HRP20110739T1 - Farmaceutski pripravak za oralno davanje sa kontroliranim otpuštanjem lijeka u tankom crijevu i postupak njegovog dobivanja - Google Patents
Farmaceutski pripravak za oralno davanje sa kontroliranim otpuštanjem lijeka u tankom crijevu i postupak njegovog dobivanja Download PDFInfo
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- HRP20110739T1 HRP20110739T1 HR20110739T HRP20110739T HRP20110739T1 HR P20110739 T1 HRP20110739 T1 HR P20110739T1 HR 20110739 T HR20110739 T HR 20110739T HR P20110739 T HRP20110739 T HR P20110739T HR P20110739 T1 HRP20110739 T1 HR P20110739T1
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- active substance
- pharmaceutical preparation
- preparation according
- methyl
- methyl methacrylate
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- 210000000813 small intestine Anatomy 0.000 title claims abstract 8
- 239000000825 pharmaceutical preparation Substances 0.000 title claims 27
- 238000000034 method Methods 0.000 title claims 3
- 238000002360 preparation method Methods 0.000 title claims 2
- 210000001072 colon Anatomy 0.000 title 1
- 238000013267 controlled drug release Methods 0.000 title 1
- 239000013543 active substance Substances 0.000 claims abstract 30
- 238000009792 diffusion process Methods 0.000 claims abstract 26
- 229920001577 copolymer Polymers 0.000 claims abstract 25
- 239000004480 active ingredient Substances 0.000 claims abstract 20
- 239000003795 chemical substances by application Substances 0.000 claims abstract 14
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract 8
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract 8
- 150000003839 salts Chemical class 0.000 claims abstract 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract 6
- 239000011159 matrix material Substances 0.000 claims abstract 6
- 230000035699 permeability Effects 0.000 claims abstract 6
- -1 4-diethylamino -2-butynyl Chemical group 0.000 claims abstract 5
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract 5
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims abstract 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims abstract 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract 3
- 229930195725 Mannitol Natural products 0.000 claims abstract 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract 3
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract 3
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract 3
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- 229920000609 methyl cellulose Polymers 0.000 claims abstract 3
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- 239000011148 porous material Substances 0.000 claims abstract 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract 3
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- 239000005720 sucrose Substances 0.000 claims abstract 3
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 3
- MWHXMIASLKXGBU-RNCYCKTQSA-N (e)-but-2-enedioic acid;[2-[(1r)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl] 2-methylpropanoate Chemical compound OC(=O)\C=C\C(O)=O.C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(CO)C=2)OC(=O)C(C)C)=CC=CC=C1 MWHXMIASLKXGBU-RNCYCKTQSA-N 0.000 claims abstract 2
- UVKFSMBPRQBNCH-UHFFFAOYSA-M 4,4-diphenylbutan-2-yl-ethyl-dimethylazanium;bromide Chemical compound [Br-].C=1C=CC=CC=1C(CC(C)[N+](C)(C)CC)C1=CC=CC=C1 UVKFSMBPRQBNCH-UHFFFAOYSA-M 0.000 claims abstract 2
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims abstract 2
- 238000013270 controlled release Methods 0.000 claims abstract 2
