HRP20080119T5 - Derivati benzotiadizina, postupak njihove priprave i farmaceutske smjese koje ih sadrže - Google Patents
Derivati benzotiadizina, postupak njihove priprave i farmaceutske smjese koje ih sadržeInfo
- Publication number
- HRP20080119T5 HRP20080119T5 HR20080119T HRP20080119T HRP20080119T5 HR P20080119 T5 HRP20080119 T5 HR P20080119T5 HR 20080119 T HR20080119 T HR 20080119T HR P20080119 T HRP20080119 T HR P20080119T HR P20080119 T5 HRP20080119 T5 HR P20080119T5
- Authority
- HR
- Croatia
- Prior art keywords
- straight
- branched
- group
- branched alkyl
- same
- Prior art date
Links
- 150000007658 benzothiadiazines Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 1
- -1 (trifluoromethylsulfonyl) amino Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 101100134929 Gallus gallus COR9 gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000006684 polyhaloalkyl group Polymers 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
Spojevi formule (I): naznačeni time, da: R1 predstavlja skupinu ravni ili razgranani alkil (C1-C6) supstituiranu s jednim ili više atoma halogena, R2 predstavlja atom vodika ili halogena ili skupinu hidroksi, R3 predstavlja nesupstituiranu arilnu skupinu ili arilnu skupinu supstituiranu s jednom ili više skupina, koje mogu biti jednake ili različite, a odabrane su između: ravni ili razgranani alkil (C1-C6); ravni ili razgranani alkoksi (C1-C6); ravni ili razgranani polihaloalkil (C1-C6); atom halogena; ravni ili razgranani alkoksikarbonil (C1-C6); ravni ili razgranani alkiltio (C1-C6); karboksi; ravni ili razgranani acil (C1-C6); ravni ili razgranani polihaloalkoksi (C1-C6); hidroksi; cijano; nitro; amidino (po izboru supstituiran s jednomili dvije skupine, koje mogu biti jednake ili različite, a odabrane su između ravni ili razgranani alkil (C1-C6), hidroksi, ravni ili razgranani alkoksi (C1-C6) i );amino (po izboru susptituiran s jednom ili dvije skupine ravni ili razgranani alkil (C1-C6)); aminokarbonil (po izboru supstituiran s jednom ili dvije skupine ravni ili razgranani alkil (C1-C6); benziloksi; (C1-C6)alkilsulfonilamino (po izboru supstituiran na dušiku skupinom ravni ili razgranani (C1-C6); (trifluorometilsulfonil)amino; heterociklička skupina; i ravni ili razgranani alkil (C1-C6) supstituiran, s jedne strane, s jednom ili više skupina, koje mogu biti jednake ili različite, a odabrane su između atoma vodika ili halogena i skupine ravni ili razgranani alkil (C1-C6), i s druge strane, supstituiran skupinom odabranom između NR4R5, S(O)nR6, OR7, amidino (po izboru susptituiran s jednom ili dvije skupine koje mogu biti jednake ili različite, a odabrane su između ravni ili razgranani alkil (C1-C6), hidroksi, ravni ili razgranani alkoksi (C1-C6) i);i hidrocikličke skupine, u kojima: R4 predstavlja atom vodika ili skupinu ravni ili razgranani alkil (C1-C6), S(O)pR8, COR9 ili P(O)(OR10)(OR11),R5 predstavlja atom vodika ili skupinu ravni ili razgranani alkil (C1-C6), iliR4 i R5, zajedno s atomom dušika na kojem se nalaze, heterocikličku skupinu, R6, R8, R9, R10,R11 i R12, koji mogu biti jednaki ili različiti, a svaki predstavlja atom vodika ili skupinu ravni ili razgranani alkil (C1-C6), po izboru supstituiran s jednim ili više atoma halogena; skupinu ravniili razgranani arilalkil (C1-C6); ili arilnu skupinu, R7 predstavlja skupinu ravni ili razgranani alkil (C1-C6) ili skupinu ravni ili razgranani acil(C1-C6),n i p, koji mogu biti jednaki ili različiti, svaki označava 0, 1 ili 2, njihovi enantiomerii dijastereoizomeri, kao i njihove adicijske solis farmaceutski prihvatljivom kiselinom ili bazom.Patent sadrži još 10 patentnih zahtjeva.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0411690A FR2877338B1 (fr) | 2004-11-03 | 2004-11-03 | Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20080119T3 HRP20080119T3 (hr) | 2008-04-30 |
HRP20080119T5 true HRP20080119T5 (hr) | 2008-10-31 |
Family
ID=34950935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20080119T HRP20080119T5 (hr) | 2004-11-03 | 2008-03-19 | Derivati benzotiadizina, postupak njihove priprave i farmaceutske smjese koje ih sadrže |
Country Status (26)
Country | Link |
---|---|
US (2) | US7268130B2 (hr) |
EP (1) | EP1655030B1 (hr) |
JP (1) | JP2006151972A (hr) |
KR (1) | KR100818431B1 (hr) |
CN (1) | CN100396673C (hr) |
AR (1) | AR051149A1 (hr) |
AT (1) | ATE381338T1 (hr) |
AU (1) | AU2005229698A1 (hr) |
