HRP20130161T1 - Granulat koji sadrži nikotin - Google Patents
Granulat koji sadrži nikotin Download PDFInfo
- Publication number
- HRP20130161T1 HRP20130161T1 HRP20130161AT HRP20130161T HRP20130161T1 HR P20130161 T1 HRP20130161 T1 HR P20130161T1 HR P20130161A T HRP20130161A T HR P20130161AT HR P20130161 T HRP20130161 T HR P20130161T HR P20130161 T1 HRP20130161 T1 HR P20130161T1
- Authority
- HR
- Croatia
- Prior art keywords
- nicotine
- granules containing
- containing nicotine
- accordance
- complex
- Prior art date
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims 27
- 229960002715 nicotine Drugs 0.000 title claims 20
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title claims 20
- 239000008187 granular material Substances 0.000 title claims 19
- 238000000034 method Methods 0.000 claims 12
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 4
- -1 nicotine-polacrylin Chemical compound 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 229940127557 pharmaceutical product Drugs 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims 2
- 229920002774 Maltodextrin Polymers 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 235000019700 dicalcium phosphate Nutrition 0.000 claims 2
- 239000008240 homogeneous mixture Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 150000005846 sugar alcohols Chemical class 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 229930091371 Fructose Natural products 0.000 claims 1
- 239000005715 Fructose Substances 0.000 claims 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 229920001202 Inulin Polymers 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 239000005913 Maltodextrin Substances 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 1
- 235000019568 aromas Nutrition 0.000 claims 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000002016 disaccharides Chemical class 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 235000019441 ethanol Nutrition 0.000 claims 1
- 239000004088 foaming agent Substances 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims 1
- 229940029339 inulin Drugs 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 229940035034 maltodextrin Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 1
- 235000019426 modified starch Nutrition 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- LDMPZNTVIGIREC-ZGPNLCEMSA-N nicotine bitartrate Chemical compound O.O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 LDMPZNTVIGIREC-ZGPNLCEMSA-N 0.000 claims 1
- 229940069688 nicotine bitartrate Drugs 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 238000004064 recycling Methods 0.000 claims 1
- 238000007873 sieving Methods 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 235000010356 sorbitol Nutrition 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
Claims (12)
1. Postupak dobivanja granulata koji sadrži nikotin, naznačen time što se sastoji u koracima
(a) miješanja nikotina ili farmaceutski prihvatljive nikotinske soli ili kompleksa s pomoćnom tvari;
(b) sabijanje smjese dobivene u koraku (a) u kompaktoru s valjcima kako bi se dobile granule; i
(c) prosijavanja granula dobivenih u koraku (b) kako bi se uklonile čestice manje od 150 µm.
2. Postupak dobivanja granulata koji sadrži nikotin u skladu s patentnim zahtjevom 1, naznačen time što dodatno uključuje korak
(d) recikliranja malih čestica uklonjenih u koraku (c) i njihovog dodavanja u smjesu iz koraka (a).
3. Postupak dobivanja granulata koji sadrži nikotin u skladu s patentnim zahtjevom 1 ili 2, naznačen time što se granulat koji sadrži nikotin proizvodi kontinuirano.
4. Postupak dobivanja granulata koji sadrži nikotin koji ima veličinu čestica od najmanje 150 µm u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačen time što se homogena smjesa 1-50%, težinski, nikotina ili farmaceutski prihvatljive nikotinske soli ili kompleksa i 50-99%, težinski, pomoćne tvari pripravlja u koraku (a).
5. Postupak dobivanja granulata koji sadrži nikotin u skladu s patentnim zahtjevom 4, naznačen time što se homogena smjesa 10-30%, težinski, nikotina ili farmaceutski prihvatljive nikotinske soli ili kompleksa i 70-90%, težinski, pomoćne tvari pripravlja u koraku (a).
