HRP20161716T1 - Uporaba ekstrakata iz upaljene kože kunića uslijed vakcinija virusa za proizvodnju lijeka za liječenje akutne cerebrovaskularne bolesti - Google Patents
Uporaba ekstrakata iz upaljene kože kunića uslijed vakcinija virusa za proizvodnju lijeka za liječenje akutne cerebrovaskularne bolesti Download PDFInfo
- Publication number
- HRP20161716T1 HRP20161716T1 HRP20161716TT HRP20161716T HRP20161716T1 HR P20161716 T1 HRP20161716 T1 HR P20161716T1 HR P20161716T T HRP20161716T T HR P20161716TT HR P20161716 T HRP20161716 T HR P20161716T HR P20161716 T1 HRP20161716 T1 HR P20161716T1
- Authority
- HR
- Croatia
- Prior art keywords
- analgesics
- cerebral
- treatment
- cerebrovascular disease
- medicament
- Prior art date
Links
- 230000001154 acute effect Effects 0.000 title claims 3
- 239000003814 drug Substances 0.000 title claims 3
- 208000026106 cerebrovascular disease Diseases 0.000 title claims 2
- 241000283973 Oryctolagus cuniculus Species 0.000 title 1
- 241000700618 Vaccinia virus Species 0.000 title 1
- 239000000284 extract Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940035676 analgesics Drugs 0.000 claims 6
- 239000000730 antalgic agent Substances 0.000 claims 6
- 230000000302 ischemic effect Effects 0.000 claims 3
- 210000005013 brain tissue Anatomy 0.000 claims 2
- 230000005779 cell damage Effects 0.000 claims 2
- 208000037887 cell injury Diseases 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 claims 1
- 206010008088 Cerebral artery embolism Diseases 0.000 claims 1
- 206010008132 Cerebral thrombosis Diseases 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 claims 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 claims 1
- 102000019197 Superoxide Dismutase Human genes 0.000 claims 1
- 108010012715 Superoxide dismutase Proteins 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000036592 analgesia Effects 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 206010008087 cerebral arteritis Diseases 0.000 claims 1
- 210000001627 cerebral artery Anatomy 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 210000002895 cranial sinus Anatomy 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 201000005851 intracranial arteriosclerosis Diseases 0.000 claims 1
- 201000010849 intracranial embolism Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- 210000003556 vascular endothelial cell Anatomy 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (2)
1. Analgecine za uporabu kao lijek za liječenje akutne ishemijske cerebrovaskularne bolesti, gdje se nakon ishemije moždanog tkiva analgecine koristi za zaštitu živčanih stanica od ozljede ili za smanjenje razine mliječne kiseline u moždanom tkivu ili za povećanje aktivnosti superoksid dismutaze, i gdje se akutna ishemijska cerebrovaskularna bolest odabire iz skupine koju čine cerebralna embolija, tranzitna cerebralna ishemijska ataka, cerebralna tromboza, cerebralna arterioskleroza, cerebralni arteritis, sindrom krađe cerebralne arterije, kranijalni venski sinus i venski tromb.
