HRP20130001T1 - Postupak za stereoselektivno pripremanje (-)-halofenata i njegovih intermedijara - Google Patents
Postupak za stereoselektivno pripremanje (-)-halofenata i njegovih intermedijara Download PDFInfo
- Publication number
- HRP20130001T1 HRP20130001T1 HRP20130001TT HRP20130001T HRP20130001T1 HR P20130001 T1 HRP20130001 T1 HR P20130001T1 HR P20130001T T HRP20130001T T HR P20130001TT HR P20130001 T HRP20130001 T HR P20130001T HR P20130001 T1 HRP20130001 T1 HR P20130001T1
- Authority
- HR
- Croatia
- Prior art keywords
- formula
- image
- compound
- group
- index
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 23
- 229950000958 halofenate Drugs 0.000 title claims 4
- 239000000543 intermediate Substances 0.000 title 1
- 230000000707 stereoselective effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 23
- 239000002904 solvent Substances 0.000 claims 15
- -1 (C1-C4)sulfamylalkyl Chemical group 0.000 claims 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 5
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 5
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 5
- 125000003368 amide group Chemical group 0.000 claims 5
- 125000004103 aminoalkyl group Chemical group 0.000 claims 5
- 150000008064 anhydrides Chemical class 0.000 claims 5
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 5
- 229910052794 bromium Inorganic materials 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 125000004404 heteroalkyl group Chemical group 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 125000004963 sulfonylalkyl group Chemical group 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000032050 esterification Effects 0.000 claims 4
- 238000005886 esterification reaction Methods 0.000 claims 4
- 230000003213 activating effect Effects 0.000 claims 3
- 150000001735 carboxylic acids Chemical class 0.000 claims 3
- 150000007970 thio esters Chemical group 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 150000004820 halides Chemical group 0.000 claims 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical group ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical group ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims 1
- CDPKJZJVTHSESZ-UHFFFAOYSA-N 4-chlorophenylacetic acid Chemical compound OC(=O)CC1=CC=C(Cl)C=C1 CDPKJZJVTHSESZ-UHFFFAOYSA-N 0.000 claims 1
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 1
- 230000031709 bromination Effects 0.000 claims 1
- 238000005893 bromination reaction Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72030005P | 2005-09-23 | 2005-09-23 | |
| US11/525,200 US7714131B2 (en) | 2005-09-23 | 2006-09-20 | Process for the stereoselective preparation of (−)-halofenate and derivatives thereof |
| PCT/US2006/036928 WO2007038243A1 (en) | 2005-09-23 | 2006-09-21 | Process for the stereoselective preparation of (-)-halofenate and intermediates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20130001T1 true HRP20130001T1 (hr) | 2013-02-28 |
Family
ID=37894903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20130001TT HRP20130001T1 (hr) | 2005-09-23 | 2013-01-02 | Postupak za stereoselektivno pripremanje (-)-halofenata i njegovih intermedijara |
Country Status (18)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009121940A1 (en) * | 2008-04-03 | 2009-10-08 | Janssen Pharmaceutica Nv | Process for the preparation of (-)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester |
| US8383833B2 (en) * | 2008-06-03 | 2013-02-26 | Kaneka Corporation | Method for producing optically active amino acid derivative |
| US9060987B2 (en) | 2011-11-04 | 2015-06-23 | Cymabay Therapeutics, Inc. | Methods for treating gout flares |
| US9023856B2 (en) | 2011-11-04 | 2015-05-05 | Cymabay Therapeutics, Inc. | Methods for treating hyperuricemia in patients with gout using halofenate or halogenic acid and a second urate-lowering agent |
| WO2021236395A1 (en) | 2020-05-18 | 2021-11-25 | Cymabay Therapeutics, Inc. | Cb-0406 choline salt |
| US20210355065A1 (en) | 2020-05-18 | 2021-11-18 | Cymabay Therapeutics, Inc. | CB-0406 tromethamine salt |
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| CA2529774C (en) | 2003-06-20 | 2014-05-27 | Metabolex, Inc. | Resolution of .alpha.-(phenoxy)phenylacetic acid derivatives |
-
2006
- 2006-09-20 US US11/525,200 patent/US7714131B2/en not_active Expired - Fee Related
- 2006-09-21 RS RS20130001A patent/RS52608B/en unknown
- 2006-09-21 PT PT68151505T patent/PT1940387E/pt unknown
- 2006-09-21 KR KR1020087009709A patent/KR101309605B1/ko not_active IP Right Cessation
- 2006-09-21 AU AU2006294950A patent/AU2006294950A1/en not_active Abandoned
- 2006-09-21 CA CA2623350A patent/CA2623350C/en not_active Expired - Fee Related
- 2006-09-21 DK DK06815150.5T patent/DK1940387T3/da active
- 2006-09-21 JP JP2008532404A patent/JP2009515817A/ja not_active Withdrawn
- 2006-09-21 BR BRPI0616188-0A patent/BRPI0616188A2/pt not_active IP Right Cessation
- 2006-09-21 SI SI200631502T patent/SI1940387T1/sl unknown
- 2006-09-21 WO PCT/US2006/036928 patent/WO2007038243A1/en active Application Filing
- 2006-09-21 EP EP06815150A patent/EP1940387B1/en active Active
- 2006-09-21 EA EA200800884A patent/EA015673B1/ru not_active IP Right Cessation
- 2006-09-21 PL PL06815150T patent/PL1940387T3/pl unknown
- 2006-09-21 ES ES06815150T patent/ES2394973T3/es active Active
-
2008
- 2008-03-20 IL IL190325A patent/IL190325A/en not_active IP Right Cessation
- 2008-12-29 HK HK08114045.8A patent/HK1119953A1/xx not_active IP Right Cessation
-
2013
- 2013-01-02 HR HRP20130001TT patent/HRP20130001T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1119953A1 (en) | 2009-03-20 |
| EP1940387B1 (en) | 2012-11-28 |
| EP1940387A1 (en) | 2008-07-09 |
| CA2623350C (en) | 2014-08-19 |
| EP1940387A4 (en) | 2010-11-03 |
| KR101309605B1 (ko) | 2013-09-17 |
| WO2007038243A1 (en) | 2007-04-05 |
| US7714131B2 (en) | 2010-05-11 |
| AU2006294950A1 (en) | 2007-04-05 |
| PL1940387T3 (pl) | 2013-02-28 |
| BRPI0616188A2 (pt) | 2011-06-14 |
| IL190325A (en) | 2013-04-30 |
| DK1940387T3 (da) | 2013-01-02 |
| JP2009515817A (ja) | 2009-04-16 |
| EA015673B1 (ru) | 2011-10-31 |
| CA2623350A1 (en) | 2007-04-05 |
| KR20080050527A (ko) | 2008-06-05 |
| SI1940387T1 (sl) | 2013-04-30 |
| EA200800884A1 (ru) | 2008-12-30 |
| ES2394973T3 (es) | 2013-02-07 |
| IL190325A0 (en) | 2009-09-22 |
| US20070072858A1 (en) | 2007-03-29 |
| RS52608B (en) | 2013-04-30 |
| PT1940387E (pt) | 2012-12-17 |
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