HRP20171949T1 - Poboljšana veziva za tnf - Google Patents

Poboljšana veziva za tnf Download PDF

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Publication number
HRP20171949T1
HRP20171949T1 HRP20171949TT HRP20171949T HRP20171949T1 HR P20171949 T1 HRP20171949 T1 HR P20171949T1 HR P20171949T T HRP20171949T T HR P20171949TT HR P20171949 T HRP20171949 T HR P20171949T HR P20171949 T1 HRP20171949 T1 HR P20171949T1
Authority
HR
Croatia
Prior art keywords
tnf binders
improved tnf
improved
binders
isvd
Prior art date
Application number
HRP20171949TT
Other languages
English (en)
Croatian (hr)
Inventor
Marie-Ange Buyse
Joachim Boucneau
Peter Casteels
Gino Van Heeke
Original Assignee
Ablynx Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablynx Nv filed Critical Ablynx Nv
Publication of HRP20171949T1 publication Critical patent/HRP20171949T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Organic Insulating Materials (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
HRP20171949TT 2015-11-12 2016-11-14 Poboljšana veziva za tnf HRP20171949T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562254375P 2015-11-12 2015-11-12
PCT/EP2016/077595 WO2017081320A1 (en) 2015-11-12 2016-11-14 Improved tnf binders
EP16798122.4A EP3191511B1 (en) 2015-11-12 2016-11-14 Improved tnf binders

Publications (1)

Publication Number Publication Date
HRP20171949T1 true HRP20171949T1 (hr) 2018-01-26

Family

ID=57348648

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20171949TT HRP20171949T1 (hr) 2015-11-12 2016-11-14 Poboljšana veziva za tnf

Country Status (37)

Country Link
US (2) US10544211B2 (index.php)
EP (2) EP3191511B1 (index.php)
JP (2) JP6962915B2 (index.php)
KR (2) KR20240029115A (index.php)
CN (1) CN108473563B (index.php)
AU (2) AU2016352943B2 (index.php)
BR (1) BR112018009714A8 (index.php)
CA (2) CA3005085C (index.php)
CL (1) CL2018001291A1 (index.php)
CO (1) CO2018005915A2 (index.php)
CR (1) CR20180311A (index.php)
CY (1) CY1120303T1 (index.php)
DK (1) DK3191511T3 (index.php)
DO (1) DOP2018000122A (index.php)
EC (1) ECSP18042569A (index.php)
ES (1) ES2662418T3 (index.php)
GT (1) GT201800095A (index.php)
HK (1) HK1248716A1 (index.php)
HR (1) HRP20171949T1 (index.php)
HU (1) HUE035805T2 (index.php)
IL (2) IL259269B2 (index.php)
LT (1) LT3191511T (index.php)
MA (1) MA41653A (index.php)
MD (1) MD3191511T2 (index.php)
ME (1) ME02954B (index.php)
MX (1) MX385207B (index.php)
NO (1) NO2768984T3 (index.php)
PE (1) PE20181317A1 (index.php)
PH (1) PH12018501025A1 (index.php)
PL (1) PL3191511T3 (index.php)
PT (1) PT3191511T (index.php)
RS (1) RS56676B1 (index.php)
SG (1) SG11201803975SA (index.php)
SI (1) SI3191511T1 (index.php)
SM (1) SMT201700590T1 (index.php)
TN (1) TN2018000159A1 (index.php)
WO (1) WO2017081320A1 (index.php)

