HRP20140594T1 - Spoj i njegova primjena u lijeäśenju analnih ragada - Google Patents
Spoj i njegova primjena u lijeäśenju analnih ragada Download PDFInfo
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- HRP20140594T1 HRP20140594T1 HRP20140594AT HRP20140594T HRP20140594T1 HR P20140594 T1 HRP20140594 T1 HR P20140594T1 HR P20140594A T HRP20140594A T HR P20140594AT HR P20140594 T HRP20140594 T HR P20140594T HR P20140594 T1 HRP20140594 T1 HR P20140594T1
- Authority
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- Croatia
- Prior art keywords
- compound
- use according
- hibiscus
- extract
- glucan
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- 239000000203 mixture Substances 0.000 title claims 4
- 241000842539 Rhagades Species 0.000 title 1
- 206010040849 Skin fissures Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 18
- 229920002498 Beta-glucan Polymers 0.000 claims 8
- 235000018102 proteins Nutrition 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 241000218033 Hibiscus Species 0.000 claims 6
- 235000005206 Hibiscus Nutrition 0.000 claims 6
- 235000007185 Hibiscus lunariifolius Nutrition 0.000 claims 6
- 239000003995 emulsifying agent Substances 0.000 claims 6
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims 5
- 239000003921 oil Substances 0.000 claims 3
- 235000019198 oils Nutrition 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- 244000215068 Acacia senegal Species 0.000 claims 2
- 206010002153 Anal fissure Diseases 0.000 claims 2
- 208000016583 Anus disease Diseases 0.000 claims 2
- 240000001432 Calendula officinalis Species 0.000 claims 2
- 208000009531 Fissure in Ano Diseases 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 229920000084 Gum arabic Polymers 0.000 claims 2
- 240000000982 Malva neglecta Species 0.000 claims 2
- 235000000060 Malva neglecta Nutrition 0.000 claims 2
- 235000010489 acacia gum Nutrition 0.000 claims 2
- 239000000205 acacia gum Substances 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- 239000006071 cream Substances 0.000 claims 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 2
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims 1
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims 1
- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 claims 1
- 240000004507 Abelmoschus esculentus Species 0.000 claims 1
- 235000003934 Abelmoschus esculentus Nutrition 0.000 claims 1
- 235000019489 Almond oil Nutrition 0.000 claims 1
- 240000004355 Borago officinalis Species 0.000 claims 1
- 235000007689 Borago officinalis Nutrition 0.000 claims 1
- 235000003880 Calendula Nutrition 0.000 claims 1
- 235000005881 Calendula officinalis Nutrition 0.000 claims 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims 1
- 229920001353 Dextrin Polymers 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- 244000303040 Glycyrrhiza glabra Species 0.000 claims 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims 1
- 244000141009 Hypericum perforatum Species 0.000 claims 1
- 235000017309 Hypericum perforatum Nutrition 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- 229920002774 Maltodextrin Polymers 0.000 claims 1
- 235000013939 Malva Nutrition 0.000 claims 1
- 235000017011 Mandorlo dulce Nutrition 0.000 claims 1
- 244000076313 Mandorlo dulce Species 0.000 claims 1
- 102000015636 Oligopeptides Human genes 0.000 claims 1
- 108010038807 Oligopeptides Proteins 0.000 claims 1
- 229920006243 acrylic copolymer Polymers 0.000 claims 1
- 239000008168 almond oil Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 235000021324 borage oil Nutrition 0.000 claims 1
- 229960000541 cetyl alcohol Drugs 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- 229940008099 dimethicone Drugs 0.000 claims 1
- 239000003974 emollient agent Substances 0.000 claims 1
- 230000001804 emulsifying effect Effects 0.000 claims 1
- 229940100524 ethylhexylglycerin Drugs 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 229940075529 glyceryl stearate Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229940101267 panthenol Drugs 0.000 claims 1
- 235000020957 pantothenol Nutrition 0.000 claims 1
- 239000011619 pantothenol Substances 0.000 claims 1
- 229960005323 phenoxyethanol Drugs 0.000 claims 1
- 229940057874 phenyl trimethicone Drugs 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 239000003531 protein hydrolysate Substances 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 claims 1
- 229940048081 trisodium ethylenediamine disuccinate Drugs 0.000 claims 1
- QEHXDDFROMGLSP-VDBFCSKJSA-K trisodium;(2s)-2-[2-[[(1s)-1-carboxy-2-carboxylatoethyl]amino]ethylamino]butanedioate Chemical compound [Na+].[Na+].[Na+].OC(=O)C[C@@H](C([O-])=O)NCCN[C@H](C([O-])=O)CC([O-])=O QEHXDDFROMGLSP-VDBFCSKJSA-K 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (18)
1. Spoj koji sadrži barem jedan proteinski ekstrakt hibiskusa i barem jedan beta glukan ili njegovu sol za primjenu u liječenju.
