HRP20150387T1 - Sol kolina i trometamina od likofelona - Google Patents
Sol kolina i trometamina od likofelona Download PDFInfo
- Publication number
- HRP20150387T1 HRP20150387T1 HRP20150387TT HRP20150387T HRP20150387T1 HR P20150387 T1 HRP20150387 T1 HR P20150387T1 HR P20150387T T HRP20150387T T HR P20150387TT HR P20150387 T HRP20150387 T HR P20150387T HR P20150387 T1 HRP20150387 T1 HR P20150387T1
- Authority
- HR
- Croatia
- Prior art keywords
- choline
- licofelone
- salt
- tromethamine salt
- treatment
- Prior art date
Links
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 title 1
- 229960001231 choline Drugs 0.000 title 1
- UAWXGRJVZSAUSZ-UHFFFAOYSA-N licofelone Chemical compound OC(=O)CC=1N2CC(C)(C)CC2=C(C=2C=CC=CC=2)C=1C1=CC=C(Cl)C=C1 UAWXGRJVZSAUSZ-UHFFFAOYSA-N 0.000 title 1
- 229950003488 licofelone Drugs 0.000 title 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000004381 Choline salt Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (4)
1. Spoj, naznačen time, da je to 6-(4-klorofenil)-2,2-dimetil-7-fenil-2,3-dihidro-1H- pirolizin-5-il-octena kiselina-kolinska sol formule I:
[image]
2. Farmaceutski sastav, naznačen time, da obuhvaća sol iz zahtjeva 1 ijedno ili više farmaceutski prihvatljivih pomoćnih sredstava.
3. Uporaba soli prema zahtjevu 1, naznačena time, da je za proizvodnju lijeka za liječenje reumatoidne bolesti.
4. Sol prema zahtjevu 1, naznačena time, da se upotrebljava u liječenju reumatoidne bolesti.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08168127 | 2008-10-31 | ||
| EP09744401.2A EP2350082B1 (en) | 2008-10-31 | 2009-10-30 | Choline and tromethamine salt of licofelone |
| PCT/EP2009/064390 WO2010049525A1 (en) | 2008-10-31 | 2009-10-30 | Choline and tromethamine salt of licofelone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20150387T1 true HRP20150387T1 (hr) | 2015-06-05 |
Family
ID=41376293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20150387TT HRP20150387T1 (hr) | 2008-10-31 | 2015-04-03 | Sol kolina i trometamina od likofelona |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8519155B2 (hr) |
| EP (1) | EP2350082B1 (hr) |
| JP (1) | JP5628816B2 (hr) |
| KR (1) | KR101688238B1 (hr) |
| CN (1) | CN102264741B (hr) |
| AU (1) | AU2009309575B2 (hr) |
| BR (1) | BRPI0920300A2 (hr) |
| CA (1) | CA2741941C (hr) |
| CY (1) | CY1116205T1 (hr) |
| DK (1) | DK2350082T3 (hr) |
| ES (1) | ES2534772T3 (hr) |
| HR (1) | HRP20150387T1 (hr) |
| MX (1) | MX2011004298A (hr) |
| NZ (1) | NZ592378A (hr) |
| PL (1) | PL2350082T3 (hr) |
| PT (1) | PT2350082E (hr) |
| SI (1) | SI2350082T1 (hr) |
| SM (1) | SMT201500105B (hr) |
| WO (1) | WO2010049525A1 (hr) |
| ZA (1) | ZA201103911B (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10206904B2 (en) | 2015-07-17 | 2019-02-19 | The Board Of Regents Of The University Of Oklahoma | Licofelone derivatives and methods of use |
| EP3593792A1 (de) * | 2018-07-11 | 2020-01-15 | Welding GmbH & Co. KG | Pharmazeutische zusammensetzung umfassend 6-(4-chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-yl-essigsäurecholinsalz |
| WO2023089636A1 (en) * | 2021-11-21 | 2023-05-25 | Aizant Drug Research Solutions Private Limited | Pharmaceutical compositions of licofelone |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1250636B (it) | 1991-07-04 | 1995-04-21 | Ricerche Di Schiena Del Dr Mic | Sale del diclofenac, metodo di preparazione e composizioni farmaceutiche che lo contengono. |
| ES2058024B1 (es) * | 1992-11-10 | 1995-05-01 | Menarini Lab | Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico. |
| IT1290448B1 (it) * | 1997-04-01 | 1998-12-03 | Schiena Michele Giuseppe Di | Nimesulide sale di colina,metodo di preparazione e composizioni farmaceutiche che lo contengono |
