ltd. | Compounds and methods for tumour-specific cell depletion |
AR112603A1 (en) * | 2017-07-10 | 2019-11-20 | Lilly Co Eli | BIS SPECIFIC ANTIBODIES CONTROL POINT INHIBITORS |
BR112020000523A2 (en) | 2017-07-14 | 2020-07-14 | Innate Tumor Immunity, Inc. | nlrp3 modulators |
CN111163798A (en) | 2017-07-20 | 2020-05-15 | 诺华股份有限公司 | Dosing regimens for anti-LAG-3 antibodies and uses thereof |
ES2932354T3 (en) | 2017-07-28 | 2023-01-18 | Bristol Myers Squibb Co | Cyclic dinucleotides as anticancer agents |
BR112020002013B1 (en) | 2017-08-03 | 2023-01-24 | Amgen Inc | IL-21 MUTEINS, METHOD OF PREPARATION, NUCLEIC ACID, VECTOR, HOST CELL, KIT, USE OF THEM AND PHARMACEUTICAL COMPOSITION |
WO2019046496A1 (en) | 2017-08-31 | 2019-03-07 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
KR102651946B1 (en) | 2017-08-31 | 2024-03-26 | 브리스톨-마이어스 스큅 컴퍼니 | Cyclic dinucleotides as anticancer agents |
US10953032B2 (en) | 2017-08-31 | 2021-03-23 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
CN111133005A (en) | 2017-09-07 | 2020-05-08 | 奥古斯塔大学研究所公司 | Programmed cell death protein 1 antibodies |
JP7196160B2 (en) | 2017-09-12 | 2022-12-26 | スミトモ ファーマ オンコロジー, インコーポレイテッド | Treatment Regimens for Cancers Insensitive to BCL-2 Inhibitors Using the MCL-1 Inhibitor Albocidib |
UY37900A (en) | 2017-09-26 | 2019-04-30 | Novartis Ag | NEW DERIVATIVES OF RAPAMYCIN |
WO2019063802A1 (en) | 2017-09-29 | 2019-04-04 | Boehringer Ingelheim International Gmbh | Anti igf, anti pd-1 anti-cancer combination therapy |
WO2019070908A1 (en) * | 2017-10-03 | 2019-04-11 | Cedars-Sinai Medical Center | Methods for targeting the immune checkpoint pd1 pathway for treating pulmonary fibrosis |
US10973882B2 (en) | 2017-10-03 | 2021-04-13 | Cedars-Sinai Medical Center | Methods for reducing severity of pulmonary fibrosis |
JP7212683B2 (en) | 2017-10-10 | 2023-01-25 | ブリストル-マイヤーズ スクイブ カンパニー | Cyclic dinucleotides as anticancer agents |
WO2019075468A1 (en) | 2017-10-15 | 2019-04-18 | Bristol-Myers Squibb Company | Methods of treating tumor |
JP7254821B2 (en) | 2017-10-16 | 2023-04-10 | ブリストル-マイヤーズ スクイブ カンパニー | Cyclic dinucleotides as anticancer agents |
EP3700933A1 (en) | 2017-10-25 | 2020-09-02 | Novartis AG | Antibodies targeting cd32b and methods of use thereof |
AU2018360800A1 (en) | 2017-11-01 | 2020-05-14 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for B-cell maturation antigen (BCMA) |
SG11202003501XA (en) | 2017-11-01 | 2020-05-28 | Juno Therapeutics Inc | Antibodies and chimeric antigen receptors specific for b-cell maturation antigen |
US20210132042A1 (en) | 2017-11-01 | 2021-05-06 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
CA3077664A1 (en) | 2017-11-06 | 2019-05-09 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
CN111315397A (en) | 2017-11-06 | 2020-06-19 | 百时美施贵宝公司 | Method for treating tumors |
CA3082383A1 (en) * | 2017-11-08 | 2019-05-16 | Xencor, Inc. | Bispecific and monospecific antibodies using novel anti-pd-1 sequences |
AU2018369841A1 (en) | 2017-11-14 | 2020-05-07 | Pfizer Inc. | EZH2 inhibitor combination therapies |
CN109793892B (en) * | 2017-11-16 | 2022-07-26 | 江苏恒瑞医药股份有限公司 | Application of anti-PD-1 antibody in preparation of medicine for treating esophageal cancer |
CN111065411B (en) * | 2017-11-16 | 2023-03-10 | 江苏恒瑞医药股份有限公司 | Use of PD-1 antibody and VEGFR inhibitor for combined treatment of small cell lung cancer |
US20200277378A1 (en) | 2017-11-16 | 2020-09-03 | Novartis Ag | Combination therapies |
TW201925194A (en) | 2017-11-20 | 2019-07-01 | 美商雅里俊公司 | Indole compounds and their use |
US11786529B2 (en) | 2017-11-29 | 2023-10-17 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors |
EP3717907A1 (en) | 2017-11-30 | 2020-10-07 | Novartis AG | Bcma-targeting chimeric antigen receptor, and uses thereof |
JP2021505659A (en) * | 2017-12-01 | 2021-02-18 | ソリシメド バイオファーマ インコーポレイテッド | TRPV6 Inhibitors and Combination Therapies for Cancer Treatment |
DK3720879T3 (en) * | 2017-12-05 | 2022-06-20 | Progastrine Et Cancers S A R L | Combination therapy between anti-progastrin antibody and immunotherapy to treat cancer |
MA51184A (en) | 2017-12-15 | 2020-10-21 | Juno Therapeutics Inc | ANTI-CCT5 BINDING MOLECULES AND RELATED METHODS OF USE |
US20220133788A1 (en) * | 2017-12-19 | 2022-05-05 | The Johns Hopkins University | Baff therapy to promote anti-tumor immunity |
WO2019122882A1 (en) | 2017-12-19 | 2019-06-27 | Kymab Limited | Bispecific antibody for icos and pd-l1 |
WO2019136432A1 (en) | 2018-01-08 | 2019-07-11 | Novartis Ag | Immune-enhancing rnas for combination with chimeric antigen receptor therapy |
CA3087273A1 (en) | 2018-01-12 | 2019-07-18 | Amgen Inc. | Anti-pd-1 antibodies and methods of treatment |
KR20200120641A (en) | 2018-01-15 | 2020-10-21 | 난징 레전드 바이오테크 씨오., 엘티디. | Single-domain antibody against PD-1 and variants thereof |
WO2019143607A1 (en) | 2018-01-16 | 2019-07-25 | Bristol-Myers Squibb Company | Methods of treating cancer with antibodies against tim3 |
EP3743061A1 (en) | 2018-01-22 | 2020-12-02 | Pascal Biosciences Inc. | Cannabinoids and derivatives for promoting immunogenicity of tumor and infected cells |
KR20200112904A (en) | 2018-01-22 | 2020-10-05 | 브리스톨-마이어스 스큅 컴퍼니 | Compositions and methods for treating cancer |
JP2021511793A (en) | 2018-01-31 | 2021-05-13 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Bispecific antibody containing an antigen binding site that binds to LAG3 |
US20210069246A1 (en) | 2018-01-31 | 2021-03-11 | Celgene Corporation | Combination therapy using adoptive cell therapy and checkpoint inhibitor |
CN108314734B (en) * | 2018-01-31 | 2021-11-05 | 中国药科大学 | anti-PD-1 monoclonal antibody and application thereof |
CA3090249A1 (en) | 2018-01-31 | 2019-08-08 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
WO2019152979A1 (en) | 2018-02-05 | 2019-08-08 | Orionis Biosciences, Inc. | Fibroblast binding agents and use thereof |
WO2019153200A1 (en) | 2018-02-08 | 2019-08-15 | 北京韩美药品有限公司 | Anti-pd-1/anti-her2 natural antibody structure-like bispecific antibody in heterodimeric form and preparation thereof |
US20200399383A1 (en) | 2018-02-13 | 2020-12-24 | Novartis Ag | Chimeric antigen receptor therapy in combination with il-15r and il15 |
US10519187B2 (en) | 2018-02-13 | 2019-12-31 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
US20200399348A1 (en) * | 2018-02-20 | 2020-12-24 | Emory University | HPV Proteins, Antibodies, and Uses in Managing Abnormal Epithelial Cell Growth |
KR20200130362A (en) | 2018-03-08 | 2020-11-18 | 브리스톨-마이어스 스큅 컴퍼니 | Cyclic dinucleotide as anticancer agent |
BR112020016519A2 (en) | 2018-03-13 | 2020-12-15 | Tusk Therapeutics Ltd. | ANTIBODY OR ANTIGEN BINDING FRAGMENT OF THE SAME, ANTIBODY OR AN ANTIGEN BINDING FRAGMENT THAT SPECIFICALLY LINKS TO A HUMAN CD25 EPOTYPE, AFFINITY MATERIAL, NUCLEAR, NUCLEAR, NUCLEAR, NUCLEAR, NUCLEAR, NUCLEAR, AN ANTIGEN OR ANTIGEN BINDING FRAGMENT OF THE SAME, PHARMACEUTICAL COMPOSITION, USE OF AN ANTIGEN BINDING ANTIBODY OR FRAGMENT, METHOD OF TREATING CANCER IN AN INDIVIDUAL, METHOD OF EMOTION IN AN EMOTIONAL EMOTION ANTIGEN BINDING FRAGMENT THAT COMPETES WITH AN ANTIBODY, KIT, METHOD FOR PREPARING AN ANTI-CD25 ANTIBODY AND METHOD FOR PREPARING A PHARMACEUTICAL COMPOSITION |
US20190284553A1 (en) | 2018-03-15 | 2019-09-19 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
CA3094534A1 (en) * | 2018-03-19 | 2019-09-26 | Abeome Corporation | High affinity neutralizing monoclonal antibodies to programmed death ligand 1 (pd-l1) and uses thereof |
CN111868088A (en) * | 2018-03-20 | 2020-10-30 | 诺华股份有限公司 | Pharmaceutical combination |
CN111886256A (en) | 2018-03-23 | 2020-11-03 | 百时美施贵宝公司 | anti-MICA and/or MICB antibodies and uses thereof |
KR20240017090A (en) | 2018-03-23 | 2024-02-06 | 일라이 릴리 앤드 캄파니 | Anti-cd137 antibodies for combination with anti-pd-1 antibodies |
CN111971306A (en) | 2018-03-30 | 2020-11-20 | 百时美施贵宝公司 | Method for treating tumors |
US20210155703A1 (en) | 2018-04-04 | 2021-05-27 | Bristol-Myers Squibb Company | Anti-cd27 antibodies and uses thereof |
US20210147547A1 (en) | 2018-04-13 | 2021-05-20 | Novartis Ag | Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof |
US11524991B2 (en) | 2018-04-18 | 2022-12-13 | Xencor, Inc. | PD-1 targeted heterodimeric fusion proteins containing IL-15/IL-15Ra Fc-fusion proteins and PD-1 antigen binding domains and uses thereof |
US20190365861A1 (en) | 2018-04-18 | 2019-12-05 | Xencor, Inc. | Il-15/il-15ra heterodimeric fc fusion proteins and uses thereof |
US20210267964A1 (en) | 2018-04-25 | 2021-09-02 | Innate Tumor Immunity, Inc. | Nlrp3 modulators |
EP3788369A1 (en) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
AU2019263850A1 (en) * | 2018-05-03 | 2020-11-19 | Shanghai Epimab Biotherapeutics Co., Ltd. | High affinity antibodies to PD-1 and LAG-3 and bispecific binding proteins made therefrom |
EP3569618A1 (en) | 2018-05-19 | 2019-11-20 | Boehringer Ingelheim International GmbH | Antagonizing cd73 antibody |
TWI806870B (en) * | 2018-05-23 | 2023-07-01 | 中國大陸商大有華夏生物醫藥集團有限公司 | Anti-pd-1 antibodies and uses thereof |
UY38247A (en) | 2018-05-30 | 2019-12-31 | Novartis Ag | ANTIBODIES AGAINST ENTPD2, COMBINATION THERAPIES AND METHODS OF USE OF ANTIBODIES AND COMBINATION THERAPIES |
WO2019232244A2 (en) | 2018-05-31 | 2019-12-05 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
US20210253614A1 (en) | 2018-05-31 | 2021-08-19 | Peloton Therapeutics, Inc. | Compositions and methods for inhibiting cd73 |
CA3102256A1 (en) | 2018-06-01 | 2019-12-05 | Novartis Ag | Dosing of a bispecific antibody that bind cd123 and cd3 |
CA3098420A1 (en) | 2018-06-01 | 2019-12-05 | Novartis Ag | Binding molecules against bcma and uses thereof |
JP7399895B2 (en) | 2018-06-23 | 2023-12-18 | ジェネンテック, インコーポレイテッド | Method of treating lung cancer with PD-1 axis binding antagonists, platinum agents, and topoisomerase II inhibitors |
CN110680919A (en) * | 2018-07-06 | 2020-01-14 | 江苏恒瑞医药股份有限公司 | Application of CDK4/6 inhibitor in preparation of medicine for treating tumors in combination with immunotherapy |
AR116109A1 (en) | 2018-07-10 | 2021-03-31 | Novartis Ag | DERIVATIVES OF 3- (5-AMINO-1-OXOISOINDOLIN-2-IL) PIPERIDINE-2,6-DIONA AND USES OF THE SAME |
AU2019301944B2 (en) | 2018-07-10 | 2022-02-24 | Novartis Ag | 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of IKAROS Family Zinc Finger 2 (IKZF2)-dependent diseases |
BR112021000673A2 (en) | 2018-07-18 | 2021-04-20 | Genentech, Inc. | methods for treating an individual with lung cancer, kits, anti-pd-l1 antibody and compositions |
WO2020021465A1 (en) | 2018-07-25 | 2020-01-30 | Advanced Accelerator Applications (Italy) S.R.L. | Method of treatment of neuroendocrine tumors |
PE20210406A1 (en) | 2018-07-25 | 2021-03-02 | Novartis Ag | INFLAMASOME INHIBITORS NLRP3 |
EP3826660A1 (en) | 2018-07-26 | 2021-06-02 | Bristol-Myers Squibb Company | Lag-3 combination therapy for the treatment of cancer |
JP7364663B2 (en) | 2018-08-16 | 2023-10-18 | イネイト・テューマー・イミュニティ・インコーポレイテッド | NLRP3 modulators of imidazo[4,5-c]quinoline derivatives |
JP7433291B2 (en) | 2018-08-16 | 2024-02-19 | イネイト・テューマー・イミュニティ・インコーポレイテッド | NLRP3 modulators of imidazo[4,5-c]quinoline derivatives |
SG11202101486RA (en) | 2018-08-16 | 2021-03-30 | Innate Tumor Immunity Inc | Substitued 4-amino-1h-imidazo[4,5-c]quinoline compounds and improved methods for their preparation |
WO2020041655A1 (en) | 2018-08-24 | 2020-02-27 | Sanofi | Therapeutic rna for solid tumor cancers |
WO2020044252A1 (en) | 2018-08-31 | 2020-03-05 | Novartis Ag | Dosage regimes for anti-m-csf antibodies and uses thereof |
TW202024023A (en) | 2018-09-03 | 2020-07-01 | 瑞士商赫孚孟拉羅股份公司 | Therapeutic compounds and methods of use |
WO2020049534A1 (en) | 2018-09-07 | 2020-03-12 | Novartis Ag | Sting agonist and combination therapy thereof for the treatment of cancer |
EP3856782A1 (en) | 2018-09-28 | 2021-08-04 | Novartis AG | Cd19 chimeric antigen receptor (car) and cd22 car combination therapies |
EP3856779A1 (en) | 2018-09-28 | 2021-08-04 | Novartis AG | Cd22 chimeric antigen receptor (car) therapies |
CN113195523A (en) | 2018-10-03 | 2021-07-30 | Xencor股份有限公司 | IL-12 heterodimer Fc fusion proteins |
CN112839962A (en) | 2018-10-09 | 2021-05-25 | 百时美施贵宝公司 | Anti-merk antibodies for the treatment of cancer |
CN112867803A (en) | 2018-10-16 | 2021-05-28 | 诺华股份有限公司 | Tumor mutational burden alone or in combination with immune markers as biomarkers for predicting response to targeted therapy |
AU2019361124A1 (en) | 2018-10-19 | 2021-06-03 | Bristol-Myers Squibb Company | Combination therapy for melanoma |
EP3870609A1 (en) | 2018-10-23 | 2021-09-01 | Bristol-Myers Squibb Company | Methods of treating tumor |
WO2020089811A1 (en) | 2018-10-31 | 2020-05-07 | Novartis Ag | Dc-sign antibody drug conjugates |
PE20211058A1 (en) | 2018-11-01 | 2021-06-07 | Juno Therapeutics Inc | SPECIFIC CHEMERIC ANTIGEN RECEPTORS FOR MEMBER D OF GROUP 5 OF CLASS C OF THE RECEPTOR COUPLED TO PROTEIN G (GPRC5D) |
