HRP20100158T1 - Novi indolizinski derivati, postupak njihovog dobivanja i terapijski pripravci koji iz sadrže - Google Patents
Novi indolizinski derivati, postupak njihovog dobivanja i terapijski pripravci koji iz sadrže Download PDFInfo
- Publication number
- HRP20100158T1 HRP20100158T1 HR20100158T HRP20100158T HRP20100158T1 HR P20100158 T1 HRP20100158 T1 HR P20100158T1 HR 20100158 T HR20100158 T HR 20100158T HR P20100158 T HRP20100158 T HR P20100158T HR P20100158 T1 HRP20100158 T1 HR P20100158T1
- Authority
- HR
- Croatia
- Prior art keywords
- phenyl
- propyl
- methanone
- butyl
- methanone hydrochloride
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 4
- 125000003406 indolizinyl group Chemical class C=1(C=CN2C=CC=CC12)* 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 6
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 125000001424 substituent group Chemical group 0.000 claims abstract 3
- 125000005842 heteroatom Chemical group 0.000 claims abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 2
- 150000002478 indolizines Chemical class 0.000 claims 6
- 206010019280 Heart failures Diseases 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- MUFUIGUYKDROCP-UHFFFAOYSA-N (2-butylindolizin-3-yl)-[4-[3-(dipropylamino)propyl]phenyl]methanone;hydrochloride Chemical compound Cl.CCCCC=1C=C2C=CC=CN2C=1C(=O)C1=CC=C(CCCN(CCC)CCC)C=C1 MUFUIGUYKDROCP-UHFFFAOYSA-N 0.000 claims 2
- 206010002383 Angina Pectoris Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 206010061216 Infarction Diseases 0.000 claims 2
- 206010042600 Supraventricular arrhythmias Diseases 0.000 claims 2
- 206010047281 Ventricular arrhythmia Diseases 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 230000002861 ventricular Effects 0.000 claims 2
- WXVZHOARMPPZNL-UHFFFAOYSA-N (2-butyl-6-ethylindolizin-3-yl)-[4-[3-(dipropylamino)propyl]phenyl]methanone;hydrochloride Chemical compound Cl.CCCCC=1C=C2C=CC(CC)=CN2C=1C(=O)C1=CC=C(CCCN(CCC)CCC)C=C1 WXVZHOARMPPZNL-UHFFFAOYSA-N 0.000 claims 1
- NLMNTBNIFULSJM-UHFFFAOYSA-N (2-butyl-6-ethylindolizin-3-yl)-[4-[3-[ethyl(propyl)amino]propyl]phenyl]methanone;hydrochloride Chemical compound Cl.CCCCC=1C=C2C=CC(CC)=CN2C=1C(=O)C1=CC=C(CCCN(CC)CCC)C=C1 NLMNTBNIFULSJM-UHFFFAOYSA-N 0.000 claims 1
- PNFBXLWONFKQCP-UHFFFAOYSA-N (2-butyl-6-methylindolizin-3-yl)-[4-[3-(dipropylamino)propyl]phenyl]methanone;hydrochloride Chemical compound Cl.CCCCC=1C=C2C=CC(C)=CN2C=1C(=O)C1=CC=C(CCCN(CCC)CCC)C=C1 PNFBXLWONFKQCP-UHFFFAOYSA-N 0.000 claims 1
- XZRYOPDUCAKOSC-UHFFFAOYSA-N (2-butyl-6-methylindolizin-3-yl)-[4-[3-[ethyl(propyl)amino]propyl]phenyl]methanone;hydrochloride Chemical compound Cl.CCCCC=1C=C2C=CC(C)=CN2C=1C(=O)C1=CC=C(CCCN(CC)CCC)C=C1 XZRYOPDUCAKOSC-UHFFFAOYSA-N 0.000 claims 1
