HRP20120394T1 - Derivati karbonata kinuklodina i njihovi medicinski pripravci - Google Patents
Derivati karbonata kinuklodina i njihovi medicinski pripravci Download PDFInfo
- Publication number
- HRP20120394T1 HRP20120394T1 HRP20120394AT HRP20120394T HRP20120394T1 HR P20120394 T1 HRP20120394 T1 HR P20120394T1 HR P20120394A T HRP20120394A T HR P20120394AT HR P20120394 T HRP20120394 T HR P20120394T HR P20120394 T1 HRP20120394 T1 HR P20120394T1
- Authority
- HR
- Croatia
- Prior art keywords
- group
- substituted
- alkyl
- compound
- formula
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 2
- ABKAPBFQXANQAO-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octane;carbonic acid Chemical class OC(O)=O.C1CC2CCN1CC2 ABKAPBFQXANQAO-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 25
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims abstract 23
- 125000005843 halogen group Chemical group 0.000 claims abstract 21
- 125000003118 aryl group Chemical group 0.000 claims abstract 14
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 14
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 6
- 150000001334 alicyclic compounds Chemical class 0.000 claims abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims abstract 4
- 229910052799 carbon Inorganic materials 0.000 claims abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims abstract 4
- 125000005842 heteroatom Chemical group 0.000 claims abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 4
- 125000001424 substituent group Chemical group 0.000 claims abstract 4
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims abstract 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims abstract 2
- 101100519284 Cercospora nicotianae PDX1 gene Proteins 0.000 claims abstract 2
- 101100277598 Sorghum bicolor DES3 gene Proteins 0.000 claims abstract 2
- 150000001450 anions Chemical class 0.000 claims abstract 2
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims abstract 2
- 125000004122 cyclic group Chemical group 0.000 claims abstract 2
- 229910052736 halogen Inorganic materials 0.000 claims abstract 2
- 150000002367 halogens Chemical class 0.000 claims abstract 2
- 125000006678 phenoxycarbonyl group Chemical group 0.000 claims abstract 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims abstract 2
- 101150073238 sor1 gene Proteins 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 6
- -1 NR2CO-(C1-CX)-alkyl Chemical group 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 125000006573 (C1-C10) heteroaryl group Chemical group 0.000 claims 1
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical class C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 208000007451 chronic bronchitis Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08162066A EP2154136A1 (en) | 2008-08-08 | 2008-08-08 | Quinuclidine carbonate derivatives and medicinal compositions thereof |
| PCT/EP2009/005272 WO2010015324A1 (en) | 2008-08-08 | 2009-07-21 | Quinuclidine carbonate derivatives and medicinal composition thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120394T1 true HRP20120394T1 (hr) | 2012-06-30 |
Family
