HRP20100287T1 - Postupak i intermedijerni spojevi korisni za dobivanje statina, naročito rosuvastatina - Google Patents
Postupak i intermedijerni spojevi korisni za dobivanje statina, naročito rosuvastatina Download PDFInfo
- Publication number
- HRP20100287T1 HRP20100287T1 HR20100287T HRP20100287T HRP20100287T1 HR P20100287 T1 HRP20100287 T1 HR P20100287T1 HR 20100287 T HR20100287 T HR 20100287T HR P20100287 T HRP20100287 T HR P20100287T HR P20100287 T1 HRP20100287 T1 HR P20100287T1
- Authority
- HR
- Croatia
- Prior art keywords
- group
- formula
- compound
- alkyl group
- protecting
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 30
- 238000000034 method Methods 0.000 title claims abstract 4
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title 1
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 title 1
- 229960000672 rosuvastatin Drugs 0.000 title 1
- 125000006239 protecting group Chemical group 0.000 claims abstract 29
- 125000000217 alkyl group Chemical group 0.000 claims abstract 23
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 13
- 239000001257 hydrogen Substances 0.000 claims abstract 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 8
- 125000003118 aryl group Chemical group 0.000 claims abstract 7
- 150000002431 hydrogen Chemical class 0.000 claims abstract 5
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 3
- 150000001450 anions Chemical group 0.000 claims abstract 3
- 125000004104 aryloxy group Chemical group 0.000 claims abstract 3
- 230000008878 coupling Effects 0.000 claims abstract 3
- 238000010168 coupling process Methods 0.000 claims abstract 3
- 238000005859 coupling reaction Methods 0.000 claims abstract 3
- 125000005843 halogen group Chemical group 0.000 claims abstract 2
- 238000007142 ring opening reaction Methods 0.000 claims abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000033444 hydroxylation Effects 0.000 claims 1
- 238000005805 hydroxylation reaction Methods 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 230000000640 hydroxylating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0406757A GB0406757D0 (en) | 2004-03-26 | 2004-03-26 | Process and compounds |
| PCT/GB2005/001099 WO2005092867A2 (en) | 2004-03-26 | 2005-03-23 | Process and intermediate compounds useful in the preparation of statins, particularly rosuvastatin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100287T1 true HRP20100287T1 (hr) | 2010-07-31 |
Family
ID=32188702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100287T HRP20100287T1 (hr) | 2004-03-26 | 2010-05-21 | Postupak i intermedijerni spojevi korisni za dobivanje statina, naročito rosuvastatina |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8703945B2 (de) |
| EP (2) | EP1958633B1 (de) |
| JP (1) | JP5016478B2 (de) |
| KR (1) | KR20060130765A (de) |
| CN (1) | CN101022807B (de) |
| AT (2) | ATE536875T1 (de) |
| AU (1) | AU2005225602A1 (de) |
| BR (1) | BRPI0507999A (de) |
| CA (1) | CA2561059C (de) |
| CY (2) | CY1110091T1 (de) |
| DE (1) | DE602005019547D1 (de) |
| DK (2) | DK1729775T3 (de) |
| ES (2) | ES2379481T3 (de) |
| GB (1) | GB0406757D0 (de) |
| HR (1) | HRP20100287T1 (de) |
| IL (1) | IL178274A0 (de) |
| PL (2) | PL1729775T3 (de) |
| PT (2) | PT1729775E (de) |
| RS (1) | RS51306B (de) |
| SI (2) | SI1958633T1 (de) |
| WO (1) | WO2005092867A2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003006439A1 (en) | 2001-07-13 | 2003-01-23 | Astrazeneca Uk Limited | Preparation of aminopyrimidine compounds |
| GB0218781D0 (en) | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
| GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
| GB0406757D0 (en) * | 2004-03-26 | 2004-04-28 | Avecia Ltd | Process and compounds |
| GB0427491D0 (en) | 2004-12-16 | 2005-01-19 | Avecia Ltd | Process and compounds |
| US9150518B2 (en) | 2005-06-24 | 2015-10-06 | Lek Pharmaceuticals, D.D. | Process for preparing amorphous rosuvastatin calcium of impurities |
| US8183397B2 (en) | 2007-04-03 | 2012-05-22 | Lek Pharmaceuticals D.D. | Synthesis of statins |
| EP1978020A1 (de) * | 2007-04-03 | 2008-10-08 | LEK Pharmaceuticals D.D. | Verfahren zur Herstellung von Statinen, insbesondere von Rosuvastatin, und Zwischenprodukt für deren Herstellung |
| CN101952453B (zh) | 2008-01-23 | 2015-02-25 | 力奇制药公司 | ((2s,4r)-4,6-二羟基四氢-2h-吡喃-2-基)甲基羧酸酯及使用2-脱氧核糖-5-磷酸醛缩酶的制备方法 |