CN113646335A (en) | 2018-11-01 | 2021-11-12 | 朱诺治疗学股份有限公司 | Methods of treatment using chimeric antigen receptors specific for B cell maturation antigen |
JP2022509942A (en) | 2018-11-16 | 2022-01-25 | ブリストル-マイヤーズ スクイブ カンパニー | Anti-NKG2A antibody and its use |
MX2021005734A (en) | 2018-11-16 | 2021-09-10 | Juno Therapeutics Inc | Methods of dosing engineered t cells for the treatment of b cell malignancies. |
US20230054194A1 (en) | 2018-11-19 | 2023-02-23 | Ariagen, Inc. | Methods of Treating Cancer |
JP2022513685A (en) | 2018-11-30 | 2022-02-09 | ジュノー セラピューティクス インコーポレイテッド | Methods for Treatment with Adoptive Cell Therapy |
JP2022511029A (en) | 2018-12-04 | 2022-01-28 | スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド | CDK9 Inhibitors and Their Polymorphs for Use as Drugs for the Treatment of Cancer |
KR20210098504A (en) | 2018-12-04 | 2021-08-10 | 브리스톨-마이어스 스큅 컴퍼니 | Analytical Methods Using In-Sample Calibration Curves by Monitoring Multiple Isotope Responses |
TW202039459A (en) | 2018-12-11 | 2020-11-01 | 美商施萬生物製藥研發 Ip有限責任公司 | Alk5 inhibitors |
EP3666905A1 (en) | 2018-12-11 | 2020-06-17 | Sanofi | E. coli positive for pks island as marker of positive response to anti-pd1 therapy in colorectal cancer |
CN113271945A (en) | 2018-12-20 | 2021-08-17 | 诺华股份有限公司 | Dosing regimens and pharmaceutical combinations comprising 3- (1-oxoisoindolin-2-yl) piperidine-2, 6-dione derivatives |
EP3897853A1 (en) | 2018-12-20 | 2021-10-27 | Xencor, Inc. | Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and nkg2d antigen binding domains |
US20220025036A1 (en) | 2018-12-21 | 2022-01-27 | Novartis Ag | Use of il-1beta binding antibodies |
CN111349162A (en) * | 2018-12-21 | 2020-06-30 | 神州细胞工程有限公司 | Humanized anti-PD-1 antibodies and uses thereof |
WO2020128637A1 (en) | 2018-12-21 | 2020-06-25 | Novartis Ag | Use of il-1 binding antibodies in the treatment of a msi-h cancer |
WO2020128620A1 (en) | 2018-12-21 | 2020-06-25 | Novartis Ag | Use of il-1beta binding antibodies |
KR20210107730A (en) | 2018-12-21 | 2021-09-01 | 노파르티스 아게 | Use of IL-1 beta antibodies in the treatment or prevention of myelodysplastic syndrome |
CA3123996A1 (en) | 2018-12-21 | 2019-12-18 | Novartis Ag | Antibodies to pmel17 and conjugates thereof |
JP7340021B2 (en) | 2018-12-23 | 2023-09-06 | エフ. ホフマン-ラ ロシュ アーゲー | Tumor classification based on predicted tumor mutational burden |
CN111423512B (en) * | 2019-01-10 | 2024-01-05 | 北京比洋生物技术有限公司 | Multi-targeting fusion protein for blocking vascular endothelial cell growth and activating T cells and pharmaceutical composition comprising same |
KR20210102327A (en) | 2019-01-11 | 2021-08-19 | 일라이 릴리 앤드 캄파니 | Combination of TIM-3 Antibodies and Other Checkpoint Inhibitors for the Treatment of Cancer |
CN115120716A (en) | 2019-01-14 | 2022-09-30 | 健泰科生物技术公司 | Methods of treating cancer with PD-1 axis binding antagonists and RNA vaccines |
EP3911416A1 (en) | 2019-01-14 | 2021-11-24 | Innate Tumor Immunity, Inc. | Substituted quinazolines as nlrp3 modulators, for use in the treatment of cancer |
WO2020150116A1 (en) | 2019-01-14 | 2020-07-23 | Innate Tumor Immunity, Inc. | Nlrp3 modulators |
CN113301962A (en) | 2019-01-14 | 2021-08-24 | 先天肿瘤免疫公司 | Heterocyclic NLRP3 modulators for the treatment of cancer |
US20220089572A1 (en) | 2019-01-14 | 2022-03-24 | Innate Tumor Immunity, Inc. | Nlrp3 modulators |
EP3914355A1 (en) | 2019-01-21 | 2021-12-01 | Sanofi | Therapeutic rna and anti-pd1 antibodies for advanced stage solid tumor cancers |
TW202043466A (en) | 2019-01-25 | 2020-12-01 | 德商百靈佳殷格翰國際股份有限公司 | Recombinant rhabdovirus encoding for ccl21 |
US20220096651A1 (en) | 2019-01-29 | 2022-03-31 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for receptor tyrosine kinase like orphan receptor 1 (ror1) |
JP2022519328A (en) * | 2019-02-08 | 2022-03-22 | マディソン ヴァクシーンズ インコーポレイテッド | Cancer treatment |
US11471456B2 (en) | 2019-02-12 | 2022-10-18 | Sumitomo Pharma Oncology, Inc. | Formulations comprising heterocyclic protein kinase inhibitors |
WO2020165733A1 (en) | 2019-02-12 | 2020-08-20 | Novartis Ag | Pharmaceutical combination comprising tno155 and a pd-1 inhibitor |
JP2022520448A (en) | 2019-02-15 | 2022-03-30 | ノバルティス アーゲー | Substituted 3- (1-oxoisoindoline-2-yl) piperidine-2,6-dione derivative and its use |
WO2020165833A1 (en) | 2019-02-15 | 2020-08-20 | Novartis Ag | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
WO2020172553A1 (en) | 2019-02-22 | 2020-08-27 | Novartis Ag | Combination therapies of egfrviii chimeric antigen receptors and pd-1 inhibitors |
US11793802B2 (en) | 2019-03-20 | 2023-10-24 | Sumitomo Pharma Oncology, Inc. | Treatment of acute myeloid leukemia (AML) with venetoclax failure |
CA3133460A1 (en) | 2019-03-22 | 2020-10-01 | Sumitomo Dainippon Pharma Oncology, Inc. | Compositions comprising pkm2 modulators and methods of treatment using the same |
EP3946625A1 (en) | 2019-03-28 | 2022-02-09 | Bristol-Myers Squibb Company | Methods of treating tumor |
KR20210146349A (en) | 2019-03-28 | 2021-12-03 | 브리스톨-마이어스 스큅 컴퍼니 | how to treat a tumor |
WO2020214740A1 (en) | 2019-04-15 | 2020-10-22 | Ariagen, Inc. | Chiral indole compounds and their use |
EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
WO2020214995A1 (en) | 2019-04-19 | 2020-10-22 | Genentech, Inc. | Anti-mertk antibodies and their methods of use |
US20230242478A1 (en) | 2019-05-13 | 2023-08-03 | Bristol-Myers Squibb Company | AGONISTS OF ROR GAMMAt |
US20230295087A1 (en) | 2019-05-13 | 2023-09-21 | Bristol-Myers Squibb Company | AGONISTS OF ROR GAMMAt |
AR119731A1 (en) | 2019-05-17 | 2022-01-05 | Novartis Ag | NLRP3 INFLAMASOME INHIBITORS |
AU2020281535A1 (en) | 2019-05-24 | 2022-01-27 | Merck Patent Gmbh | Combination therapies using CDK inhibitors |
JP2022534967A (en) | 2019-05-30 | 2022-08-04 | ブリストル-マイヤーズ スクイブ カンパニー | Multiple tumor gene signatures and their uses |
CN114174537A (en) | 2019-05-30 | 2022-03-11 | 百时美施贵宝公司 | Cell localization features and combination therapies |
JP2022534982A (en) | 2019-05-30 | 2022-08-04 | ブリストル-マイヤーズ スクイブ カンパニー | Cellular localization signatures and their uses |
MX2022000164A (en) | 2019-07-03 | 2022-04-01 | Sumitomo Pharma Oncology Inc | Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof. |
US11083705B2 (en) | 2019-07-26 | 2021-08-10 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
US20220306630A1 (en) | 2019-08-06 | 2022-09-29 | Bristol-Myers Squibb Company | AGONISTS OF ROR GAMMAt |
TW202124446A (en) | 2019-09-18 | 2021-07-01 | 瑞士商諾華公司 | Combination therapies with entpd2 antibodies |
JP2022548881A (en) | 2019-09-18 | 2022-11-22 | ノバルティス アーゲー | ENTPD2 Antibodies, Combination Therapy and Methods of Using Antibodies and Combination Therapy |
AU2020350795A1 (en) | 2019-09-22 | 2022-03-31 | Bristol-Myers Squibb Company | Quantitative spatial profiling for LAG-3 antagonist therapy |
CA3155341A1 (en) | 2019-09-25 | 2021-04-01 | Seagen Inc. | Combination anti-cd30 adc, anti-pd-1 and chemotherapeutic for treatment of hematopoietic cancers |
KR20220066950A (en) | 2019-09-25 | 2022-05-24 | 브리스톨-마이어스 스큅 컴퍼니 | Complex biomarkers for cancer therapy |
US11851466B2 (en) | 2019-10-03 | 2023-12-26 | Xencor, Inc. | Targeted IL-12 heterodimeric Fc-fusion proteins |
CA3158298A1 (en) | 2019-10-21 | 2021-04-29 | Novartis Ag | Combination therapies with venetoclax and tim-3 inhibitors |
KR20220087498A (en) | 2019-10-21 | 2022-06-24 | 노파르티스 아게 | TIM-3 inhibitors and uses thereof |
US20220409724A1 (en) | 2019-10-29 | 2022-12-29 | Eisai R&D Management Co., Ltd. | Combination of a pd-1 antagonist, a vegfr/fgfr/ret tyrosine kinase inhibitor and a cbp/beta-catenin inhibitor for treating cancer |
JP2022553821A (en) | 2019-11-05 | 2022-12-26 | ブリストル-マイヤーズ スクイブ カンパニー | M-protein assay and its use |
WO2021092220A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
WO2021092221A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
US20220411499A1 (en) | 2019-11-08 | 2022-12-29 | Bristol-Myers Squibb Company | LAG-3 Antagonist Therapy for Melanoma |
CN114728905A (en) | 2019-11-13 | 2022-07-08 | 基因泰克公司 | Therapeutic compounds and methods of use |
EP4058465A1 (en) | 2019-11-14 | 2022-09-21 | Cohbar Inc. | Cxcr4 antagonist peptides |
IL293084A (en) | 2019-11-22 | 2022-07-01 | Theravance Biopharma R& D Ip Llc | Substituted 1,5-naphthyridines or quinolines as alk5 inhibitors |
WO2021102343A1 (en) | 2019-11-22 | 2021-05-27 | Sumitomo Dainippon Pharma Oncology, Inc. | Solid dose pharmaceutical composition |
MX2022006891A (en) | 2019-12-09 | 2022-09-09 | Seagen Inc | Combination therapy with liv1-adc and pd-1 antagonist. |
CN115243721A (en) | 2019-12-19 | 2022-10-25 | 百时美施贵宝公司 | Combination of DGK inhibitors and checkpoint antagonists |
CA3165399A1 (en) | 2019-12-20 | 2021-06-24 | Novartis Ag | Uses of anti-tgf-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases |
KR20220127848A (en) | 2020-01-10 | 2022-09-20 | 인네이트 튜머 이뮤니티, 인코포레이티드 | NLRP3 modulators |
TW202128131A (en) * | 2020-01-17 | 2021-08-01 | 大陸商信達生物制藥(蘇州)有限公司 | Recombinant anti-programmed cell death protein 1 and anti-cluster of differentiation antigen 137 bispecific antibody preparation and use thereof |
AU2021207348A1 (en) | 2020-01-17 | 2022-08-11 | Novartis Ag | Combination comprising a TIM-3 inhibitor and a hypomethylating agent for use in treating myelodysplastic syndrome or chronic myelomonocytic leukemia |
BR112022014962A2 (en) | 2020-01-30 | 2022-09-20 | Ona Therapeutics S L | COMBINATION THERAPY FOR TREATMENT OF CANCER AND CANCER METASTASIS |
BR112022015077A2 (en) | 2020-01-31 | 2022-10-04 | Genentech Inc | METHODS TO INDUCE NEOEPITOPE-SPECIFIC CD8+ T CELLS IN AN INDIVIDUAL WITH A TUMOR AND TO INDUCE CD8+ T CELL TRAFFICKING, RNA VACCINES, RNA VACCINE FOR USE AND BINDING ANTAGONISTS |
JP2023514152A (en) | 2020-02-06 | 2023-04-05 | ブリストル-マイヤーズ スクイブ カンパニー | IL-10 and its uses |
EP4110341A2 (en) | 2020-02-28 | 2023-01-04 | Novartis AG | A triple pharmaceutical combination comprising dabrafenib, an erk inhibitor and a raf inhibitor |
AU2021226023A1 (en) | 2020-02-28 | 2022-09-15 | Tallac Therapeutics, Inc. | Transglutaminase-mediated conjugation |
WO2021171264A1 (en) | 2020-02-28 | 2021-09-02 | Novartis Ag | Dosing of a bispecific antibody that binds cd123 and cd3 |
US20230235073A1 (en) | 2020-03-06 | 2023-07-27 | Ona Therapeutics, S.L. | Anti-cd36 antibodies and their use to treat cancer |
BR112022017637A2 (en) | 2020-03-06 | 2022-11-08 | Celgene Quanticel Res Inc | METHODS OF TREATMENT OF SMALL CELL LUNG CANCER AND/OR NON-SMALL CELL LUNG CANCER |
EP3878446A1 (en) | 2020-03-09 | 2021-09-15 | Universite De Geneve | Hsd11b1 inhibitors for use in immunotherapy and uses thereof |
IL296673A (en) | 2020-03-23 | 2022-11-01 | Bristol Myers Squibb Co | Anti-ccr8 antibodies for treating cancer |
EP4126824A1 (en) | 2020-03-31 | 2023-02-08 | Theravance Biopharma R&D IP, LLC | Substituted pyrimidines and methods of use |
WO2021207689A2 (en) | 2020-04-10 | 2021-10-14 | Juno Therapeutics, Inc. | Methods and uses related to cell therapy engineered with a chimeric antigen receptor targeting b-cell maturation antigen |
US20230181756A1 (en) | 2020-04-30 | 2023-06-15 | Novartis Ag | Ccr7 antibody drug conjugates for treating cancer |
WO2021226984A1 (en) * | 2020-05-15 | 2021-11-18 | 三生国健药业(上海)股份有限公司 | Tetravalent bispecific antibody against pd-1 and pd-l1 |
CN116249555A (en) | 2020-05-19 | 2023-06-09 | 勃林格殷格翰国际有限公司 | Binding molecules for cancer treatment |
CN111537726A (en) * | 2020-05-29 | 2020-08-14 | 武汉大学 | Method for efficiently and quantitatively detecting PD-L1 level in extracellular vesicle, ELISA kit and using method |
PE20231078A1 (en) | 2020-06-02 | 2023-07-17 | Arcus Biosciences Inc | ANTI-TIGIT ANTIBODIES |
CN115916231A (en) | 2020-06-03 | 2023-04-04 | 勃林格殷格翰国际有限公司 | Recombinant rhabdovirus encoding CD80 ectodomain Fc fusion protein |
US20210387983A1 (en) | 2020-06-10 | 2021-12-16 | Theravance Biopharma R&D Ip, Llc | Crystalline alk5 inhibitors and uses thereof |
AU2021288224A1 (en) | 2020-06-11 | 2023-01-05 | Novartis Ag | ZBTB32 inhibitors and uses thereof |
US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
IL298262A (en) | 2020-06-23 | 2023-01-01 | Novartis Ag | Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
KR20230033647A (en) | 2020-06-30 | 2023-03-08 | 멘두스 비.브이. | Use of leukemia-derived cells in ovarian cancer vaccines |
AU2021306613A1 (en) | 2020-07-07 | 2023-02-02 | BioNTech SE | Therapeutic RNA for HPV-positive cancer |
WO2022009157A1 (en) | 2020-07-10 | 2022-01-13 | Novartis Ag | Lhc165 and spartalizumab combinations for treating solid tumors |
US11787775B2 (en) | 2020-07-24 | 2023-10-17 | Genentech, Inc. | Therapeutic compounds and methods of use |
EP4188549A1 (en) | 2020-08-03 | 2023-06-07 | Novartis AG | Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
BR112023003427A2 (en) | 2020-08-28 | 2023-03-21 | Bristol Myers Squibb Co | LAG-3 ANTAGONIST THERAPY FOR HEPATOCELLULAR CARCINOMA |
EP4204453A1 (en) | 2020-08-31 | 2023-07-05 | Bristol-Myers Squibb Company | Cell localization signature and immunotherapy |
EP4204020A1 (en) | 2020-08-31 | 2023-07-05 | Advanced Accelerator Applications International S.A. | Method of treating psma-expressing cancers |
WO2022043557A1 (en) | 2020-08-31 | 2022-03-03 | Advanced Accelerator Applications International Sa | Method of treating psma-expressing cancers |
JP2023540490A (en) | 2020-09-02 | 2023-09-25 | ファーマブシン インコーポレイテッド | Combination therapy of PD-1 antagonists and VEGFR-2 antagonists to treat cancer patients |
JP2023542297A (en) | 2020-09-14 | 2023-10-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Heterogeneous prime-boost vaccine |
JP2023545926A (en) | 2020-09-24 | 2023-11-01 | メルク・シャープ・アンド・ドーム・エルエルシー | Stable formulations of programmed death receptor 1 (PD-1) antibodies and hyaluronidase variants and fragments thereof and methods of use thereof |
CN111920948B (en) * | 2020-09-25 | 2021-02-02 | 安可瑞(山西)生物细胞有限公司 | Pharmaceutical composition comprising immune cells for treating cancer |
KR20230080460A (en) | 2020-10-05 | 2023-06-07 | 브리스톨-마이어스 스큅 컴퍼니 | How to Concentrate Protein |
US20230364127A1 (en) | 2020-10-06 | 2023-11-16 | Codiak Biosciences, Inc. | Extracellular vesicle-aso constructs targeting stat6 |
TW202233671A (en) | 2020-10-20 | 2022-09-01 | 美商建南德克公司 | Peg-conjugated anti-mertk antibodies and methods of use |
CA3196496A1 (en) | 2020-10-23 | 2022-04-28 | Laurence David TOMS | Lag-3 antagonist therapy for lung cancer |
KR20230098279A (en) | 2020-10-28 | 2023-07-03 | 이케나 온콜로지, 인코포레이티드 | Combinations of PDX inhibitors or doxorubicin with AHR inhibitors |
WO2022093981A1 (en) | 2020-10-28 | 2022-05-05 | Genentech, Inc. | Combination therapy comprising ptpn22 inhibitors and pd-l1 binding antagonists |
US20220153842A1 (en) | 2020-11-04 | 2022-05-19 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies and anti-cd79b antibody drug conjugates |
WO2022098638A2 (en) | 2020-11-04 | 2022-05-12 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies |
JP2023548069A (en) | 2020-11-04 | 2023-11-15 | ジェネンテック, インコーポレイテッド | Subcutaneous dosing of anti-CD20/anti-CD3 bispecific antibodies |
EP4240491A1 (en) | 2020-11-06 | 2023-09-13 | Novartis AG | Cd19 binding molecules and uses thereof |
WO2022118197A1 (en) | 2020-12-02 | 2022-06-09 | Pfizer Inc. | Time to resolution of axitinib-related adverse events |
JP2023551906A (en) | 2020-12-02 | 2023-12-13 | ジェネンテック, インコーポレイテッド | Methods and compositions for neoadjuvant and adjuvant urothelial carcinoma therapy |
WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
TW202237119A (en) | 2020-12-10 | 2022-10-01 | 美商住友製藥腫瘤公司 | Alk-5 inhibitors and uses thereof |
JP2024500847A (en) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス,インコーポレイテッド | Chimeric antigen receptor systems with compatible receptor specificities |
WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
TW202245808A (en) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | Therapeutic rna for treating cancer |
WO2022146947A1 (en) | 2020-12-28 | 2022-07-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
WO2022146948A1 (en) | 2020-12-28 | 2022-07-07 | Bristol-Myers Squibb Company | Subcutaneous administration of pd1/pd-l1 antibodies |
EP4271709A1 (en) | 2020-12-31 | 2023-11-08 | Sanofi | Multifunctional natural killer (nk) cell engagers binding to nkp46 and cd123 |
WO2022156773A1 (en) * | 2021-01-21 | 2022-07-28 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd | Protein complexes targeting il12 pathway |
KR20230135075A (en) | 2021-01-22 | 2023-09-22 | 멘두스 비.브이. | Tumor Vaccination Method |
WO2022162569A1 (en) | 2021-01-29 | 2022-08-04 | Novartis Ag | Dosage regimes for anti-cd73 and anti-entpd2 antibodies and uses thereof |
US20240109899A1 (en) | 2021-02-04 | 2024-04-04 | Bristol-Myers Squibb Company | Benzofuran compounds as sting agonists |
JP2024510989A (en) | 2021-03-12 | 2024-03-12 | メンドゥス・ベスローテン・フェンノートシャップ | Vaccination methods and use of CD47 blockers |
CN117321418A (en) | 2021-03-18 | 2023-12-29 | 诺华股份有限公司 | Cancer biomarkers and methods of use thereof |
TW202304506A (en) | 2021-03-25 | 2023-02-01 | 日商安斯泰來製藥公司 | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
EP4313127A1 (en) | 2021-03-29 | 2024-02-07 | Juno Therapeutics, Inc. | Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy |
JP2024514530A (en) | 2021-04-02 | 2024-04-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Antibodies against truncated CDCP1 and uses thereof |
TW202304979A (en) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | USES OF ANTI-TGFβ ANTIBODIES AND OTHER THERAPEUTIC AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES |
TW202309022A (en) | 2021-04-13 | 2023-03-01 | 美商努法倫特公司 | Amino-substituted heterocycles for treating cancers with egfr mutations |
AU2022258829A1 (en) | 2021-04-16 | 2023-10-26 | Novartis Ag | Antibody drug conjugates and methods for making thereof |
JP2024516230A (en) | 2021-04-30 | 2024-04-12 | ジェネンテック, インコーポレイテッド | Therapeutic and diagnostic methods and compositions for cancer |
JP2024517535A (en) | 2021-04-30 | 2024-04-23 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Administration of combination therapy with anti-CD20/anti-CD3 bispecific antibody and anti-CD79B antibody drug conjugate |
AR125874A1 (en) | 2021-05-18 | 2023-08-23 | Novartis Ag | COMBINATION THERAPIES |
AU2022281461A1 (en) | 2021-05-25 | 2024-01-04 | Edelweiss Immune Inc | C-x-c motif chemokine receptor 6 (cxcr6) binding molecules, and methods of using the same |
AR125966A1 (en) | 2021-05-26 | 2023-08-30 | Novartis Ag | NEW BICYCLIC COMPOUNDS AND THEIR USES |
WO2022251359A1 (en) | 2021-05-26 | 2022-12-01 | Theravance Biopharma R&D Ip, Llc | Bicyclic inhibitors of alk5 and methods of use |
EP4346903A1 (en) | 2021-06-03 | 2024-04-10 | Synthorx, Inc. | Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab |
GB202107994D0 (en) | 2021-06-04 | 2021-07-21 | Kymab Ltd | Treatment of cancer |
CA3224018A1 (en) | 2021-06-18 | 2022-12-22 | Genzyme Corporation | Anti-tgf-beta antibody formulations and their use |
KR20240028452A (en) | 2021-07-02 | 2024-03-05 | 제넨테크, 인크. | Methods and compositions for treating cancer |
AU2022312698A1 (en) | 2021-07-13 | 2024-01-25 | BioNTech SE | Multispecific binding agents against cd40 and cd137 in combination therapy for cancer |
WO2023010094A2 (en) | 2021-07-28 | 2023-02-02 | Genentech, Inc. | Methods and compositions for treating cancer |
CN117715936A (en) | 2021-07-28 | 2024-03-15 | 豪夫迈·罗氏有限公司 | Methods and compositions for treating cancer |
WO2023007472A1 (en) | 2021-07-30 | 2023-02-02 | ONA Therapeutics S.L. | Anti-cd36 antibodies and their use to treat cancer |
WO2023051926A1 (en) | 2021-09-30 | 2023-04-06 | BioNTech SE | Treatment involving non-immunogenic rna for antigen vaccination and pd-1 axis binding antagonists |
TW202321308A (en) | 2021-09-30 | 2023-06-01 | 美商建南德克公司 | Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists |
TW202327595A (en) | 2021-10-05 | 2023-07-16 | 美商輝瑞大藥廠 | Combinations of azalactam compounds for the treatment of cancer |
WO2023057534A1 (en) | 2021-10-06 | 2023-04-13 | Genmab A/S | Multispecific binding agents against pd-l1 and cd137 in combination |
TW202333802A (en) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | Therapeutic rna for lung cancer |
WO2023077090A1 (en) | 2021-10-29 | 2023-05-04 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hematological cancer |
WO2023079428A1 (en) | 2021-11-03 | 2023-05-11 | Pfizer Inc. | Combination therapies using tlr7/8 agonist |
WO2023080900A1 (en) | 2021-11-05 | 2023-05-11 | Genentech, Inc. | Methods and compositions for classifying and treating kidney cancer |
WO2023083439A1 (en) | 2021-11-09 | 2023-05-19 | BioNTech SE | Tlr7 agonist and combinations for cancer treatment |
AU2022384793A1 (en) | 2021-11-12 | 2024-04-11 | Advanced Accelerator Applications | Combination therapy for treating lung cancer |
WO2023097194A2 (en) | 2021-11-24 | 2023-06-01 | Genentech, Inc. | Therapeutic compounds and methods of use |
TW202332429A (en) | 2021-11-24 | 2023-08-16 | 美商建南德克公司 | Therapeutic compounds and methods of use |
WO2023122573A1 (en) | 2021-12-20 | 2023-06-29 | Synthorx, Inc. | Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab |
WO2023147371A1 (en) | 2022-01-26 | 2023-08-03 | Bristol-Myers Squibb Company | Combination therapy for hepatocellular carcinoma |
WO2023164638A1 (en) | 2022-02-25 | 2023-08-31 | Bristol-Myers Squibb Company | Combination therapy for colorectal carcinoma |
WO2023168404A1 (en) | 2022-03-04 | 2023-09-07 | Bristol-Myers Squibb Company | Methods of treating a tumor |
WO2023170606A1 (en) | 2022-03-08 | 2023-09-14 | Alentis Therapeutics Ag | Use of anti-claudin-1 antibodies to increase t cell availability |
CN114573698B (en) * | 2022-03-16 | 2023-01-06 | 沈阳三生制药有限责任公司 | FcRn antigen binding protein and preparation method and application thereof |
WO2023178329A1 (en) | 2022-03-18 | 2023-09-21 | Bristol-Myers Squibb Company | Methods of isolating polypeptides |
WO2023191816A1 (en) | 2022-04-01 | 2023-10-05 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
CN116925223A (en) * | 2022-04-02 | 2023-10-24 | 普米斯生物技术(珠海)有限公司 | anti-PD-1 monoclonal antibody, derivative and application thereof |
WO2023196987A1 (en) | 2022-04-07 | 2023-10-12 | Bristol-Myers Squibb Company | Methods of treating tumor |
WO2023196964A1 (en) | 2022-04-08 | 2023-10-12 | Bristol-Myers Squibb Company | Machine learning identification, classification, and quantification of tertiary lymphoid structures |
WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
WO2023219613A1 (en) | 2022-05-11 | 2023-11-16 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
WO2023218046A1 (en) | 2022-05-12 | 2023-11-16 | Genmab A/S | Binding agents capable of binding to cd27 in combination therapy |
WO2023230554A1 (en) | 2022-05-25 | 2023-11-30 | Pfizer Inc. | Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer |
WO2023235847A1 (en) | 2022-06-02 | 2023-12-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
WO2023240058A2 (en) | 2022-06-07 | 2023-12-14 | Genentech, Inc. | Prognostic and therapeutic methods for cancer |
WO2023250400A1 (en) | 2022-06-22 | 2023-12-28 | Juno Therapeutics, Inc. | Treatment methods for second line therapy of cd19-targeted car t cells |
WO2024015897A1 (en) | 2022-07-13 | 2024-01-18 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
WO2024020432A1 (en) | 2022-07-19 | 2024-01-25 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
EP4310197A1 (en) | 2022-07-21 | 2024-01-24 | Fundación para la Investigación Biomédica del Hospital Universitario Puerta de Hierro Majadahonda | Method for identifying lung cancer patients for a combination treatment of immuno- and chemotherapy |
WO2024023740A1 (en) | 2022-07-27 | 2024-02-01 | Astrazeneca Ab | Combinations of recombinant virus expressing interleukin-12 with pd-1/pd-l1 inhibitors |
US20240067627A1 (en) | 2022-08-03 | 2024-02-29 | Novartis Ag | Nlrp3 inflammasome inhibitors |
US20240041929A1 (en) | 2022-08-05 | 2024-02-08 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for gprc5d and bcma |
WO2024049949A1 (en) | 2022-09-01 | 2024-03-07 | Genentech, Inc. | Therapeutic and diagnostic methods for bladder cancer |
WO2024069009A1 (en) | 2022-09-30 | 2024-04-04 | Alentis Therapeutics Ag | Treatment of drug-resistant hepatocellular carcinoma |
WO2024077095A1 (en) | 2022-10-05 | 2024-04-11 | Genentech, Inc. | Methods and compositions for classifying and treating bladder cancer |
WO2024077166A1 (en) | 2022-10-05 | 2024-04-11 | Genentech, Inc. | Methods and compositions for classifying and treating lung cancer |
WO2024079623A1 (en) | 2022-10-12 | 2024-04-18 | Novartis Ag | Tricyclic compounds and their uses |
Family Cites Families (528)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0067069A1 (en) | 1981-06-10 | 1982-12-15 | Harold Swallow | Invalid chairs |
US4433059A (en) | 1981-09-08 | 1984-02-21 | Ortho Diagnostic Systems Inc. | Double antibody conjugate |
US4444878A (en) | 1981-12-21 | 1984-04-24 | Boston Biomedical Research Institute, Inc. | Bispecific antibody determinants |
GB2116183B (en) | 1982-03-03 | 1985-06-05 | Genentech Inc | Human antithrombin iii dna sequences therefore expression vehicles and cloning vectors containing such sequences and cell cultures transformed thereby a process for expressing human antithrombin iii and pharmaceutical compositions comprising it |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS6147500A (en) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | Chimera monoclonal antibody and its preparation |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
JPS61134325A (en) | 1984-12-04 | 1986-06-21 | Teijin Ltd | Expression of hybrid antibody gene |
US4978672A (en) | 1986-03-07 | 1990-12-18 | Ciba-Geigy Corporation | Alpha-heterocyclc substituted tolunitriles |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5869620A (en) | 1986-09-02 | 1999-02-09 | Enzon, Inc. | Multivalent antigen-binding proteins |
EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
WO1988008135A1 (en) | 1987-04-10 | 1988-10-20 | Xoma Corporation | Human monoclonal antibodies binding determinants of gram negative bacteria |
ATE95193T1 (en) | 1987-06-17 | 1993-10-15 | Sandoz Ag | CYCLOSPORINS AND THEIR USE AS MEDICINAL PRODUCTS. |
JPH021556A (en) | 1988-06-09 | 1990-01-05 | Snow Brand Milk Prod Co Ltd | Hybrid antibody and production thereof |
EP1026240A3 (en) | 1988-09-02 | 2004-04-07 | Dyax Corp. | Generation and selection of recombinant varied binding proteins |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
FR2636953B1 (en) | 1988-09-26 | 1990-12-14 | Roussy Inst Gustave | NOVEL POLYPEPTIDES PRODUCED BY HUMAN LYMPHOCYTES, GENES ENCODING THESE POLYPEPTIDES AND PHARMACEUTICAL AND BIOLOGICAL APPLICATIONS |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
GB8905669D0 (en) | 1989-03-13 | 1989-04-26 | Celltech Ltd | Modified antibodies |
DE3920358A1 (en) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE |
WO1991000906A1 (en) | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
WO1991003493A1 (en) | 1989-08-29 | 1991-03-21 | The University Of Southampton | Bi-or trispecific (fab)3 or (fab)4 conjugates |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
FR2656800B1 (en) | 1990-01-08 | 1992-05-15 | Roussy Inst Gustave | NEW PROTEINS PRODUCED BY HUMAN LYMPHOCYTES, DNA SEQUENCE ENCODING THESE PROTEINS AND PHARMACEUTICAL AND BIOLOGICAL APPLICATIONS. |
US5976877A (en) | 1990-01-08 | 1999-11-02 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Proteins produced by human lymphocytes DNA sequence encoding these proteins and their pharmaceutical and biological uses |
SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
US5273743A (en) | 1990-03-09 | 1993-12-28 | Hybritech Incorporated | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9012995D0 (en) | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
ATE185601T1 (en) | 1990-07-10 | 1999-10-15 | Cambridge Antibody Tech | METHOD FOR PRODUCING SPECIFIC BONDING PAIRS |
JPH06506105A (en) | 1990-08-29 | 1994-07-14 | ファーミング ビーブイ | Homologous recombination in mammalian cells |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
ES2108048T3 (en) | 1990-08-29 | 1997-12-16 | Genpharm Int | PRODUCTION AND USE OF LOWER TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGICAL ANTIBODIES. |
ES2113940T3 (en) | 1990-12-03 | 1998-05-16 | Genentech Inc | ENRICHMENT METHOD FOR PROTEIN VARIANTS WITH ALTERED UNION PROPERTIES. |
US5582996A (en) | 1990-12-04 | 1996-12-10 | The Wistar Institute Of Anatomy & Biology | Bifunctional antibodies and method of preparing same |
US6596536B1 (en) | 1991-02-08 | 2003-07-22 | Aventis Pharma S.A. | Nucleotide sequences coding for variable regions of the alpha chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses |
WO1992013949A1 (en) | 1991-02-08 | 1992-08-20 | Roussel-Uclaf | Nucleotide sequences coding for alpha chain variable regions in human lymphocyte receptors and applications thereof |
CA2079881C (en) | 1991-02-12 | 2007-11-06 | Thierry Hercend | Nucleotidic sequences coding for variable regions of .beta. chains of human t lymphocite receptors, corresponding peptidic segments and diagnostic and therapeutic applications |
JP4146512B2 (en) | 1991-03-01 | 2008-09-10 | ダイアックス コープ. | Small protein |
US6582959B2 (en) | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
US20030206899A1 (en) | 1991-03-29 | 2003-11-06 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
EP0580737B1 (en) | 1991-04-10 | 2004-06-16 | The Scripps Research Institute | Heterodimeric receptor libraries using phagemids |
EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
DE4118120A1 (en) | 1991-06-03 | 1992-12-10 | Behringwerke Ag | TETRAVALENT BISPECIFIC RECEPTORS, THEIR PRODUCTION AND USE |
US6511663B1 (en) | 1991-06-11 | 2003-01-28 | Celltech R&D Limited | Tri- and tetra-valent monospecific antigen-binding proteins |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
EP0606217B2 (en) | 1991-06-27 | 2008-12-03 | Bristol-Myers Squibb Company | Ctl4a receptor, fusion proteins containing it and uses thereof |
DE4122599C2 (en) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid for screening antibodies |
US5932448A (en) | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
WO1993015210A1 (en) | 1992-01-23 | 1993-08-05 | Merck Patent Gmbh | Monomeric and dimeric antibody-fragment fusion proteins |
WO1993016185A2 (en) | 1992-02-06 | 1993-08-19 | Creative Biomolecules, Inc. | Biosynthetic binding protein for cancer marker |
CA2076465C (en) | 1992-03-25 | 2002-11-26 | Ravi V. J. Chari | Cell binding agent conjugates of analogues and derivatives of cc-1065 |
CA2135408A1 (en) | 1992-05-08 | 1993-11-25 | Peter C. Keck | Chimeric multivalent protein analogues and methods of use thereof |
US5260074A (en) | 1992-06-22 | 1993-11-09 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
PT1498427E (en) | 1992-08-21 | 2010-03-22 | Univ Bruxelles | Immunoglobulins devoid of light chains |
US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
SG41929A1 (en) | 1992-09-25 | 1997-08-15 | Commw Scient Ind Res Org | Target binding polypeptide |
GB9221657D0 (en) | 1992-10-15 | 1992-11-25 | Scotgen Ltd | Recombinant bispecific antibodies |
DE69233803D1 (en) | 1992-10-28 | 2011-03-31 | Genentech Inc | Use of vascular endothelial growth factor antagonists |
US5837821A (en) | 1992-11-04 | 1998-11-17 | City Of Hope | Antibody construct |
GB9323648D0 (en) | 1992-11-23 | 1994-01-05 | Zeneca Ltd | Proteins |
CA2150262C (en) | 1992-12-04 | 2008-07-08 | Kaspar-Philipp Holliger | Multivalent and multispecific binding proteins, their manufacture and use |
US6476198B1 (en) | 1993-07-13 | 2002-11-05 | The Scripps Research Institute | Multispecific and multivalent antigen-binding polypeptide molecules |
US5635602A (en) | 1993-08-13 | 1997-06-03 | The Regents Of The University Of California | Design and synthesis of bispecific DNA-antibody conjugates |
WO1995009917A1 (en) | 1993-10-07 | 1995-04-13 | The Regents Of The University Of California | Genetically engineered bispecific tetravalent antibodies |
IL108501A (en) | 1994-01-31 | 1998-10-30 | Mor Research Applic Ltd | Antibodies and pharmaceutical compositions containing them |
CA2143491C (en) | 1994-03-01 | 2011-02-22 | Yasumasa Ishida | A novel peptide related to human programmed cell death and dna encoding it |
CA2189657C (en) | 1994-05-06 | 2002-03-12 | Florence Faure | Lag-3 protein soluble polypeptide fractions, method of production, therapeutic composition and anti-idiotype antibody |
WO1996013583A2 (en) | 1994-10-20 | 1996-05-09 | Morphosys Gesellschaft Für Proteinoptimierung Mbh | Targeted hetero-association of recombinant proteins to multi-functional complexes |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US6066322A (en) | 1995-03-03 | 2000-05-23 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of immune disorders |
IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
DE69633175T2 (en) | 1995-05-23 | 2005-08-11 | Morphosys Ag | MULTIMETER PROTEINS |
DK0843557T3 (en) | 1995-07-21 | 2003-03-10 | Inst Nat Sante Rech Med | Methods for detection, identification, isolation and selective labeling and targeting of Th1 lymphocytes using LAG-3 protein |
US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
US6632976B1 (en) | 1995-08-29 | 2003-10-14 | Kirin Beer Kabushiki Kaisha | Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene |
EP0843961B1 (en) | 1995-08-29 | 2007-01-24 | Kirin Beer Kabushiki Kaisha | Chimeric animal and method for constructing the same |
CN1173878A (en) | 1995-10-16 | 1998-02-18 | 尤尼利弗公司 | Bifunctional or bivalent antibody fragment analogue |
US5968511A (en) | 1996-03-27 | 1999-10-19 | Genentech, Inc. | ErbB3 antibodies |
WO1997038102A1 (en) | 1996-04-04 | 1997-10-16 | Unilever Plc | Multivalent and multispecific antigen-binding protein |
TW533205B (en) | 1996-06-25 | 2003-05-21 | Novartis Ag | Substituted 3,5-diphenyl-l,2,4-triazoles and their pharmaceutical composition |
AU4055697A (en) | 1996-08-16 | 1998-03-06 | Schering Corporation | Mammalian cell surface antigens; related reagents |
US6111090A (en) | 1996-08-16 | 2000-08-29 | Schering Corporation | Mammalian cell surface antigens; related reagents |
IL130123A (en) | 1996-11-28 | 2007-07-24 | Roussy Inst Gustave | Mutants of the lag-3 protein, their expression and use and method for their production |
NZ500077A (en) | 1997-04-07 | 2001-10-26 | Genentech Inc | Humanized antibodies to vascular endothelial growth factor (VEGF) and methods for their preparation. |
BRPI9809387B8 (en) | 1997-04-07 | 2021-05-25 | Genentech Inc | humanized anti-human vascular endothelial growth factor antibody and composition comprising it |
US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
WO1998049198A1 (en) | 1997-04-30 | 1998-11-05 | Enzon, Inc. | Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof |
US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
US20030207346A1 (en) | 1997-05-02 | 2003-11-06 | William R. Arathoon | Method for making multispecific antibodies having heteromultimeric and common components |
CA2304254C (en) | 1997-06-11 | 2012-05-22 | Hans Christian Thogersen | Trimerising module |
EP0900841A1 (en) | 1997-06-18 | 1999-03-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | LAG-3 splice variants |
CO4940418A1 (en) | 1997-07-18 | 2000-07-24 | Novartis Ag | MODIFICATION OF A CRYSTAL OF A DERIVATIVE OF N-PHENYL-2-PIRIMIDINAMINE, PROCESSES FOR ITS MANUFACTURE AND USE |
EP0893507A1 (en) | 1997-07-25 | 1999-01-27 | Institut Gustave Roussy | Use of MHC class II ligands (CD4 and LAG-3) as adjuvant for vaccination and of LAG-3 in cancer treatment |
AU1102399A (en) | 1997-10-21 | 1999-05-10 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like proteins tr11, tr11sv1, and tr11sv2 |
DE69841562D1 (en) | 1997-10-27 | 2010-04-29 | Bac Ip Bv | MULTIVALENT ANTIGENBINDING PROTEINS |
ES2234241T3 (en) | 1998-01-23 | 2005-06-16 | Vlaams Interuniversitair Instituut Voor Biotechnologie | DERIVATIVES OF ANTIBODY OF MULTIPLE PURPOSES. |
EP1053321A1 (en) | 1998-02-09 | 2000-11-22 | Genentech, Inc. | Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same |
CZ121599A3 (en) | 1998-04-09 | 1999-10-13 | Aventis Pharma Deutschland Gmbh | Single-chain molecule binding several antigens, process of its preparation and medicament in which the molecule is comprised |
CA2328725A1 (en) | 1998-04-15 | 1999-10-21 | Brigham & Women's Hospital, Inc. | T cell inhibitory receptor compositions and uses thereof |
DE19819846B4 (en) | 1998-05-05 | 2016-11-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Multivalent antibody constructs |
GB9812545D0 (en) | 1998-06-10 | 1998-08-05 | Celltech Therapeutics Ltd | Biological products |
ATE251181T1 (en) | 1998-07-28 | 2003-10-15 | Micromet Ag | HETEROMINI BODY |
US6333396B1 (en) | 1998-10-20 | 2001-12-25 | Enzon, Inc. | Method for targeted delivery of nucleic acids |
AU774962B2 (en) | 1998-12-03 | 2004-07-15 | Regents Of The University Of California, The | Stimulation of T cells against self antigens using CTLA-4 blocking agents |
US7041474B2 (en) | 1998-12-30 | 2006-05-09 | Millennium Pharmaceuticals, Inc. | Nucleic acid encoding human tango 509 |
IL129299A0 (en) | 1999-03-31 | 2000-02-17 | Mor Research Applic Ltd | Monoclonal antibodies antigens and diagnosis of malignant diseases |
US6703020B1 (en) | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
US7527787B2 (en) | 2005-10-19 | 2009-05-05 | Ibc Pharmaceuticals, Inc. | Multivalent immunoglobulin-based bioactive assemblies |
US7534866B2 (en) | 2005-10-19 | 2009-05-19 | Ibc Pharmaceuticals, Inc. | Methods and compositions for generating bioactive assemblies of increased complexity and uses |
GB9911569D0 (en) | 1999-05-18 | 1999-07-21 | Oxford Biomedica Ltd | Antibodies |
FR2794025A1 (en) | 1999-05-25 | 2000-12-01 | Transgene Sa | COMPOSITION FOR IMPLEMENTING ANTI-TUMOR OR ANTIVIRAL TREATMENT IN A MAMMAL |
AU5309600A (en) | 1999-06-02 | 2000-12-18 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the treatment and diagnosis of immune disorders |
WO2001003720A2 (en) | 1999-07-12 | 2001-01-18 | Genentech, Inc. | Promotion or inhibition of angiogenesis and cardiovascularization by tumor necrosis factor ligand/receptor homologs |
BR0013542A (en) | 1999-08-23 | 2002-05-14 | Dana Farber Cancer Inst Inc | B7-4 molecules and uses for them |
ES2539411T3 (en) | 1999-08-23 | 2015-06-30 | Dana-Farber Cancer Institute, Inc. | PD-1, receiver for B7-4 and its use |
US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
CN1371416B (en) | 1999-08-24 | 2012-10-10 | 梅达里克斯公司 | Human CTLA-4 antibodies and their uses |
US6803192B1 (en) | 1999-11-30 | 2004-10-12 | Mayo Foundation For Medical Education And Research | B7-H1, a novel immunoregulatory molecule |
ES2629683T3 (en) | 1999-11-30 | 2017-08-14 | Mayo Foundation For Medical Education And Research | B7-H1, a new immunoregulatory molecule |