- IPXRKSXQJXESAH-UHFFFAOYSA-N (2-butylindolizin-3-yl)-[4-(3-piperidin-1-ylpropyl)phenyl]methanone;oxalic acid Chemical compound OC(=O)C(O)=O.CCCCC=1C=C2C=CC=CN2C=1C(=O)C(C=C1)=CC=C1CCCN1CCCCC1 IPXRKSXQJXESAH-UHFFFAOYSA-N 0.000 claims 1
- AMTSNDJOJYRNDD-UHFFFAOYSA-N (2-butylindolizin-3-yl)-[4-[3-(dibutylamino)propyl]phenyl]methanone;hydrochloride Chemical compound Cl.C1=CC(CCCN(CCCC)CCCC)=CC=C1C(=O)C1=C(CCCC)C=C2N1C=CC=C2 AMTSNDJOJYRNDD-UHFFFAOYSA-N 0.000 claims 1
- LNEAGOOADIDYQU-UHFFFAOYSA-N (2-butylindolizin-3-yl)-[4-[3-(diethylamino)propyl]phenyl]methanone;hydrochloride Chemical compound Cl.CCCCC=1C=C2C=CC=CN2C=1C(=O)C1=CC=C(CCCN(CC)CC)C=C1 LNEAGOOADIDYQU-UHFFFAOYSA-N 0.000 claims 1
- QAQRVMPYCRRFPV-UHFFFAOYSA-N (2-butylindolizin-3-yl)-[4-[3-(dimethylamino)propyl]phenyl]methanone;hydrochloride Chemical compound Cl.CCCCC=1C=C2C=CC=CN2C=1C(=O)C1=CC=C(CCCN(C)C)C=C1 QAQRVMPYCRRFPV-UHFFFAOYSA-N 0.000 claims 1
- NGWYONANJAQZPI-UHFFFAOYSA-N (2-butylindolizin-3-yl)-[4-[3-(dipropylamino)propyl]phenyl]methanone;sulfuric acid Chemical compound OS(O)(=O)=O.CCCCC=1C=C2C=CC=CN2C=1C(=O)C1=CC=C(CCCN(CCC)CCC)C=C1 NGWYONANJAQZPI-UHFFFAOYSA-N 0.000 claims 1
- NGBJFHNFQMIRQN-UHFFFAOYSA-N (2-butylindolizin-3-yl)-[4-[3-(propylamino)propyl]phenyl]methanone;hydrochloride Chemical compound Cl.CCCCC=1C=C2C=CC=CN2C=1C(=O)C1=CC=C(CCCNCCC)C=C1 NGBJFHNFQMIRQN-UHFFFAOYSA-N 0.000 claims 1
- NRELSUBAVDXWAM-ZJXXCOCUSA-N (2-butylindolizin-3-yl)-[4-[3-[(3r,5s)-3,4,5-trimethylpiperazin-1-yl]propyl]phenyl]methanone;hydrochloride Chemical compound Cl.CCCCC=1C=C2C=CC=CN2C=1C(=O)C(C=C1)=CC=C1CCCN1C[C@H](C)N(C)[C@H](C)C1 NRELSUBAVDXWAM-ZJXXCOCUSA-N 0.000 claims 1
- OVHUYYLYEPUFLD-WHXBIKBMSA-N (2-butylindolizin-3-yl)-[4-[3-[(3r,5s)-3,5-dimethylpiperazin-1-yl]propyl]phenyl]methanone;hydrochloride Chemical compound Cl.CCCCC=1C=C2C=CC=CN2C=1C(=O)C(C=C1)=CC=C1CCCN1C[C@H](C)N[C@H](C)C1 OVHUYYLYEPUFLD-WHXBIKBMSA-N 0.000 claims 1
- JKAJPYMCIDSFJH-UHFFFAOYSA-N (2-butylindolizin-3-yl)-[4-[3-[butyl(propyl)amino]propyl]phenyl]methanone;oxalic acid Chemical compound OC(=O)C(O)=O.C1=CC(CCCN(CCC)CCCC)=CC=C1C(=O)C1=C(CCCC)C=C2N1C=CC=C2 JKAJPYMCIDSFJH-UHFFFAOYSA-N 0.000 claims 1
- CWZVEJZDDJTQNH-UHFFFAOYSA-N (2-butylindolizin-3-yl)-[4-[3-[cyclopropylmethyl(propyl)amino]propyl]phenyl]methanone;hydrochloride Chemical compound Cl.CCCCC=1C=C2C=CC=CN2C=1C(=O)C(C=C1)=CC=C1CCCN(CCC)CC1CC1 CWZVEJZDDJTQNH-UHFFFAOYSA-N 0.000 claims 1
- VETDLAHVIMUUGJ-UHFFFAOYSA-N (2-butylindolizin-3-yl)-[4-[3-[ethyl(propyl)amino]propyl]phenyl]methanone;hydrochloride Chemical compound Cl.CCCCC=1C=C2C=CC=CN2C=1C(=O)C1=CC=C(CCCN(CC)CCC)C=C1 VETDLAHVIMUUGJ-UHFFFAOYSA-N 0.000 claims 1
- DKYBVRTXRCICND-UHFFFAOYSA-N (2-butylindolizin-3-yl)-[4-[4-(dibutylamino)butyl]phenyl]methanone;oxalic acid Chemical compound OC(=O)C(O)=O.C1=CC(CCCCN(CCCC)CCCC)=CC=C1C(=O)C1=C(CCCC)C=C2N1C=CC=C2 DKYBVRTXRCICND-UHFFFAOYSA-N 0.000 claims 1
- OCDWPBJEEWOIPX-UHFFFAOYSA-N (2-butylindolizin-3-yl)-[4-[4-(diethylamino)butyl]phenyl]methanone;oxalic acid Chemical compound OC(=O)C(O)=O.CCCCC=1C=C2C=CC=CN2C=1C(=O)C1=CC=C(CCCCN(CC)CC)C=C1 OCDWPBJEEWOIPX-UHFFFAOYSA-N 0.000 claims 1
- FIMFNDMSJIKOAE-UHFFFAOYSA-N (2-butylindolizin-3-yl)-[4-[4-(dipropylamino)butyl]phenyl]methanone;hydrochloride Chemical compound Cl.CCCCC=1C=C2C=CC=CN2C=1C(=O)C1=CC=C(CCCCN(CCC)CCC)C=C1 FIMFNDMSJIKOAE-UHFFFAOYSA-N 0.000 claims 1
- XIMMANMKPGYIGU-UHFFFAOYSA-N (2-butylindolizin-3-yl)-[4-[4-[ethyl(propyl)amino]butyl]phenyl]methanone;hydrochloride Chemical compound Cl.CCCCC=1C=C2C=CC=CN2C=1C(=O)C1=CC=C(CCCCN(CC)CCC)C=C1 XIMMANMKPGYIGU-UHFFFAOYSA-N 0.000 claims 1
- NMPDRKPYIARZCT-UHFFFAOYSA-N (2-ethylindolizin-3-yl)-[4-[3-[ethyl(propyl)amino]propyl]phenyl]methanone;oxalic acid Chemical compound OC(=O)C(O)=O.C1=CC(CCCN(CC)CCC)=CC=C1C(=O)C1=C(CC)C=C2N1C=CC=C2 NMPDRKPYIARZCT-UHFFFAOYSA-N 0.000 claims 1
- DVQIVNPYDDCYOC-UHFFFAOYSA-N (2-ethylindolizin-3-yl)-[4-[4-[ethyl(propyl)amino]butyl]phenyl]methanone;oxalic acid Chemical compound OC(=O)C(O)=O.C1=CC(CCCCN(CC)CCC)=CC=C1C(=O)C1=C(CC)C=C2N1C=CC=C2 DVQIVNPYDDCYOC-UHFFFAOYSA-N 0.000 claims 1
- LWYLVHNKNMRGPG-WLHGVMLRSA-N (e)-but-2-enedioic acid;(2-butylindolizin-3-yl)-[4-[3-(dipropylamino)propyl]phenyl]methanone Chemical compound OC(=O)\C=C\C(O)=O.CCCCC=1C=C2C=CC=CN2C=1C(=O)C1=CC=C(CCCN(CCC)CCC)C=C1 LWYLVHNKNMRGPG-WLHGVMLRSA-N 0.000 claims 1
- -1 2-isopropylindolizin-3-yl Chemical group 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
- FVTMVKGVHFIRRA-UHFFFAOYSA-N [4-[3-(dibutylamino)propyl]phenyl]-(2-ethylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.C1=CC(CCCN(CCCC)CCCC)=CC=C1C(=O)C1=C(CC)C=C2N1C=CC=C2 FVTMVKGVHFIRRA-UHFFFAOYSA-N 0.000 claims 1
- HFTLTZBCUJWXGZ-UHFFFAOYSA-N [4-[3-(dibutylamino)propyl]phenyl]-(2-propylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.C1=CC(CCCN(CCCC)CCCC)=CC=C1C(=O)C1=C(CCC)C=C2N1C=CC=C2 HFTLTZBCUJWXGZ-UHFFFAOYSA-N 0.000 claims 1
- HUWKCTZUWUATIK-UHFFFAOYSA-N [4-[3-(diethylamino)propyl]phenyl]-(2-ethylindolizin-3-yl)methanone;oxalic acid Chemical compound OC(=O)C(O)=O.C1=CC(CCCN(CC)CC)=CC=C1C(=O)C1=C(CC)C=C2N1C=CC=C2 HUWKCTZUWUATIK-UHFFFAOYSA-N 0.000 claims 1
- XMCXDFCJUNZQLY-UHFFFAOYSA-N [4-[3-(diethylamino)propyl]phenyl]-(2-propylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.CCCC=1C=C2C=CC=CN2C=1C(=O)C1=CC=C(CCCN(CC)CC)C=C1 XMCXDFCJUNZQLY-UHFFFAOYSA-N 0.000 claims 1