2. Analgecine za uporabu kao lijek prema zahtjevu 1, gdje analgecine poboljšava H2O2-induciranu ozljedu PC12 stanica ili analgecine poboljšava ozljedu PC12 stanice induciranu glutaminskom kiselinom ili analgecine inhibira ekspresiju ili izlučivanje ICAM-1 iz endotelnih stanica u žilama mozga ili analgecine inhibira transformaciju T- i B-limfocita.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810176703.4A CN101732348B (zh) | 2008-11-11 | 2008-11-11 | 牛痘疫苗致炎兔皮提取物在制备急性脑血管疾病治疗药物中的用途 |
| EP09825706.6A EP2364711B2 (en) | 2008-11-11 | 2009-10-23 | Use of extracts from rabbit skin inflamed by vaccinia virus for the manufacture of a medicament for the treatment of acute cerebrovascular disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20161716T1 true HRP20161716T1 (hr) | 2017-02-10 |
Family
ID=42169603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161716TT HRP20161716T1 (hr) | 2008-11-11 | 2016-12-14 | Uporaba ekstrakata iz upaljene kože kunića uslijed vakcinija virusa za proizvodnju lijeka za liječenje akutne cerebrovaskularne bolesti |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10265345B2 (hr) |
| EP (1) | EP2364711B2 (hr) |
| JP (3) | JP6085806B2 (hr) |
| KR (1) | KR101756201B1 (hr) |
| CN (1) | CN101732348B (hr) |
| AU (1) | AU2009316168B2 (hr) |
| CA (1) | CA2743090C (hr) |
| CY (1) | CY1118457T1 (hr) |
| DK (1) | DK2364711T3 (hr) |
| ES (1) | ES2606051T5 (hr) |
| HK (1) | HK1142546A1 (hr) |
| HR (1) | HRP20161716T1 (hr) |
| HU (1) | HUE030782T2 (hr) |
| LT (1) | LT2364711T (hr) |
| NZ (1) | NZ592696A (hr) |
| PL (1) | PL2364711T3 (hr) |
| PT (1) | PT2364711T (hr) |
| SI (1) | SI2364711T1 (hr) |
| SM (1) | SMT201600477B (hr) |
| WO (1) | WO2010054531A1 (hr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732348B (zh) * | 2008-11-11 | 2015-01-14 | 威世药业（如皋）有限公司 | 牛痘疫苗致炎兔皮提取物在制备急性脑血管疾病治疗药物中的用途 |
| WO2018161211A1 (en) * | 2017-03-06 | 2018-09-13 | Nippon Zoki Pharmaceutical Co., Ltd. | INHIBITING OR ALLEVIATING AGENT FOR Aβ-INDUCED DAMAGE |
| CN109504649B (zh) * | 2017-09-15 | 2022-06-14 | 天津小西生物医药科技有限公司 | 使用兔皮提取物促进细胞增殖的方法 |
| AU2018394182A1 (en) * | 2017-12-28 | 2020-07-16 | Hyogo College Of Medicine | Lipocalin-type prostaglandin D2 synthase production accelerating agent |
| WO2020024142A1 (en) * | 2018-08-01 | 2020-02-06 | Vanford Bio-Drug Development Limited | Novel peptides and its derivatives capable of stimulating cytokine release |
| JP2022536582A (ja) | 2019-04-17 | 2022-08-18 | ▲諾▼希生物▲薬▼物▲開▼▲発▼有限公司 | ワクシニアウイルスによって炎症を起こしたウサギ皮膚由来の抽出物の造血系損傷の治療における使用 |
| JP7488588B2 (ja) * | 2019-06-14 | 2024-05-22 | 俊熙有限公司 | ワクシニアウイルスによって炎症を起こしたウサギ皮膚由来の抽出物のがん治療における使用 |
| CN110693914A (zh) * | 2019-10-28 | 2020-01-17 | 威世药业（如皋）有限公司 | 痘苗病毒致炎兔皮提取物在治疗类风湿性关节中的应用 |
| WO2023184471A1 (zh) * | 2022-04-01 | 2023-10-05 | 星亮生物技术有限公司 | 痘苗病毒致炎兔皮提取物治疗帕金森病的用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4985254A (en) * | 1987-11-06 | 1991-01-15 | Nippon Zoki Pharmaceutical Co., Ltd. | Method of treating ischemic diseases |