GB0018891D0 (en) | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
IL151853A0 (en) | 2000-04-11 | 2003-04-10 | Genentech Inc | Multivalent antibodies and uses therefor |
US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
WO2001090192A2 (en) | 2000-05-24 | 2001-11-29 | Imclone Systems Incorporated | Bispecific immunoglobulin-like antigen binding proteins and method of production |
MXPA02012106A (en) | 2000-06-06 | 2003-06-06 | Bristol Myers Squibb Co | B7-related nucleic acids and polypeptides useful for immunomodulation. |
ES2609016T3 (en) | 2000-06-16 | 2017-04-18 | Human Genome Sciences, Inc. | Antibodies that bind immunospecifically to BLyS |
CA2414331C (en) | 2000-06-28 | 2011-11-29 | Genetics Institute, Llc. | Pd-l2 molecules: novel pd-1 ligands and uses therefor |
EP1294904A1 (en) | 2000-06-30 | 2003-03-26 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Heterodimeric fusion proteins |
JP2004523205A (en) | 2000-07-25 | 2004-08-05 | イムノメディクス, インコーポレイテッド | Multivalent target binding protein |
PE20020354A1 (en) | 2000-09-01 | 2002-06-12 | Novartis Ag | HYDROXAMATE COMPOUNDS AS HISTONE-DESACETILASE (HDA) INHIBITORS |
CA2422215A1 (en) | 2000-09-20 | 2002-03-28 | Amgen Inc. | B7-like molecules and uses thereof |
US7132109B1 (en) | 2000-10-20 | 2006-11-07 | University Of Connecticut Health Center | Using heat shock proteins to increase immune response |
EP1368061B1 (en) | 2000-10-20 | 2008-12-24 | Tsuneya Ohno | Fusion cells and cytokine compositions for treatment of disease |
EP2351838A1 (en) | 2000-10-20 | 2011-08-03 | Chugai Seiyaku Kabushiki Kaisha | Crosslinking agonistic antibodies |
EP1334659B1 (en) | 2000-11-15 | 2012-01-11 | Ono Pharmaceutical Co., Ltd. | Pd-1-lacking mouse and use thereof |
JP2002194491A (en) | 2000-12-27 | 2002-07-10 | Daido Steel Co Ltd | Steel for spring |
US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
CA2438279A1 (en) | 2001-02-22 | 2002-09-26 | Institut Pasteur | Comparative mycobacterial geneomics as a tool for identifying targets for the diagnosis, prophylaxis or treatment of mycobacterioses |
WO2002072635A2 (en) | 2001-03-13 | 2002-09-19 | University College London | Specific binding members |
EP2388590A1 (en) | 2001-04-02 | 2011-11-23 | Dana Farber Cancer Institute | PD-1, a receptor for B7-4, and uses thereof |
AR036993A1 (en) | 2001-04-02 | 2004-10-20 | Wyeth Corp | USE OF AGENTS THAT MODULATE THE INTERACTION BETWEEN PD-1 AND ITS LINKS IN THE SUBMODULATION OF IMMUNOLOGICAL ANSWERS |
US20020146753A1 (en) | 2001-04-06 | 2002-10-10 | Henrik Ditzel | Autoantibodies to glucose-6-phosphate isomerase and their participation in autoimmune disease |
AU2002258941A1 (en) | 2001-04-20 | 2002-11-05 | Mayo Foundation For Medical Education And Research | Methods of enhancing cell responsiveness |
US6727072B2 (en) | 2001-05-01 | 2004-04-27 | Dako Corporation | EGF-r detection kit |
US6592849B2 (en) | 2001-06-21 | 2003-07-15 | Colgate Palmolive Company | Chewing gum to control malodorous breath |
JP4303105B2 (en) | 2001-06-28 | 2009-07-29 | ドマンティス リミテッド | Dual specific ligands and their use |
US7838220B2 (en) | 2001-06-29 | 2010-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | T cell regulatory genes associated with immune disease |
US8709412B2 (en) | 2001-06-29 | 2014-04-29 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of TIM receptor activity in combination with cytoreductive therapy |
EP1406653A4 (en) | 2001-06-29 | 2005-05-04 | Univ Leland Stanford Junior | T cell regulatory genes and methods of use thereof |
JP2003029846A (en) | 2001-07-11 | 2003-01-31 | Sanyo Electric Co Ltd | Flow rate adjusting unit and beverage supplying device equipped with flow rate adjusting unit |
ATE524495T1 (en) | 2001-07-31 | 2011-09-15 | Ono Pharmaceutical Co | PD-1 SPECIFIC SUBSTANCE |
US6833441B2 (en) | 2001-08-01 | 2004-12-21 | Abmaxis, Inc. | Compositions and methods for generating chimeric heteromultimers |
EP1293514B1 (en) | 2001-09-14 | 2006-11-29 | Affimed Therapeutics AG | Multimeric single chain tandem Fv-antibodies |
WO2003025202A2 (en) | 2001-09-19 | 2003-03-27 | Alexion Pharmaceuticals, Inc. | Engineered templates and their use in single primer amplification |
EP1295895B1 (en) | 2001-09-19 | 2011-08-10 | Institut Gustave Roussy | Peptides and proteins binding to glu-pro motifs, therapeutical compositions containing the same and applications thereof |
IL145926A0 (en) | 2001-10-15 | 2002-07-25 | Mor Research Applic Ltd | Peptide epitopes of mimotopes useful in immunomodulation |
ATE335490T1 (en) | 2001-10-30 | 2006-09-15 | Novartis Pharma Gmbh | STAUROSPORINE DERIVATIVES AS INHIBITORS OF FLT3 RECEPTOR TYROSINE KINASE ACTION |
CA2466279A1 (en) | 2001-11-13 | 2003-05-22 | Dana-Farber Cancer Institute, Inc. | Agents that modulate immune cell activation and methods of use thereof |
US20030211078A1 (en) | 2001-12-07 | 2003-11-13 | Heavner George A. | Pseudo-antibody constructs |
EP1467759A4 (en) | 2002-01-30 | 2006-05-31 | Brigham & Womens Hospital | Compositions and methods related to tim-3, a th1-specific cell surface molecule |
ES2485841T3 (en) | 2002-02-01 | 2014-08-14 | Ariad Pharmaceuticals, Inc | Compounds containing phosphorus and uses thereof |
CA2476518A1 (en) | 2002-02-22 | 2003-09-04 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
CA2478011C (en) | 2002-03-01 | 2013-05-21 | Immunomedics, Inc. | Bispecific antibody point mutations for enhancing rate of clearance |
PT3000810T (en) | 2002-03-13 | 2017-10-25 | Array Biopharma Inc | N3 alkylated benzimidazole derivative as mek inhibitor |
US8030461B2 (en) | 2002-04-15 | 2011-10-04 | Chugai Seiyaku Kabushiki Kaisha | Methods for constructing scDb libraries |
CA2481507A1 (en) | 2002-04-16 | 2003-10-30 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
IL149820A0 (en) | 2002-05-23 | 2002-11-10 | Curetech Ltd | Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency |
EP3287144A1 (en) | 2002-07-03 | 2018-02-28 | ONO Pharmaceutical Co., Ltd. | Immunopotentiating compositions |
GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
US7052694B2 (en) | 2002-07-16 | 2006-05-30 | Mayo Foundation For Medical Education And Research | Dendritic cell potentiation |
US20040047858A1 (en) | 2002-09-11 | 2004-03-11 | Blumberg Richard S. | Therapeutic anti-BGP(C-CAM1) antibodies and uses thereof |
EP2322200A3 (en) | 2002-10-29 | 2011-07-27 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
EP2287192B1 (en) | 2002-11-15 | 2015-08-26 | Novartis Vaccines and Diagnostics, Inc. | Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis |
US7449300B2 (en) | 2002-11-21 | 2008-11-11 | Mayo Foundation For Medical Education And Research | Detection of antibodies specific for B7-H1 in subjects with diseases or pathological conditions mediated by activated T cells |
CN101899114A (en) | 2002-12-23 | 2010-12-01 | 惠氏公司 | Anti-PD-1 antibody and uses thereof |
GB0230203D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
KR20050107399A (en) | 2003-01-23 | 2005-11-11 | 오노 야꾸힝 고교 가부시키가이샤 | Substance specific to human pd-1 |
BRPI0407403B1 (en) | 2003-02-11 | 2022-07-19 | Cancer Research Technology Ltd | ISOXAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITION |
WO2005035732A2 (en) | 2003-02-19 | 2005-04-21 | Dyax Corporation | Papp-a ligands |
ES2439580T3 (en) | 2003-02-28 | 2014-01-23 | The Johns Hopkins University | T cell regulation |
GB0305702D0 (en) | 2003-03-12 | 2003-04-16 | Univ Birmingham | Bispecific antibodies |
JP2006526408A (en) | 2003-04-22 | 2006-11-24 | アイビーシー、ファーマシューティカルズ | Multivalent protein complex |
NZ543654A (en) | 2003-05-23 | 2009-05-31 | Wyeth Corp | GITR ligand and GITR ligand-related molecules and antibodies and uses thereof |
ME00425B (en) | 2003-05-30 | 2011-10-10 | Genentech Inc | Treatment with anti-vegf antibodies |
AU2004252171B2 (en) | 2003-06-27 | 2011-04-21 | Biogen Ma Inc. | Modified binding molecules comprising connecting peptides |
KR20060041205A (en) | 2003-07-01 | 2006-05-11 | 이뮤노메딕스, 인코오포레이티드 | Multivalent carriers of bi-specific antibodies |
US20050048054A1 (en) | 2003-07-11 | 2005-03-03 | Shino Hanabuchi | Lymphocytes; methods |
US7696322B2 (en) | 2003-07-28 | 2010-04-13 | Catalent Pharma Solutions, Inc. | Fusion antibodies |
US20050106667A1 (en) | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
WO2005044853A2 (en) | 2003-11-01 | 2005-05-19 | Genentech, Inc. | Anti-vegf antibodies |
CA2541006C (en) | 2003-10-03 | 2015-02-17 | Brigham And Women's Hospital | Tim-3 polypeptides |
AU2004279742A1 (en) | 2003-10-08 | 2005-04-21 | Kyowa Hakko Kirin Co., Ltd. | Fused protein composition |
AU2004279441B2 (en) | 2003-10-08 | 2010-07-01 | The Feinstein Institute For Medical Research | Methods and compositions for diagnosis and treatment of B cell chronic lymphocytic leukemia |
EP1682103A1 (en) | 2003-10-27 | 2006-07-26 | Novartis AG | Indolyl-pyrroledione derivatives for the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation |
EP1692318A4 (en) | 2003-12-02 | 2008-04-02 | Genzyme Corp | Compositions and methods to diagnose and treat lung cancer |
AU2004308439A1 (en) | 2003-12-22 | 2005-07-14 | Centocor, Inc. | Methods for generating multimeric molecules |
GB0329825D0 (en) | 2003-12-23 | 2004-01-28 | Celltech R&D Ltd | Biological products |
US20050266425A1 (en) | 2003-12-31 | 2005-12-01 | Vaccinex, Inc. | Methods for producing and identifying multispecific antibodies |
AU2005207946A1 (en) | 2004-01-23 | 2005-08-11 | Amgen Inc. | Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer |
US8383575B2 (en) | 2004-01-30 | 2013-02-26 | Paul Scherrer Institut | (DI)barnase-barstar complexes |
EA200601761A1 (en) | 2004-03-24 | 2007-06-29 | Телос Фармасьютикалз, Инк. | COMPOSITIONS AS ADJUVANTS FOR STRENGTHENING IMMUNE RESPONSES TO VACCINES AND METHODS OF THEIR USE |
BR122019012028B1 (en) | 2004-04-13 | 2023-09-26 | F. Hoffmann-La Roche Ag | ANTI-P-SELECTIN ANTIBODIES, NUCLEIC ACID MOLECULE, VECTOR, AND COMPOSITION |
GB0409799D0 (en) | 2004-04-30 | 2004-06-09 | Isis Innovation | Method of generating improved immune response |
CN101031569B (en) | 2004-05-13 | 2011-06-22 | 艾科斯有限公司 | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta |
US20060002932A1 (en) | 2004-06-04 | 2006-01-05 | Duke University | Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity |
PL1761528T3 (en) | 2004-06-11 | 2008-05-30 | Japan Tobacco Inc | 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2h-pyrido[2,3-d]pyrimidine derivatives and related compounds for the treatment of cancer |
GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
US20060009360A1 (en) | 2004-06-25 | 2006-01-12 | Robert Pifer | New adjuvant composition |
EP1768999B1 (en) | 2004-06-30 | 2013-06-19 | Mayo Foundation For Medical Education And Research | sHIgM12 antibody useful to treat multiple sclerosis |
JP2008512352A (en) | 2004-07-17 | 2008-04-24 | イムクローン システムズ インコーポレイティド | Novel tetravalent bispecific antibody |
EA014182B1 (en) | 2004-07-20 | 2010-10-29 | Симфоген А/С | Anti-rhesus d recombinant polyclonal antibody composition, method for manufacturing thereof and use thereof |
JP2008515774A (en) | 2004-08-03 | 2008-05-15 | ダイアックス コーポレイション | hK1 binding protein |
US20090123413A1 (en) | 2004-08-23 | 2009-05-14 | Britta Hardy | Use of bat monoclonal antibody for immunotherapy |
CA2577082A1 (en) | 2004-09-02 | 2006-03-16 | Genentech, Inc. | Heteromultimeric molecules |
TWI380996B (en) * | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | Anti-ox40l antibodies |
AU2005292227A1 (en) | 2004-10-01 | 2006-04-13 | Medarex, Inc. | Methods of treating CD30 positive lymphomas |
PT1810026T (en) | 2004-10-06 | 2018-06-11 | Mayo Found Medical Education & Res | B7-h1 and pd-1 in treatment of renal cell carcinoma |
US7423128B2 (en) | 2004-11-03 | 2008-09-09 | Amgen Fremont Inc. | Anti-properdin antibodies, and methods for making and using same |
ES2657443T3 (en) | 2005-03-25 | 2018-03-05 | Gitr, Inc. | Anti-GITR antibodies and uses thereof |
JP5620626B2 (en) | 2005-03-31 | 2014-11-05 | 中外製薬株式会社 | Polypeptide production method by association control |
CN101484182B (en) | 2005-04-06 | 2014-06-11 | Ibc药品公司 | Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses |
US9296816B2 (en) | 2005-04-15 | 2016-03-29 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
PL2439273T3 (en) | 2005-05-09 | 2019-08-30 | Ono Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
WO2006124269A2 (en) | 2005-05-16 | 2006-11-23 | Amgen Fremont Inc. | Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
US20060263367A1 (en) | 2005-05-23 | 2006-11-23 | Fey Georg H | Bispecific antibody devoid of Fc region and method of treatment using same |
PL1907000T5 (en) | 2005-06-08 | 2020-11-16 | Dana-Farber Cancer Institute | Methods and compositions for the treatment of persistent HIV infections by inhibiting the programmed cell death 1 (PD-1) pathway |
AU2006261127B2 (en) * | 2005-06-17 | 2012-03-15 | Merck Sharp & Dohme Corp. | ILT3 binding molecules and uses therefor |