6. Postupak dobivanja granulata koji sadrži nikotin u skladu s patentnim zahtjevom 4 ili 5, naznačen time što je farmaceutski prihvatljiva nikotinska sol ili kompleks upotrijebljeni u koraku (a) čvrsta nikotinska sol ili kompleks, a osobito čvrsta nikotinska sol ili kompleks koje se bira iz skupine koju čine nikotin-bitartarat, nikotin-polakrilin, nikotin-betadeks, nikotin-polakrileks, te njihove kombinacije.
7. Postupak dobivanja granulata koji sadrži nikotin u skladu s bilo kojim od patentnih zahtjeva 4 do 6, naznačen time što se pomoćnu tvar upotrijebljenu u koraku (a) bira iz skupine koju čine monosaharidi, disaharidi, hidratirani ili nehidratirani oligosaharidi, monosaharidni alkoholi, disaharidni alkoholi, škrob, škrobni derivati, celuloza, inulin, šećerni alkoholi, kalcijev karbonat, kalcijev hidrogenfosfat, maltodekstrini, polisaharidi, te njihove kombinacije.
8. Postupak dobivanja granulata koji sadrži nikotin u skladu s patentnim zahtjevom 7, naznačen time što se pomoćnu tvar upotrijebljenu u koraku (a) bira iz skupine koju čine saharoza, laktoza, glukoza, fruktoza, ksiloza, škrob, sorbitol, manitol, ksilitol, šećerni alkoholi, celuloza, kalcijev karbonat, kalcijev hidrogenfosfat, maltodekstrin, te njihove kombinacije.
9. Postupak dobivanja granulata koji sadrži nikotin u skladu s bilo kojim od patentnih zahtjeva 4 do 8, naznačen time što se sladila, veziva, sredstva za razdvajanje, maziva, bojila, arome, kiseline, pjenila, antioksidante, sredstva za kliženje i/ili konzervanse pomiješa s drugim komponentama u koraku (a).
10. Upotreba granulata koji sadrži nikotin, dobivenog postupkom u skladu s patentnim zahtjevom 1, naznačena time što je granulat namijenjen pripravi farmaceutskog proizvoda koji sadrži nikotin.
11. Upotreba granulata koji sadrži nikotin, dobivenog postupkom u skladu s patentnim zahtjevom 1, naznačena time što je granulat namijenjen pripravi farmaceutskog proizvoda koji sadrži nikotin, namijenjenog za oralnu primjenu.
12. Upotreba granulata koji sadrži nikotin, dobivenog postupkom u skladu s patentnim zahtjevom 1, naznačena time što je granulat namijenjen pripravi farmaceutskog proizvoda koji sadrži nikotin, namijenjenog za transdermalnu primjenu.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08016336A EP2177213B1 (en) | 2008-09-17 | 2008-09-17 | Nicotine-containing granulate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20130161T1 true HRP20130161T1 (hr) | 2013-03-31 |
Family
ID=40091848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20130161AT HRP20130161T1 (hr) | 2008-09-17 | 2013-02-25 | Granulat koji sadrži nikotin |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10413512B2 (hr) |
| EP (1) | EP2177213B1 (hr) |
| AR (1) | AR073604A1 (hr) |
| AU (1) | AU2009294964B2 (hr) |
| CA (1) | CA2734402C (hr) |
| DK (1) | DK2177213T3 (hr) |
| ES (1) | ES2401912T3 (hr) |
| HR (1) | HRP20130161T1 (hr) |
| MX (1) | MX2011002696A (hr) |
| NZ (1) | NZ591198A (hr) |
| PA (1) | PA8842701A1 (hr) |
| PL (1) | PL2177213T3 (hr) |
| PT (1) | PT2177213E (hr) |
| SI (1) | SI2177213T1 (hr) |