ID=40228074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120394AT HRP20120394T1 (hr) | 2008-08-08 | 2012-05-10 | Derivati karbonata kinuklodina i njihovi medicinski pripravci |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US8039483B2 (xx) |
| EP (2) | EP2154136A1 (xx) |
| JP (1) | JP2011530489A (xx) |
| KR (1) | KR20110044221A (xx) |
| CN (1) | CN102112474B (xx) |
| AR (1) | AR072994A1 (xx) |
| AT (1) | ATE551341T1 (xx) |
| AU (1) | AU2009278306B2 (xx) |
| CA (1) | CA2733380A1 (xx) |
| CO (1) | CO6351790A2 (xx) |
| CY (1) | CY1112724T1 (xx) |
| DK (1) | DK2313404T3 (xx) |
| EA (1) | EA019166B1 (xx) |
| ES (1) | ES2384914T3 (xx) |
| GE (1) | GEP20135744B (xx) |
| HK (1) | HK1156032A1 (xx) |
| HR (1) | HRP20120394T1 (xx) |
| IL (1) | IL211103A (xx) |
| JO (1) | JO2831B1 (xx) |
| MA (1) | MA32622B1 (xx) |
| ME (1) | ME01283A (xx) |
| MX (1) | MX2011001504A (xx) |
| MY (1) | MY156332A (xx) |
| NZ (1) | NZ590987A (xx) |
| PL (1) | PL2313404T3 (xx) |
| PT (1) | PT2313404E (xx) |
| RS (1) | RS52370B (xx) |
| SI (1) | SI2313404T1 (xx) |
| TW (1) | TWI455938B (xx) |
| UA (1) | UA102857C2 (xx) |
| WO (1) | WO2010015324A1 (xx) |
| ZA (1) | ZA201100963B (xx) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2534957B1 (en) | 2007-12-14 | 2015-05-27 | AeroDesigns, Inc | Delivering aerosolizable products |
| EP2154136A1 (en) | 2008-08-08 | 2010-02-17 | CHIESI FARMACEUTICI S.p.A. | Quinuclidine carbonate derivatives and medicinal compositions thereof |
| EP2206712A1 (en) | 2008-12-23 | 2010-07-14 | CHIESI FARMACEUTICI S.p.A. | "Alkaloid aminoester derivatives and medicinal composition thereof" |
| EP2560611B1 (en) | 2010-04-21 | 2018-01-03 | Chiesi Farmaceutici S.p.A. | "process for providing particles with reduced electrostatic charges" |
| BR112012032332A2 (pt) | 2010-06-22 | 2016-11-08 | Chiesi Farma Spa | composto, uso de um composto, composição farmacêutica, combinação de um composto e dispositivo |
| BR112012031967A2 (pt) | 2010-06-22 | 2019-09-24 | Chiesi Farm Spa | composto, uso de um composto, combinação de um composto e composição farmacêutica |
| CA2803416A1 (en) | 2010-06-22 | 2011-12-29 | Chiesi Farmaceutici S.P.A. | Alkaloid aminoester derivatives and medicinal composition thereof |
| WO2012041717A1 (en) * | 2010-09-30 | 2012-04-05 | Chiesi Farmaceutici S.P.A. | Use of magnesium stearate in dry powder formulations for inhalation |
| KR20130140672A (ko) * | 2010-10-20 | 2013-12-24 | 키에시 파르마슈티시 엣스. 피. 에이. | 기침 치료용 카보네이트 유도체 |
| WO2012069275A1 (en) | 2010-11-26 | 2012-05-31 | Chiesi Farmaceutici S.P.A. | Glycine derivatives and their use as muscarinic receptor antagonists |
| DK2685986T3 (da) * | 2011-03-18 | 2020-03-02 | Genzyme Corp | Glucosylceramidsyntasehæmmer |
| CN103502213B (zh) * | 2011-04-29 | 2016-09-28 | 奇斯药制品公司 | 生物碱酯及其氨基甲酸酯衍生物和医学组合物 |
| EP2797910B1 (en) | 2011-12-30 | 2015-09-16 | Chiesi Farmaceutici S.p.A. | Quinuclidine esters of 1-azaheterocyclylacetic acid as antimuscarinic agents, process for their preparation and medicinal compositions thereof |
| MA37975B2 (fr) | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| US9427376B2 (en) | 2013-10-10 | 2016-08-30 | Chiesi Farmaceutici S.P.A. | Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient |
| AU2021215396A1 (en) | 2020-02-03 | 2022-09-29 | Genzyme Corporation | Methods for treating neurological symptoms associated with lysosomal storage diseases |