- HBHFXEFKYQRTPQ-UHFFFAOYSA-N [4-[3-(dipropylamino)propyl]phenyl]-(2-ethylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.C1=CC(CCCN(CCC)CCC)=CC=C1C(=O)C1=C(CC)C=C2N1C=CC=C2 HBHFXEFKYQRTPQ-UHFFFAOYSA-N 0.000 claims 1
- GGZFCBXCDJSAAH-UHFFFAOYSA-N [4-[3-(dipropylamino)propyl]phenyl]-(2-methylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.C1=CC(CCCN(CCC)CCC)=CC=C1C(=O)C1=C(C)C=C2N1C=CC=C2 GGZFCBXCDJSAAH-UHFFFAOYSA-N 0.000 claims 1
- YBISRJRRQWWAQW-UHFFFAOYSA-N [4-[3-(dipropylamino)propyl]phenyl]-(2-propylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.C1=CC(CCCN(CCC)CCC)=CC=C1C(=O)C1=C(CCC)C=C2N1C=CC=C2 YBISRJRRQWWAQW-UHFFFAOYSA-N 0.000 claims 1
- DWTYPWQJVPSSLD-UHFFFAOYSA-N [4-[3-[bis(2-methoxyethyl)amino]propyl]phenyl]-(2-butylindolizin-3-yl)methanone;oxalic acid Chemical compound OC(=O)C(O)=O.CCCCC=1C=C2C=CC=CN2C=1C(=O)C1=CC=C(CCCN(CCOC)CCOC)C=C1 DWTYPWQJVPSSLD-UHFFFAOYSA-N 0.000 claims 1
- BNSPGBOQOJARJP-UHFFFAOYSA-N [4-[3-[butyl(ethyl)amino]propyl]phenyl]-(2-butylindolizin-3-yl)methanone;oxalic acid Chemical compound OC(=O)C(O)=O.C1=CC(CCCN(CC)CCCC)=CC=C1C(=O)C1=C(CCCC)C=C2N1C=CC=C2 BNSPGBOQOJARJP-UHFFFAOYSA-N 0.000 claims 1
- QQANJZJCAUKPSI-UHFFFAOYSA-N [4-[3-[ethyl(propyl)amino]propyl]phenyl]-(2-methylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.C1=CC(CCCN(CC)CCC)=CC=C1C(=O)C1=C(C)C=C2N1C=CC=C2 QQANJZJCAUKPSI-UHFFFAOYSA-N 0.000 claims 1
- QDBHUSLVHSCNDS-UHFFFAOYSA-N [4-[3-[ethyl(propyl)amino]propyl]phenyl]-(2-propan-2-ylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.C1=CC(CCCN(CC)CCC)=CC=C1C(=O)C1=C(C(C)C)C=C2N1C=CC=C2 QDBHUSLVHSCNDS-UHFFFAOYSA-N 0.000 claims 1
- BOEMUZIDTIGAIC-UHFFFAOYSA-N [4-[3-[ethyl(propyl)amino]propyl]phenyl]-(2-propylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.C1=CC(CCCN(CC)CCC)=CC=C1C(=O)C1=C(CCC)C=C2N1C=CC=C2 BOEMUZIDTIGAIC-UHFFFAOYSA-N 0.000 claims 1
- QXWIWTDMWOALLM-UHFFFAOYSA-N [4-[4-(dibutylamino)butyl]phenyl]-(2-ethylindolizin-3-yl)methanone;oxalic acid Chemical compound OC(=O)C(O)=O.C1=CC(CCCCN(CCCC)CCCC)=CC=C1C(=O)C1=C(CC)C=C2N1C=CC=C2 QXWIWTDMWOALLM-UHFFFAOYSA-N 0.000 claims 1
- XBRISISQGFESCE-UHFFFAOYSA-N [4-[4-(dibutylamino)butyl]phenyl]-(2-propylindolizin-3-yl)methanone;oxalic acid Chemical compound OC(=O)C(O)=O.C1=CC(CCCCN(CCCC)CCCC)=CC=C1C(=O)C1=C(CCC)C=C2N1C=CC=C2 XBRISISQGFESCE-UHFFFAOYSA-N 0.000 claims 1
- BTYQHUVRLUJFIV-UHFFFAOYSA-N [4-[4-(diethylamino)butyl]phenyl]-(2-ethylindolizin-3-yl)methanone;oxalic acid Chemical compound OC(=O)C(O)=O.C1=CC(CCCCN(CC)CC)=CC=C1C(=O)C1=C(CC)C=C2N1C=CC=C2 BTYQHUVRLUJFIV-UHFFFAOYSA-N 0.000 claims 1
