HK1119953A1 - Process for the stereoselective preparation of (-)-halofenate and intermediates thereof - Google Patents

Process for the stereoselective preparation of (-)-halofenate and intermediates thereof

Info

Publication number
HK1119953A1
HK1119953A1 HK08114045.8A HK08114045A HK1119953A1 HK 1119953 A1 HK1119953 A1 HK 1119953A1 HK 08114045 A HK08114045 A HK 08114045A HK 1119953 A1 HK1119953 A1 HK 1119953A1
Authority
HK
Hong Kong
Prior art keywords
halofenate
intermediates
stereoselective preparation
stereoselective
preparation
Prior art date
Application number
HK08114045.8A
Other languages
English (en)
Inventor
Yan Zhu
Peng Cheng
Xin Chen
Jingyuan Ma
Zuchun Zhao
Original Assignee
Metabolex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolex Inc filed Critical Metabolex Inc
Publication of HK1119953A1 publication Critical patent/HK1119953A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
HK08114045.8A 2005-09-23 2008-12-29 Process for the stereoselective preparation of (-)-halofenate and intermediates thereof HK1119953A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72030005P 2005-09-23 2005-09-23
US11/525,200 US7714131B2 (en) 2005-09-23 2006-09-20 Process for the stereoselective preparation of (−)-halofenate and derivatives thereof
PCT/US2006/036928 WO2007038243A1 (en) 2005-09-23 2006-09-21 Process for the stereoselective preparation of (-)-halofenate and intermediates thereof

Publications (1)

Publication Number Publication Date
HK1119953A1 true HK1119953A1 (en) 2009-03-20

Family

ID=37894903

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08114045.8A HK1119953A1 (en) 2005-09-23 2008-12-29 Process for the stereoselective preparation of (-)-halofenate and intermediates thereof

Country Status (18)

Country Link
US (1) US7714131B2 (xx)
EP (1) EP1940387B1 (xx)
JP (1) JP2009515817A (xx)
KR (1) KR101309605B1 (xx)
AU (1) AU2006294950A1 (xx)
BR (1) BRPI0616188A2 (xx)
CA (1) CA2623350C (xx)
DK (1) DK1940387T3 (xx)
EA (1) EA015673B1 (xx)
ES (1) ES2394973T3 (xx)
HK (1) HK1119953A1 (xx)
HR (1) HRP20130001T1 (xx)
IL (1) IL190325A (xx)
PL (1) PL1940387T3 (xx)
PT (1) PT1940387E (xx)
RS (1) RS52608B (xx)
SI (1) SI1940387T1 (xx)
WO (1) WO2007038243A1 (xx)

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US8383833B2 (en) * 2008-06-03 2013-02-26 Kaneka Corporation Method for producing optically active amino acid derivative
US9023856B2 (en) 2011-11-04 2015-05-05 Cymabay Therapeutics, Inc. Methods for treating hyperuricemia in patients with gout using halofenate or halogenic acid and a second urate-lowering agent
US9060987B2 (en) 2011-11-04 2015-06-23 Cymabay Therapeutics, Inc. Methods for treating gout flares
US20210355065A1 (en) 2020-05-18 2021-11-18 Cymabay Therapeutics, Inc. CB-0406 tromethamine salt
US20210355066A1 (en) 2020-05-18 2021-11-18 Cymabay Therapeutics, Inc. CB-0406 choline salt

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Also Published As

Publication number Publication date
SI1940387T1 (sl) 2013-04-30
JP2009515817A (ja) 2009-04-16
BRPI0616188A2 (pt) 2011-06-14
PT1940387E (pt) 2012-12-17
WO2007038243A1 (en) 2007-04-05
US20070072858A1 (en) 2007-03-29
ES2394973T3 (es) 2013-02-07
EA200800884A1 (ru) 2008-12-30
IL190325A0 (en) 2009-09-22
AU2006294950A1 (en) 2007-04-05
US7714131B2 (en) 2010-05-11
PL1940387T3 (pl) 2013-02-28
CA2623350C (en) 2014-08-19
DK1940387T3 (da) 2013-01-02
IL190325A (en) 2013-04-30
EP1940387B1 (en) 2012-11-28
HRP20130001T1 (hr) 2013-02-28
KR101309605B1 (ko) 2013-09-17
EP1940387A4 (en) 2010-11-03
EP1940387A1 (en) 2008-07-09
KR20080050527A (ko) 2008-06-05
CA2623350A1 (en) 2007-04-05
EA015673B1 (ru) 2011-10-31
RS52608B (en) 2013-04-30

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180921