| IL300090A (en) | 2020-07-24 | 2023-03-01 | Genzyme Corp | Pharmaceutical preparations containing VENGLUSTAT |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) * | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| JP4445704B2 (ja) | 2000-12-22 | 2010-04-07 | アルミラル・ソシエダッド・アノニマ | キヌクリジンカルバメート誘導体およびｍ３アンダゴニストとしてのそれらの使用 |
| US20020169208A1 (en) * | 2001-04-03 | 2002-11-14 | Pascal Druzgala | Novel anticholinergic compounds and methods of use |
| CN1832948B (zh) | 2001-12-20 | 2011-06-15 | 基耶西药品股份公司 | 1-烷基-1-氮*双环[2.2.2]辛烷氨基甲酸酯衍生物及其用作蕈毒碱受体拮抗剂的用途 |
| EP1882691A1 (en) | 2006-07-26 | 2008-01-30 | CHIESI FARMACEUTICI S.p.A. | Quinuclidine derivatives as M3 antagonists |
| EP2154136A1 (en) | 2008-08-08 | 2010-02-17 | CHIESI FARMACEUTICI S.p.A. | Quinuclidine carbonate derivatives and medicinal compositions thereof |
| EP2206712A1 (en) | 2008-12-23 | 2010-07-14 | CHIESI FARMACEUTICI S.p.A. | "Alkaloid aminoester derivatives and medicinal composition thereof" |
| WO2011160920A1 (en) | 2010-06-22 | 2011-12-29 | Chiesi Farmaceutici S.P.A. | Dry powder formulation comprising an antimuscarinic drug |
| KR20130140672A (ko) | 2010-10-20 | 2013-12-24 | 키에시 파르마슈티시 엣스. 피. 에이. | 기침 치료용 카보네이트 유도체 |
| US20120220557A1 (en) | 2011-02-17 | 2012-08-30 | Chiesi Farmaceutici S.P.A. | Liquid propellant-free formulation comprising an antimuscarinic drug |
| CN103502213B (zh) | 2011-04-29 | 2016-09-28 | 奇斯药制品公司 | 生物碱酯及其氨基甲酸酯衍生物和医学组合物 |
-
2008
- 2008-08-08 EP EP08162066A patent/EP2154136A1/en not_active Withdrawn
-
2009
- 2009-07-21 EA EA201100161A patent/EA019166B1/ru not_active IP Right Cessation
- 2009-07-21 SI SI200930266T patent/SI2313404T1/sl unknown
- 2009-07-21 JP JP2011521454A patent/JP2011530489A/ja active Pending
- 2009-07-21 RS RS20120262A patent/RS52370B/en unknown
- 2009-07-21 AT AT09777321T patent/ATE551341T1/de active
- 2009-07-21 WO PCT/EP2009/005272 patent/WO2010015324A1/en active Application Filing
- 2009-07-21 PT PT09777321T patent/PT2313404E/pt unknown
- 2009-07-21 AU AU2009278306A patent/AU2009278306B2/en not_active Ceased
- 2009-07-21 MY MYPI2011000542A patent/MY156332A/en unknown
- 2009-07-21 KR KR1020117002974A patent/KR20110044221A/ko not_active Application Discontinuation
- 2009-07-21 CN CN200980130187.4A patent/CN102112474B/zh active Active
- 2009-07-21 ES ES09777321T patent/ES2384914T3/es active Active
- 2009-07-21 DK DK09777321.2T patent/DK2313404T3/da active
- 2009-07-21 ME MEP-2011-24A patent/ME01283A/me unknown
- 2009-07-21 CA CA2733380A patent/CA2733380A1/en not_active Abandoned
- 2009-07-21 NZ NZ590987A patent/NZ590987A/xx not_active IP Right Cessation
- 2009-07-21 PL PL09777321T patent/PL2313404T3/pl unknown
- 2009-07-21 UA UAA201101383A patent/UA102857C2/ru unknown
- 2009-07-21 MX MX2011001504A patent/MX2011001504A/es active IP Right Grant
- 2009-07-21 EP EP09777321A patent/EP2313404B1/en active Active
- 2009-07-21 GE GEAP200912093A patent/GEP20135744B/en unknown
- 2009-07-30 US US12/512,262 patent/US8039483B2/en active Active
- 2009-08-06 JO JO2009296A patent/JO2831B1/en active
- 2009-08-06 TW TW098126682A patent/TWI455938B/zh not_active IP Right Cessation
- 2009-08-07 AR ARP090103053A patent/AR072994A1/es unknown
-
2011
