HRP20090548T1 - Poboljšani postupak za pročišćavanje perindoprila - Google Patents
Poboljšani postupak za pročišćavanje perindoprila Download PDFInfo
- Publication number
- HRP20090548T1 HRP20090548T1 HR20090548T HRP20090548T HRP20090548T1 HR P20090548 T1 HRP20090548 T1 HR P20090548T1 HR 20090548 T HR20090548 T HR 20090548T HR P20090548 T HRP20090548 T HR P20090548T HR P20090548 T1 HRP20090548 T1 HR P20090548T1
- Authority
- HR
- Croatia
- Prior art keywords
- perindopril
- dicyclohexylamine
- salt
- compound
- formula
- Prior art date
Links
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title claims abstract 26
- 229960002582 perindopril Drugs 0.000 title claims abstract 25
- 238000000034 method Methods 0.000 title claims 8
- 238000000746 purification Methods 0.000 title claims 4
- XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical class C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 claims abstract 19
- 150000001875 compounds Chemical class 0.000 claims abstract 12
- 238000000634 powder X-ray diffraction Methods 0.000 claims abstract 2
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 9
- 239000002904 solvent Substances 0.000 claims 8
- 238000002955 isolation Methods 0.000 claims 5
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical class CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 238000002441 X-ray diffraction Methods 0.000 claims 2
- 239000012445 acidic reagent Substances 0.000 claims 2
- 239000012458 free base Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- HEWZVZIVELJPQZ-UHFFFAOYSA-N 2,2-dimethoxypropane Chemical compound COC(C)(C)OC HEWZVZIVELJPQZ-UHFFFAOYSA-N 0.000 claims 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 claims 1
- 150000001241 acetals Chemical class 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000001938 differential scanning calorimetry curve Methods 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 150000002825 nitriles Chemical class 0.000 claims 1
- 125000004971 nitroalkyl group Chemical group 0.000 claims 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 claims 1
- 238000001757 thermogravimetry curve Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN275MU2005 | 2005-03-14 | ||
PCT/IN2005/000189 WO2006097941A1 (en) | 2005-03-14 | 2005-06-09 | An improved process for the purification of perindopril |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20090548T1 true HRP20090548T1 (hr) | 2009-11-30 |
Family
ID=35840279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20090548T HRP20090548T1 (hr) | 2005-03-14 | 2009-10-14 | Poboljšani postupak za pročišćavanje perindoprila |
Country Status (18)
Country | Link |
---|---|
US (1) | US7728151B2 (de) |
EP (1) | EP1861367B1 (de) |
AU (1) | AU2005329237B2 (de) |
CA (1) | CA2601647C (de) |
CY (1) | CY1109432T1 (de) |
DE (1) | DE602005015492D1 (de) |
DK (1) | DK1861367T3 (de) |
EA (1) | EA012420B1 (de) |
ES (1) | ES2329923T3 (de) |
HR (1) | HRP20090548T1 (de) |
NO (1) | NO20075237L (de) |
NZ (1) | NZ561684A (de) |
PL (1) | PL1861367T3 (de) |
PT (1) | PT1861367E (de) |
RS (1) | RS51147B (de) |
SI (1) | SI1861367T1 (de) |
WO (1) | WO2006097941A1 (de) |
ZA (1) | ZA200708802B (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007020009A1 (en) * | 2005-08-12 | 2007-02-22 | Sandoz Ag | New crystalline form of perindopril erbumine |
SI22543A (sl) * | 2007-06-27 | 2008-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nove soli perindoprila |
GB0910692D0 (en) | 2009-06-20 | 2009-08-05 | Teva Pharma | Compound |
CN110944996A (zh) * | 2017-07-24 | 2020-03-31 | 因特奎姆私人控股公司 | 制备和纯化lfa-1拮抗剂立他司特的方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
FR2838648B1 (fr) * | 2002-04-18 | 2004-05-21 | Servier Lab | Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent |
DE60321233D1 (de) * | 2003-02-28 | 2008-07-03 | Servier S A Lab | Verfahren zur herstellung von perindopril |
US7445296B1 (en) * | 2006-07-24 | 2008-11-04 | Chosen Co., Ltd. | Bicycle hub having enhanced strength |
-
