HRP20201151T1 - Pripravak protiv znojenja s dugotrajnom zaštitom mirisa - Google Patents
Pripravak protiv znojenja s dugotrajnom zaštitom mirisa Download PDFInfo
- Publication number
- HRP20201151T1 HRP20201151T1 HRP20201151TT HRP20201151T HRP20201151T1 HR P20201151 T1 HRP20201151 T1 HR P20201151T1 HR P20201151T T HRP20201151T T HR P20201151TT HR P20201151 T HRP20201151 T HR P20201151T HR P20201151 T1 HRP20201151 T1 HR P20201151T1
- Authority
- HR
- Croatia
- Prior art keywords
- chitosan
- microcapsule
- alginate
- genipin
- amount
- Prior art date
Links
- 230000001166 anti-perspirative effect Effects 0.000 title claims 13
- 239000003213 antiperspirant Substances 0.000 title claims 13
- 230000005923 long-lasting effect Effects 0.000 title 1
- 239000003094 microcapsule Substances 0.000 claims 23
- 229920001661 Chitosan Polymers 0.000 claims 21
- AZKVWQKMDGGDSV-BCMRRPTOSA-N Genipin Chemical compound COC(=O)C1=CO[C@@H](O)[C@@H]2C(CO)=CC[C@H]12 AZKVWQKMDGGDSV-BCMRRPTOSA-N 0.000 claims 10
- AZKVWQKMDGGDSV-UHFFFAOYSA-N genipin Natural products COC(=O)C1=COC(O)C2C(CO)=CCC12 AZKVWQKMDGGDSV-UHFFFAOYSA-N 0.000 claims 10
- 239000004480 active ingredient Substances 0.000 claims 9
- 238000002360 preparation method Methods 0.000 claims 9
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 7
- 229940072056 alginate Drugs 0.000 claims 7
- 229920000615 alginic acid Polymers 0.000 claims 7
- 235000010443 alginic acid Nutrition 0.000 claims 7
- 230000000699 topical effect Effects 0.000 claims 7
- 239000000243 solution Substances 0.000 claims 5
- 239000007864 aqueous solution Substances 0.000 claims 3
- 238000010521 absorption reaction Methods 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- 238000004132 cross linking Methods 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000001694 spray drying Methods 0.000 claims 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000002781 deodorant agent Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Claims (14)
1. Genipinom umrežena alginat-kitosan mikrokapsula koja sadrži efikasnu količinu jednog ili više inkapsuliranih aktivnih sastojaka protiv znojenja koji se sastoje od 92% do 98% težine mase mikrokapsule, pri čemu mikrokapsula ima postotak umreženosti od 20% do 40% izraženo u vrijednosti apsorpcije za slobodne amino skupine, u skladu s ovdje opisanim testom.
2. Mikrokapsula prema zahtjevu 1, naznačena time što je postotak umreženosti od 25% do 35% izražen u vrijednostima apsorpcije.
3. Genipinom umrežena alginat-kitosan mikrokapsula prema bilo kojem od zahtjeva 1-2, naznačena time što je inkapsulirani aktivni sastojak protiv znojenja jedna ili više soli koje sadrže aluminij.
4. Genipinom umrežena alginat-kitosan mikrokapsula prema bilo kojem od zahtjeva 1-3, naznačena time što:
količina genipina sastoji se od 0.001% do 5% težine mase mikrokapsule;
količina alginata sastoji se od 1% do 20% težine mase mikrokapsule;
količina kitosana sastoji se od 1% do 20% težine mase mikrokapsule;
težinski omjer između kitosana i inkapsuliranog aktivnog sastojka protiv znojenja sastoji se od 1: 2 do 1:50; i
težinski omjer između kitosana i alginata sastoji se od 1: 1 do 4: 1.
5. Genipinom umrežena alginat-kitosan mikrokapsula prema bilo kojem od zahtjeva 1-4, naznačena time što:
količina genipina sastoji se od 0.001% do 1% težine mase mikrokapsule;
količina alginata sastoji se od 1% do 3% težine mase mikrokapsule;
količina kitosana sastoji se od 1.5% do 4% težine mase mikrokapsule;
težinski omjer između kitosana i inkapsuliranog aktivnog sastojka protiv znojenja sastoji se od 1:10 do 1:40; i
težinski omjer između kitosana i alginata sastoji se od 1: 1 do 2: 1.
6. Genipinom umrežena alginat-kitosan mikrokapsula prema bilo kojem od zahtjeva 1-5, naznačena time što je količina genipina 0.004 težine mase mikrokapsule; količina alginata je 1.2% težine mase mikrokapsule; količina kitosana je 2.4% težine mase mikrokapsule; težinski omjer između kitosana i inkapsuliranog aktivnog sastojka protiv znojenja je 1:40; i
težinski omjer kitosana i alginata je 2: 1.
7. Genipinom umrežena alginat-kitosan mikrokapsula prema bilo kojem od zahtjeva 1-6, ima raspodjelu veličine čestica D90 koja je od 20 do 80 μm.
