HRP20160842T1 - Postupak za doziranje analita u tekućem mediju - Google Patents
Postupak za doziranje analita u tekućem mediju Download PDFInfo
- Publication number
- HRP20160842T1 HRP20160842T1 HRP20160842TT HRP20160842T HRP20160842T1 HR P20160842 T1 HRP20160842 T1 HR P20160842T1 HR P20160842T T HRP20160842T T HR P20160842TT HR P20160842 T HRP20160842 T HR P20160842T HR P20160842 T1 HRP20160842 T1 HR P20160842T1
- Authority
- HR
- Croatia
- Prior art keywords
- magnetic field
- application
- time
- parameter
- cycle
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 14
- 239000012491 analyte Substances 0.000 title claims 8
- 239000007788 liquid Substances 0.000 title claims 8
- 238000004364 calculation method Methods 0.000 claims 5
- 239000003446 ligand Substances 0.000 claims 5
- 239000006249 magnetic particle Substances 0.000 claims 4
- 238000005259 measurement Methods 0.000 claims 3
- 238000013459 approach Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000001186 cumulative effect Effects 0.000 claims 1
- 238000013213 extrapolation Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 230000003071 parasitic effect Effects 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Claims (12)
1. Postupak kvantificiranja analita u tekućem mediju, koji se sastoji u postavljanju magnetskih čestica u navedeni medij, a koje su funkcionalizirane sa specifičnim ligandima analita koji se kvantificira, koje uzrokuju da magnetsko polje djeluje na tekući medij, čime se omogućuje adhezija magnetskih čestica i stvaranje klastera magnetskih čestica, te u određivanju prisutnosti i koncentracije analita iz varijacije parametara, kao što su na primjer, optička gustoća tekućeg medija, vrijednost tog parametra mjeri se prije primjene magnetskog polja, naznačen time da uključuje ponavljanje ciklusa koji obuhvaćaju prvu fazu primjene magnetskog polja na tekući medij i drugu fazu u kojoj je magnetsko polje nula, parametar koji se mjeri na početku i na kraju svakog ciklusa, razdoblje primjene magnetskog polja tijekom svakog ciklusa je kraće nego razdoblje reakcije između analita koji se kvantificira i liganada magnetskih čestica, te se postupak također sastoji od izračunavanja, na temelju prethodno navedenih mjerenja, ograničavajuće vrijednosti varijacije parametra za beskonačno vrijeme primjene magnetskog polja, te iz toga u izvođenju koncentracije analita u tekućem mediju.
2. Postupak prema zahtjevu 1, naznačen time da uključuje n ciklusa primjene magnetskog polja i mjerenja parametara tijekom trajanja reakcije između analita i liganda, gdje je n između 2 i 100.
3. Postupak prema zahtjevu 2, naznačen time da n je između 5 i 60.
4. Postupak prema jednom od prethodnih zahtjeva, naznačen time da je vrijeme primjene magnetskog polja tijekom jednog ciklusa između 1 sekunde i 1 minute.
5. Postupak prema zahtjevu 4, naznačen time da je vrijeme primjene magnetskog polja tijekom jednog ciklusa između 10 sekundi i 50 sekundi.
6. Postupak prema jednom od zahtjeva 1 do 5, naznačen time da se sastoji od mjerenja gore navedenog parametra na kraju svakog ciklusa, nakon povratka ravnoteže u tekući medij.
7. Postupak prema jednom od prethodnih zahtjeva, naznačen time da se sastoji od određivanja broja ciklusa n tako da je ukupno vrijeme primjene magnetskog polja jednako p puta vremenska konstanta promjene mjerenog parametra, ova promjena je eksponencijalnog tipa.
8. Postupak prema zahtjevu 7, naznačen time da p je jednak 2.
9. Postupak prema jednom od prethodnih zahtjeva, naznačen time da se na kraju svakog ciklusa, sastoji od izračunavanja varijacije mjerenog parametra, kroz vrijeme primjene magnetskog polja akumulirano iz provedenog prvog ciklusa, te od izračunavanja, pomoću ekstrapolacije, ograničavajuće vrijednosti kojoj se približava izračunata vrijednost tijekom beskonačnog vremena primjene magnetskog polja.
10. Postupak prema jednom od prethodnih zahtjeva, naznačen time da se izračuni razlike u parametru provode u realnom vremenu, na kraju svakog ciklusa.
11. Postupak prema zahtjevu 9, naznačen time da se izračuni razlike u parametru provode na kraju reakcije između analita i liganada, te time da se uparuju izračuni razlike u parametru tijekom vremenskih razdoblja akumuliranih iz prvog ciklusa i razlike u parametru tijekom beskonačnog vremena primjene magnetskog polja, te time da se tijekom izračunavanja varijacija parametra tijekom kumulativnog vremena primjene magnetskih polja, vodi računa o smanjenju pokretljivosti tekućeg medija.