| JP5143326B2 (ja) * | 2000-01-28 | 2013-02-13 | メルクル・ゲーエムベーハー | ６−（４−クロロフェニル）−２，２−ジメチル−７−フェニル−２，３−ジヒドロ−１ｈ−ピロリジン−５−イル酢酸の製造法 |
| BR0212244A (pt) * | 2001-08-30 | 2004-10-05 | Merckle Gmbh | Uso de um ou mais do que um composto e seus isÈmeros ópticos, derivados e sais fisiologicamente aceitáveis, composição farmacêutica, e, método de tratamento ou de prevenção da degeneração ou da destruição de cartilagem articular e/ou de osso subcondral em uma ou mais articulações de um mamìfero |
| BR0310068A (pt) * | 2002-05-17 | 2005-03-08 | Merckle Gmbh | Uso de um ou mais de um composto, combinação, e, composição farmacêutica |
| WO2006083687A1 (en) * | 2005-01-28 | 2006-08-10 | Cardiome Pharma Corp. | Crystal salt of xanthine oxidase inhibitors |
| TW200726755A (en) * | 2005-07-07 | 2007-07-16 | Astellas Pharma Inc | A crystalline choline salt of an azulene derivative |
| CN101228171A (zh) * | 2005-07-26 | 2008-07-23 | 默克勒有限公司 | 作为5-脂氧化酶和环加氧酶抑制剂的吡咯里嗪和中氮茚化合物的大环内酯偶联物 |
| WO2007015724A1 (en) * | 2005-08-01 | 2007-02-08 | Mallinckrodt Baker, Inc. | Tromethamine salt of valproic acid |
| GB0603522D0 (en) * | 2006-02-22 | 2006-04-05 | Avidex Ltd | Kinase inhibition |
| EP1884239A1 (en) * | 2006-07-28 | 2008-02-06 | Merckle Gmbh | Annellated pyrrole compounds for cancer management |
-
2009
- 2009-10-30 CN CN200980142866.3A patent/CN102264741B/zh not_active Expired - Fee Related
- 2009-10-30 US US13/126,216 patent/US8519155B2/en active Active
- 2009-10-30 MX MX2011004298A patent/MX2011004298A/es active IP Right Grant
- 2009-10-30 ES ES09744401.2T patent/ES2534772T3/es active Active
- 2009-10-30 WO PCT/EP2009/064390 patent/WO2010049525A1/en active Application Filing
- 2009-10-30 DK DK09744401.2T patent/DK2350082T3/en active
- 2009-10-30 AU AU2009309575A patent/AU2009309575B2/en not_active Ceased
- 2009-10-30 PT PT97444012T patent/PT2350082E/pt unknown
- 2009-10-30 PL PL09744401T patent/PL2350082T3/pl unknown
- 2009-10-30 SI SI200931176T patent/SI2350082T1/sl unknown
- 2009-10-30 CA CA2741941A patent/CA2741941C/en not_active Expired - Fee Related
- 2009-10-30 NZ NZ592378A patent/NZ592378A/xx not_active IP Right Cessation
- 2009-10-30 BR BRPI0920300-1A patent/BRPI0920300A2/pt active Search and Examination
- 2009-10-30 EP EP09744401.2A patent/EP2350082B1/en active Active
- 2009-10-30 JP JP2011533741A patent/JP5628816B2/ja not_active Expired - Fee Related
- 2009-10-30 KR KR1020117009835A patent/KR101688238B1/ko active IP Right Grant
-
2011
- 2011-05-27 ZA ZA2011/03911A patent/ZA201103911B/en unknown
-
2015
- 2015-04-03 HR HRP20150387TT patent/HRP20150387T1/hr unknown
- 2015-04-07 CY CY20151100360T patent/CY1116205T1/el unknown
- 2015-04-30 SM SM201500105T patent/SMT201500105B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2741941A1 (en) | 2010-05-06 |
| US20120010261A1 (en) | 2012-01-12 |
| AU2009309575A1 (en) | 2010-05-06 |
| PL2350082T3 (pl) | 2015-08-31 |
| SI2350082T1 (sl) | 2015-05-29 |
| ES2534772T3 (es) | 2015-04-28 |
| US8519155B2 (en) | 2013-08-27 |
| EP2350082B1 (en) | 2015-01-14 |
| ZA201103911B (en) | 2012-02-29 |
| JP5628816B2 (ja) | 2014-11-19 |
| BRPI0920300A2 (pt) | 2020-08-11 |
| CY1116205T1 (el) | 2017-02-08 |
| KR20110126582A (ko) | 2011-11-23 |
| CN102264741B (zh) | 2014-07-16 |
| NZ592378A (en) | 2012-09-28 |
| KR101688238B1 (ko) | 2016-12-20 |
| JP2012506899A (ja) | 2012-03-22 |
| WO2010049525A1 (en) | 2010-05-06 |
| CA2741941C (en) | 2016-09-06 |
| PT2350082E (pt) | 2015-04-30 |
| SMT201500105B (it) | 2015-07-09 |
| MX2011004298A (es) | 2011-10-21 |
| EP2350082A1 (en) | 2011-08-03 |
| AU2009309575B2 (en) | 2015-02-26 |
| CN102264741A (zh) | 2011-11-30 |
| DK2350082T3 (en) | 2015-04-20 |
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