BR (1) | BRPI0504780A (hr) |
CA (1) | CA2524859A1 (hr) |
DE (1) | DE602005003907D1 (hr) |
DK (1) | DK1655030T3 (hr) |
EA (1) | EA011212B1 (hr) |
ES (1) | ES2298970T3 (hr) |
FR (1) | FR2877338B1 (hr) |
GE (1) | GEP20074256B (hr) |
HR (1) | HRP20080119T5 (hr) |
MA (1) | MA27917A1 (hr) |
MX (1) | MXPA05011820A (hr) |
NO (1) | NO20055167L (hr) |
NZ (1) | NZ543358A (hr) |
PL (1) | PL1655030T3 (hr) |
PT (1) | PT1655030E (hr) |
SG (1) | SG121999A1 (hr) |
SI (1) | SI1655030T1 (hr) |
ZA (1) | ZA200508911B (hr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2005280058B2 (en) * | 2004-08-25 | 2010-09-02 | Essentialis, Inc. | Pharmaceutical formulations of potassium ATP channel openers and uses thereof |
US7799777B2 (en) | 2006-01-05 | 2010-09-21 | Essentialis, Inc. | Salts of potassium ATP channel openers and uses thereof |
JP2010532383A (ja) * | 2007-07-02 | 2010-10-07 | エッセンシャリス,インク. | カリウムatpチャネル開口薬の塩およびその使用 |
US8124793B2 (en) * | 2007-11-27 | 2012-02-28 | Gail Marie Cronyn, legal representative | Derivatives of ethylene methanedisulfonate as cancer chemotherapeutic agents |
FR2943342B1 (fr) | 2009-03-20 | 2011-03-04 | Servier Lab | Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
US20120100229A1 (en) * | 2009-03-27 | 2012-04-26 | Yale University | Treatment and Prevention of White Matter Injury with KATP Channel Activators |
FR2955106B1 (fr) * | 2010-01-08 | 2011-12-23 | Servier Lab | Nouveaux derives de benzothiadiazines cyclopropylees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
KR101633632B1 (ko) | 2015-09-30 | 2016-06-27 | 김동용 | 방사능 차폐재 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2722502B1 (fr) | 1994-07-12 | 1996-08-23 | Adir | Nouveau derive de benzothiadiazine, son procede depreparation et les compositions pharmaceutiques qui le contiennent |
AU4345297A (en) * | 1996-09-17 | 1998-04-14 | Regents Of The University Of California, The | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
EE200000468A (et) | 1998-02-18 | 2002-04-15 | Neurosearch A/S | Ühendid, nende kasutamine ja farmatseutiline kompositsioon |
FR2801587B1 (fr) * | 1999-11-30 | 2002-01-11 | Adir | Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2833950B1 (fr) * | 2001-12-21 | 2005-12-16 | Servier Lab | Nouveaux derives de benzothiazine et de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2833956B1 (fr) * | 2001-12-21 | 2004-01-30 | Servier Lab | Nouveaux derives de benzothiazine et de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2004
- 2004-11-03 FR FR0411690A patent/FR2877338B1/fr not_active Expired - Fee Related
-
2005
- 2005-10-17 SG SG200506773A patent/SG121999A1/en unknown
- 2005-10-17 MA MA28554A patent/MA27917A1/fr unknown
- 2005-10-28 EA EA200501530A patent/EA011212B1/ru not_active IP Right Cessation
- 2005-10-31 CA CA002524859A patent/CA2524859A1/fr not_active Abandoned
- 2005-11-01 BR BRPI0504780-3A patent/BRPI0504780A/pt not_active IP Right Cessation
- 2005-11-02 US US11/265,011 patent/US7268130B2/en not_active Expired - Fee Related
- 2005-11-02 AR ARP050104582A patent/AR051149A1/es unknown
- 2005-11-02 ES ES05292310T patent/ES2298970T3/es active Active
- 2005-11-02 EP EP05292310A patent/EP1655030B1/fr active Active
- 2005-11-02 PL PL05292310T patent/PL1655030T3/pl unknown
- 2005-11-02 DK DK05292310T patent/DK1655030T3/da active
- 2005-11-02 SI SI200530159T patent/SI1655030T1/sl unknown
- 2005-11-02 KR KR1020050104300A patent/KR100818431B1/ko not_active IP Right Cessation
- 2005-11-02 DE DE602005003907T patent/DE602005003907D1/de active Active
- 2005-11-02 GE GEAP20059036A patent/GEP20074256B/en unknown
- 2005-11-02 NZ NZ543358A patent/NZ543358A/en unknown
- 2005-11-02 AT AT05292310T patent/ATE381338T1/de not_active IP Right Cessation
- 2005-11-02 PT PT05292310T patent/PT1655030E/pt unknown
- 2005-11-03 MX MXPA05011820A patent/MXPA05011820A/es unknown
- 2005-11-03 AU AU2005229698A patent/AU2005229698A1/en not_active Abandoned
- 2005-11-03 NO NO20055167A patent/NO20055167L/no not_active Application Discontinuation
- 2005-11-03 ZA ZA200508911A patent/ZA200508911B/en unknown
- 2005-11-03 CN CNB2005101316002A patent/CN100396673C/zh not_active Expired - Fee Related
- 2005-11-04 JP JP2005320478A patent/JP2006151972A/ja active Pending
-
2007
- 2007-07-27 US US11/881,438 patent/US20070270415A1/en not_active Abandoned
-
2008
- 2008-03-19 HR HR20080119T patent/HRP20080119T5/hr unknown
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