12. Postupak prema jednom od prethodnih zahtjeva, naznačen time da se sastoji od identificiranja i od uklanjanja pomoću filtracije parazitskog fenomena koji utječe na izmjereni parametar, te kako bi se to postiglo, u mjerenju vremenskih konstanti za reakciju liganada i analita, za visoke koncentracije analita, u razbijanju vremenske evolucije izmjerenih vrijednosti u funkcijama koje kao osnovu imaju različite vremenske konstante i u zadržavanju samo onih komponenata izmjerenih vrijednosti koje imaju vremenske konstante koje odgovaraju onima za reakciju ligandi-analit.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0705530A FR2919390B1 (fr) | 2007-07-27 | 2007-07-27 | Procede de dosage d'un analyte dans un milieu liquide |
| PCT/FR2008/001023 WO2009034271A1 (fr) | 2007-07-27 | 2008-07-11 | Procede de dosage d'un analyte dans un milieu liquide |
| EP08831120.4A EP2171459B1 (fr) | 2007-07-27 | 2008-07-11 | Procede de dosage d'un analyte dans un milieu liquide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20160842T1 true HRP20160842T1 (hr) | 2016-11-18 |
Family
ID=38982781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160842TT HRP20160842T1 (hr) | 2007-07-27 | 2016-07-12 | Postupak za doziranje analita u tekućem mediju |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8358123B2 (hr) |
| EP (1) | EP2171459B1 (hr) |
| JP (1) | JP2010534829A (hr) |
| CY (1) | CY1118028T1 (hr) |
| ES (1) | ES2581929T3 (hr) |
| FR (1) | FR2919390B1 (hr) |
| HR (1) | HRP20160842T1 (hr) |
| HU (1) | HUE028157T2 (hr) |
| PL (1) | PL2171459T3 (hr) |
| PT (1) | PT2171459T (hr) |
| SI (1) | SI2171459T1 (hr) |
| WO (1) | WO2009034271A1 (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2959820B1 (fr) * | 2010-05-10 | 2013-03-15 | Bertin Technologies Sa | Procede de dosage d'un analyte dans un milieu liquide |
| CN114136927A (zh) * | 2021-10-15 | 2022-03-04 | 国科温州研究院(温州生物材料与工程研究所) | 一种溶液磁性的检测装置及其检测方法 |
| FR3130994A1 (fr) | 2021-12-21 | 2023-06-23 | Horiba Abx Sas | Procédé de dosage |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6294362B1 (en) * | 1996-10-04 | 2001-09-25 | Mbx Systems, Inc. | Rapid ferrous sulfate biooxidation |
| WO2001014591A1 (en) * | 1999-08-21 | 2001-03-01 | Fox John S | High sensitivity biomolecule detection with magnetic particles |
| US6294342B1 (en) * | 1999-09-29 | 2001-09-25 | Abbott Laboratories | Magnetically assisted binding assays utilizing a magnetically responsive reagent |
| JP2004530103A (ja) * | 2000-10-20 | 2004-09-30 | ビナックス インコーポレーティッド | 超常磁性標識を用いて生物学的反応を検出または定量する方法 |
| FR2832507B1 (fr) * | 2001-11-20 | 2004-02-20 | Stago Diagnostica | Methode de detection d'analyte(s) a l'aide de particules magnetiques colloidales |
| ATE326697T1 (de) * | 2001-12-21 | 2006-06-15 | Koninkl Philips Electronics Nv | Sensor und methode zur messung der flächendichte von magnetischen nanopartikeln auf einem mikroarray |
| DE10309132A1 (de) * | 2003-02-28 | 2004-11-18 | Forschungszentrum Jülich GmbH | Verfahren und Vorrichtung zum selektiven Nachweis magnetischer Partikel |
| WO2005010543A1 (en) * | 2003-07-30 | 2005-02-03 | Koninklijke Philips Electronics N.V. | On-chip magnetic sensor device with suppressed cross-talk |
| US7759134B2 (en) * | 2003-09-10 | 2010-07-20 | Auburn University | Magnetostrictive ligand sensor |
| US9494581B2 (en) * | 2004-08-24 | 2016-11-15 | University Of Wyoming | System and method for Raman spectroscopy assay using paramagnetic particles |
-
2007
- 2007-07-27 FR FR0705530A patent/FR2919390B1/fr active Active
-
2008
- 2008-07-11 US US12/670,175 patent/US8358123B2/en not_active Expired - Fee Related
- 2008-07-11 JP JP2010517438A patent/JP2010534829A/ja not_active Withdrawn
- 2008-07-11 EP EP08831120.4A patent/EP2171459B1/fr active Active
- 2008-07-11 HU HUE08831120A patent/HUE028157T2/en unknown
- 2008-07-11 SI SI200831647A patent/SI2171459T1/sl unknown
- 2008-07-11 PL PL08831120T patent/PL2171459T3/pl unknown
- 2008-07-11 PT PT88311204T patent/PT2171459T/pt unknown
- 2008-07-11 ES ES08831120.4T patent/ES2581929T3/es active Active
- 2008-07-11 WO PCT/FR2008/001023 patent/WO2009034271A1/fr active Application Filing
-
2016
- 2016-07-12 CY CY20161100665T patent/CY1118028T1/el unknown
- 2016-07-12 HR HRP20160842TT patent/HRP20160842T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL2171459T3 (pl) | 2017-11-30 |
| PT2171459T (pt) | 2016-07-19 |
| FR2919390A1 (fr) | 2009-01-30 |
| EP2171459A1 (fr) | 2010-04-07 |
| US8358123B2 (en) | 2013-01-22 |
| JP2010534829A (ja) | 2010-11-11 |
| FR2919390B1 (fr) | 2009-10-30 |
| US20100207606A1 (en) | 2010-08-19 |
| CY1118028T1 (el) | 2017-05-17 |
| HUE028157T2 (en) | 2016-12-28 |
| WO2009034271A1 (fr) | 2009-03-19 |
| ES2581929T3 (es) | 2016-09-08 |
| SI2171459T1 (sl) | 2016-12-30 |
| EP2171459B1 (fr) | 2016-04-13 |
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