| GB0904104D0 (en) | 2009-03-10 | 2009-04-22 | Bradford Pharma Ltd | Atorvastatin and rosuvastatin derivatives |
| AU2013202895B2 (en) * | 2009-03-10 | 2014-09-18 | Redx Pharma Plc | Rosuvastatin and atorvastatin derivatives |
| GB0904100D0 (en) | 2009-03-10 | 2009-04-22 | Bradford Pharma Ltd | Use of rosuvastatin lactols as medicaments |
| GB0904102D0 (en) * | 2009-03-10 | 2009-04-22 | Bradford Pharma Ltd | Use of atorvastatin lactols as medicaments |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4474971A (en) * | 1982-09-29 | 1984-10-02 | Sandoz, Inc. | (Tetrahydropyran-2-yl)-aldehydes |
| US4625039A (en) * | 1983-12-21 | 1986-11-25 | Sandoz Pharm. Corp. | 4-trisubstituted silyl protected hydroxy-6-oxo-tetrahydropyran-2-yl-aldehyde intermediates |
| US4677211A (en) | 1984-06-29 | 1987-06-30 | Sandoz Pharmaceuticals Corp. | Preparation of lactones |
| JP2648897B2 (ja) | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
| US5795749A (en) | 1995-04-05 | 1998-08-18 | The Scripps Research Institution | Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives |
| GB9903472D0 (en) | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Chemical process |
| WO2001022962A1 (en) * | 1999-09-30 | 2001-04-05 | Merck & Co., Inc. | Anti-hypercholesterolemic drug combination |
| GB0003305D0 (en) * | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
| GB0011163D0 (en) * | 2000-05-10 | 2000-06-28 | Astrazeneca Ab | Chemical compound |
| EP1465667A4 (de) * | 2001-09-24 | 2007-06-27 | Merck & Co Inc | Screening- und auswahlverfahren für statin-kombinationen |
| DE10216967A1 (de) * | 2002-04-16 | 2003-11-13 | Bayer Ag | Verfahren zur Herstellung spezieller aromatischer Aldehyde |
| US7371759B2 (en) | 2003-09-25 | 2008-05-13 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
| WO2005040134A1 (en) * | 2003-10-22 | 2005-05-06 | Ranbaxy Laboratories Limited | Process for the preparation of amorphous rosuvastatin calcium |
| DE10352659B4 (de) | 2003-11-11 | 2007-09-13 | Ratiopharm Gmbh | Verfahren zur Herstellung von Statinen und Tetrahydropyranonderivate zur Verwendung in dem Verfahren |
| GB0406757D0 (en) * | 2004-03-26 | 2004-04-28 | Avecia Ltd | Process and compounds |
-
2004
- 2004-03-26 GB GB0406757A patent/GB0406757D0/en not_active Ceased
-
2005
- 2005-03-23 ES ES08157487T patent/ES2379481T3/es active Active
- 2005-03-23 SI SI200531491T patent/SI1958633T1/sl unknown
- 2005-03-23 EP EP20080157487 patent/EP1958633B1/de not_active Not-in-force
- 2005-03-23 AU AU2005225602A patent/AU2005225602A1/en not_active Abandoned
- 2005-03-23 EP EP20050731809 patent/EP1729775B1/de active Active
- 2005-03-23 DK DK05731809T patent/DK1729775T3/da active
- 2005-03-23 PT PT05731809T patent/PT1729775E/pt unknown
- 2005-03-23 PL PL05731809T patent/PL1729775T3/pl unknown
- 2005-03-23 CN CN2005800096821A patent/CN101022807B/zh not_active Expired - Fee Related
- 2005-03-23 ES ES05731809T patent/ES2341658T3/es active Active
- 2005-03-23 DK DK08157487T patent/DK1958633T3/da active
- 2005-03-23 RS RSP20100217 patent/RS51306B/sr unknown
- 2005-03-23 PL PL08157487T patent/PL1958633T3/pl unknown
- 2005-03-23 CA CA 2561059 patent/CA2561059C/en not_active Expired - Fee Related
- 2005-03-23 DE DE200560019547 patent/DE602005019547D1/de active Active
- 2005-03-23 BR BRPI0507999-3A patent/BRPI0507999A/pt not_active Application Discontinuation
- 2005-03-23 US US10/594,380 patent/US8703945B2/en not_active Expired - Fee Related
- 2005-03-23 KR KR20067021900A patent/KR20060130765A/ko not_active Application Discontinuation
- 2005-03-23 AT AT08157487T patent/ATE536875T1/de active
- 2005-03-23 PT PT08157487T patent/PT1958633E/pt unknown
- 2005-03-23 AT AT05731809T patent/ATE458484T1/de active
- 2005-03-23 WO PCT/GB2005/001099 patent/WO2005092867A2/en active Application Filing
- 2005-03-23 JP JP2007504474A patent/JP5016478B2/ja not_active Expired - Fee Related
- 2005-03-23 SI SI200531001T patent/SI1729775T1/sl unknown
-
2006
- 2006-09-25 IL IL178274A patent/IL178274A0/en unknown
-
2010
- 2010-05-21 HR HR20100287T patent/HRP20100287T1/hr unknown
- 2010-05-21 CY CY101100456T patent/CY1110091T1/el unknown
-
2012
- 2012-03-14 CY CY20121100274T patent/CY1115040T1/el unknown
-
2014
- 2014-03-25 US US14/225,018 patent/US9024025B2/en not_active Expired - Fee Related
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