HRP20140696T1 - Aprotininu sliäśni polipeptidi za dostavu na njih konjugiranih sredstava u tkiva - Google Patents
Aprotininu sliäśni polipeptidi za dostavu na njih konjugiranih sredstava u tkiva Download PDFInfo
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- HRP20140696T1 HRP20140696T1 HRP20140696AT HRP20140696T HRP20140696T1 HR P20140696 T1 HRP20140696 T1 HR P20140696T1 HR P20140696A T HRP20140696A T HR P20140696AT HR P20140696 T HRP20140696 T HR P20140696T HR P20140696 T1 HRP20140696 T1 HR P20140696T1
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- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 claims 1
- 229960005353 testolactone Drugs 0.000 claims 1
- BPEWUONYVDABNZ-DZBHQSCQSA-N testolactone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(OC(=O)CC4)[C@@H]4[C@@H]3CCC2=C1 BPEWUONYVDABNZ-DZBHQSCQSA-N 0.000 claims 1
- 229960003433 thalidomide Drugs 0.000 claims 1
- 229960003087 tioguanine Drugs 0.000 claims 1
- MNRILEROXIRVNJ-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=NC=N[C]21 MNRILEROXIRVNJ-UHFFFAOYSA-N 0.000 claims 1
- 229960000303 topotecan Drugs 0.000 claims 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 1
- 229960005026 toremifene Drugs 0.000 claims 1
- XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 claims 1
- 229960001727 tretinoin Drugs 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 229960001055 uracil mustard Drugs 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 229960000653 valrubicin Drugs 0.000 claims 1
- ZOCKGBMQLCSHFP-KQRAQHLDSA-N valrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC(OC)=C4C(=O)C=3C(O)=C21)(O)C(=O)COC(=O)CCCC)[C@H]1C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O1 ZOCKGBMQLCSHFP-KQRAQHLDSA-N 0.000 claims 1
- 229960003048 vinblastine Drugs 0.000 claims 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 1
- 229960004528 vincristine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims 1
- 229960002066 vinorelbine Drugs 0.000 claims 1
- WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims 1
- 229960000237 vorinostat Drugs 0.000 claims 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (22)
1. Polipeptid naznačen time da sadrži aminokiselinsku sekvencu koja ima slijedeću formulu:
X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16-X17-X18-X19
pri čemu X1-X19 su bilo koja aminokiselina ili nisu prisutni;
barem jedan od X10 i X15 je Arg; i
navedena aminokiselinska sekvenca ima barem 80 % identičnosti sa Angiopep-7, koji ima aminokiselinsku sekvencu SEQ ID NO: 112, pri čemu se navedeni polipeptid učinkovito transportira u barem jednu stanicu ili tkivo odabrano iz skupine koja sadrži jetru, pluća i bubreg, te pri čemu se navedeni polipeptid je transportira kroz krvno-moždanu barijeru na razinama nižim nego Angiopep-6, koji ima aminokiselinsku sekvencu SEQ ID NO: 111.
2. Polipeptid prema zahtjevu 1, naznačen time da je navedeni polipeptid, kada se konjugira na neko sredstvo, sposoban povećati akumuliranje tog sredstva za barem 50 % u navedenoj barem jednoj stanici ili tkivu u usporedbi sa nekonjugiranim sredstvom.
3. Polipeptid prema zahtjevu 2, naznačen time da navedeno sredstvo je paklitaksel.
4. Farmaceutski pripravak naznačen time da sadrži polipeptid prema bilo kojem zahtjevu od 1 do 3 i farmaceutski prihvatljiv nosač.
5. Konjugat naznačen time da sadrži:
(a) vektor koji sadrži polipeptid prema bilo kojem zahtjevu od 1 do 3; i
(b) terapijsko sredstvo, dijagnostičko sredstvo, ili detektirajuću oznaku, pri čemu navedeno sredstvo ili oznaka je konjugirano na navedeni vektor.
6. Polipeptid prema bilo kojem zahtjevu od 1 do 3 ili konjugat prema zahtjevu 5, naznačen time da navedena identičnost je barem 90%.
7. Polipeptid prema bilo kojem zahtjevu od 1 do 3 ili konjugat prema zahtjevu 5, naznačen time da
a.) X10 je Lys ili Arg; X15 je Lys ili Arg; ili oboje,
b.) pri čemu X1 je Arg,
c.) pri čemu X10 je Arg,
d.) pri čemu X15 je Arg,
e.) pri čemu X10 i X15 are Arg,
f.) pri čemu X7 je Ser ili Cys, ili
g.) pri čemu X7 je Ser.
