HRP20110110T1 - Porozni kompozitni materijal, postupak njegove pripreme i uporaba za realizaciju uređaja za tkivni inženjering - Google Patents
Porozni kompozitni materijal, postupak njegove pripreme i uporaba za realizaciju uređaja za tkivni inženjering Download PDFInfo
- Publication number
- HRP20110110T1 HRP20110110T1 HR20110110T HRP20110110T HRP20110110T1 HR P20110110 T1 HRP20110110 T1 HR P20110110T1 HR 20110110 T HR20110110 T HR 20110110T HR P20110110 T HRP20110110 T HR P20110110T HR P20110110 T1 HRP20110110 T1 HR P20110110T1
- Authority
- HR
- Croatia
- Prior art keywords
- composite material
- porous composite
- material according
- mineral component
- biopolymer
- Prior art date
Links
- 239000002131 composite material Substances 0.000 title claims abstract 17
- 238000002360 preparation method Methods 0.000 title 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract 11
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract 10
- 239000011707 mineral Substances 0.000 claims abstract 10
- 229920001222 biopolymer Polymers 0.000 claims abstract 8
- 210000000988 bone and bone Anatomy 0.000 claims abstract 6
- 229910000392 octacalcium phosphate Inorganic materials 0.000 claims abstract 6
- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 claims abstract 5
- 210000001519 tissue Anatomy 0.000 claims abstract 2
- 239000006260 foam Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- AZKVWQKMDGGDSV-BCMRRPTOSA-N Genipin Chemical compound COC(=O)C1=CO[C@@H](O)[C@@H]2C(CO)=CC[C@H]12 AZKVWQKMDGGDSV-BCMRRPTOSA-N 0.000 claims 2
- 239000012736 aqueous medium Substances 0.000 claims 2
- 210000000845 cartilage Anatomy 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- 238000004108 freeze drying Methods 0.000 claims 2
- AZKVWQKMDGGDSV-UHFFFAOYSA-N genipin Natural products COC(=O)C1=COC(O)C2C(CO)=CCC12 AZKVWQKMDGGDSV-UHFFFAOYSA-N 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract 1
- 239000001506 calcium phosphate Substances 0.000 abstract 1
- 229960001714 calcium phosphate Drugs 0.000 abstract 1
- 235000011010 calcium phosphates Nutrition 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000002159 nanocrystal Substances 0.000 abstract 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Inorganic Chemistry (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials For Medical Uses (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
- Laminated Bodies (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Porozni kompozitni materijal, naznačen time što sadržava barem jedan interdispergirani biopolimer s mineralnom komponentom koja sadržava od 50 w/% do 95 w/% α-trikalcij fosfata (α-TCP) i od 5 w/% do 50 w/% oktakalcij fosfata (OCP), u odnosu na ukupnu težinu mineralne komponente. Patent sadrži još 16 patentnih zahtjeva.
Claims (17)
1. Porozni kompozitni materijal, naznačen time što sadržava barem jedan interdispergirani biopolimer s mineralnom komponentom koja sadržava od 50 w/% do 95 w/% α-trikalcij fosfata (α-TCP) i od 5 w/% do 50 w/% oktakalcij fosfata (OCP), u odnosu na ukupnu težinu mineralne komponente.
2. Porozni kompozitni materijal prema zahtjevu 1, naznačen time što mineralna komponenta sadržava od 60 w/% do 85 w/% α-TCP i od 15 w/% do 40 w/% OCP.
3. Porozni kompozitni materijal prema zahtjevu 2, naznačen time što mineralna komponenta sadržava od 70w/% do 80 w/% α-TCP i od 20 w/% do 30 w/% OCP.
4. Porozni kompozitni materijal prema bilo kojem od prethodnih zahtjeva, naznačen time što se mineralna komponenta dobiva in situ parcijalnom hidrolizom α-TCP.
5. Porozni kompozitni materijal prema bilo kojem od prethodnih zahtjeva, naznačen time što je barem jedan biopolimer protein ili polisaharid.
6. Porozni kompozitni materijal prema bilo kojem od prethodnih zahtjeva, naznačen time što sadržava od 30 w/% do 99 w/%, poželjnije od 55 w/% do 95 w/% barem jednog biopolimera, i od 1 w/% do 70 w/%, poželjnije od 5 w/% do 45 w/% mineralne komponente.