| JP2539665B2 (ja) | 1988-06-20 | 1996-10-02 | 日本臓器製薬株式会社 | 神経疾患治療剤 |
| JP2732379B2 (ja) | 1995-12-18 | 1998-03-30 | 日本臓器製薬株式会社 | 知覚異常改善剤 |
| US6197806B1 (en) | 1995-12-20 | 2001-03-06 | Nippon Zoki Pharmaceutical Co., Ltd. | Eliminating agent for activated oxygen and free radicals |
| AU4594297A (en) * | 1996-09-27 | 1998-04-17 | Trustees Of Columbia University In The City Of New York, The | Methods for treating an ischemic disorder and improving stroke outcome |
| JP4033936B2 (ja) * | 1997-01-08 | 2008-01-16 | 日本臓器製薬株式会社 | 一酸化窒素産生抑制剤 |
| CN1235054A (zh) | 1998-04-27 | 1999-11-17 | 日本脏器制药株式会社 | 缺血性疾病治疗药 |
| JP2000016942A (ja) | 1998-04-27 | 2000-01-18 | Nippon Zoki Pharmaceut Co Ltd | 虚血性疾患治療剤 |
| CN1055249C (zh) * | 1998-07-15 | 2000-08-09 | 沈继平 | 一种镇痛药和其制造方法 |
| JP2000143536A (ja) | 1998-11-13 | 2000-05-23 | Nippon Zoki Pharmaceut Co Ltd | 抗浮腫剤 |
| JP2001058949A (ja) | 1999-08-20 | 2001-03-06 | Fujimoto Brothers:Kk | 抗ショック剤 |
| JP4612924B2 (ja) | 1999-08-20 | 2011-01-12 | 藤本製薬株式会社 | サイトカイン調節剤 |
| CN1207005C (zh) * | 2002-10-31 | 2005-06-22 | 威世药业（如皋）有限公司 | 含生物活性物质的兔皮和其用途 |
| JP3818657B2 (ja) | 2004-12-01 | 2006-09-06 | 日本臓器製薬株式会社 | 乾燥物及びその製造方法 |
| KR101307999B1 (ko) * | 2004-12-01 | 2013-09-12 | 니폰 조키 세야쿠 가부시키가이샤 | 건조물 및 그 제조방법 |
| CA2635588C (en) * | 2005-12-30 | 2015-11-10 | Dyax Corp. | Metalloproteinase binding proteins |
| TWI406664B (zh) | 2006-03-30 | 2013-09-01 | Univ Kyoto | 硫氧還蛋白（ｔｈｉｏｒｅｄｏｘｉｎ）產生促進劑 |
| CN101732348B (zh) * | 2008-11-11 | 2015-01-14 | 威世药业（如皋）有限公司 | 牛痘疫苗致炎兔皮提取物在制备急性脑血管疾病治疗药物中的用途 |
-
2008
- 2008-11-11 CN CN200810176703.4A patent/CN101732348B/zh not_active Ceased
-
2009
- 2009-10-23 KR KR1020117012994A patent/KR101756201B1/ko active IP Right Grant
- 2009-10-23 CA CA2743090A patent/CA2743090C/en active Active
- 2009-10-23 AU AU2009316168A patent/AU2009316168B2/en active Active
- 2009-10-23 HU HUE09825706A patent/HUE030782T2/en unknown
- 2009-10-23 US US13/128,254 patent/US10265345B2/en active Active
- 2009-10-23 SI SI200931579A patent/SI2364711T1/sl unknown
- 2009-10-23 JP JP2011534986A patent/JP6085806B2/ja active Active
- 2009-10-23 EP EP09825706.6A patent/EP2364711B2/en active Active
- 2009-10-23 NZ NZ592696A patent/NZ592696A/xx unknown
- 2009-10-23 PL PL09825706T patent/PL2364711T3/pl unknown
- 2009-10-23 PT PT98257066T patent/PT2364711T/pt unknown
- 2009-10-23 DK DK09825706.6T patent/DK2364711T3/en active
- 2009-10-23 WO PCT/CN2009/001181 patent/WO2010054531A1/zh active Application Filing
- 2009-10-23 ES ES09825706T patent/ES2606051T5/es active Active
- 2009-10-23 LT LTEP09825706.6T patent/LT2364711T/lt unknown
-
2010
- 2010-09-24 HK HK10109154.1A patent/HK1142546A1/xx unknown
-
2014
- 2014-10-20 JP JP2014213882A patent/JP2015028076A/ja active Pending
-
2016
- 2016-11-14 JP JP2016221621A patent/JP2017052788A/ja not_active Withdrawn
- 2016-12-14 HR HRP20161716TT patent/HRP20161716T1/hr unknown