2. Spoj koji sadrži barem jedan proteinski ekstrakt hibiskusa ili barem jedan karboksimetil-beta-glukan ili njegovu sol za primjenu u liječenju.
3. Spoj za primjenu prema zahtjevima 1 ili 2 za primjenu u liječenju analnih ragada.
4. Spoj za primjenu prema zahtjevu 3, pri čemu su analne ragade akutnog i/ili kroničnog tipa, prvenstveno akutnog tipa.
5. Spoj za primjenu prema bilo kojem od zahtjeva 1-4 u kombinaciji sa metodom i/ili protokolom za liječenje analnih ragada, prvenstveno sa metodom i/ili protokolom koji koristi analni dilatator.
6. Spoj za primjenu prema bilo kojem od zahtjeva 1-5, pri čemu je spomenuti hibiscus Hibiscus esculentus.
7. Spoj za primjenu prema bilo kojem od zahtjeva 1-6, pri čemu spomenuti proteinski ekstrakt potječe od sjemena spomenutog hibiskusa, poželjno je da su sjemenke delipidirane.
8. Spoj za primjenu prema bilo kojem od zahtjeva 1-7, pri čemu je spomenuti proteinski ekstrakt barem proteinska frakcija, poželjno solubilna proteinska frakcija, poželjno proteinski hidrolizat.
9. Spoj za primjenu prema zahtjevu 8, pri čemu je spomenuti hidrolizat mješavina oligopeptida, prije svega sa vezujućim sredstvom.
10. Spoj za primjenu prema bilo kojem od zahtjeva 1-9, pri čemu je spomenuti proteinski ekstrakt hibiskusa prisutan u koncentraciji koja je u opsegu od 0.1 do 10%; poželjno u opsegu od 0.4 do 5%.
11. Spoj za primjenu prema bilo kojem od zahtjeva 1-10, pri čemu je barem jedan spomenuti beta glukan karboksimetil-beta-glukan ili njegova sol; poželjno natrijum karboksimetil-beta-glukan.
12. Spoj za primjenu prema bilo kojem od zahtjeva 1-11, pri čemu je spomenuti beta glukan prisutan u koncentraciji koja je u opsegu od 0.004 do 0.4% poželjno od 0.02 do 0.08%.
13. Spoj za primjenu prema bilo kojem od zahtjeva 1-12, pri čemu je odnos između spomenutog barem jednog proteinskog ekstrakta i spomenutog barem jednog beta glukana 50-10: 1, poželjno 35-20: 1.
14. Spoj za primjenu prema bilo kojem od zahtjeva 1-13, koje dalje sadrži emulgatore iz grupe koja obuhvaća: dimetikon, ili dimetil polisiloksan, poželjno linearni, glicerin, ulje badema (poželjno uljeiz Prunus amygdalus dulcis), fenil trimetikon, ulje boražine (poželjno ulje iz sjemena Borago officinalis), ekstrakt malve i/ili gumarabiku, poželjno gumarabiku iz vrste Malva sylvetris, pantenol, ekstrakt nevena, poželjno od Calendula officinalis, etilheksilglicerin, kaprilil glikol, asparaginsku kiselinu, maltodekstrine i gliceril stearat.