8. Polipeptid prema bilo kojem zahtjevu od 1 do 3 ili konjugat prema zahtjevu 5, naznačen time da navedeni polipeptid ili navedeni vektor sadrži aminokiselinsku sekvencu SEQ ID NO: 112.
9. Polipeptid prema bilo kojem zahtjevu od 1 do 3 ili konjugat prema zahtjevu 5, naznačen time da navedeni polipeptid ili navedeni vektor uključuje aminokiselinsku sekvencu SEQ ID NO: 112.
10. Konjugat prema zahtjevu 5, naznačen time da se navedeni vektor konjugira na terapijsko sredstvo.
11. Konjugat prema zahtjevu 5, naznačen time da navedeno terapijsko sredstvo je anti-kancerogeno sredstvo.
12. Konjugat prema zahtjevu 11, naznačen time da je navedeno anti-kancerogeno sredstvo odabrano iz skupine koja sadrži abareliks, aldesleukin, alemtuzumab, alitretinoin, alopurinol, altretamin, amifostin, anakinra, anastrozol, arsenov trioksid, asparaginazu, azacitidin, BCG Live, bevacuzimab, beksaroten, bleomicin, bleomicin, bortezomib, busulfan, kalusteron, kapecitabin, karboplatin, karmustin, celekoksib, cetuksimab, klorambucil, cisplatin, kladribin, klofarabin, ciklofosfamid, citarabin, dakarbazin, daktinomicin, aktinomicin D, dalteparin, darbepoetin alfa, dasatinib, daunorubicin, daunomicin, decitabin, denileukin, Denileukin diftitoks, deksrazoksan, docetaksel, doksorubicin, dromostanolon propionat, ekulizumab, epirubicin, epoetin alfa, erlotinib, estramustin, etopozid, eksemestan, fentanil, filgrastim, floksuridin, fludarabin, fluorouracil, 5-FU, fulvestrant, gefitinib, gemcitabin, gemtuzumab ozogamicin, goserelin, histrelin, hidroksiurea, ibritumomab tiuksetan, idarubicin, ifosfamid, imatinib, Interferon alfa-2b, irinotekan, lapatinib ditosilat, lenalidomid, letrozol, leukovorin, leuprolid, levamizol, lomustin, CCNU, mekloretamin, megestrol, melfalan, merkaptopurin, mesna, metotreksat, metoksalen, mitomicin C, mitotan, mitoksantron, nandrolon fenpropionat, nelarabin, nofetumomab, oprelvekin, oksaliplatin, paklitaksel, palifermin, pamidronat, panitumumab, pegademaz, pegaspargaz, pegfilgrastim, peginterferon alfa-2b, pemetreksed, pentostatin, pipobroman, plikamicin, porfimer, prokarbazin, kvinakrin, rasburicase, rituksimab, sargramostim, sorafenib, streptozocin, sunitinib, sunitinib maleat, talk, tamoksifen, temozolomid, tenipozid, testolakton, talidomid, tiogvanin, tiotepa, tiotepa, tiotepa, topotekan, toremifen, Tositumomab/I-131, trastuzumab, trastuzumab, tretinoin, uracil mustard, valrubicin, vinblastin, vinkristin, vinorelbin, vorinostat, zoledronat, te zoledronsku kiselinu.
13. Konjugat prema zahtjevu 12, naznačen time da navedeno sredstvo je paklitaksel.
14. Konjugat prema zahtjevu 11, naznačen time da navedeno sredstvo je antitijelo.
15. Konjugat prema zahtjevu 14, naznačen time da je navedeno antitijelo odabrano iz skupine koja sadrži ABX-EGF, OvaRex, Theragyn, Therex, Bivatuzumab, Panorex, ReoPro, Bexxar, MAb, idiotipski 105AD7, Anti-EpCAM, MAb rak pluća, Herceptin, Rituxan, Avastin, AMD Fab, E-26, Zevalin, Cetuximab, BEC2, IMC-1C11, nuC242-DM1, LymphoCide, LymphoCide Y-90, CEA-Cide, CEA-Cide Y-90, HumaRAD-HN, MDX-101, MDX-210, MDX-210/MAK, Vitaxin, MAb 425, IS-IL-2, Campath, CD20 streptavidin, Avidicin, Oncolym, Cotara, C215, nakolomab tafenatoks, Nuvion, SMART M195, SMART 1D10, CEA Vac, TriGem, TriAb, NovoMAb-G2 radio-označen, Monopharm C, GlioMAb-H, Rituxan, te ING-1.
16. Konjugat prema zahtjevu 5, naznačen time da se navedeni konjugat akumulira znatno brže, akumulira se u višoj koncentraciji, ili iskazuje smanjeni P-gp posredovan efluks u stanici jetre, pluća, bubrega, ili slezene, u usporedbi sa navedenim sredstvom ili oznakom kada nije konjugirano na navedeni vektor.