- GUBNMFJOJGDCEL-UHFFFAOYSA-N dicyclomine hydrochloride Chemical compound [Cl-].C1CCCCC1C1(C(=O)OCC[NH+](CC)CC)CCCCC1 GUBNMFJOJGDCEL-UHFFFAOYSA-N 0.000 claims abstract 2
- JEJBJBKVPOWOQK-UHFFFAOYSA-N emepronium Chemical compound C=1C=CC=CC=1C(CC(C)[N+](C)(C)CC)C1=CC=CC=C1 JEJBJBKVPOWOQK-UHFFFAOYSA-N 0.000 claims abstract 2
- XOEVKNFZUQEERE-UHFFFAOYSA-N flavoxate hydrochloride Chemical compound Cl.C1=CC=C2C(=O)C(C)=C(C=3C=CC=CC=3)OC2=C1C(=O)OCCN1CCCCC1 XOEVKNFZUQEERE-UHFFFAOYSA-N 0.000 claims abstract 2
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- JACRWUWPXAESPB-UHFFFAOYSA-M tropate Chemical compound OCC(C([O-])=O)C1=CC=CC=C1 JACRWUWPXAESPB-UHFFFAOYSA-M 0.000 claims abstract 2
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
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- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 3
- NZEXUPLJXSDMCK-UHFFFAOYSA-N methyl 2-methylprop-2-enoate;methyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound COC(=O)C=C.CC(=C)C(O)=O.COC(=O)C(C)=C NZEXUPLJXSDMCK-UHFFFAOYSA-N 0.000 claims 3
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- 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims 1
- 239000004816 latex Substances 0.000 claims 1
- 229920000126 latex Polymers 0.000 claims 1
- 229960003511 macrogol Drugs 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229940057917 medium chain triglycerides Drugs 0.000 claims 1
- 239000004200 microcrystalline wax Substances 0.000 claims 1
- 235000019808 microcrystalline wax Nutrition 0.000 claims 1
- 235000019426 modified starch Nutrition 0.000 claims 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 229940116317 potato starch Drugs 0.000 claims 1
- 235000013772 propylene glycol Nutrition 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 235000009566 rice Nutrition 0.000 claims 1
- 229920002379 silicone rubber Polymers 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000001509 sodium citrate Substances 0.000 claims 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 1
- 229960001790 sodium citrate Drugs 0.000 claims 1
- 235000011083 sodium citrates Nutrition 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 239000004408 titanium dioxide Substances 0.000 claims 1
- 229960002622 triacetin Drugs 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- 235000019731 tricalcium phosphate Nutrition 0.000 claims 1
- 229940078499 tricalcium phosphate Drugs 0.000 claims 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims 1
- 239000001069 triethyl citrate Substances 0.000 claims 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 1
- 235000013769 triethyl citrate Nutrition 0.000 claims 1
- 239000001993 wax Substances 0.000 claims 1
- 229940045860 white wax Drugs 0.000 claims 1
- 239000012530 fluid Substances 0.000 abstract 2
- XIQVNETUBQGFHX-QFIPXVFZSA-N (R)-oxybutynin Chemical compound C1([C@](O)(C(=O)OCC#CCN(CC)CC)C=2C=CC=CC=2)CCCCC1 XIQVNETUBQGFHX-QFIPXVFZSA-N 0.000 abstract 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 abstract 1
- QZVCTJOXCFMACW-UHFFFAOYSA-N Phenoxybenzamine Chemical compound C=1C=CC=CC=1CN(CCCl)C(C)COC1=CC=CC=C1 QZVCTJOXCFMACW-UHFFFAOYSA-N 0.000 abstract 1
- 239000000679 carrageenan Substances 0.000 abstract 1
- 235000010418 carrageenan Nutrition 0.000 abstract 1
- 229920001525 carrageenan Polymers 0.000 abstract 1
- 229940113118 carrageenan Drugs 0.000 abstract 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- HXGBXQDTNZMWGS-RUZDIDTESA-N darifenacin Chemical compound C=1C=CC=CC=1C([C@H]1CN(CCC=2C=C3CCOC3=CC=2)CC1)(C(=O)N)C1=CC=CC=C1 HXGBXQDTNZMWGS-RUZDIDTESA-N 0.000 abstract 1
