HRP20161635T1 - Novi derivati monenzina za liječenje i prevenciju protozoalnih infekcija - Google Patents
Novi derivati monenzina za liječenje i prevenciju protozoalnih infekcija Download PDFInfo
- Publication number
- HRP20161635T1 HRP20161635T1 HRP20161635TT HRP20161635T HRP20161635T1 HR P20161635 T1 HRP20161635 T1 HR P20161635T1 HR P20161635T T HRP20161635T T HR P20161635TT HR P20161635 T HRP20161635 T HR P20161635T HR P20161635 T1 HRP20161635 T1 HR P20161635T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- use according
- prevention
- animal
- coccidiosis
- Prior art date
Links
- 230000002265 prevention Effects 0.000 title claims 4
- 206010037075 Protozoal infections Diseases 0.000 title claims 3
- GAOZTHIDHYLHMS-KEOBGNEYSA-N monensin A Chemical class C([C@@](O1)(C)[C@H]2CC[C@@](O2)(CC)[C@H]2[C@H](C[C@@H](O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C[C@@]21C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H](OC)[C@H](C)C(O)=O)O2 GAOZTHIDHYLHMS-KEOBGNEYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 21
- 241001465754 Metazoa Species 0.000 claims 5
- 208000003495 Coccidiosis Diseases 0.000 claims 4
- 206010023076 Isosporiasis Diseases 0.000 claims 4
- 241000283690 Bos taurus Species 0.000 claims 3
- 241000223924 Eimeria Species 0.000 claims 3
- 230000008030 elimination Effects 0.000 claims 2
- 238000003379 elimination reaction Methods 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000009467 reduction Effects 0.000 claims 2
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 241000223933 Eimeria bovis Species 0.000 claims 1
- 201000008680 babesiosis Diseases 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003651 drinking water Substances 0.000 claims 1
- 235000020188 drinking water Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 244000079386 endoparasite Species 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000000287 oocyte Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Claims (15)
1. Spoj, naznačen time, da je odabran od sljedećih:
[image]
[image]
ili njegova veterinarski ili farmaceutski prihvatljiva sol.
2. Veterinarski ili farmaceutski sastav, naznačen time, da obuhvaća paraziticidno djelotvornu količinu spoja prema zahtjevu 1, u kombinaciji s veterinarski ili farmaceutski prihvatljivim nosačem ili razrjeđivačem.
3. Spoj prema zahtjevu 1, naznačen time, da se upotrebljava kao lijek.
4. Spoj prema zahtjevu 1, naznačen time, da se upotrebljava u liječenju ili prevenciji kokcidioze kod životinje, pri čemu ta životinja je ptica.
5. Spoj za uporabu prema zahtjevu 4, naznačen time, da se spoj primjenjuje oralno preko vode za piće ili kao dodatak prehrambenim sastavima.
6. Spoj prema za uporabu prema bilo kojem od zahtjeva 3 do 5, naznačen time, da se spoj primjenjuje u količini od 0,1 do 10 mg/kg prema tjelesnoj masi životinje.
7. Spoj prema za uporabu prema bilo kojem od zahtjeva 3 do 6, naznačen time, da se spoj primjenjuje s učinkovitom količinom cjepiva koje je djelotvorno za zaštitu ptica protiv protozoalnih zaraza.
8. Spoj prema zahtjevu 1, naznačen time, da se upotrebljava za smanjivanje ili eliminaciju babesioze kod goveda.
9. Spoj prema zahtjevu 1, naznačen time, da se upotrebljava u smanjivanju, prevenciji ili eliminaciji protozoalnih zaraza kod ljudi ili kod životinja.
10. Spoj prema zahtjevu 1, naznačen time, da se upotrebljava u smanjivanju, prevenciji ili eliminaciji malarije kod ljudi.
11. Spoj prema zahtjevu 1, naznačen time, da se upotrebljava u liječenju kokcidioze kod goveda, pri čemu se spoj primjenjuje kada postoje klinički pokazatelji kokcidiozne infekcije.