17. Pripravak naznačen time da sadrži konjugat prema zahtjevu 5 i farmaceutski prihvatljiv nosač.
18. Konjugat prema bilo kojem zahtjevu od 11 do 15 naznačen time da je za uporabu u postupku liječenja subjekta koji ima rak, te navedeni postupak sadrži pružanje navedenom subjektu konjugata u količini koja je dovoljna za liječenje navedenog subjekta.
19. Konjugat za uporabu prema zahtjevu 18, naznačen time da navedeni rak je rak pluća, rak jetre, rak bubrega, ili rak slezene.
20. Konjugat za uporabu prema zahtjevu 19, naznačen time da je navedeni rak odabran iz skupine koja sadrži hepatocelularni karcinom, rak dojke, karcinom glave i vrata, limfom, limfom plaštenih stanica, ne-Hodgkinov limfom, adenom, karcinom skvamoznih stanica, karcinom grkljana, karcinome mrežnice, karcinome jednjaka, multipli mijelom, rak jajnika, rak maternice, melanom, rak debelog crijeva, rak mokraćnog mjehura, rak prostate, rak pluća, karcinom pluća ne-malih stanica, rak gušterače, rak grlića maternice, rak glave i vrata, karcinome kože, karcinom nazofarinksa, liposarkom, epitelni karcinom, karcinom bubrežnih stanica, adenokarcinom žučnog mjehura, adenokarcinom parotidne žlijezde, sarkom endometrija, te karcinome rezistentne na višestruke lijekove.
21. Konjugat za uporabu prema zahtjevu 18, naznačen time da navedeno anti-kancerogeno sredstvo ima povećanu efikasnost ili smanjene nuspojave kada je konjugirano na navedeni polipeptid, u usporedbi sa navedenim sredstvom kada nije konjugirano na navedeni polipeptid.
22. Konjugat za uporabu prema zahtjevu 18, naznačen time da navedeni subjekt je čovjek.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/807,597 US20090016959A1 (en) | 2005-02-18 | 2007-05-29 | Delivery of antibodies to the central nervous system |
| US11/807,917 US8969310B2 (en) | 2005-07-15 | 2007-05-30 | Potentiation of anticancer agents |
| US888007P | 2007-12-20 | 2007-12-20 | |
| PCT/CA2008/001030 WO2008144919A1 (en) | 2007-05-29 | 2008-05-29 | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
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| Publication Number | Publication Date |
|---|---|
| HRP20140696T1 true HRP20140696T1 (hr) | 2014-11-21 |
Family
ID=42767988
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140696AT HRP20140696T1 (hr) | 2007-05-29 | 2014-07-22 | Aprotininu sliäśni polipeptidi za dostavu na njih konjugiranih sredstava u tkiva |
Country Status (5)
| Country | Link |
|---|---|
| JP (2) | JP5844971B2 (hr) |
| DK (1) | DK2164866T3 (hr) |
| ES (1) | ES2488668T3 (hr) |
| HR (1) | HRP20140696T1 (hr) |
| PT (1) | PT2164866E (hr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011274229A1 (en) * | 2010-07-02 | 2013-01-10 | Angiochem Inc. | Short and D-amino acid-containing polypeptides for therapeutic conjugates and uses thereof |
| TW202140776A (zh) * | 2016-04-26 | 2021-11-01 | 美商美國泰福生技股份有限公司 | 細胞培養基 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2368941T3 (es) * | 2003-01-06 | 2011-11-23 | Angiochem Inc. | Angiopep-1, compuestos relacionados y utilizaciones correspondientes. |
| CN104311653B (zh) * | 2005-02-18 | 2017-12-05 | 安吉奥开米公司 | 转运化合物穿过血脑屏障的分子 |
| BRPI0613005A8 (pt) * | 2005-07-15 | 2017-12-26 | Angiochem Inc | uso de polipeptídeos de aprotinina como veículos em conjugados farmacêuticos. |
-
2008
- 2008-05-29 DK DK08757166.7T patent/DK2164866T3/da active
- 2008-05-29 JP JP2010509648A patent/JP5844971B2/ja active Active
- 2008-05-29 ES ES08757166.7T patent/ES2488668T3/es active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2016006089A (ja) | 2016-01-14 |
| PT2164866E (pt) | 2014-08-04 |
| DK2164866T3 (da) | 2014-07-28 |
| ES2488668T3 (es) | 2014-08-28 |
| JP5844971B2 (ja) | 2016-01-20 |
| JP2010528058A (ja) | 2010-08-19 |
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