- DFJITGQKHMFYNX-UHFFFAOYSA-N [4-[4-(diethylamino)butyl]phenyl]-(2-propylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.CCCC=1C=C2C=CC=CN2C=1C(=O)C1=CC=C(CCCCN(CC)CC)C=C1 DFJITGQKHMFYNX-UHFFFAOYSA-N 0.000 claims 1
- YVYSDISKYMFAIM-UHFFFAOYSA-N [4-[4-(dipropylamino)butyl]phenyl]-(2-ethylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.C1=CC(CCCCN(CCC)CCC)=CC=C1C(=O)C1=C(CC)C=C2N1C=CC=C2 YVYSDISKYMFAIM-UHFFFAOYSA-N 0.000 claims 1
- HFWMATXNAPKRIW-UHFFFAOYSA-N [4-[4-(dipropylamino)butyl]phenyl]-(2-methylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.C1=CC(CCCCN(CCC)CCC)=CC=C1C(=O)C1=C(C)C=C2N1C=CC=C2 HFWMATXNAPKRIW-UHFFFAOYSA-N 0.000 claims 1
- GVIUAECWEHCIQS-UHFFFAOYSA-N [4-[4-(dipropylamino)butyl]phenyl]-(2-propan-2-ylindolizin-3-yl)methanone;oxalic acid Chemical compound OC(=O)C(O)=O.C1=CC(CCCCN(CCC)CCC)=CC=C1C(=O)C1=C(C(C)C)C=C2N1C=CC=C2 GVIUAECWEHCIQS-UHFFFAOYSA-N 0.000 claims 1
- WXHSIVYHOXTBMU-UHFFFAOYSA-N [4-[4-(dipropylamino)butyl]phenyl]-(2-propylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.C1=CC(CCCCN(CCC)CCC)=CC=C1C(=O)C1=C(CCC)C=C2N1C=CC=C2 WXHSIVYHOXTBMU-UHFFFAOYSA-N 0.000 claims 1
- MDRRSGAQIYWMCQ-UHFFFAOYSA-N [4-[4-(propylamino)butyl]phenyl]-(2-propylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.C1=CC(CCCCNCCC)=CC=C1C(=O)C1=C(CCC)C=C2N1C=CC=C2 MDRRSGAQIYWMCQ-UHFFFAOYSA-N 0.000 claims 1
- KZHICXCKFDUEDE-UHFFFAOYSA-N [4-[4-[ethyl(propyl)amino]butyl]phenyl]-(2-methylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.C1=CC(CCCCN(CC)CCC)=CC=C1C(=O)C1=C(C)C=C2N1C=CC=C2 KZHICXCKFDUEDE-UHFFFAOYSA-N 0.000 claims 1
- FQMOGAZLIACAOG-UHFFFAOYSA-N [4-[4-[ethyl(propyl)amino]butyl]phenyl]-(2-propan-2-ylindolizin-3-yl)methanone;oxalic acid Chemical compound OC(=O)C(O)=O.C1=CC(CCCCN(CC)CCC)=CC=C1C(=O)C1=C(C(C)C)C=C2N1C=CC=C2 FQMOGAZLIACAOG-UHFFFAOYSA-N 0.000 claims 1
- RRRNQDUDUMFPTL-UHFFFAOYSA-N [4-[4-[ethyl(propyl)amino]butyl]phenyl]-(2-propylindolizin-3-yl)methanone;hydrochloride Chemical compound Cl.C1=CC(CCCCN(CC)CCC)=CC=C1C(=O)C1=C(CCC)C=C2N1C=CC=C2 RRRNQDUDUMFPTL-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 210000000748 cardiovascular system Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- WTDFFADXONGQOM-UHFFFAOYSA-N formaldehyde;hydrochloride Chemical compound Cl.O=C WTDFFADXONGQOM-UHFFFAOYSA-N 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0511849A FR2893616B1 (fr) | 2005-11-23 | 2005-11-23 | Nouveaux derives d'indolizine, leur procede de preparation et les compositions therapeutiques les comprenant |
PCT/FR2006/002551 WO2007060318A1 (fr) | 2005-11-23 | 2006-11-21 | Nouveaux derives d'indolizine, leur procede de preparation et les compositions therapeutiques les comprenant. |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20100158T1 true HRP20100158T1 (hr) | 2010-05-31 |