- 230000002497 edematous effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06014244A EP1880718B1 (de) | 2006-07-10 | 2006-07-10 | Pharmazeutische Zubereitung für die orale Verabreichung mit gesteuerter Wirkstofffreisetzung im Dünndarm und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110739T1 true HRP20110739T1 (hr) | 2011-11-30 |
Family
ID=37496994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110739T HRP20110739T1 (hr) | 2006-07-10 | 2011-10-12 | Farmaceutski pripravak za oralno davanje sa kontroliranim otpuštanjem lijeka u tankom crijevu i postupak njegovog dobivanja |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8221787B2 (ja) |
| EP (1) | EP1880718B1 (ja) |
| JP (1) | JP5424877B2 (ja) |
| KR (1) | KR101451233B1 (ja) |
| CN (1) | CN101495103B (ja) |
| AR (1) | AR061860A1 (ja) |
| AT (1) | ATE525065T1 (ja) |
| CA (1) | CA2655838C (ja) |
| CL (1) | CL2007002000A1 (ja) |
| DK (1) | DK1880718T3 (ja) |
| EA (1) | EA016683B1 (ja) |
| ES (1) | ES2374158T3 (ja) |
| HK (1) | HK1109858A1 (ja) |
| HR (1) | HRP20110739T1 (ja) |
| IL (1) | IL195931A (ja) |
| JO (1) | JO2801B1 (ja) |
| MX (1) | MX2009000379A (ja) |
| PL (1) | PL1880718T3 (ja) |
| SI (1) | SI1880718T1 (ja) |
| TW (1) | TWI375573B (ja) |
| UA (1) | UA95805C2 (ja) |
| WO (1) | WO2008006506A1 (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009130712A2 (en) * | 2008-04-22 | 2009-10-29 | Lupin Limited | Controlled release pharmaceutical compositions of trospium |
| EP2133072A1 (en) | 2008-06-13 | 2009-12-16 | KRKA, D.D., Novo Mesto | Gastro-resistant pharmaceutical oral compositions comprising duloxetine or its pharmaceutically acceptable derivatives |
| WO2010043408A2 (de) * | 2008-10-17 | 2010-04-22 | Ratiopharm Gmbh | Mikroverkapseltes fesoterodin |
| DE102009001636A1 (de) * | 2009-03-18 | 2010-09-23 | Henkel Ag & Co. Kgaa | Bleichmittel mit verzögertem Bleichbeginn |
| US20100303920A1 (en) * | 2009-05-27 | 2010-12-02 | Johan Hjartstam | Aqueous Film Coating Composition / 841 |
| EP3318247A1 (en) * | 2011-08-12 | 2018-05-09 | Boehringer Ingelheim Vetmedica GmbH | Taste masked pharmaceutical composition |
| US20140348936A1 (en) * | 2011-12-16 | 2014-11-27 | Celanese Eva Performance Polymers, Inc. | Gastroretentive controlled release vehicles that include ethylene copolymers, ethyl celluloses, and/or thermoplastic polyurethanes |
| JP2013145174A (ja) * | 2012-01-13 | 2013-07-25 | Panasonic Corp | 近接センサ |
| CN107823719B (zh) * | 2013-05-02 | 2021-01-29 | 德国凯德诺有限责任公司 | 球囊表面涂层 |
| JP6168673B2 (ja) * | 2015-10-07 | 2017-07-26 | 協和発酵キリン株式会社 | アリールアルキルアミン化合物含有医薬組成物 |
| ITUA20161799A1 (it) * | 2016-03-18 | 2017-09-18 | Recordati Ind Chimica E Farmaceutica S P A | Composizione farmaceutica a rilascio prolungato comprendente cisteamina o un suo sale |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI101344B (fi) * | 1988-03-31 | 1998-06-15 | Tanabe Seiyaku Co | Menetelmä valmistaa valmiste, josta kontrolloidusti vapautuu farmaseut tisesti aktiivista ainetta |
| US5840329A (en) * | 1997-05-15 | 1998-11-24 | Bioadvances Llc | Pulsatile drug delivery system |
| ES2168043B1 (es) * | 1999-09-13 | 2003-04-01 | Esteve Labor Dr | Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido. |
| JP3888064B2 (ja) * | 2000-01-27 | 2007-02-28 | 田辺製薬株式会社 | 徐放性製剤およびその製法 |
| CA2398199A1 (en) * | 2000-01-28 | 2001-08-02 | Asahi Kasei Kabushiki Kaisha | Novel therapeutic agents that use a .beta.3 agonist |