| UY (1) | UY32127A (hr) |
| WO (1) | WO2010031536A1 (hr) |
| ZA (1) | ZA201101123B (hr) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE533487T1 (de) * | 2008-12-19 | 2011-12-15 | Siegfried Ltd | Nikotinhaltiges produkt |
| US9629805B2 (en) | 2013-03-07 | 2017-04-25 | Amneal Pharmaceuticals Llc | Stabilization of moisture-sensitive drugs |
| EP3052081B1 (en) * | 2013-10-03 | 2020-12-09 | Altria Client Services LLC | Lozenge |
| US10105320B2 (en) | 2013-10-03 | 2018-10-23 | Altria Client Services | Soluble fiber lozenge |
| US11779045B2 (en) | 2013-10-03 | 2023-10-10 | Altria Client Services Llc | Dissolvable-chewable exhausted-tobacco tablet |
| US9999243B2 (en) | 2013-10-03 | 2018-06-19 | Altria Client Services Llc | Exhausted tobacco lozenge |
| US9351936B2 (en) | 2013-10-03 | 2016-05-31 | Altria Client Services Llc | Nicotine lozenge |
| US10244786B2 (en) | 2013-10-03 | 2019-04-02 | Altria Client Services Llc | Tobacco lozenge |
| CN108024966A (zh) * | 2015-09-14 | 2018-05-11 | 默克专利股份有限公司 | 具有受控延迟活性成分释放的制剂 |
| EP3445344B1 (en) | 2016-04-21 | 2020-08-19 | Fertin Pharma A/S | Nicotine delivery product, related uses and oral dosage forms, and methods of production |
| WO2018233795A1 (en) * | 2017-06-23 | 2018-12-27 | Fertin Pharma A/S | NICOTINE POCKET |
| AU2018378648B2 (en) | 2017-12-08 | 2021-06-03 | Fertin Pharma A/S | Nicotine tablet |
| CA3085063A1 (en) * | 2017-12-08 | 2019-06-13 | Fertin Pharma A/S | Solid oral nicotine formulation |
| EP3993646B1 (en) * | 2019-07-05 | 2023-08-16 | Swedish Match North Europe AB | An oral pouched nicotine product including a filling material comprising nicotine-containing particles |
| ES2967603T3 (es) | 2019-11-20 | 2024-05-03 | Swedish Match North Europe Ab | Un producto de nicotina en bolsa oral que incluye un material de relleno que comprende partículas de nicotina |
| US11969502B2 (en) | 2019-12-09 | 2024-04-30 | Nicoventures Trading Limited | Oral products |
| US11793230B2 (en) | 2019-12-09 | 2023-10-24 | Nicoventures Trading Limited | Oral products with improved binding of active ingredients |
| US11826462B2 (en) | 2019-12-09 | 2023-11-28 | Nicoventures Trading Limited | Oral product with sustained flavor release |
| US11672862B2 (en) * | 2019-12-09 | 2023-06-13 | Nicoventures Trading Limited | Oral products with reduced irritation |
| US11872231B2 (en) | 2019-12-09 | 2024-01-16 | Nicoventures Trading Limited | Moist oral product comprising an active ingredient |
| US20220313678A1 (en) * | 2021-04-06 | 2022-10-06 | Altria Client Services Llc | Spray dried nicotine for inclusion in oral products |
| US20220313614A1 (en) * | 2021-04-06 | 2022-10-06 | Altria Client Services Llc | Encapsulated nicotine granules and methods of preparation thereof |
| US20220354785A1 (en) * | 2021-04-22 | 2022-11-10 | Nicoventures Trading Limited | Oral lozenge products |
| CN114304712A (zh) * | 2021-12-17 | 2022-04-12 | 深圳市元雾科技有限公司 | 一种液体高负载的尼古丁口含制品颗粒及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI104787B (fi) | 1989-06-07 | 2000-04-14 | Xyrofin Oy | Fruktoosipohjainen rakeistettu tuote ja menetelmä sen valmistamiseksi |