- 2011-02-07 IL IL211103A patent/IL211103A/en not_active IP Right Cessation
- 2011-02-07 CO CO11013721A patent/CO6351790A2/es active IP Right Grant
- 2011-02-07 ZA ZA2011/00963A patent/ZA201100963B/en unknown
- 2011-03-08 MA MA33683A patent/MA32622B1/fr unknown
- 2011-08-26 US US13/219,109 patent/US8440690B2/en active Active
- 2011-09-14 US US13/232,415 patent/US8404712B2/en active Active
- 2011-10-03 HK HK11110402.8A patent/HK1156032A1/xx unknown
-
2012
- 2012-05-10 HR HRP20120394AT patent/HRP20120394T1/hr unknown
- 2012-05-11 CY CY20121100443T patent/CY1112724T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20120394T1 (hr) | Derivati karbonata kinuklodina i njihovi medicinski pripravci | |
| HRP20192133T1 (hr) | Kemijski spoj koristan kao posrednik za pripremu inhibitora katekol-o-metiltransferaze | |
| HRP20160533T1 (hr) | Indoli kao antivirusna sredstva respiratornog sincicijskog virusa | |
| JP2007522162A5 (xx) | ||
| HRP20140051T1 (hr) | Farmaceutski pripravci koji sadrže imidazokinolin(amine) i njihovi derivati prikladni za lokalno davanje | |
| AR060316A1 (es) | Azaindoles de utilidad como inhibidores de janus quinasas | |
| JP2020128441A (ja) | インフルエンザウイルスの複製の阻害剤 | |
| ES2576980T3 (es) | Derivados químicos de jasmonato, composiciones farmacéuticas y métodos de uso de los mismos | |
| HRP20140011T1 (hr) | Derivati oksazina i njihova uporaba u lijeäśenju neuroloških poremeä†aja | |
| HRP20171793T1 (hr) | Farmaceutske formulacije koje sadrže kristalne oblike (r)-7-kloro-n-(kinuklidin-3-il)benzo(b)tiofen-2-karboksamid hidroklorid monohidrata | |
| HRP20160030T1 (hr) | Derivati 6,7-dihidro-pirazolo[1,5-a]pirazin-4-ilamina koji su korisni kao inhibitori beta-sekretaze (bace) | |
| HRP20160077T1 (hr) | Imidazotriazini i imidazopiramidini kao inhibitori kinaze | |
| HRP20120785T1 (hr) | Spojevi i postupci za inhibiciju napredovanja mitoze putem inhibicije aurora kinaze | |
| SI9300513B (sl) | Kvarterni bazični amidi, postopek za njihovo pripravo in farmacevtski sestavki, v katerih so prisotni | |
| HRP20121004T1 (hr) | (1-fenil-2-piridin-4-il)etil-esteri benzojeve kiseline kao inhibitori fosfodiesteraze | |
| JP2014503525A5 (xx) | ||
| AR082152A1 (es) | Derivados de n-(metilsulfonil)benzamida, composiciones farmaceuticas que los comprenden y su uso en la preparacion de medicamentos para el tratamiento de enfermedades mediadas por la inhibicion de nav1.7 | |
| HRP20180196T1 (hr) | Diketoni i hidroksiketoni kao aktivatori puta signalizacije katenina | |
| HRP20120351T1 (hr) | Macrociklički derivati kinazolina kao antiproliferativna sredstva | |
| DK2041133T3 (da) | Derivater af imadazol [1,2-A] pyridine-2-carboxamider, fremstilling deraf og anvendelse deraf i terapeutik | |
| SI1940349T1 (en) | Aerosol formulation for inhalation of beta agonists | |
| HRP20160044T1 (hr) | Novi spojevi fenilamino izonikotinamida | |
| RU2007125660A (ru) | Фенилпиперазиновые производные с сочетанием свойств неполного агонизма к рецепторам дофамина-d2 и ингибирования повторного поглощения серотонина | |
| HRP20192010T1 (hr) | Muskarinski antagonisti i njihove kombinacije za liječenje bolesti dišnih puteva kod konja | |
| WO2011128407A3 (en) | Substituted 2,3-dihydroimidazo[1,2-c]quinazoline-containing combinations |