12. Spoj za uporabu prema zahtjevu 11, naznačen time, da se spoj primjenjuje u količini koja povećava dobitak na masi ugojenog goveda.
13. Spoj za uporabu prema zahtjevu 11 ili 12, naznačen time, da kokcidioza rezultira iz infekcije sa sljedećima: Eimeria bovis, E. aubemensis, ili Eimeria zuemii.
14. Spoj za uporabu prema bilo kojem od zahtjeva 11 do 13, naznačen time, da se navedeni spoj također upotrebljava za smanjivanje proljeva ili odbacivanja Eimeria oocyte kod navedene životinje.
15. Spoj, naznačen time, da ima sljedeću formulu (7):
[image]
koji se upotrebljava za suzbijanje endoparazita iz roda Eimeria spp.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41423410P | 2010-11-16 | 2010-11-16 | |
| EP11791699.9A EP2640728B1 (en) | 2010-11-16 | 2011-11-16 | Novel monensin derivatives for the treatment and prevention of protozoal infections |
| PCT/US2011/060913 WO2012068202A1 (en) | 2010-11-16 | 2011-11-16 | Novel monensin derivatives for the treatment and prevention of protozoal infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20161635T1 true HRP20161635T1 (hr) | 2017-02-24 |
Family
ID=45099195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161635TT HRP20161635T1 (hr) | 2010-11-16 | 2016-12-05 | Novi derivati monenzina za liječenje i prevenciju protozoalnih infekcija |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8822528B2 (hr) |
| EP (1) | EP2640728B1 (hr) |
| AU (1) | AU2011328948B2 (hr) |
| CA (1) | CA2818563C (hr) |
| DK (1) | DK2640728T3 (hr) |
| HR (1) | HRP20161635T1 (hr) |
| HU (1) | HUE031125T2 (hr) |
| LT (1) | LT2640728T (hr) |
| MX (1) | MX2013005414A (hr) |
| NZ (1) | NZ610547A (hr) |
| SI (1) | SI2640728T1 (hr) |
| WO (1) | WO2012068202A1 (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015025159A2 (pt) * | 2013-04-04 | 2017-07-18 | Harvard College | macrolídeos e métodos de sua preparação e uso |
| CN110078749B (zh) * | 2019-06-04 | 2021-01-01 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 3a，3a′-双呋喃[2,3-b]吲哚啉类化合物、制备方法、药物组合物及应用 |
| RU2750707C1 (ru) * | 2020-07-22 | 2021-07-01 | Федеральное государственное бюджетное учреждение науки Сибирский федеральный научный центр агробиотехнологий Российской академии наук (СФНЦА РАН) | Способ профилактики эймериоза кур |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL160809C (nl) | 1970-05-15 | 1979-12-17 | Duphar Int Res | Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen. |
| US3950360A (en) | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
| JPS4914624A (hr) | 1972-06-08 | 1974-02-08 | ||
| US3818047A (en) | 1972-08-07 | 1974-06-18 | C Henrick | Substituted pyrones |
| US3832358A (en) | 1973-01-15 | 1974-08-27 | Lilly Co Eli | Deshydroxymethyl derivatives of monensin |
| SE434277B (sv) | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| CH604517A5 (hr) | 1976-08-19 | 1978-09-15 | Ciba Geigy Ag | |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4134973A (en) | 1977-04-11 | 1979-01-16 | Merck & Co., Inc. | Carbohydrate derivatives of milbemycin and processes therefor |
| US4199569A (en) | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
| US4144352A (en) | 1977-12-19 | 1979-03-13 | Merck & Co., Inc. | Milbemycin compounds as anthelmintic agents |