| SE8904295D0 (sv) * | 1989-12-21 | 1989-12-21 | Pharmacia Ab | Smoking substitute |
| US5135753A (en) * | 1991-03-12 | 1992-08-04 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
| US6276917B1 (en) * | 1999-01-28 | 2001-08-21 | Botanicals International | Powder processing apparatus |
| FR2792200B3 (fr) * | 1999-04-16 | 2001-06-08 | Unicliffe Ltd | Substitut du tabac sous forme d'un comprime ou d'une pastille a sucer |
| DE19943496C1 (de) | 1999-09-10 | 2001-05-17 | Suedzucker Ag | Direkt verpressbarer Rohstoff für Komprimate |
| WO2002076605A1 (de) | 2001-03-23 | 2002-10-03 | Symrise Gmbh & Co. Kg | Verfahren zur herstellung von einkapselungen |
| WO2004056363A2 (en) | 2002-12-20 | 2004-07-08 | Niconovum Ab | A physically and chemically stable nicotine-containing particulate material |
| US20070269492A1 (en) * | 2006-05-16 | 2007-11-22 | Per Steen | New product and use and manufacture thereof |
| WO2008012071A2 (en) | 2006-07-24 | 2008-01-31 | Antares Pharma Ipl Ag | Pharmaceutical compositions of nicotine and methods of use thereof |
-
2008
- 2008-09-17 PT PT80163363T patent/PT2177213E/pt unknown
- 2008-09-17 SI SI200830890T patent/SI2177213T1/sl unknown
- 2008-09-17 EP EP08016336A patent/EP2177213B1/en active Active
- 2008-09-17 DK DK08016336.3T patent/DK2177213T3/da active
- 2008-09-17 ES ES08016336T patent/ES2401912T3/es active Active
- 2008-09-17 PL PL08016336T patent/PL2177213T3/pl unknown
-
2009
- 2009-09-16 NZ NZ591198A patent/NZ591198A/en unknown
- 2009-09-16 AU AU2009294964A patent/AU2009294964B2/en active Active
- 2009-09-16 US US13/058,769 patent/US10413512B2/en active Active
- 2009-09-16 MX MX2011002696A patent/MX2011002696A/es active IP Right Grant
- 2009-09-16 WO PCT/EP2009/006676 patent/WO2010031536A1/en active Application Filing
- 2009-09-16 CA CA2734402A patent/CA2734402C/en active Active
- 2009-09-17 UY UY0001032127A patent/UY32127A/es not_active Application Discontinuation
- 2009-09-17 AR ARP090103574A patent/AR073604A1/es unknown
- 2009-09-17 PA PA20098842701A patent/PA8842701A1/es unknown
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2011
- 2011-02-11 ZA ZA2011/01123A patent/ZA201101123B/en unknown
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2013
- 2013-02-25 HR HRP20130161AT patent/HRP20130161T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2177213B1 (en) | 2013-01-02 |
| US20110165253A1 (en) | 2011-07-07 |
| AU2009294964B2 (en) | 2012-12-13 |
| PT2177213E (pt) | 2013-02-21 |
| PA8842701A1 (es) | 2010-04-21 |
| ZA201101123B (en) | 2012-04-25 |
| CA2734402C (en) | 2013-05-14 |
| PL2177213T3 (pl) | 2013-08-30 |
| DK2177213T3 (da) | 2013-02-11 |
| MX2011002696A (es) | 2011-04-05 |
| SI2177213T1 (sl) | 2013-03-29 |
| WO2010031536A1 (en) | 2010-03-25 |
| US10413512B2 (en) | 2019-09-17 |
| CA2734402A1 (en) | 2010-03-25 |
| AR073604A1 (es) | 2010-11-17 |
| NZ591198A (en) | 2012-03-30 |
| AU2009294964A1 (en) | 2010-03-25 |
| EP2177213A1 (en) | 2010-04-21 |
| UY32127A (es) | 2010-04-30 |
| ES2401912T3 (es) | 2013-04-25 |
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