8. Postupak za pripremu genipinom umrežene alginat-kitosan mikrokapsule kako je definirano u bilo kojem od zahtjeva 1-7, naznačen time što sadrži:
i) priprema kisele vodene otopine kitosana kontaktom kisele vodene otopine s kitosanom;
ii) dodavanje inkapsuliranog aktivnog sastojka protiv znojenja u otopinu dobivenu u koraku (i) da se dobije otopina A;
iii) pripremu vodene otopine alginata i genipina za dobivanje otopine B;
iv) dodavanje otopine B u otopinu A i miješanje dobivene emulzije u vremenskom periodu od 1 do 6 sati da se dobije vlažna genipinom umrežena alginat-kitosan mikrokapsula koja sadrži efikasnu količinu jednog ili više inkapsuliranih aktivnih sastojaka protiv znojenja; i
v) sušenje raspršivanjem mokre mikrokapsule dobivene u koraku (iv).
9. Postupak prema zahtjevu 8, naznačen time što se sušenje prskanjem iz koraka (v) izvodi u slijedećim uvjetima:
ulazna temperatura je od 170 ° C do 210 ° C;
izlazna temperatura je od 102 ° C do 119 ° C; i
protok dovoda je od 2 do 15 ml / min.
10. Lokalni farmaceutski ili kozmetički pripravak, koji sadrži učinkovitu količinu genipinom umreženih alkanat-kitosan mikrokapsula kako je definirano u bilo kojem od zahtjeva 1-9, zajedno s odgovarajućim lokalnim farmaceutski ili kozmetički prihvatljivim pomoćnim tvarima ili nosačima.
11. Lokalni pripravak prema zahtjevu 10, koji nadalje sadrži efikasnu količinu jednog ili više aktivnih sastojaka protiv znojenja.
12. Lokalni pripravak prema zahtjevu 11, naznačen time što jedan ili više nekapsuliranih aktivnih sastojaka protiv znojenja sadrži količinu od 10% do 40% težine inkapsuliranog aktivnog sastojka protiv znojenja.
13. Lokalni pripravak kako je definirano u bilo kojem od zahtjeva 10-12, naznačen time što je lokalni pripravak u obliku kreme, praha, štapića, rol-ona, spreja, mekih čvrstih tvari i gelova.
14. Uporaba genipinom umrežene alginat-kitosan mikrokapsule koja sadrži učinkovitu količinu jednog ili više inkapsuliranih aktivnih sastojaka protiv znojenja kako je definirano u bilo kojem od zahtjeva 1 do 7, ili alternativno lokalnog pripravka kako je definirano u bilo kojem od zahtjeva 10-13 kao sredstvo protiv znojenja i dezodorans.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16382105.1A EP3216441A1 (en) | 2016-03-09 | 2016-03-09 | A antiperspirant composition having long-lasting odor protection |
| EP17708553.7A EP3426223B1 (en) | 2016-03-09 | 2017-03-08 | A antiperspirant composition having long-lasting odor protection |
| PCT/EP2017/055434 WO2017153468A1 (en) | 2016-03-09 | 2017-03-08 | A antiperspirant composition having long-lasting odor protection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201151T1 true HRP20201151T1 (hr) | 2021-01-22 |
Family
ID=55527498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201151TT HRP20201151T1 (hr) | 2016-03-09 | 2020-07-23 | Pripravak protiv znojenja s dugotrajnom zaštitom mirisa |
Country Status (7)
| Country | Link |
|---|---|
| EP (2) | EP3216441A1 (hr) |
| ES (1) | ES2808936T3 (hr) |
| HR (1) | HRP20201151T1 (hr) |
| HU (1) | HUE050931T2 (hr) |
| PL (1) | PL3426223T3 (hr) |
| PT (1) | PT3426223T (hr) |
| WO (1) | WO2017153468A1 (hr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023078894A1 (en) * | 2021-11-03 | 2023-05-11 | Unilever Ip Holdings B.V. | Hygiene composition for reduction of malodour |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10014529A1 (de) * | 2000-03-23 | 2001-09-27 | Cognis Deutschland Gmbh | Desodorierende Zubereitungen mit nanoskaligen Chitosanen und/oder Chitosanderivaten |
| DE50010978D1 (de) * | 2000-09-01 | 2005-09-22 | Cognis Ip Man Gmbh | Kosmetische Stiftzubereitung |
-
2016
- 2016-03-09 EP EP16382105.1A patent/EP3216441A1/en not_active Withdrawn
-
2017
- 2017-03-08 WO PCT/EP2017/055434 patent/WO2017153468A1/en active Application Filing
- 2017-03-08 PL PL17708553T patent/PL3426223T3/pl unknown
- 2017-03-08 PT PT177085537T patent/PT3426223T/pt unknown
- 2017-03-08 HU HUE17708553A patent/HUE050931T2/hu unknown
- 2017-03-08 EP EP17708553.7A patent/EP3426223B1/en active Active
- 2017-03-08 ES ES17708553T patent/ES2808936T3/es active Active
-
2020
- 2020-07-23 HR HRP20201151TT patent/HRP20201151T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3426223A1 (en) | 2019-01-16 |
| HUE050931T2 (hu) | 2021-01-28 |
| PL3426223T3 (pl) | 2021-01-11 |
| PT3426223T (pt) | 2020-08-13 |
| ES2808936T3 (es) | 2021-03-02 |
| WO2017153468A1 (en) | 2017-09-14 |
| EP3216441A1 (en) | 2017-09-13 |
| EP3426223B1 (en) | 2020-05-06 |
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