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PH12013502669B1 (en) 2011-06-23 2018-08-10 Ablynx Nv Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
RU2746738C2 (ru) 2014-05-16 2021-04-20 Аблинкс Нв Улучшенные вариабельные домены иммуноглобулина
KR20250099289A (ko) 2014-05-16 2025-07-01 아블린쓰 엔.브이. 개선된 면역글로불린 가변 도메인
NO2768984T3 (index.php) * 2015-11-12 2018-06-09
GB201522394D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibodies
JP7719775B2 (ja) 2019-12-06 2025-08-06 アブリンクス エン．ヴェー． ＴＮＦαおよびＯＸ４０Ｌを標的とする免疫グロブリン単一可変ドメインを含むポリペプチド
IL293561A (en) 2019-12-06 2022-08-01 Ablynx Nv Polypeptides comprising immunoglobulin with one variable domain targeting TNFa and IL-23
CN112300289B (zh) * 2019-12-30 2022-06-10 中国药科大学 RGD4C融合抗TNFα纳米抗体蛋白、制备方法及其应用
US11897951B2 (en) * 2020-12-18 2024-02-13 Ablynx N.V. Polypeptides comprising immunoglobulin single variable domains targeting IL-6 and TNF-α
US20250026842A1 (en) * 2021-11-29 2025-01-23 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Modified protein or polypeptide
AU2023373192A1 (en) * 2022-11-04 2025-04-17 St. Jude Children's Research Hospital, Inc. Nlrp12 and nlrc5 modulators and methods for using the same to modulate diseases
US20240415974A1 (en) 2022-12-23 2024-12-19 Ablynx N.V. Protein-based conjugation carriers
AU2024221136A1 (en) 2023-02-17 2025-10-02 Ablynx N.V. Polypeptides binding to the neonatal fc receptor

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JP7540877B2 (ja) * 2016-02-12 2024-08-27 アブリンクス エン．ヴェー． 免疫グロブリン単一可変ドメインの生成方法

Also Published As

Publication number Publication date
CY1120303T1 (el) 2019-07-10
PE20181317A1 (es) 2018-08-14
AU2023200113A1 (en) 2023-02-16
EP3191511A1 (en) 2017-07-19
MX385207B (es) 2025-03-04
ES2662418T3 (es) 2018-04-06
US20170267752A1 (en) 2017-09-21
CR20180311A (es) 2018-10-18
JP6962915B2 (ja) 2021-11-10
US9745372B2 (en) 2017-08-29
PL3191511T3 (pl) 2018-03-30
EP3266798A3 (en) 2018-03-28
CL2018001291A1 (es) 2018-09-14
DK3191511T3 (en) 2018-01-08
SMT201700590T1 (it) 2018-01-11
GT201800095A (es) 2019-08-15
PH12018501025A1 (en) 2019-01-28
JP2022020666A (ja) 2022-02-01
AU2016352943A1 (en) 2018-06-07
CN108473563B (zh) 2022-06-14
IL259269B2 (en) 2024-07-01
EP3191511B1 (en) 2017-09-20
IL259269B1 (en) 2024-03-01
CO2018005915A2 (es) 2018-06-20
CA3005085C (en) 2024-09-10
LT3191511T (lt) 2018-01-10
RS56676B1 (sr) 2018-03-30
US20170190769A1 (en) 2017-07-06
RU2018120524A3 (index.php) 2020-09-24
JP2019506839A (ja) 2019-03-14
US10544211B2 (en) 2020-01-28
EP3266798A2 (en) 2018-01-10
MX2018005992A (es) 2019-01-31
BR112018009714A8 (pt) 2019-02-26
CN108473563A (zh) 2018-08-31
IL259269A (en) 2018-07-31
IL310373A (en) 2024-03-01
AU2016352943B2 (en) 2022-10-20
SI3191511T1 (en) 2018-01-31
WO2017081320A1 (en) 2017-05-18
KR102641194B1 (ko) 2024-02-26
TN2018000159A1 (en) 2019-10-04
JP7357038B2 (ja) 2023-10-05
SG11201803975SA (en) 2018-06-28
MA41653A (fr) 2018-01-09
CA3234178A1 (en) 2017-05-18
NO2768984T3 (index.php) 2018-06-09
KR20180083382A (ko) 2018-07-20
ECSP18042569A (es) 2018-07-31
HK1248716A1 (en) 2018-10-19
DOP2018000122A (es) 2018-09-30
MD3191511T2 (ro) 2018-03-31
BR112018009714A2 (en) 2018-11-21
CA3005085A1 (en) 2017-05-18
ME02954B (me) 2018-07-20
HUE035805T2 (en) 2018-05-28
RU2018120524A (ru) 2019-12-13
KR20240029115A (ko) 2024-03-05
PT3191511T (pt) 2017-11-30

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