| US4203976A (en) | 1978-08-02 | 1980-05-20 | Merck & Co., Inc. | Sugar derivatives of C-076 compounds |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| JPS57139012A (en) | 1981-02-23 | 1982-08-27 | Sankyo Co Ltd | Anthelmintic composition |
| US4427663A (en) | 1982-03-16 | 1984-01-24 | Merck & Co., Inc. | 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof |
| DE3235931A1 (de) | 1982-09-29 | 1984-03-29 | Bayer Ag, 5090 Leverkusen | Koeder zur bekaempfung von ungeziefer |
| JPS59199673A (ja) | 1983-04-25 | 1984-11-12 | Sumitomo Chem Co Ltd | 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤 |
| DE3580444D1 (en) | 1984-10-18 | 1990-12-13 | Ciba Geigy Ag | Benzoylphenylharnstoffe. |
| EP0192060B1 (de) | 1985-02-04 | 1991-09-18 | Nihon Bayer Agrochem K.K. | Heterocyclische Verbindungen |
| EP0237482A1 (de) | 1986-03-06 | 1987-09-16 | Ciba-Geigy Ag | C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen |
| RU2024527C1 (ru) | 1986-03-25 | 1994-12-15 | Санкио Компани Лимитед | Способ получения макролидных соединений |
| DE3778768D1 (de) | 1986-07-02 | 1992-06-11 | Ciba Geigy Ag | Pestizide. |
| FR2605221B1 (fr) * | 1986-10-20 | 1989-09-01 | Sanofi Sa | Compositions pharmaceutiques ou veterinaires contenant de la de(hydroxymethyl)-25 deoxy-25 oxo-25 monensine |
| US4855317A (en) | 1987-03-06 | 1989-08-08 | Ciba-Geigy Corporation | Insecticides and parasiticides |
| US4871719A (en) | 1987-03-24 | 1989-10-03 | Ciba-Geigy Corporation | Composition for controlling parasites in productive livestock |
| US4874749A (en) | 1987-07-31 | 1989-10-17 | Merck & Co., Inc. | 4"-Deoxy-4-N-methylamino avermectin Bla/Blb |
| EP0319142B1 (en) | 1987-11-03 | 1994-04-06 | Beecham Group Plc | Intermediates for the preparation of anthelmintic macrolide antibiotics |
| NZ232422A (en) | 1989-02-16 | 1992-11-25 | Merck & Co Inc | 13-ketal milbemycin derivatives and parasiticides |
| IE904606A1 (en) | 1989-12-21 | 1991-07-03 | Beecham Group Plc | Novel products |
| WO1992022555A1 (en) | 1991-06-17 | 1992-12-23 | Beecham Group Plc | Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents |
| US5345377A (en) | 1992-10-30 | 1994-09-06 | Electric Power Research Institute, Inc. | Harmonic controller for an active power line conditioner |
| GB9300883D0 (en) | 1993-01-18 | 1993-03-10 | Pfizer Ltd | Antiparasitic agents |
| US5399582A (en) | 1993-11-01 | 1995-03-21 | Merck & Co., Inc. | Antiparasitic agents |
| AUPM969994A0 (en) | 1994-11-28 | 1994-12-22 | Virbac S.A. | Equine anthelmintic formulations |
| JPH08231410A (ja) | 1995-02-23 | 1996-09-10 | Takasago Internatl Corp | コクシジウム症軽減剤及びそれを含有する飼料 |
| US6221894B1 (en) | 1995-03-20 | 2001-04-24 | Merck & Co., Inc. | Nodulisporic acid derivatives |
| US5962499A (en) | 1995-03-20 | 1999-10-05 | Merck & Co., Inc. | Nodulisporic acid derivatives |
| MY113806A (en) | 1995-07-21 | 2002-05-31 | Upjohn Co | Antiparasitic marcfortines and paraherquamides |
| FR2739255B1 (fr) | 1995-09-29 | 1998-09-04 | Rhone Merieux | Composition antiparasitaire pour le traitement et la protection des animaux de compagnie |
| US5885607A (en) | 1996-03-29 | 1999-03-23 | Rhone Merieux | N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs |
| IE80657B1 (en) | 1996-03-29 | 1998-11-04 | Merial Sas | Insecticidal combination to control mammal fleas in particular fleas on cats and dogs |
| US6010710A (en) | 1996-03-29 | 2000-01-04 | Merial | Direct pour-on skin solution for antiparasitic use in cattle and sheep |
| FR2752525B1 (fr) | 1996-08-20 | 2000-05-05 | Rhone Merieux | Procede de lutte contre les myiases des cheptels bovins et ovins et compositions pour la mise en oeuvre de ce procede |
| US6426333B1 (en) | 1996-09-19 | 2002-07-30 | Merial | Spot-on formulations for combating parasites |
| FR2753377B1 (fr) | 1996-09-19 | 1999-09-24 | Rhone Merieux | Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides |
| US6998131B2 (en) | 1996-09-19 | 2006-02-14 | Merial Limited | Spot-on formulations for combating parasites |
| US6207647B1 (en) | 1997-07-18 | 2001-03-27 | Smithkline Beecham Corporation | RatA |
| US6174540B1 (en) | 1998-09-14 | 2001-01-16 | Merck & Co., Inc. | Long acting injectable formulations containing hydrogenated caster oil |
| US6787342B2 (en) | 2000-02-16 | 2004-09-07 | Merial Limited | Paste formulations |
| PE20011289A1 (es) | 2000-04-07 | 2001-12-21 | Upjohn Co | Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles |
| US6399786B1 (en) | 2000-07-14 | 2002-06-04 | Merck & Co., Inc. | Nonacyclic nodulisporic acid derivatives |
| US7001889B2 (en) | 2002-06-21 | 2006-02-21 | Merial Limited | Anthelmintic oral homogeneous veterinary pastes |
| TW200409760A (en) | 2002-09-11 | 2004-06-16 | Novartis Ag | Organic compounds |
| CN101686962B (zh) | 2007-06-29 | 2012-05-23 | 辉瑞大药厂 | 驱虫药联合用药 |
| EP2070522A1 (en) | 2007-12-11 | 2009-06-17 | Universite Pierre Et Marie Curie Paris Vi | Compounds for preventing and treating plasmodium infections. |
-
2011
- 2011-11-16 HU HUE11791699A patent/HUE031125T2/en unknown
- 2011-11-16 MX MX2013005414A patent/MX2013005414A/es active IP Right Grant
- 2011-11-16 US US13/297,367 patent/US8822528B2/en active Active
- 2011-11-16 NZ NZ610547A patent/NZ610547A/en unknown
- 2011-11-16 SI SI201131046A patent/SI2640728T1/sl unknown
- 2011-11-16 LT LTEP11791699.9T patent/LT2640728T/lt unknown
- 2011-11-16 EP EP11791699.9A patent/EP2640728B1/en active Active
- 2011-11-16 WO PCT/US2011/060913 patent/WO2012068202A1/en active Application Filing
- 2011-11-16 CA CA2818563A patent/CA2818563C/en active Active
- 2011-11-16 DK DK11791699.9T patent/DK2640728T3/en active
- 2011-11-16 AU AU2011328948A patent/AU2011328948B2/en active Active
-
2016
- 2016-12-05 HR HRP20161635TT patent/HRP20161635T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011328948B2 (en) | 2016-08-04 |
| CA2818563A1 (en) | 2012-05-24 |
| NZ610547A (en) | 2015-07-31 |
| EP2640728A1 (en) | 2013-09-25 |
| DK2640728T3 (en) | 2016-11-28 |
| HUE031125T2 (en) | 2017-07-28 |
| LT2640728T (lt) | 2017-03-27 |
| US20120128722A1 (en) | 2012-05-24 |
| CA2818563C (en) | 2019-11-12 |
| MX2013005414A (es) | 2013-08-29 |
| AU2011328948A1 (en) | 2013-06-06 |
| WO2012068202A1 (en) | 2012-05-24 |
| US8822528B2 (en) | 2014-09-02 |
| EP2640728B1 (en) | 2016-09-07 |
| SI2640728T1 (sl) | 2017-03-31 |
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