15. Spoj za primjenu prema bilo kojem od zahtjeva 1-14, koji dalje sadrži površinski aktivnematerije iz grupe koja obuhvata: cetil alcohol, cetil(20) OE ili cetet-20, stearil(20)OE ili stearet-20 i PEG-75 stearat.
16. Spoj za primjenu prema bilo kojem od zahtjeva 1-15, koje dalje sadrži konzervans, poželjno fenoksietanol; ili antioksidant, poželjno tokoferol i/ili suvi ekstrakt gospinog bilja (glycyrrhiza glabra); ili vezujuće sredstvo, poželjno dekstrin; ili stabilizirajući agens, poželjno emulgujući stabilizirajući agens, još poželjnije umreženi akrilni kopolimer; ili helatni agens, poželjno trinatrijum etilendiamin disukcinat.
17. Spoj za primjenu prema bilo kojem od zahtjeva 1-16, formulisan kao krema, gel-krema, gel, ulje, emulzija, gel-emulzija (emulgel), mast, sprej, supozitorija ili stik.
18. Metoda za proizvodnju spoja prema bio kojem od zahtjeva 1-17 koji obuhvaća slijedeće korake:
(i) Topljenje emulgacijskih agenasa, poželjno okluzivnih i/ili emolijentnih emulgacijskih agenasa, i/ili površinski aktivnih materija, poželjno emulgatora i/ili površinski aktivnih materija za čišćenje, na temperaturi u opsegu od 70 do 90°C; poželjnije u opsegu od 75 do 80°C;
(ii) Miješanje rastvarača, emulgacijskih agenasa, poželjno onih koji povećavaju vlažnost, helatnih agenasa i/ili stabilizirajućih emulgacijskih agenasa sa sirovinama topljenim prema koraku (i);
(iii) Dodavanje barem jednog ekstrakta hibiskusa miksturi prema koraku (ii);
(iv) Dodavanje barem jednog beta glukana miksturi prema koraku (iii).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IT2012/000027 WO2013114410A1 (en) | 2012-01-30 | 2012-01-30 | A composition and use thereof in the treatment of anal rhagades |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140594T1 true HRP20140594T1 (hr) | 2014-10-24 |
Family
ID=46001672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140594AT HRP20140594T1 (hr) | 2012-01-30 | 2014-06-26 | Spoj i njegova primjena u lijeäśenju analnih ragada |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9345747B2 (hr) |
| EP (1) | EP2646039B1 (hr) |
| JP (1) | JP5903505B2 (hr) |
| KR (1) | KR101599447B1 (hr) |
| CN (2) | CN109865000A (hr) |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6523291B2 (ja) | 2013-12-24 | 2019-05-29 | ザ プロクター アンド ギャンブル カンパニーＴｈｅ Ｐｒｏｃｔｅｒ ＆ Ｇａｍｂｌｅ Ｃｏｍｐａｎｙ | スキンケア有効成分の高い浸透性を与える美容組成物及び方法 |
| ITRM20150163A1 (it) * | 2015-04-17 | 2016-10-17 | Uniderm Farm S R L | Composizioni farmaceutiche per il trattamento delle ragadi anali |
| US10117826B2 (en) | 2016-03-31 | 2018-11-06 | Peter Angia Pham | Bodily lubricating and moisturizing compositions containing plant mucilage |
| US10835504B2 (en) | 2018-04-18 | 2020-11-17 | G&S Laboratories, Inc. | Compositions to treat anal itch |
| EP3787654A4 (en) * | 2018-05-02 | 2022-04-20 | Montero Gida Sanayi Ve Ticaret Anonim Sirketi | TOPICAL COMPOSITIONS AGAINST STRETCH MARKS ON THE SKIN |
| RU2771015C2 (ru) * | 2020-09-25 | 2022-04-25 | Общество с ограниченной ответственностью "ФАРМКОММ" | Фармацевтическая композиция в виде мази для лечения геморроя |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5622939A (en) * | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
| AU7340098A (en) * | 1997-04-16 | 1998-11-11 | Laboratoires Serobiologiques (Societe Anonyme) | Use in cosmetics of a protein fraction extracted from okra seeds |