7. Porozni kompozitni materijal prema bilo kojem od prethodnih zahtjeva, naznačen time što je barem jedan biopolimer umrežen.
8. Porozni kompozitni materijal prema zahtjevu 7, naznačen time što je barem jedan biopolimer umrežen genipinom.
9. Porozni kompozitni materijal prema bilo kojem od prethodnih zahtjeva, naznačen time što ima poroznu strukturu sa srednjom veličinom čestica od 1 do 500 Pm.
10. Porozni kompozitni materijal prema bilo kojem od prethodnih zahtjeva, naznačen time što dalje sadržava diferencirane i/ili nediferencirane stanice, autologne ili homologne, fakotre rasta i druge proteine i/ili biološke stimulatore.
11. Postupak pripreme poroznog kompozitnog materijala prema bilo kojem od prethodnih zahtjeva, naznačen time što obuhvaća:
miješanje barem jednog biopolimera s mineralnom komponentom koja je u biti sastavljena od α-trikalcij fosfata (α-TCP), u vodenom mediju tako da se dobije pjena;
ostavljanje dobivene pjene kroz vrijeme dovoljno da se dobije gelirani biopolimer;
hlađenje pjene pri temperaturi nižoj od -20°C, poželjno nižoj od -90°C;
sušenje zamrzavanjem ohlađene pjene.
12. Postupak prema zahtjevu 11, naznačen time što se dalje u vodeni medij dodaje barem jedno sredstvo za umrežavanje.
13. Postupak prema zahtjevu 12, naznačen time što je to sredstvo za umrežavanje genipin.
14. Postupak prema bilo kojem od zahtjeva 11 do 13, naznačen time što se faza sušenja zamrzavanjem provodi pri temperaturi koja ne prelazi -20°C, poželjno od -40 i -60°C, kroz vrijeme koje nije kraće od 18 sati, poželjno između 24 sata i 3 dana, pod sniženim tlakom, manjim od 10 milibara, poželjno od 0.1 i 1.0 milibar.
15. Uporaba poroznog kompozitnog materijala prema bilo kojem od zahtjeva 1 do 10, naznačena time što je za proizvodnju materijala za regeneraciju kosti i/ili koštane hrskavice.
16. Uporaba poroznog kompozitnog materijala prema bilo kojem od zahtjeva 1 do 10, naznačena time što je za proizvodnju uređaja za tkivni inženjering.
17. Uporaba poroznog kompozitnog materijala prema bilo kojem od zahtjeva 1 do 10, naznačena time što je za proizvodnju zamjene za kost i/ili koštanu hrskavicu.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001298A ITMI20071298A1 (it) | 2007-06-29 | 2007-06-29 | Materiale composito poroso, relativo processo di preparazione e suo uso per la realizzazione di dispositivi per l'ingegneria tissutale |
| PCT/IB2008/001688 WO2009004445A2 (en) | 2007-06-29 | 2008-06-27 | Porous composite material, preparation process thereof and use to realize tissue engineering devices |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110110T1 true HRP20110110T1 (hr) | 2011-03-31 |
Family
ID=40226590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110110T HRP20110110T1 (hr) | 2007-06-29 | 2011-02-15 | Porozni kompozitni materijal, postupak njegove pripreme i uporaba za realizaciju uređaja za tkivni inženjering |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20100183569A1 (hr) |
| EP (1) | EP2167150B1 (hr) |
| JP (1) | JP2010531704A (hr) |
| CN (1) | CN101801428B (hr) |
| AT (1) | ATE492303T1 (hr) |
| AU (1) | AU2008272581A1 (hr) |
| BR (1) | BRPI0812810A2 (hr) |
| CA (1) | CA2691801A1 (hr) |
| DE (1) | DE602008004150D1 (hr) |
| DK (1) | DK2167150T3 (hr) |
| ES (1) | ES2357191T3 (hr) |
| HK (1) | HK1140435A1 (hr) |
| HR (1) | HRP20110110T1 (hr) |
| IT (1) | ITMI20071298A1 (hr) |
| PT (1) | PT2167150E (hr) |
| SI (1) | SI2167150T1 (hr) |
| WO (1) | WO2009004445A2 (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5647432B2 (ja) * | 2010-05-06 | 2014-12-24 | ニプロ株式会社 | 骨再生材料 |
| JP5881206B2 (ja) * | 2011-11-17 | 2016-03-09 | ニプロ株式会社 | 骨再生材料 |
| AU2015321554C1 (en) * | 2014-09-25 | 2018-10-11 | Acell, Inc. | Porous foams derived from extracellular matrix, porous foam ECM medical devices, and methods of use and making thereof |
| JPWO2019069825A1 (ja) * | 2017-10-05 | 2020-09-17 | 国立研究開発法人産業技術総合研究所 | β−ＴＣＰ基材とＯＣＰ結晶層を含む複合体及びその製造方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5776193A (en) * | 1995-10-16 | 1998-07-07 | Orquest, Inc. | Bone grafting matrix |
| US7758882B2 (en) * | 2000-01-31 | 2010-07-20 | Indiana University Research And Technology Corporation | Composite biomaterial including anisometric calcium phosphate reinforcement particles and related methods |
| US7294187B2 (en) * | 2001-01-24 | 2007-11-13 | Ada Foundation | Rapid-hardening calcium phosphate cement compositions |
| EP1642599B1 (en) * | 2003-05-26 | 2010-12-01 | HOYA Corporation | Porous composite containing calcium phosphate and process for producing the same |
| EP1744793A2 (en) * | 2003-10-22 | 2007-01-24 | University of Florida | Biomimetic organic/inorganic composites, processes for their production, and methods of use |
| EP1708652A4 (en) * | 2004-01-30 | 2011-08-24 | Warsaw Orthopedic Inc | STACK IMPLANTS AT THE SPINAL FUSION |
| US20090012625A1 (en) * | 2004-09-14 | 2009-01-08 | Ying Jackie Y | Porous biomaterial-filler composite and method for making the same |
-
2007
- 2007-06-29 IT IT001298A patent/ITMI20071298A1/it unknown
-
2008
- 2008-06-27 DE DE602008004150T patent/DE602008004150D1/de active Active
- 2008-06-27 CA CA002691801A patent/CA2691801A1/en not_active Abandoned
- 2008-06-27 ES ES08776302T patent/ES2357191T3/es active Active
- 2008-06-27 JP JP2010514169A patent/JP2010531704A/ja active Pending
- 2008-06-27 US US12/665,461 patent/US20100183569A1/en not_active Abandoned
- 2008-06-27 PT PT08776302T patent/PT2167150E/pt unknown
- 2008-06-27 DK DK08776302.5T patent/DK2167150T3/da active
- 2008-06-27 SI SI200830178T patent/SI2167150T1/sl unknown
- 2008-06-27 WO PCT/IB2008/001688 patent/WO2009004445A2/en active Application Filing
- 2008-06-27 EP EP08776302A patent/EP2167150B1/en not_active Not-in-force
- 2008-06-27 BR BRPI0812810-3A2A patent/BRPI0812810A2/pt not_active IP Right Cessation
- 2008-06-27 CN CN2008800221670A patent/CN101801428B/zh not_active Expired - Fee Related
- 2008-06-27 AT AT08776302T patent/ATE492303T1/de active
- 2008-06-27 AU AU2008272581A patent/AU2008272581A1/en not_active Abandoned
-
2010
- 2010-07-13 HK HK10106765.8A patent/HK1140435A1/xx unknown
-
2011
- 2011-02-15 HR HR20110110T patent/HRP20110110T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2167150E (pt) | 2011-03-03 |
| CA2691801A1 (en) | 2009-01-08 |
| BRPI0812810A2 (pt) | 2014-12-09 |
| ES2357191T3 (es) | 2011-04-19 |
| HK1140435A1 (en) | 2010-10-15 |
| DE602008004150D1 (de) | 2011-02-03 |
| DK2167150T3 (da) | 2011-03-28 |
| SI2167150T1 (sl) | 2011-05-31 |
| JP2010531704A (ja) | 2010-09-30 |
| US20100183569A1 (en) | 2010-07-22 |
| CN101801428A (zh) | 2010-08-11 |
| WO2009004445A2 (en) | 2009-01-08 |
| ITMI20071298A1 (it) | 2008-12-30 |
| EP2167150A2 (en) | 2010-03-31 |
| ATE492303T1 (de) | 2011-01-15 |
| CN101801428B (zh) | 2013-10-23 |
| EP2167150B1 (en) | 2010-12-22 |
| WO2009004445A3 (en) | 2009-12-23 |
| AU2008272581A1 (en) | 2009-01-08 |
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