Family
ID=37027751
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20100158T HRP20100158T1 (hr) | 2005-11-23 | 2010-03-18 | Novi indolizinski derivati, postupak njihovog dobivanja i terapijski pripravci koji iz sadrže |
Country Status (34)
Country | Link |
---|---|
US (1) | US7799799B2 (da) |
EP (1) | EP1957490B1 (da) |
JP (1) | JP5372514B2 (da) |
KR (1) | KR101419066B1 (da) |
CN (1) | CN101312973B (da) |
AR (1) | AR058208A1 (da) |
AT (1) | ATE454386T1 (da) |
AU (1) | AU2006316381B2 (da) |
BR (1) | BRPI0618975A2 (da) |
CA (1) | CA2629738C (da) |
CR (1) | CR9927A (da) |
CY (1) | CY1110623T1 (da) |
DE (1) | DE602006011649D1 (da) |
DK (1) | DK1957490T3 (da) |
DO (1) | DOP2006000254A (da) |
EA (1) | EA014158B1 (da) |
EC (1) | ECSP088455A (da) |
ES (1) | ES2338922T3 (da) |
FR (1) | FR2893616B1 (da) |
GT (1) | GT200600489A (da) |
HK (1) | HK1126198A1 (da) |
HR (1) | HRP20100158T1 (da) |
IL (1) | IL190861A (da) |
MA (1) | MA30055B1 (da) |
NO (1) | NO20082589L (da) |
PE (1) | PE20071083A1 (da) |
PL (1) | PL1957490T3 (da) |
PT (1) | PT1957490E (da) |
SI (1) | SI1957490T1 (da) |
TN (1) | TNSN08162A1 (da) |
TW (1) | TW200738705A (da) |
UY (1) | UY29965A1 (da) |
WO (1) | WO2007060318A1 (da) |
ZA (1) | ZA200803565B (da) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2893616B1 (fr) | 2005-11-23 | 2008-01-04 | Sanofi Aventis Sa | Nouveaux derives d'indolizine, leur procede de preparation et les compositions therapeutiques les comprenant |
FR2962437B1 (fr) | 2010-07-06 | 2012-08-17 | Sanofi Aventis | Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique |
FR2962438B1 (fr) | 2010-07-06 | 2012-08-17 | Sanofi Aventis | Derives d'indolizines, procedes de preparation et application en therapeutique |
CN103360390B (zh) * | 2013-07-23 | 2015-06-17 | 东南大学 | 中氮茚甲酰甲基对甲磺酰胺苯乙胺衍生物及其医药用途 |
CN110156776A (zh) * | 2019-04-30 | 2019-08-23 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 一种c-3芳甲酰基吲嗪类化合物的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI61030C (fi) * | 1976-02-19 | 1982-05-10 | Sanofi Sa | Foerfarande foer framstaellning av terapeutiskt verkande 2-substituerade-1- eller 3-benzoyl-indolizinderivat |
FR2665444B1 (fr) * | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
US5334716A (en) * | 1991-06-17 | 1994-08-02 | Fujisawa Pharmaceutical Co., Ltd. | Heterocyclic derivatives |
US6593322B1 (en) * | 1999-03-17 | 2003-07-15 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
FR2813306B1 (fr) * | 2000-08-23 | 2005-10-21 | Sanofi Synthelabo | Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant |
FR2893616B1 (fr) | 2005-11-23 | 2008-01-04 | Sanofi Aventis Sa | Nouveaux derives d'indolizine, leur procede de preparation et les compositions therapeutiques les comprenant |
-
2005
- 2005-11-23 FR FR0511849A patent/FR2893616B1/fr not_active Expired - Fee Related
-
2006
- 2006-11-15 DO DO2006000254A patent/DOP2006000254A/es unknown
- 2006-11-20 PE PE2006001477A patent/PE20071083A1/es not_active Application Discontinuation
- 2006-11-20 GT GT200600489A patent/GT200600489A/es unknown
- 2006-11-21 EA EA200801400A patent/EA014158B1/ru not_active IP Right Cessation
- 2006-11-21 ES ES06831144T patent/ES2338922T3/es active Active
- 2006-11-21 PT PT06831144T patent/PT1957490E/pt unknown
- 2006-11-21 AU AU2006316381A patent/AU2006316381B2/en not_active Ceased
- 2006-11-21 SI SI200630601T patent/SI1957490T1/sl unknown
- 2006-11-21 AR ARP060105086A patent/AR058208A1/es not_active Application Discontinuation
- 2006-11-21 AT AT06831144T patent/ATE454386T1/de active
- 2006-11-21 DK DK06831144.8T patent/DK1957490T3/da active
- 2006-11-21 DE DE602006011649T patent/DE602006011649D1/de active Active
- 2006-11-21 BR BRPI0618975-0A patent/BRPI0618975A2/pt not_active IP Right Cessation
- 2006-11-21 CN CN2006800437271A patent/CN101312973B/zh not_active Expired - Fee Related
- 2006-11-21 TW TW095143038A patent/TW200738705A/zh unknown
- 2006-11-21 JP JP2008541787A patent/JP5372514B2/ja not_active Expired - Fee Related
- 2006-11-21 PL PL06831144T patent/PL1957490T3/pl unknown
- 2006-11-21 ZA ZA200803565A patent/ZA200803565B/xx unknown
- 2006-11-21 EP EP06831144A patent/EP1957490B1/fr active Active
- 2006-11-21 CA CA2629738A patent/CA2629738C/fr not_active Expired - Fee Related
- 2006-11-21 KR KR1020087012214A patent/KR101419066B1/ko not_active IP Right Cessation
- 2006-11-21 WO PCT/FR2006/002551 patent/WO2007060318A1/fr active Application Filing
- 2006-11-23 UY UY29965A patent/UY29965A1/es unknown
-
2008
- 2008-04-10 TN TNP2008000162A patent/TNSN08162A1/en unknown
- 2008-04-14 IL IL190861A patent/IL190861A/en not_active IP Right Cessation
- 2008-04-25 CR CR9927A patent/CR9927A/es not_active Application Discontinuation
- 2008-05-08 US US12/116,996 patent/US7799799B2/en not_active Expired - Fee Related
- 2008-05-16 EC EC2008008455A patent/ECSP088455A/es unknown
- 2008-06-10 NO NO20082589A patent/NO20082589L/no not_active Application Discontinuation
- 2008-06-16 MA MA31037A patent/MA30055B1/fr unknown
-
2009
- 2009-05-19 HK HK09104558.7A patent/HK1126198A1/xx not_active IP Right Cessation
-
2010
- 2010-03-18 HR HR20100158T patent/HRP20100158T1/hr unknown
- 2010-03-31 CY CY20101100303T patent/CY1110623T1/el unknown
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