DE69626218D1 - 4-pyrimidinyl- or 4-pyrazinyl-piperazinyl-phenyl-oxazolidinon derivate, deren herstellung und deren verwendung als antibakterielle mittel - Google Patents
4-pyrimidinyl- or 4-pyrazinyl-piperazinyl-phenyl-oxazolidinon derivate, deren herstellung und deren verwendung als antibakterielle mittelInfo
- Publication number
- DE69626218D1 DE69626218D1 DE69626218T DE69626218T DE69626218D1 DE 69626218 D1 DE69626218 D1 DE 69626218D1 DE 69626218 T DE69626218 T DE 69626218T DE 69626218 T DE69626218 T DE 69626218T DE 69626218 D1 DE69626218 D1 DE 69626218D1
- Authority
- DE
- Germany
- Prior art keywords
- pyrimidinyl
- pyrazinyl
- piperazinyl
- phenyl
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US855495P | 1995-12-13 | 1995-12-13 | |
PCT/US1996/019149 WO1997021708A1 (en) | 1995-12-13 | 1996-12-09 | 4-pyrimidinyl- or 4-pyrazinyl-piperazinyl-phenyl-oxazolidinone derivatives, their preparation and their use as anti-bacterial agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69626218D1 true DE69626218D1 (de) | 2003-03-20 |
DE69626218T2 DE69626218T2 (de) | 2003-08-14 |
Family
ID=21732266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69626218T Expired - Fee Related DE69626218T2 (de) | 1995-12-13 | 1996-12-09 | 4-pyrimidinyl- or 4-pyrazinyl-piperazinyl-phenyl-oxazolidinon derivate, deren herstellung und deren verwendung als antibakterielle mittel |
Country Status (15)
Country | Link |
---|---|
US (1) | US5719154A (de) |
EP (1) | EP0868424B1 (de) |
JP (1) | JP2000501731A (de) |
KR (1) | KR19990072109A (de) |
AT (1) | ATE232530T1 (de) |
AU (1) | AU703784B2 (de) |
CA (1) | CA2236677C (de) |
DE (1) | DE69626218T2 (de) |
DK (1) | DK0868424T3 (de) |
ES (1) | ES2192235T3 (de) |
PT (1) | PT868424E (de) |
SI (1) | SI0868424T1 (de) |
TW (1) | TW403749B (de) |
WO (1) | WO1997021708A1 (de) |
ZA (1) | ZA969622B (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
GB9609919D0 (en) | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
GB9614238D0 (en) * | 1996-07-06 | 1996-09-04 | Zeneca Ltd | Chemical compounds |
US6037354A (en) * | 1997-06-18 | 2000-03-14 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
US6562844B2 (en) | 1998-01-23 | 2003-05-13 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
CN1288462A (zh) | 1998-01-23 | 2001-03-21 | 法玛西雅厄普约翰美国公司 | 噁唑烷酮组合库、组合物和制备方法 |
US7002020B1 (en) | 1998-01-23 | 2006-02-21 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
ATE222894T1 (de) * | 1998-02-13 | 2002-09-15 | Upjohn Co | Substituierte aminophenylisoxazolinderivate verwendbar als antimikrobielle agenzien |
CN1311787A (zh) | 1998-06-05 | 2001-09-05 | 阿斯特拉曾尼卡有限公司 | 噁唑烷酮衍生物、其制备方法以及含有它们的药物组合物 |
EP1147422A1 (de) | 1999-01-27 | 2001-10-24 | Pharmacia & Upjohn Company | Assays für modulatoren der "elongation factor p"-aktivität |
KR100333493B1 (ko) * | 1999-05-27 | 2002-04-25 | 박호군 | 이소옥사졸릴 카르보닐 옥사졸리디논 유도체 및 이의 제조방법 |
KR100333492B1 (ko) * | 1999-05-27 | 2002-04-25 | 박호군 | 이소옥사졸릴 메틸렌 옥사졸리디논 유도체 및 이의 제조방법 |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
KR100674096B1 (ko) * | 2000-06-05 | 2007-01-26 | 동아제약주식회사 | 피리미딘 고리를 포함하는 신규 옥사졸리디논 유도체와그의 제조방법 |
GB0118407D0 (en) * | 2001-07-27 | 2001-09-19 | Cipla Ltd | Oxazolidinone derivatives as antibacterial agents |
US7125568B2 (en) * | 2001-08-23 | 2006-10-24 | Sung Michael T | Lipophilic drug compositions |
US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
MXPA05001199A (es) * | 2002-07-29 | 2005-05-16 | Ranbaxy Lab Ltd | Derivados de oxazolidinona como antimicrobianos. |
WO2004026848A1 (en) * | 2002-09-20 | 2004-04-01 | Lupin Limited | Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents |
MXPA05005472A (es) | 2002-11-21 | 2005-07-25 | Pharmacia & Upjohn Co Llc | Derivados de n-(4-piparazin-1-il)-fenil-2-oxazolidinona-5-carboxamida y compuestos relacionados como agentes antibacterianos. |
GB0229521D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
JP4958784B2 (ja) | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ステアロイル−CoAデサチュラーゼ酵素によって媒介される疾患の処置のための複素環誘導体 |
EP1799664A1 (de) | 2004-09-20 | 2007-06-27 | Xenon Pharmaceuticals Inc. | Heterozyklische derivate und ihre verwendung als stearoyl-coa-desaturase-inhibitoren |
EP1827438B2 (de) * | 2004-09-20 | 2014-12-10 | Xenon Pharmaceuticals Inc. | Piperazine derivate zur hemmung der menschlichen stearoyl-coa-desaturase |
JP5043668B2 (ja) | 2004-09-20 | 2012-10-10 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体および治療薬としてのそれらの使用 |
WO2006034338A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase |
EP1804792A1 (de) * | 2004-09-20 | 2007-07-11 | Xenon Pharmaceuticals Inc. | Bicyclische heterocyclische derivate und ihre verwendung als hemmer von stearoyl-coa-desaturase (scd) |
US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
CA2580855A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
AR051093A1 (es) * | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa desaturasa |
WO2007130075A1 (en) * | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100257418B1 (ko) * | 1991-11-01 | 2000-05-15 | 로렌스 티. 마이젠헬더 | 치환된 아릴-및 헤테로아릴-페닐옥사졸리디논 |
SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
US5556873A (en) * | 1993-02-24 | 1996-09-17 | Rhone-Poulenc Inc. | Pesticidal 1-aryl-5-(substituted alkyl (thio) amido)pyrazoles |
EP0730591B1 (de) * | 1993-11-22 | 1999-07-14 | PHARMACIA & UPJOHN COMPANY | Substituierte hydroxyacetyl piperazine phenyl oxazolidinonsäureester |
US5609996A (en) * | 1996-02-29 | 1997-03-11 | Eastman Kodak Company | Photographic emulsion layer containing pyrazoloazole coupler exhibiting improved dye light fade |
GB9614238D0 (en) * | 1996-07-06 | 1996-09-04 | Zeneca Ltd | Chemical compounds |
-
1996
- 1996-11-15 ZA ZA9609622A patent/ZA969622B/xx unknown
- 1996-11-27 TW TW085114663A patent/TW403749B/zh not_active IP Right Cessation
- 1996-12-09 SI SI9630589T patent/SI0868424T1/xx unknown
- 1996-12-09 AU AU14077/97A patent/AU703784B2/en not_active Ceased
- 1996-12-09 DK DK96944212T patent/DK0868424T3/da active
- 1996-12-09 CA CA002236677A patent/CA2236677C/en not_active Expired - Fee Related
- 1996-12-09 KR KR1019980704424A patent/KR19990072109A/ko not_active Application Discontinuation
- 1996-12-09 WO PCT/US1996/019149 patent/WO1997021708A1/en not_active Application Discontinuation
- 1996-12-09 PT PT96944212T patent/PT868424E/pt unknown
- 1996-12-09 AT AT96944212T patent/ATE232530T1/de not_active IP Right Cessation
- 1996-12-09 EP EP96944212A patent/EP0868424B1/de not_active Expired - Lifetime
- 1996-12-09 JP JP09522076A patent/JP2000501731A/ja not_active Withdrawn
- 1996-12-09 DE DE69626218T patent/DE69626218T2/de not_active Expired - Fee Related
- 1996-12-09 ES ES96944212T patent/ES2192235T3/es not_active Expired - Lifetime
- 1996-12-09 US US08/762,478 patent/US5719154A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5719154A (en) | 1998-02-17 |
ATE232530T1 (de) | 2003-02-15 |
EP0868424A1 (de) | 1998-10-07 |
DE69626218T2 (de) | 2003-08-14 |
EP0868424B1 (de) | 2003-02-12 |
TW403749B (en) | 2000-09-01 |
ZA969622B (en) | 1998-05-15 |
AU703784B2 (en) | 1999-04-01 |
ES2192235T3 (es) | 2003-10-01 |
CA2236677A1 (en) | 1997-06-19 |
KR19990072109A (ko) | 1999-09-27 |
WO1997021708A1 (en) | 1997-06-19 |
AU1407797A (en) | 1997-07-03 |
SI0868424T1 (en) | 2003-08-31 |
CA2236677C (en) | 2005-05-03 |
PT868424E (pt) | 2003-06-30 |
DK0868424T3 (da) | 2003-05-19 |
JP2000501731A (ja) | 2000-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |