HRP20182169T1 - Modulacija ekspresije transduktora signala i aktivatora transkripcije 3 (stat3) - Google Patents

Modulacija ekspresije transduktora signala i aktivatora transkripcije 3 (stat3)

Info

Publication number
HRP20182169T1
HRP20182169T1 HRP20182169TT HRP20182169T HRP20182169T1 HR P20182169 T1 HRP20182169 T1 HR P20182169T1 HR P20182169T T HRP20182169T T HR P20182169TT HR P20182169 T HRP20182169 T HR P20182169T HR P20182169 T1 HRP20182169 T1 HR P20182169T1
Authority
HR
Croatia
Prior art keywords
stat3
activator
transcription
modulation
expression
Prior art date
Application number
HRP20182169TT
Other languages
English (en)
Croatian (hr)
Inventor
Eric E. Swayze
Susan M. Freier
Robert A. Macleod
Youngsoo Kim
Original Assignee
Ionis Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionis Pharmaceuticals, Inc. filed Critical Ionis Pharmaceuticals, Inc.
Publication of HRP20182169T1 publication Critical patent/HRP20182169T1/hr

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • C07—ORGANIC CHEMISTRY
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3525—MOE, methoxyethoxy
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    • C12N2320/30—Special therapeutic applications

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
HRP20182169TT 2011-04-01 2012-03-30 Modulacija ekspresije transduktora signala i aktivatora transkripcije 3 (stat3) HRP20182169T1 (hr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201161471001P 2011-04-01 2011-04-01
US201161471015P 2011-04-01 2011-04-01
US201161471035P 2011-04-01 2011-04-01
US201161471045P 2011-04-01 2011-04-01
US201161558316P 2011-11-10 2011-11-10
US201161558308P 2011-11-10 2011-11-10
EP12763390.7A EP2697243B1 (en) 2011-04-01 2012-03-30 Modulation of signal transducer and activator of transcription 3 (stat3) expression
PCT/US2012/031642 WO2012135736A2 (en) 2011-04-01 2012-03-30 Modulation of signal transducer and activator of transcription 3 (stat3) expression

Publications (1)

Publication Number Publication Date
HRP20182169T1 true HRP20182169T1 (hr) 2019-04-19

Family

ID=46932413

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20182169TT HRP20182169T1 (hr) 2011-04-01 2012-03-30 Modulacija ekspresije transduktora signala i aktivatora transkripcije 3 (stat3)

Country Status (35)

Country Link
US (4) US8816056B2 (https=)
EP (2) EP2697243B1 (https=)
JP (1) JP5943993B2 (https=)
KR (2) KR20190092590A (https=)
CN (2) CN103562215B (https=)
AU (1) AU2012236206C1 (https=)
BR (1) BR112013024768B1 (https=)
CA (1) CA2831915C (https=)
CL (1) CL2013002773A1 (https=)
CO (1) CO6821885A2 (https=)
CY (1) CY1121460T1 (https=)
DK (1) DK2697243T3 (https=)
DO (1) DOP2013000216A (https=)
EA (2) EA201792185A3 (https=)
EC (1) ECSP13012909A (https=)
ES (1) ES2709495T3 (https=)
GT (1) GT201300232A (https=)
HR (1) HRP20182169T1 (https=)
HU (1) HUE042173T2 (https=)
IL (2) IL228569A (https=)
LT (1) LT2697243T (https=)
ME (1) ME03317B (https=)
MX (1) MX340086B (https=)
MY (1) MY163004A (https=)
NI (1) NI201300101A (https=)
PE (2) PE20142463A1 (https=)
PH (1) PH12013502049A1 (https=)
PL (1) PL2697243T3 (https=)
PT (1) PT2697243T (https=)
RS (1) RS58489B1 (https=)
SG (1) SG193504A1 (https=)
SI (1) SI2697243T1 (https=)
SM (1) SMT201900060T1 (https=)
WO (1) WO2012135736A2 (https=)
ZA (1) ZA201308153B (https=)

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