| US6379719B1 (en) * | 1998-04-08 | 2002-04-30 | Laboratories Serobiologiques (Societe Anonyme) | Use of at least one protein fraction extracted from Hibiscus esculentus seeds and cosmetic composition containing such a fraction |
| CN1233469A (zh) * | 1998-04-28 | 1999-11-03 | 王京杭 | 组织修复促进剂 |
| JP2002204687A (ja) * | 2000-11-09 | 2002-07-23 | Onaka Yasushi | β−１．３−１．６グルカン（アウレオバシジウム培養液）の医療、保健、福祉、食品および各種産業分野での応用 |
| US6956120B2 (en) * | 2000-11-09 | 2005-10-18 | Yasushi Onaka | β-1.3-1.6 glucan (Aureobasidium medium) |
| JP2003104832A (ja) * | 2001-09-28 | 2003-04-09 | Chifure Keshohin:Kk | 皮膚外用剤 |
| JP4544500B2 (ja) * | 2002-07-19 | 2010-09-15 | 一丸ファルコス株式会社 | ヒアルロン酸合成促進剤 |
| CA2523021C (en) * | 2003-05-02 | 2013-06-11 | Ceapro Inc. | Improved extraction and purification method for cereal beta-glucan |
| RU2277920C2 (ru) * | 2004-02-24 | 2006-06-20 | Государственное Учреждение "Пятигорский Государственный Научно-Исследовательский Институт Курортологии Министерства Здравоохранения Российской Федерации" | Способ лечения детей, больных хроническим вирусным гепатитом, с применением сульфидных ванн и слабоуглекислой минеральной водой |
| ITMI20042111A1 (it) * | 2004-11-04 | 2005-02-04 | Biofarmitalia Spa | Cerotto contenenti una sostanza scelta tra i catrami aventi caratteristiche riducenti in dermatologia |
| JP5048935B2 (ja) * | 2005-08-24 | 2012-10-17 | 株式会社ヤクルト本社 | 保湿剤 |
| DE202007004856U1 (de) * | 2007-04-01 | 2007-06-06 | Rühle, Wilfried, Dipl.-Ing. | CHM Anti Aging Komplex |
| CN101095482B (zh) * | 2007-07-05 | 2012-02-15 | 中国科学院长春应用化学研究所 | 制备膳食纤维食品用大麦麦麸或燕麦麦麸的制法 |
| US20090202664A1 (en) * | 2008-02-11 | 2009-08-13 | Svetislav Mikalacki | Herbal cream or oil for the treatment hemorroids and wounds |
| ITUD20100112A1 (it) * | 2010-06-09 | 2011-12-10 | Farma Derma S R L | Preparazione per uso vaginale e rettale e relativo procedimento di produzione |
| CN102084963A (zh) * | 2010-09-29 | 2011-06-08 | 吉林省农业机械研究院 | 一种制备燕麦麦麸膳食纤维食品的方法 |
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2012
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- 2012-01-30 ES ES12716670.0T patent/ES2485490T3/es active Active
- 2012-01-30 DK DK12716670.0T patent/DK2646039T3/da active
- 2012-01-30 RU RU2014129391/15A patent/RU2580622C2/ru not_active IP Right Cessation
- 2012-01-30 CA CA2863369A patent/CA2863369C/en active Active
- 2012-01-30 CN CN201910159524.8A patent/CN109865000A/zh active Pending
- 2012-01-30 BR BR112014018850A patent/BR112014018850A8/pt not_active IP Right Cessation
- 2012-01-30 JP JP2014553861A patent/JP5903505B2/ja active Active
- 2012-01-30 EP EP12716670.0A patent/EP2646039B1/en active Active
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- 2012-01-30 CN CN201280068454.1A patent/CN104114177A/zh active Pending
- 2012-01-30 US US14/359,504 patent/US9345747B2/en active Active
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- 2012-01-30 KR KR1020147024430A patent/KR101599447B1/ko not_active IP Right Cessation
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2013
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- 2013-12-10 HK HK13113705.4A patent/HK1186378A1/xx not_active IP Right Cessation
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2014
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