2005
- 2005-06-09 SI SI200530795T patent/SI1861367T1/sl unknown
- 2005-06-09 US US11/886,382 patent/US7728151B2/en not_active Expired - Fee Related
- 2005-06-09 EP EP05799448A patent/EP1861367B1/de active Active
- 2005-06-09 PL PL05799448T patent/PL1861367T3/pl unknown
- 2005-06-09 DE DE602005015492T patent/DE602005015492D1/de active Active
- 2005-06-09 PT PT05799448T patent/PT1861367E/pt unknown
- 2005-06-09 EA EA200701862A patent/EA012420B1/ru not_active IP Right Cessation
- 2005-06-09 DK DK05799448T patent/DK1861367T3/da active
- 2005-06-09 WO PCT/IN2005/000189 patent/WO2006097941A1/en active Application Filing
- 2005-06-09 NZ NZ561684A patent/NZ561684A/en not_active IP Right Cessation
- 2005-06-09 CA CA2601647A patent/CA2601647C/en not_active Expired - Fee Related
- 2005-06-09 ES ES05799448T patent/ES2329923T3/es active Active
- 2005-06-09 ZA ZA200708802A patent/ZA200708802B/xx unknown
- 2005-06-09 RS RSP-2009/0430A patent/RS51147B/sr unknown
- 2005-06-09 AU AU2005329237A patent/AU2005329237B2/en not_active Ceased
-
2007
- 2007-10-12 NO NO20075237A patent/NO20075237L/no unknown
-
2009
- 2009-09-24 CY CY20091100999T patent/CY1109432T1/el unknown
- 2009-10-14 HR HR20090548T patent/HRP20090548T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
AU2005329237A1 (en) | 2006-09-21 |
CA2601647C (en) | 2013-07-30 |
NZ561684A (en) | 2009-10-30 |
WO2006097941A1 (en) | 2006-09-21 |
EA200701862A1 (ru) | 2008-02-28 |
CY1109432T1 (el) | 2014-08-13 |
CA2601647A1 (en) | 2006-09-21 |
AU2005329237B2 (en) | 2011-09-01 |
PL1861367T3 (pl) | 2009-12-31 |
ZA200708802B (en) | 2009-01-28 |
RS51147B (sr) | 2010-10-31 |
EA012420B1 (ru) | 2009-10-30 |
ES2329923T3 (es) | 2009-12-02 |
DK1861367T3 (da) | 2009-11-02 |
EP1861367A1 (de) | 2007-12-05 |
PT1861367E (pt) | 2009-10-08 |
EP1861367B1 (de) | 2009-07-15 |
NO20075237L (no) | 2007-10-12 |
SI1861367T1 (sl) | 2009-12-31 |
US7728151B2 (en) | 2010-06-01 |
DE602005015492D1 (de) | 2009-08-27 |
US20080139823A1 (en) | 2008-06-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20170621T1 (hr) | Postupak za pripremanje derivata piperazinil i diazepanil benzamida | |
HRP20090548T1 (hr) | Poboljšani postupak za pročišćavanje perindoprila | |
HRP20090441T1 (en) | Process for the preparation of n-amino substituted heterocyclic compounds | |
Wang et al. | Synthesis of tetrazole containing 1, 2, 3-thiadiazole derivatives via U-4CR and their anti-TMV activity | |
Kong et al. | Synthesis of N-sulfonylamidines by catalyst-free hydroamination of ynamides and amines | |
CN104356110B (zh) | 一种硫诱导3,6‑芳香杂环不对称取代‑1,2,4,5‑四嗪化合物及其合成方法 | |
CN108610275A (zh) | 一种3-(2-氰基乙烯基)吲哚衍生物的合成方法 | |
WO2015018289A1 (zh) | 一种合成阿哌沙班重要中间体的新方法 | |
CN103724223A (zh) | 偶氮厚朴酚/和厚朴酚及硝化厚朴酚类衍生物及制备植物源杀虫剂的应用 | |
CN110511193A (zh) | 一种α-酮硫代酰胺类化合物及其合成方法 | |
AU2013366494A1 (en) | Spiroisoxazoline compounds having an activity potentiating the activity of an antibiotic | |
CN104418784B (zh) | 一种抗病毒药物中间体的拆分方法 | |
CN102659658A (zh) | 一种高度官能化的吡咯类化合物的合成方法 | |
Osuna et al. | Asymmetric synthesis of amathamides A and B: novel alkaloids isolated from Amathia wilsoni | |
Pan et al. | Palladium-catalyzed three-component reaction of 2-alkynylbromobenzene, 2-alkynylaniline, and electrophile: an efficient pathway for the synthesis of diverse 11 H-indeno [1, 2-c] quinolines | |
HRP20010759A2 (en) | Novel synthesis of piperazine ring | |
CN100546969C (zh) | 拆分2-羟甲基-3-苯基丙酸光学异构体的方法 | |
CN103965203B (zh) | 一类咪唑[1,2-c]-喹唑啉-3(2H)-酮稠杂环化合物及其制备方法 | |
JP5864107B2 (ja) | 新規な抗癌剤としてのパルテニンのスピロ誘導体 | |
Srinivas et al. | Synthesis and characterization of novel and potential impurities of Darifenacin, a potent muscarinic m3 receptor antagonist | |
Padmavathi et al. | E, E-Bis (styryl) sulfones—Synthons for a new class of bis (heterocycles). | |
CN107056635B (zh) | 一种炔酰胺类化合物的合成方法 | |
GB0229688D0 (en) | Solid-phase preparation of [18F] Fluorohaloalkanes | |
CN109956973A (zh) | 一种放射性同位素碳-14标记毒氟磷的合成方法 | |
Skerlj et al. | Facile synthesis of a selectively protected triazamacrocycle |