JP4557003B2 (en) | 2005-07-01 | 2010-10-06 | 株式会社村田製作所 | MULTILAYER CERAMIC SUBSTRATE, MANUFACTURING METHOD THEREOF, AND COMPOSITE GREEN SHEET FOR PRODUCTION OF MULTILAYER CERAMIC SUBSTRATE |
RS54271B1 (en) | 2005-07-01 | 2016-02-29 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death ligand 1 (pd-l1) |
HUE035853T2 (en) | 2005-07-18 | 2018-05-28 | Seattle Genetics Inc | Beta-glucuronide-linker drug conjugates |
US20070041905A1 (en) | 2005-08-19 | 2007-02-22 | Hoffman Rebecca S | Method of treating depression using a TNF-alpha antibody |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
MY169746A (en) | 2005-08-19 | 2019-05-14 | Abbvie Inc | Dual variable domain immunoglobulin and uses thereof |
GT200600381A (en) | 2005-08-25 | 2007-03-28 | ORGANIC COMPOUNDS | |
DE602005018477D1 (en) | 2005-08-26 | 2010-02-04 | Pls Design Gmbh | Bivalent IgY antibody constructs for diagnostic and therapeutic applications |
PE20070335A1 (en) | 2005-08-30 | 2007-04-21 | Novartis Ag | SUBSTITUTE BENZIMIDAZOLES AND METHODS FOR THEIR PREPARATION |
WO2007044887A2 (en) | 2005-10-11 | 2007-04-19 | Transtarget, Inc. | Method for producing a population of homogenous tetravalent bispecific antibodies |
ES2577292T3 (en) | 2005-11-07 | 2016-07-14 | Genentech, Inc. | Binding polypeptides with diversified VH / VL hypervariable sequences and consensus |
EP1962961B1 (en) | 2005-11-29 | 2013-01-09 | The University Of Sydney | Demibodies: dimerisation-activated therapeutic agents |
JP2009518320A (en) | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | Anti-orthopox virus recombinant polyclonal antibody |
DK2348023T5 (en) | 2005-12-13 | 2017-05-15 | Incyte Holdings Corp | Heteroberl-substituted pyrrolo [2,3-b] pyridines and pyrrolo [2,3-b] pyrimidines as Janus kinase inhibitors |
US20090215084A1 (en) | 2006-01-05 | 2009-08-27 | Mayo Foundation For Medical Education And Research | B7-h1 and b7-h4 in cancer |
US20110212086A1 (en) | 2006-01-19 | 2011-09-01 | Genzyme Corporation | GITR Antibodies For The Treatment of Cancer |
JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | PI-3 Kinase inhibitors and methods of their use |
JP2009526857A (en) | 2006-02-15 | 2009-07-23 | イムクローン・リミテッド・ライアビリティ・カンパニー | Functional antibody |
SG170750A1 (en) | 2006-03-17 | 2011-05-30 | Biogen Idec Inc | Stabilized polypeptide compositions |
CA2646965C (en) | 2006-03-24 | 2016-06-21 | Jonathan H. Davis | Engineered heterodimeric protein domains |
WO2007112362A2 (en) | 2006-03-24 | 2007-10-04 | The Regents Of The University Of California | Construction of a multivalent scfv through alkyne-azide 1,3-dipolar cycloaddition |
EP2009101B1 (en) | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
WO2007113648A2 (en) | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Ctla4 antibody combination therapy |
UA93548C2 (en) | 2006-05-05 | 2011-02-25 | Айерем Елелсі | Compounds and compositions as hedgehog pathway modulators |
ES2469676T3 (en) | 2006-05-25 | 2014-06-18 | Bayer Intellectual Property Gmbh | Dimeric molecular complexes |
US20070274985A1 (en) | 2006-05-26 | 2007-11-29 | Stefan Dubel | Antibody |
CA2654317A1 (en) | 2006-06-12 | 2007-12-21 | Trubion Pharmaceuticals, Inc. | Single-chain multivalent binding proteins with effector function |
WO2008007648A1 (en) | 2006-07-10 | 2008-01-17 | Institute For Antibodies Co., Ltd. | Method of classifying antigen, method of identifying antigen, method of obtaining antibody or antibody set, method of constructing antibody panel and antibody or antibody set and use of the same |
PE20110220A1 (en) | 2006-08-02 | 2011-04-11 | Novartis Ag | DERIVATIVES OF 2-OXO-ETHYL-AMINO-PROPIONAMIDE-PYRROLIDIN-2-IL-SUBSTITUTED AS INHIBITORS OF THE BINDING OF THE PROTEIN Smac TO THE INHIBITOR OF THE PROTEIN OF APOPTOSIS |
WO2008073160A2 (en) | 2006-08-17 | 2008-06-19 | The Trustees Of Columbia University In The City Of New York | Methods for converting or inducing protective immunity |
US8497246B2 (en) | 2006-08-18 | 2013-07-30 | Armagen Technologies, Inc. | Methods for diagnosing and treating CNS disorders by trans-blood-brain barrier delivery of protein compositions |
TW201441262A (en) | 2006-08-18 | 2014-11-01 | Novartis Ag | PRLR-specific antibody and uses thereof |
ATE531720T1 (en) | 2006-08-21 | 2011-11-15 | Genentech Inc | AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE THEREOF |
US10118970B2 (en) | 2006-08-30 | 2018-11-06 | Genentech, Inc. | Multispecific antibodies |
EP2061504A4 (en) | 2006-09-20 | 2010-01-27 | Univ Johns Hopkins | Combinatorieal therapy of cancer and infectious diseases with anti-b7-h1 antibodies |
US20080254512A1 (en) | 2006-11-02 | 2008-10-16 | Capon Daniel J | Hybrid immunoglobulins with moving parts |
WO2008060617A2 (en) | 2006-11-15 | 2008-05-22 | The Brigham And Women's Hospital, Inc. | Therapeutic uses of tim-3 modulators |
MY188338A (en) | 2006-11-22 | 2021-11-30 | Incyte Holdings Corp | Imidazotriazines and imidazopyrimidines as kinase inhibitors |
EP2962697A1 (en) | 2006-11-27 | 2016-01-06 | diaDexus, Inc. | Ovr110 antibody compositions and methods of use |
EA019941B1 (en) | 2006-12-08 | 2014-07-30 | АйАрЭм ЭлЭлСи | Compounds and compositions as protein kinase inhibitors |
CN103641833A (en) | 2006-12-08 | 2014-03-19 | Irm责任有限公司 | Compounds and compositions as protein kinase inhibitors |
CA2672595A1 (en) | 2006-12-15 | 2008-06-19 | Guy Hermans | Amino acid sequences that modulate the interaction between cells of the immune system |
NZ600281A (en) * | 2006-12-27 | 2013-03-28 | Harvard College | Compositions and methods for the treatment of infections and tumors |
MX2009010282A (en) | 2007-03-29 | 2009-10-12 | Genmab As | Bispecific antibodies and methods for production thereof. |
EP2144930A1 (en) | 2007-04-18 | 2010-01-20 | ZymoGenetics, Inc. | Single chain fc, methods of making and methods of treatment |
EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
US9244059B2 (en) | 2007-04-30 | 2016-01-26 | Immutep Parc Club Orsay | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
EP2170959B1 (en) | 2007-06-18 | 2013-10-02 | Merck Sharp & Dohme B.V. | Antibodies to human programmed death receptor pd-1 |
ES2776406T3 (en) | 2007-07-12 | 2020-07-30 | Gitr Inc | Combination therapies using GITR-binding molecules |
EP2170946A2 (en) | 2007-07-13 | 2010-04-07 | The Johns Hopkins University | B7-dc variants |
US20090028857A1 (en) | 2007-07-23 | 2009-01-29 | Cell Genesys, Inc. | Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof |
KR20100058509A (en) | 2007-07-31 | 2010-06-03 | 메디뮨 엘엘씨 | Multispecific epitope binding proteins and uses thereof |
CA2696263C (en) | 2007-08-15 | 2017-06-13 | Bing Liu | Monospecific and multispecific antibodies and method of use |
WO2009024531A1 (en) | 2007-08-17 | 2009-02-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating and diagnosing hematologic malignancies |
WO2009032256A2 (en) | 2007-08-30 | 2009-03-12 | Cell Genesys, Inc. | Apc activators in combination with a cytokine-secreting cell and methods of use thereof |
EP2195342A1 (en) | 2007-09-07 | 2010-06-16 | Ablynx N.V. | Binding molecules with multiple binding sites, compositions comprising the same and uses thereof |
EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
AU2008328781A1 (en) | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same |
GB2468232B (en) | 2007-11-30 | 2012-10-24 | Glaxo Group Ltd | Antigen-bindng constructs |
PE20091158A1 (en) | 2007-12-19 | 2009-08-28 | Genentech Inc | 5-ANILINOIMIDAZOPYRIDINES AND METHODS OF USE |
US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
PL2235064T3 (en) | 2008-01-07 | 2016-06-30 | Amgen Inc | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
CA3221018A1 (en) | 2008-01-15 | 2009-07-23 | Ravindra Majeti | Markers of acute myeloid leukemia stem cells |
US20110059106A1 (en) | 2008-01-29 | 2011-03-10 | Brigham And Women's Hospital, Inc. | Methods for modulating a population of myeloid-derived suppressor cells and uses thereof |
HUE034465T2 (en) * | 2008-02-11 | 2018-02-28 | Cure Tech Ltd | Monoclonal antibodies for tumor treatment |
EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | Pd-1 binding proteins |
WO2009114870A2 (en) | 2008-03-14 | 2009-09-17 | Intellikine, Inc. | Kinase inhibitors and methods of use |
AR070924A1 (en) | 2008-03-19 | 2010-05-12 | Novartis Ag | CRYSTAL FORMS AND TWO SOLVATED FORMS OF LACTIC ACID SALTS OF 4- AMINO -5- FLUORO-3- (5- (4-METHYLIPIPERAZIN-1-IL) -1H- BENCIMIDAZOL-2-IL) QUINOLIN -2- (1H) - ONA |
EP2271673B1 (en) | 2008-03-26 | 2016-02-24 | Cellerant Therapeutics, Inc. | Cytokine receptors associated with myelogenous haematological proliferative disorders and uses thereof |
US20100260668A1 (en) | 2008-04-29 | 2010-10-14 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
US9029508B2 (en) | 2008-04-29 | 2015-05-12 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
EP2300455B1 (en) | 2008-05-21 | 2017-07-19 | Incyte Holdings Corporation | Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same |
MX2010012699A (en) | 2008-05-23 | 2010-12-07 | Novartis Ag | Derivatives of quinolines and quinoxalines as protein tyrosine kinase inhibitors. |
KR20110016959A (en) | 2008-06-03 | 2011-02-18 | 아보트 러보러터리즈 | Dual variable domain immunoglobulins and uses thereof |
BRPI0913406A2 (en) | 2008-06-03 | 2018-01-09 | Abbott Lab | double variable domain immunoglobulins and their uses |
UY31929A (en) | 2008-06-25 | 2010-01-05 | Irm Llc | COMPOUNDS AND COMPOSITIONS AS CINASE INHIBITORS |
JP2011526794A (en) | 2008-07-02 | 2011-10-20 | エマージェント プロダクト デベロップメント シアトル, エルエルシー | TGF-β antagonist multi-target binding molecule |
WO2010001617A1 (en) | 2008-07-04 | 2010-01-07 | Ono Pharmaceutical Co., Ltd. | Use of an efficacy marker for optimizing therapeutic efficacy of an anti-human pd-1 antibody on cancers |
BRPI0915231A2 (en) | 2008-07-08 | 2018-06-12 | Intellikine Inc | kinase inhibitor compounds and methods of use |
MX2010014574A (en) | 2008-07-08 | 2011-04-27 | Abbott Lab | Prostaglandin e2 dual variable domain immunoglobulins and uses thereof. |
US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
AR072999A1 (en) | 2008-08-11 | 2010-10-06 | Medarex Inc | HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE |
US8575427B2 (en) | 2008-08-12 | 2013-11-05 | The United States Of America As Represented By The Secretary Of Agriculture | Chorismate mutase gene from the potato cyst nematode Globodera rostochiensis |
PL2331547T3 (en) | 2008-08-22 | 2015-01-30 | Novartis Ag | Pyrrolopyrimidine compounds as cdk inhibitors |
KR20110074850A (en) | 2008-08-25 | 2011-07-04 | 앰플리뮨, 인크. | Pd-1 antagonists and methods of use thereof |
MX2011002252A (en) | 2008-08-25 | 2011-06-24 | Amplimmune Inc | Compositions of pd-1 antagonists and methods of use. |
BRPI0918268B1 (en) | 2008-09-02 | 2021-08-03 | Novartis Ag | PICOLINAMIDE DERIVATIVES, THEIR USE, AND PHARMACEUTICAL COMPOSITION |
UA104147C2 (en) | 2008-09-10 | 2014-01-10 | Новартис Аг | Pyrrolidine dicarboxylic acid derivative and use thereof in the treatment of proliferative diseases |
US8586023B2 (en) | 2008-09-12 | 2013-11-19 | Mie University | Cell capable of expressing exogenous GITR ligand |
AU2009290544B2 (en) | 2008-09-12 | 2015-07-16 | Oxford University Innovation Limited | PD-1 specific antibodies and uses thereof |
EP2342228B1 (en) | 2008-09-12 | 2017-09-06 | Oxford University Innovation Limited | Pd-1 specific antibodies and uses thereof |
AU2009296392B2 (en) * | 2008-09-26 | 2016-06-02 | Dana-Farber Cancer Institute, Inc. | Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor |
JP5731978B2 (en) | 2008-09-26 | 2015-06-10 | インテリカイン, エルエルシー | Heterocyclic kinase inhibitor |
KR101050829B1 (en) | 2008-10-02 | 2011-07-20 | 서울대학교산학협력단 | Anticancer agents comprising an anti-PD-1 antibody or an anti-PD-L1 antibody |
US8734795B2 (en) | 2008-10-31 | 2014-05-27 | Biogen Idec Ma Inc. | Light targeting molecules and uses thereof |
WO2010056735A1 (en) | 2008-11-11 | 2010-05-20 | The Trustees Of The University Of Pennsylvania | Compositions and methods for inhibiting an oncogenic protein to enhance immunogenicity |
PL2370076T3 (en) | 2008-11-28 | 2017-06-30 | Novartis Ag | Pharmaceutical combination comprising a Hsp 90 inhibitor and a mTOR inhibitor |
WO2010063011A2 (en) | 2008-11-28 | 2010-06-03 | Emory University | Methods for the treatment of infections and tumors |
CN102300879A (en) | 2008-12-04 | 2011-12-28 | 雅培制药有限公司 | Dual Variable Domain Immunoglobulins And Uses Thereof |
CN114835812A (en) | 2008-12-09 | 2022-08-02 | 霍夫曼-拉罗奇有限公司 | anti-PD-L1 antibodies and their use for enhancing T cell function |
JP5569946B2 (en) | 2009-01-26 | 2014-08-13 | 国立大学法人 岡山大学 | Immunosuppressants and preventive and therapeutic agents for autoimmune diseases |
ES2629337T3 (en) | 2009-02-09 | 2017-08-08 | Inserm - Institut National De La Santé Et De La Recherche Médicale | Antibodies against PD-1 and antibodies against PD-L1 and uses thereof |
UA103918C2 (en) | 2009-03-02 | 2013-12-10 | Айерем Элелси | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators |
NZ611324A (en) | 2009-03-05 | 2015-02-27 | Abbvie Inc | Il-17 binding proteins |
WO2010102278A1 (en) | 2009-03-06 | 2010-09-10 | President And Fellows Of Harvard College | Methods and compositions for the generation and maintenance of regulatory t cells |
EP2412825B8 (en) | 2009-03-24 | 2018-01-10 | Riken | Leukemia stem cell markers |
JP5748653B2 (en) | 2009-04-10 | 2015-07-15 | 協和発酵キリン株式会社 | Hematological tumor therapy using anti-TIM-3 antibody |
WO2010129304A2 (en) | 2009-04-27 | 2010-11-11 | Oncomed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
CN102482354B (en) | 2009-04-30 | 2015-02-25 | 特尔汗什莫尔医学基础设施研究和服务公司 | Anti CEACAM1 antibodies and methods of using same |
SG175427A1 (en) | 2009-05-01 | 2011-12-29 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
US20110008766A1 (en) | 2009-05-01 | 2011-01-13 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
US20120141501A1 (en) * | 2009-05-29 | 2012-06-07 | Forerunner Pharma Research Co. Ltd | Pharmaceutical Composition Containing Antagonist of EGF Family Ligand as Component |
JP5918129B2 (en) | 2009-06-22 | 2016-05-18 | メディミューン,エルエルシー | Engineered Fc region for site-specific conjugation |
UA105794C2 (en) | 2009-06-26 | 2014-06-25 | Новартіс Аг | 1,3-DISUBSTITUTED IMIDAZOLIDIN-2-ONE DERIVATIVES AS Cyp17 INHIBITORS |
PL2769737T3 (en) | 2009-07-20 | 2017-08-31 | Bristol-Myers Squibb Company | Combination of an anti-CTLA4 antibody with etoposide for the synergistic treatment of proliferative diseases |
TW201109438A (en) | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
JO3002B1 (en) | 2009-08-28 | 2016-09-05 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
RU2012112550A (en) | 2009-09-01 | 2013-10-10 | Эбботт Лэборетриз | IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND THEIR APPLICATION |
US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
IN2012DN01920A (en) | 2009-09-03 | 2015-07-24 | Schering Corp | |
IT1395574B1 (en) | 2009-09-14 | 2012-10-16 | Guala Dispensing Spa | DISTRIBUTION DEVICE |
RU2573915C2 (en) | 2009-09-16 | 2016-01-27 | Дженентек, Инк. | Protein complexes containing superhelix and/or banding, and their use |
ES2681214T3 (en) | 2009-09-30 | 2018-09-12 | Memorial Sloan-Kettering Cancer Center | Combination immunotherapy for cancer treatment |
BR112012008833A2 (en) | 2009-10-15 | 2015-09-08 | Abbott Lab | double variable domain immunoglobulins and uses thereof |
UY32979A (en) | 2009-10-28 | 2011-02-28 | Abbott Lab | IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME |
GB0919054D0 (en) | 2009-10-30 | 2009-12-16 | Isis Innovation | Treatment of obesity |
LT3279215T (en) | 2009-11-24 | 2020-04-10 | Medimmune Limited | Targeted binding agents against b7-h1 |
US20130017199A1 (en) | 2009-11-24 | 2013-01-17 | AMPLIMMUNE ,Inc. a corporation | Simultaneous inhibition of pd-l1/pd-l2 |
BR112012012983A2 (en) | 2009-12-04 | 2020-09-15 | Genentech Inc | method of synthesizing a multispecific antibody, method of synthesizing a panel of multispecific antibodies, method of synthesizing an antibody analog, method of synthesizing a panel of antibody analogs and compositions |
US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
PT2519543T (en) | 2009-12-29 | 2016-10-07 | Emergent Product Dev Seattle | Heterodimer binding proteins and uses thereof |
US8362210B2 (en) | 2010-01-19 | 2013-01-29 | Xencor, Inc. | Antibody variants with enhanced complement activity |
US20130202623A1 (en) | 2010-02-16 | 2013-08-08 | Nicolas Chomont | Pd-1 modulation and uses thereof for modulating hiv replication |
UY33227A (en) | 2010-02-19 | 2011-09-30 | Novartis Ag | PIRROLOPIRIMIDINE COMPOUNDS AS INHIBITORS OF THE CDK4 / 6 |
EP3798237A1 (en) | 2010-03-05 | 2021-03-31 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
TW201134488A (en) | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
CA2791930A1 (en) | 2010-03-11 | 2011-09-15 | Kerry Louise Tyson | Pd-1 antibody |
CN103097417B (en) | 2010-04-20 | 2019-04-09 | 根马布股份公司 | Albumen of the FC containing heterodimeric antibodies and preparation method thereof |
US8828944B2 (en) | 2010-04-22 | 2014-09-09 | Institut Gustave Roussy | Compounds and uses thereof to induce an immunogenic cancer cell death in a subject |
CN105001330B (en) | 2010-04-23 | 2020-05-01 | 弗·哈夫曼-拉罗切有限公司 | Production of heteromultimeric proteins |
US20110280877A1 (en) | 2010-05-11 | 2011-11-17 | Koji Tamada | Inhibition of B7-H1/CD80 interaction and uses thereof |
PE20130205A1 (en) | 2010-05-14 | 2013-03-24 | Abbvie Inc | IL-1 BINDING PROTEINS |
CN103079644B (en) | 2010-06-11 | 2017-02-15 | 协和发酵麒麟株式会社 | Anti-TIM-3 antibody |
JP2013532153A (en) | 2010-06-18 | 2013-08-15 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | Bispecific antibodies against TIM-3 and PD-1 for immunotherapy against chronic immune disease |
UY33492A (en) | 2010-07-09 | 2012-01-31 | Abbott Lab | IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME |
WO2012018538A2 (en) | 2010-07-26 | 2012-02-09 | Schering Corporation | Bioassays for determining pd-1 modulation |
JP2013537415A (en) | 2010-08-03 | 2013-10-03 | アッヴィ・インコーポレイテッド | Dual variable domain immunoglobulins and uses thereof |
PE20140230A1 (en) | 2010-08-20 | 2014-02-26 | Novartis Ag | ANTIBODIES TO THE EPIDERMAL GROWTH FACTOR RECEPTOR 3 (HER3) |
JP2013539364A (en) | 2010-08-26 | 2013-10-24 | アッヴィ・インコーポレイテッド | Dual variable domain immunoglobulins and uses thereof |
WO2012054438A1 (en) | 2010-10-22 | 2012-04-26 | Schering Corporation | Anti-pcsk9 |
US9155802B2 (en) | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
WO2012061374A2 (en) | 2010-11-02 | 2012-05-10 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
US20120263722A1 (en) | 2010-11-04 | 2012-10-18 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
WO2012064733A2 (en) | 2010-11-09 | 2012-05-18 | Medimmune, Llc | Antibody scaffold for homogenous conjugation |
SG10201510092QA (en) | 2010-12-09 | 2016-01-28 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
US20120195900A1 (en) | 2010-12-22 | 2012-08-02 | Abbott Laboratories | Tri-variable domain binding proteins and uses thereof |
UY33827A (en) | 2010-12-22 | 2012-07-31 | Abbott Lab | MEDIUM-IMMUNOGLOBULIN UNION PROTEINS AND ITS USES |
US8814630B2 (en) | 2011-01-04 | 2014-08-26 | Carl T. Rittberger | PVC beehive |
AR085138A1 (en) | 2011-02-04 | 2013-09-11 | Genentech Inc | Fc VARIATIONS AND METHODS FOR PRODUCTION |
PT2691112T (en) | 2011-03-31 | 2018-07-10 | Merck Sharp & Dohme | Stable formulations of antibodies to human programmed death receptor pd-1 and related treatments |
DK2699264T3 (en) | 2011-04-20 | 2018-06-25 | Medimmune Llc | ANTIBODIES AND OTHER MOLECULES BINDING B7-H1 AND PD-1 |
EP2714738B1 (en) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
US20140234320A1 (en) | 2011-06-20 | 2014-08-21 | La Jolla Institute For Allergy And Immunology | Modulators of 4-1bb and immune responses |
WO2012177624A2 (en) | 2011-06-21 | 2012-12-27 | The Johns Hopkins University | Focused radiation for augmenting immune-based therapies against neoplasms |
US8841418B2 (en) | 2011-07-01 | 2014-09-23 | Cellerant Therapeutics, Inc. | Antibodies that specifically bind to TIM3 |
AU2012290121B2 (en) | 2011-08-01 | 2015-11-26 | Genentech, Inc. | Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors |
US20130058947A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc | Novel Modulators and Methods of Use |
WO2013039954A1 (en) | 2011-09-14 | 2013-03-21 | Sanofi | Anti-gitr antibodies |
US9308253B2 (en) | 2011-09-19 | 2016-04-12 | The Johns Hopkins University | Cancer immunotherapy |
WO2013054320A1 (en) | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
KR102049803B1 (en) | 2011-10-27 | 2019-11-29 | 젠맵 에이/에스 | Production of heterodimeric proteins |
CN104011076A (en) | 2011-10-31 | 2014-08-27 | 默沙东公司 | Method for preparing antibodies having improved properties |
CN103987405B (en) | 2011-11-28 | 2017-03-29 | 默克专利股份公司 | Anti- PD L1 antibody and application thereof |
GB201120527D0 (en) | 2011-11-29 | 2012-01-11 | Ucl Business Plc | Method |
US9556271B2 (en) | 2011-12-01 | 2017-01-31 | The Brigham And Women's Hospital, Inc. | Anti-CEACAM1 recombinant antibodies for cancer therapy |
CN102492038B (en) | 2011-12-09 | 2014-05-28 | 中国人民解放军军事医学科学院基础医学研究所 | Anti-human Tim-3 neutralized monoclonal antibody L3D and application thereof |
UY34591A (en) | 2012-01-26 | 2013-09-02 | Novartis Ag | IMIDAZOPIRROLIDINONA COMPOUNDS |
UY34632A (en) | 2012-02-24 | 2013-05-31 | Novartis Ag | OXAZOLIDIN- 2- ONA COMPOUNDS AND USES OF THE SAME |
WO2013169693A1 (en) | 2012-05-09 | 2013-11-14 | Bristol-Myers Squibb Company | Methods of treating cancer using an il-21 polypeptide and an anti-pd-1 antibody |
WO2013171641A1 (en) | 2012-05-15 | 2013-11-21 | Novartis Ag | Compounds and compositions for inhibiting the activity of abl1, abl2 and bcr-abl1 |
US9340537B2 (en) | 2012-05-15 | 2016-05-17 | Novatis Ag | Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 |
SG11201407190TA (en) | 2012-05-15 | 2014-12-30 | Bristol Myers Squibb Co | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
ES2670601T3 (en) | 2012-05-15 | 2018-05-31 | Novartis Ag | Benzamide derivatives for the inhibition of the activity of ABL1, ABL2 and BCR-ABL1 |
US9278981B2 (en) | 2012-05-15 | 2016-03-08 | Novartis Ag | Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 |
EP3553086A1 (en) | 2012-05-31 | 2019-10-16 | Sorrento Therapeutics Inc. | Antigen binding proteins that bind pd-l1 |
WO2013181452A1 (en) | 2012-05-31 | 2013-12-05 | Genentech, Inc. | Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists |
JO3300B1 (en) | 2012-06-06 | 2018-09-16 | Novartis Ag | Compounds and compositions for modulating egfr activity |
AR091649A1 (en) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES |
MX2015001269A (en) | 2012-07-27 | 2015-05-08 | Novartis Ag | Prediction of treatment response to jak/stat inhibitor. |
KR20150038066A (en) | 2012-07-30 | 2015-04-08 | 알렉스 와 힌 영 | Cancer vaccine comprises tumor cells, an oncolytic virus vector and/or an immune checkpoint modulator |
CA2916638C (en) | 2012-07-31 | 2021-01-12 | The Brigham And Women's Hospital, Inc. | Modulation of the immune response |
JP6403166B2 (en) | 2012-08-03 | 2018-10-10 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | Single antigen anti-PD-L1 and PD-L2 double-binding antibodies and methods of use thereof |
US20150250837A1 (en) | 2012-09-20 | 2015-09-10 | Morningside Technology Ventures Ltd. | Oncolytic virus encoding pd-1 binding agents and uses of the same |
SI2904011T1 (en) | 2012-10-02 | 2017-10-30 | Bristol-Myers Squibb Company | Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer |
CA3139031A1 (en) | 2012-10-04 | 2014-04-10 | Dana-Farber Cancer Institute, Inc. | Human monoclonal anti-pd-l1 antibodies and methods of use |
BR112015010477A2 (en) | 2012-11-08 | 2017-07-11 | Novartis Ag | A pharmaceutical combination comprising a b-raf inhibitor and a histone deacetylase inhibitor and their use in the treatment of proliferative diseases. |
BR112015012197A8 (en) | 2012-11-28 | 2019-10-01 | Novartis Ag | cdk mtor inhibitor uses, and pharmaceutical combination comprising the same |
AR093984A1 (en) | 2012-12-21 | 2015-07-01 | Merck Sharp & Dohme | ANTIBODIES THAT JOIN LEGEND 1 OF SCHEDULED DEATH (PD-L1) HUMAN |
WO2014165082A2 (en) | 2013-03-13 | 2014-10-09 | Medimmune, Llc | Antibodies and methods of detection |
US9498532B2 (en) | 2013-03-13 | 2016-11-22 | Novartis Ag | Antibody drug conjugates |
TW201514188A (en) | 2013-03-13 | 2015-04-16 | Lantheus Medical Imaging Inc | Process for manufacture of gadofosveset trisodium monohydrate |
US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
PE20151939A1 (en) | 2013-03-14 | 2016-01-08 | Novartis Ag | 3-PYRIMIDIN-4-IL-OXAZOLIDIN-2-ONAS AS INHIBITORS OF MUTANT HDI |
PE20151530A1 (en) | 2013-03-15 | 2015-11-06 | Glaxosmithkline Ip Dev Ltd | ANTIGEN BINDING PROTEINS |
WO2014165422A1 (en) | 2013-04-02 | 2014-10-09 | Merck Sharp & Dohme Corp. | Immunohistochemical assay for detecting expression of programmed death ligand 1 (pd-l1) in tumor tissue |
LT2992017T (en) | 2013-05-02 | 2021-02-25 | Anaptysbio, Inc. | Antibodies directed against programmed death-1 (pd-1) |
DK2996473T3 (en) | 2013-05-18 | 2019-11-04 | Aduro Biotech Inc | COMPOSITIONS AND METHODS FOR ACTIVATING THE "INTERFERON GENE STIMULATOR" -DENGED SIGNAL |
CN103242448B (en) * | 2013-05-27 | 2015-01-14 | 郑州大学 | Full-humanized anti-PD-1 monoclonal antibody and preparation method and application thereof |
KR20160013049A (en) | 2013-06-03 | 2016-02-03 | 노파르티스 아게 | Combinations of an anti-pd-l1 antibody and a mek inhibitor and/or a braf inhibitor |
CA2916681A1 (en) | 2013-07-16 | 2015-01-22 | Genentech, Inc. | Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors |
US9827309B2 (en) | 2013-08-20 | 2017-11-28 | Merck Sharp & Dohme Corp. | Treating cancer with a combination of a PD-1 antagonist and dinaciclib |
AR097306A1 (en) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | MODULATION OF TUMOR IMMUNITY |
US10077305B2 (en) | 2013-09-10 | 2018-09-18 | Medimmune Limited | Antibodies against PD-1 and uses thereof |
EP3656398A1 (en) | 2013-09-11 | 2020-05-27 | MedImmune Limited | Anti-b7-h1 antibodies for treating tumors |
AR097584A1 (en) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | ANTIBODY COMBINATION THERAPY AGAINST HUMAN CSF-1R AND ANTIBODIES AGAINST HUMAN PD-L1 |
CN112552401B (en) | 2013-09-13 | 2023-08-25 | 广州百济神州生物制药有限公司 | anti-PD 1 antibodies and their use as therapeutic and diagnostic agents |
RS64268B1 (en) | 2013-09-20 | 2023-07-31 | Bristol Myers Squibb Co | Combination of anti-lag-3 antibodies and anti-pd-1 antibodies to treat tumors |
EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
CA2925310C (en) | 2013-09-27 | 2022-12-06 | Genentech, Inc. | Anti-pdl1 antibody formulations |
US10202454B2 (en) | 2013-10-25 | 2019-02-12 | Dana-Farber Cancer Institute, Inc. | Anti-PD-L1 monoclonal antibodies and fragments thereof |
WO2015070060A1 (en) | 2013-11-11 | 2015-05-14 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
WO2015081158A1 (en) | 2013-11-26 | 2015-06-04 | Bristol-Myers Squibb Company | Method of treating hiv by disrupting pd-1/pd-l1 signaling |
US20160303231A1 (en) | 2013-12-11 | 2016-10-20 | Robert Iannone | Treating cancer with a combination of a pd-1 antagonist and a vegfr inhibitor |
ME03527B (en) | 2013-12-12 | 2020-04-20 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
SG11201604979WA (en) | 2013-12-17 | 2016-07-28 | Genentech Inc | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
US9045545B1 (en) | 2014-07-15 | 2015-06-02 | Kymab Limited | Precision medicine by targeting PD-L1 variants for treatment of cancer |
NZ721908A (en) | 2013-12-20 | 2022-12-23 | Massachusetts Gen Hospital | Combination therapy with neoantigen vaccine |
EP4070818A3 (en) | 2014-01-06 | 2023-01-11 | The Trustees of the University of Pennsylvania | Pd1 and pdl1 antibodies and vaccine combinations and use of same for immunotherapy |
PL3094351T3 (en) | 2014-01-15 | 2022-06-27 | Kadmon Corporation, Llc | Immunomodulatory agents |
TWI680138B (en) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | Human antibodies to pd-l1 |
TWI681969B (en) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | Human antibodies to pd-1 |
JOP20200094A1 (en) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | Antibody molecules to pd-1 and uses thereof |
US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
MX2016009010A (en) | 2014-01-28 | 2017-01-18 | Bristol Myers Squibb Co | Anti-lag-3 antibodies to treat hematological malignancies. |
JOP20200096A1 (en) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | Antibody molecules to tim-3 and uses thereof |
CN106456753B (en) | 2014-02-04 | 2021-05-11 | 因塞特公司 | Combination of a PD-1 antagonist and an IDO1 inhibitor for the treatment of cancer |
CN105979961B (en) | 2014-02-05 | 2020-12-18 | 西达-赛奈医疗中心 | Methods and compositions for treating cancer and infectious diseases |
KR102363008B1 (en) | 2014-02-10 | 2022-02-16 | 메르크 파텐트 게엠베하 | TARGETED TGFβ INHIBITION |
KR20160119867A (en) | 2014-03-05 | 2016-10-14 | 브리스톨-마이어스 스큅 컴퍼니 | Treatment of renal cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent |
MX2016011993A (en) | 2014-03-14 | 2016-12-09 | Novartis Ag | Antibody molecules to lag-3 and uses thereof. |
EP3142697A1 (en) | 2014-05-15 | 2017-03-22 | Bristol-Myers Squibb Company | Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent |
JP6666905B2 (en) | 2014-05-29 | 2020-03-18 | スプリング バイオサイエンス コーポレーション | PD-L1 antibody and use thereof |
WO2015195163A1 (en) | 2014-06-20 | 2015-12-23 | R-Pharm Overseas, Inc. | Pd-l1 antagonist fully human antibody |
US10544225B2 (en) | 2014-07-03 | 2020-01-28 | Beigene, Ltd. | Anti-PD-L1 antibodies and their use as therapeutics and diagnostics |
JO3663B1 (en) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | Anti-lag3 antibodies and antigen-binding fragments |
CN107108744B (en) | 2014-08-19 | 2020-09-25 | 诺华股份有限公司 | anti-CD 123 Chimeric Antigen Receptor (CAR) for cancer therapy |
EP3925622A1 (en) | 2014-09-13 | 2021-12-22 | Novartis AG | Combination therapies |
CN107106687A (en) | 2014-10-03 | 2017-08-29 | 诺华股份有限公司 | Combined therapy |
EP4245376A3 (en) | 2014-10-14 | 2023-12-13 | Novartis AG | Antibody molecules to pd-l1 and uses thereof |
IL251464B2 (en) | 2014-10-29 | 2023-03-01 | Five Prime Therapeutics Inc | Combination therapy for cancer |
US20170320954A1 (en) | 2014-11-17 | 2017-11-09 | Medimmune Limited | Therapeutic combinations and methods for treating neoplasia |
TWI595006B (en) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | Anti-pd-1 antibodies and methods of use thereof |
EP3233918A1 (en) | 2014-12-19 | 2017-10-25 | Novartis AG | Combination therapies |
MA41867A (en) | 2015-04-01 | 2018-02-06 | Anaptysbio Inc | T-CELL IMMUNOGLOBULIN AND MUCINE PROTEIN 3 ANTIBODIES (TIM-3) |
US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
WO2016164731A2 (en) | 2015-04-08 | 2016-10-13 | Novartis Ag | Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell |
SG10201913303XA (en) * | 2015-07-13 | 2020-03-30 | Cytomx Therapeutics Inc | Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof |
CN108025051B (en) | 2015-07-29 | 2021-12-24 | 诺华股份有限公司 | Combination therapy comprising anti-PD-1 antibody molecules |
CA2991857A1 (en) | 2015-07-29 | 2017-02-02 | Novartis Ag | Novel combination for use in the treatment of cancer |
WO2017019897A1 (en) | 2015-07-29 | 2017-02-02 | Novartis Ag | Combination therapies comprising antibody molecules to tim-3 |
DK3317301T3 (en) | 2015-07-29 | 2021-06-28 | Immutep Sas | COMBINATION THERAPIES INCLUDING ANTIBODY MOLECULES AGAINST LAYER-3 |
CN108235685A (en) | 2015-07-29 | 2018-06-29 | 诺华股份有限公司 | The combination of PD-1 antagonists and EGFR inhibitor |
AU2016306090B2 (en) * | 2015-08-11 | 2019-05-02 | Novartis Ag | 5-bromo-2,6-di-(1H-pyrazol-l-yl)pyrimidin-4-amine for use in the treatment of cancer |
AR105654A1 (en) | 2015-08-24 | 2017-10-25 | Lilly Co Eli | ANTIBODIES PD-L1 (LINKING 1 OF PROGRAMMED CELL DEATH) |
MX2018005299A (en) | 2015-10-28 | 2019-03-18 | Aduro Biotech Inc | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling. |
HUE050811T2 (en) | 2015-12-07 | 2021-01-28 | Merck Patent Gmbh | Aqueous pharmaceutical formulation comprising anti-pd-1 antibody avelumab |
MX2018007423A (en) | 2015-12-17 | 2018-11-09 | Novartis Ag | Antibody molecules to pd-1 and uses thereof. |
WO2017112741A1 (en) | 2015-12-22 | 2017-06-29 | Novartis Ag | Mesothelin chimeric antigen receptor (car) and antibody against pd-l1 inhibitor for combined use in anticancer therapy |
JP6993699B2 (en) | 2016-01-11 | 2022-02-03 | ウニヴェルズィテート・ツューリヒ | Immunostimulatory humanized monoclonal antibody against human interleukin-2 and its fusion protein |
EP3448428A4 (en) | 2016-04-25 | 2019-11-27 | Medimmune, LLC | Compositions comprising coformulation of anti-pd-l1 and anti-ctla-4 antibodies |
US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
KR20190034588A (en) | 2016-07-28 | 2019-04-02 | 노파르티스 아게 | Combination therapy of chimeric antigen receptor and PD-1 inhibitor |
CA3059626A1 (en) | 2017-04-10 | 2018-10-18 | Houhua HAN | Home environment regulation system based on furniture having display devices and control method thereof |
WO2018222718A1 (en) | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Treatment of lag-3 positive tumors |
AU2018290237A1 (en) | 2017-06-22 | 2020-01-16 | Novartis Ag | Antibody molecules to CD73 and uses thereof |
CA3066747A1 (en) | 2017-06-27 | 2019-01-03 | Novartis Ag | Dosage regimens for anti-tim-3 antibodies and uses thereof |
CN111163798A (en) | 2017-07-20 | 2020-05-15 | 诺华股份有限公司 | Dosing regimens for anti-LAG-3 antibodies and uses thereof |
WO2019018640A1 (en) | 2017-07-21 | 2019-01-24 | Novartis Ag | Dosage regimens for anti-gitr antibodies and uses thereof |
US20200277378A1 (en) | 2017-11-16 | 2020-09-03 | Novartis Ag | Combination therapies |
US20210147547A1 (en) | 2018-04-13 | 2021-05-20 | Novartis Ag | Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof |
KR20210107730A (en) | 2018-12-21 | 2021-09-01 | 노파르티스 아게 | Use of IL-1 beta antibodies in the treatment or prevention of myelodysplastic syndrome |
JP2022548627A (en) | 2019-09-16 | 2022-11-21 | ノバルティス アーゲー | Use of high-affinity ligand-blocking humanized anti-T cell immunoglobulin domain and mucin domain 3 (TIM-3) IGG4 antibodies for the treatment of myelofibrosis |
KR20220087498A (en) | 2019-10-21 | 2022-06-24 | 노파르티스 아게 | TIM-3 inhibitors and uses thereof |
CA3158298A1 (en) | 2019-10-21 | 2021-04-29 | Novartis Ag | Combination therapies with venetoclax and tim-3 inhibitors |
CA3165399A1 (en) | 2019-12-20 | 2021-06-24 | Novartis Ag | Uses of anti-tgf-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases |
AU2021207348A1 (en) | 2020-01-17 | 2022-08-11 | Novartis Ag | Combination comprising a TIM-3 inhibitor and a hypomethylating agent for use in treating myelodysplastic syndrome or chronic myelomonocytic leukemia |
CN117321418A (en) | 2021-03-18 | 2023-12-29 | 诺华股份有限公司 | Cancer biomarkers and methods of use thereof |
-
2014
- 2014-01-24 JO JOP/2020/0094A patent/JOP20200094A1/en unknown
-
2015
- 2015-01-23 CN CN202010507321.6A patent/CN111909270A/en active Pending
- 2015-01-23 JP JP2016548014A patent/JP6521986B2/en active Active
- 2015-01-23 RS RS20190360A patent/RS58535B1/en unknown
- 2015-01-23 SG SG10201900002QA patent/SG10201900002QA/en unknown
- 2015-01-23 PL PL15703384T patent/PL3097121T3/en unknown
- 2015-01-23 CN CN201580015562.6A patent/CN106103485B/en active Active
- 2015-01-23 HU HUE15703384A patent/HUE043363T2/en unknown
- 2015-01-23 TW TW110146013A patent/TW202237655A/en unknown
- 2015-01-23 AU AU2015209145A patent/AU2015209145B2/en active Active
- 2015-01-23 NZ NZ721678A patent/NZ721678A/en unknown
- 2015-01-23 UY UY0001035967A patent/UY35967A/en not_active Application Discontinuation
- 2015-01-23 EP EP15703384.6A patent/EP3097121B1/en active Active
- 2015-01-23 ME MEP-2019-83A patent/ME03366B/en unknown
- 2015-01-23 UA UAA201606726A patent/UA122479C2/en unknown
- 2015-01-23 WO PCT/US2015/012754 patent/WO2015112900A1/en active Application Filing
- 2015-01-23 TW TW104102472A patent/TWI692484B/en active
- 2015-01-23 LT LTEP15703384.6T patent/LT3097121T/en unknown
- 2015-01-23 SI SI201530651T patent/SI3097121T1/en unknown
- 2015-01-23 CA CA2935423A patent/CA2935423C/en active Active
- 2015-01-23 PE PE2016001261A patent/PE20170255A1/en unknown
- 2015-01-23 SG SG11201604939SA patent/SG11201604939SA/en unknown
- 2015-01-23 EP EP18211373.8A patent/EP3514179B1/en active Active
- 2015-01-23 EA EA201691488A patent/EA201691488A1/en unknown
- 2015-01-23 TN TN2016000272A patent/TN2016000272A1/en unknown
- 2015-01-23 DK DK15703384.6T patent/DK3097121T3/en active
- 2015-01-23 MX MX2016009616A patent/MX2016009616A/en active IP Right Grant
- 2015-01-23 TW TW109112287A patent/TW202045549A/en unknown
- 2015-01-23 ES ES15703384T patent/ES2716685T3/en active Active
- 2015-01-23 PT PT15703384T patent/PT3097121T/en unknown
- 2015-01-23 KR KR1020167022709A patent/KR102357621B1/en active IP Right Grant
- 2015-01-23 CN CN202010507274.5A patent/CN111909269A/en active Pending
- 2015-01-23 MY MYPI2016702232A patent/MY184757A/en unknown
- 2015-01-23 US US14/604,415 patent/US9683048B2/en active Active
- 2015-01-23 BR BR112016015677A patent/BR112016015677A2/en not_active Application Discontinuation
- 2015-01-25 JO JOP/2015/0011A patent/JO3560B1/en active
-
2016
- 2016-06-22 IL IL246382A patent/IL246382A0/en active IP Right Grant
- 2016-07-06 CL CL2016001723A patent/CL2016001723A1/en unknown
- 2016-07-22 PH PH12016501456A patent/PH12016501456A1/en unknown
- 2016-07-22 MX MX2020001909A patent/MX2020001909A/en unknown
- 2016-08-23 EC ECIEPI201668976A patent/ECSP16068976A/en unknown
- 2016-12-13 HK HK16114181A patent/HK1225747B/en unknown
-
2017
- 2017-05-15 US US15/595,618 patent/US9815898B2/en active Active
- 2017-10-06 US US15/727,456 patent/US10752687B2/en active Active
-
2018
- 2018-07-02 JP JP2018126166A patent/JP6518370B2/en active Active
-
2019
- 2019-03-15 HR HRP20190516TT patent/HRP20190516T1/en unknown
- 2019-03-19 CY CY20191100330T patent/CY1121542T1/en unknown
- 2019-04-23 JP JP2019081583A patent/JP2019193628A/en not_active Ceased
-
2020
- 2020-06-30 AU AU2020204366A patent/AU2020204366A1/en not_active Abandoned
- 2020-07-10 US US16/925,980 patent/US11827704B2/en active Active
- 2020-11-18 IL IL278803A patent/IL278803A/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL278803A (en) | Antibody molecules to pd-1 and uses thereof | |
IL259987A (en) | Antibody molecules to pd-1 and uses thereof | |
IL288012A (en) | Antibody molecules to lag-3 and uses thereof | |
IL251563A0 (en) | Antibody molecules to pd-l1 and uses thereof | |
IL266259A (en) | Antibodies to pd-1 and uses thereof | |
HK1254337A1 (en) | Antibody molecules to april and uses thereof | |
IL246693B2 (en) | Antibody molecules to tim-3 and uses thereof |