- 2016-12-28 SM SM201600477T patent/SMT201600477B/it unknown
-
2017
- 2017-01-11 CY CY20171100033T patent/CY1118457T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012508192A (ja) | 2012-04-05 |
| CA2743090A1 (en) | 2010-05-20 |
| CN101732348B (zh) | 2015-01-14 |
| JP6085806B2 (ja) | 2017-03-01 |
| ES2606051T3 (es) | 2017-03-17 |
| WO2010054531A1 (zh) | 2010-05-20 |
| AU2009316168A1 (en) | 2010-05-20 |
| SMT201600477B (it) | 2017-03-08 |
| KR101756201B1 (ko) | 2017-07-10 |
| EP2364711B1 (en) | 2016-10-12 |
| AU2009316168B2 (en) | 2015-03-12 |
| KR20110086136A (ko) | 2011-07-27 |
| NZ592696A (en) | 2013-02-22 |
| ES2606051T5 (es) | 2020-05-14 |
| JP2017052788A (ja) | 2017-03-16 |
| SI2364711T1 (sl) | 2017-05-31 |
| HK1142546A1 (en) | 2010-12-10 |
| HUE030782T2 (en) | 2017-06-28 |
| PT2364711T (pt) | 2017-01-18 |
| CY1118457T1 (el) | 2017-07-12 |
| LT2364711T (lt) | 2017-03-10 |
| JP2015028076A (ja) | 2015-02-12 |
| DK2364711T3 (en) | 2017-01-30 |
| EP2364711A1 (en) | 2011-09-14 |
| EP2364711A4 (en) | 2012-12-12 |
| EP2364711B2 (en) | 2019-10-30 |
| US20110268814A1 (en) | 2011-11-03 |
| CN101732348A (zh) | 2010-06-16 |
| CA2743090C (en) | 2021-04-27 |
| US10265345B2 (en) | 2019-04-23 |
| PL2364711T3 (pl) | 2017-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20161716T1 (hr) | Uporaba ekstrakata iz upaljene kože kunića uslijed vakcinija virusa za proizvodnju lijeka za liječenje akutne cerebrovaskularne bolesti | |
| RU2020121715A (ru) | Синтез эластического волокна in vivo | |
| Spadaro | Interview with Pope Francis | |
| MX352904B (es) | Compuestos de piridina 3,4-di-sustituido, procedimientos de uso y composiciones que comprenden el mismo. | |
| NZ607195A (en) | Methods for treating and/or reversing neurodegenerative diseases and/or disorders | |
| CN104107190A (zh) | 一次性湿敷贴及其制备方法 | |
| CN101721474B (zh) | 一种治疗牛皮癣病的外用搽剂 | |
| CN105311195A (zh) | 一种治皮肤瘙痒的配方 | |
| CN105687640A (zh) | 一种治疗外科创面的药物及其制备方法 | |
| CN104548194A (zh) | 一种医用高性能粘合剂 | |
| Rinker | Extensor tendon injury during cesarean delivery | |
| WO2010075444A3 (en) | Nasal formulations of metoclopramide | |
| CN202234368U (zh) | 玉石艾香枕 | |
| EP4327869A3 (en) | Methods of treating fabry patients having renal impairment | |
| CN102526294B (zh) | 一种治疗腰肌扭伤的中药外敷膏 | |
| Salgado et al. | Bilateral superficial brachial artery. A rare anatomical variation with clinical and surgical implications | |
| CN201919814U (zh) | 鞋底带有穴道位凸点结构的按摩鞋 | |
| CN202554256U (zh) | 一种新型创可贴 | |
| Moreo et al. | Myocardial fibrosis severity and location: influence on diastolic dysfunction | |
| CN104367623A (zh) | 具有治疗皮肤烧创伤功能的生物制剂 | |
| CN204766272U (zh) | 一种皮肤科卧床被褥支撑架 | |
| Farbood et al. | Comparison of two different methods of limb exsanguination (Esmarch bandage and limb elevation) in intravenous regional anesthesia | |
| CN204260894U (zh) | 一种弹性绷带足弓支撑垫 | |
| CN103919897A (zh) | 一种治疗高血压的药物制剂及其制备方法 | |
| CN103706041B (zh) | 用于血管和多发性硬化的磁贴 |