| DE10013029A1 (de) * | 2000-03-17 | 2001-09-20 | Roehm Gmbh | Mehrschichtige Arzneiform für die Colonfreigabe |
| IN192159B (ja) * | 2000-05-15 | 2004-02-28 | Ranbaxy Lab Ltd | |
| US7229665B2 (en) * | 2001-05-22 | 2007-06-12 | Millipore Corporation | Process of forming multilayered structures |
| TR200300510A2 (tr) * | 2003-04-18 | 2004-11-22 | Sanovel �La� Sanay� Ve T�Caret A.�. | Dağılan alendronat mikropartikül formülasyonu |
| US8709476B2 (en) * | 2003-11-04 | 2014-04-29 | Supernus Pharmaceuticals, Inc. | Compositions of quaternary ammonium compounds containing bioavailability enhancers |
| DK2210605T3 (en) * | 2003-11-04 | 2017-05-22 | Tcd Royalty Sub Llc | Daily single dose doses of trospium. |
-
2006
- 2006-07-10 EP EP06014244A patent/EP1880718B1/de active Active
- 2006-07-10 SI SI200631131T patent/SI1880718T1/sl unknown
- 2006-07-10 PL PL06014244T patent/PL1880718T3/pl unknown
- 2006-07-10 AT AT06014244T patent/ATE525065T1/de active
- 2006-07-10 DK DK06014244.5T patent/DK1880718T3/da active
- 2006-07-10 ES ES06014244T patent/ES2374158T3/es active Active
-
2007
- 2007-06-27 TW TW096123213A patent/TWI375573B/zh not_active IP Right Cessation
- 2007-07-05 JP JP2009518762A patent/JP5424877B2/ja not_active Expired - Fee Related
- 2007-07-05 CN CN200780026301XA patent/CN101495103B/zh not_active Expired - Fee Related
- 2007-07-05 EA EA200970100A patent/EA016683B1/ru not_active IP Right Cessation
- 2007-07-05 MX MX2009000379A patent/MX2009000379A/es active IP Right Grant
- 2007-07-05 KR KR1020097002668A patent/KR101451233B1/ko not_active IP Right Cessation
- 2007-07-05 CA CA2655838A patent/CA2655838C/en not_active Expired - Fee Related
- 2007-07-05 UA UAA200900169A patent/UA95805C2/uk unknown
- 2007-07-05 US US12/309,198 patent/US8221787B2/en not_active Expired - Fee Related
- 2007-07-05 WO PCT/EP2007/005970 patent/WO2008006506A1/de active Application Filing
- 2007-07-08 JO JO2007271A patent/JO2801B1/en active
- 2007-07-09 CL CL2007002000A patent/CL2007002000A1/es unknown
- 2007-07-10 AR ARP070103054A patent/AR061860A1/es unknown
-
2008
- 2008-04-09 HK HK08103960.2A patent/HK1109858A1/xx not_active IP Right Cessation
- 2008-12-15 IL IL195931A patent/IL195931A/en not_active IP Right Cessation
-
2011
- 2011-10-12 HR HR20110739T patent/HRP20110739T1/hr unknown
-
2012
- 2012-06-15 US US13/525,029 patent/US20120294938A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PL1880718T3 (pl) | 2012-02-29 |
| IL195931A (en) | 2014-02-27 |
| SI1880718T1 (sl) | 2011-11-30 |
| CN101495103A (zh) | 2009-07-29 |
| JP2009542742A (ja) | 2009-12-03 |
| CA2655838C (en) | 2014-04-08 |
| CN101495103B (zh) | 2013-05-22 |
| EA200970100A1 (ru) | 2009-06-30 |
| KR101451233B1 (ko) | 2014-10-15 |
| EP1880718B1 (de) | 2011-09-21 |
| CA2655838A1 (en) | 2008-01-17 |
| AR061860A1 (es) | 2008-09-24 |
| TWI375573B (en) | 2012-11-01 |
| TW200808381A (en) | 2008-02-16 |
| US20120294938A1 (en) | 2012-11-22 |
| WO2008006506A1 (de) | 2008-01-17 |
| JP5424877B2 (ja) | 2014-02-26 |
| ATE525065T1 (de) | 2011-10-15 |
| CL2007002000A1 (es) | 2008-01-18 |
| KR20090029830A (ko) | 2009-03-23 |
| ES2374158T3 (es) | 2012-02-14 |
| MX2009000379A (es) | 2009-04-14 |
| HK1109858A1 (en) | 2008-06-27 |
| JO2801B1 (en) | 2014-03-15 |
| EP1880718A1 (de) | 2008-01-23 |
| UA95805C2 (uk) | 2011-09-12 |
| DK1880718T3 (da) | 2011-11-21 |
| US8221787B2 (en) | 2012-07-17 |
| US20090285891A1 (en) | 2009-11-19 |
| EA016683B1 (ru) | 2012-06-29 |
| IL195931A0 (en) | 2009-09-01 |
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