HRP20070436A2 - Tricyclic-nucleoside prodrugs for treating viral infections - Google Patents

Tricyclic-nucleoside prodrugs for treating viral infections

Info

Publication number
HRP20070436A2
HRP20070436A2 HR20070436A HRP20070436A HRP20070436A2 HR P20070436 A2 HRP20070436 A2 HR P20070436A2 HR 20070436 A HR20070436 A HR 20070436A HR P20070436 A HRP20070436 A HR P20070436A HR P20070436 A2 HRP20070436 A2 HR P20070436A2
Authority
HR
Croatia
Prior art keywords
viral infections
tricyclic
treating viral
nucleoside prodrugs
nucleoside
Prior art date
Application number
HR20070436A
Other languages
English (en)
Croatian (hr)
Inventor
D. Keicher Jesse
Don Roberts Christopher
Original Assignee
Genelabs Technologies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genelabs Technologies filed Critical Genelabs Technologies
Publication of HRP20070436A2 publication Critical patent/HRP20070436A2/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16Peri-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/22Pteridine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR20070436A 2005-02-28 2007-09-24 Tricyclic-nucleoside prodrugs for treating viral infections HRP20070436A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65746305P 2005-02-28 2005-02-28
PCT/US2006/007131 WO2006093986A1 (en) 2005-02-28 2006-02-28 Tricyclic-nucleoside prodrugs for treating viral infections

Publications (1)

Publication Number Publication Date
HRP20070436A2 true HRP20070436A2 (en) 2008-02-29

Family

ID=36570903

Family Applications (2)

Application Number Title Priority Date Filing Date
HR20070436A HRP20070436A2 (en) 2005-02-28 2007-09-24 Tricyclic-nucleoside prodrugs for treating viral infections
HR20070435A HRP20070435A9 (en) 2005-02-28 2007-09-24 Tricyclic-nucleoside compounds for treating viral infections

Family Applications After (1)

Application Number Title Priority Date Filing Date
HR20070435A HRP20070435A9 (en) 2005-02-28 2007-09-24 Tricyclic-nucleoside compounds for treating viral infections

Country Status (18)

Country Link
US (4) US7524825B2 (es)
EP (2) EP1853617A1 (es)
JP (2) JP2008531704A (es)
KR (2) KR20070106767A (es)
CN (2) CN101128474A (es)
AP (2) AP2007004128A0 (es)
AR (1) AR058419A1 (es)
AU (2) AU2006218705A1 (es)
BR (2) BRPI0607769A2 (es)
CA (2) CA2597685A1 (es)
EA (2) EA200701850A1 (es)
HR (2) HRP20070436A2 (es)
IL (2) IL184954A0 (es)
MX (2) MX2007010463A (es)
NO (2) NO20074613L (es)
TW (1) TW200640474A (es)
WO (2) WO2006093986A1 (es)
ZA (1) ZA200707410B (es)

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UY33311A (es) 2010-03-31 2011-10-31 Pharmasset Inc Fosforamidatos de nucleosidos
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US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
CN102917585A (zh) 2010-04-01 2013-02-06 埃迪尼克斯医药公司 用于治疗病毒感染的化合物和药物组合物
US8841275B2 (en) 2010-11-30 2014-09-23 Gilead Pharmasset Llc 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
CA2843324A1 (en) 2011-03-31 2012-11-15 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
US20140113958A1 (en) 2011-06-30 2014-04-24 Stella Aps HCV Combination Therapy
WO2013033093A1 (en) * 2011-08-29 2013-03-07 Biocryst Pharmaceuticals, Inc. Heterocyclic compounds as janus kinase inhibitors
EP2755983B1 (en) 2011-09-12 2017-03-15 Idenix Pharmaceuticals LLC. Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
SI2709613T2 (sl) 2011-09-16 2020-12-31 Gilead Pharmasset LLC c/o Gilead Sciences, Inc. Postopki za zdravljenje HCV
US8507460B2 (en) 2011-10-14 2013-08-13 Idenix Pharmaceuticals, Inc. Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
EP2639238A1 (en) * 2012-03-15 2013-09-18 Universität Bern Tricyclic nucleosides and oligomeric compounds prepared therefrom
AR090699A1 (es) * 2012-04-18 2014-12-03 Biocryst Pharm Inc Compuestos inhibidores de la actividad de la arn polimerasa viral
US9109001B2 (en) 2012-05-22 2015-08-18 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphoramidate prodrugs for HCV infection
WO2013177195A1 (en) 2012-05-22 2013-11-28 Idenix Pharmaceuticals, Inc. 3',5'-cyclic phosphate prodrugs for hcv infection
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US10723754B2 (en) 2012-10-22 2020-07-28 Idenix Pharmaceuticals Llc 2′,4′-bridged nucleosides for HCV infection
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SG11201506021XA (en) 2013-01-31 2015-08-28 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
US9339541B2 (en) 2013-03-04 2016-05-17 Merck Sharp & Dohme Corp. Thiophosphate nucleosides for the treatment of HCV
US9309275B2 (en) 2013-03-04 2016-04-12 Idenix Pharmaceuticals Llc 3′-deoxy nucleosides for the treatment of HCV
EP2970357A1 (en) 2013-03-13 2016-01-20 IDENIX Pharmaceuticals, Inc. Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
WO2014165542A1 (en) 2013-04-01 2014-10-09 Idenix Pharmaceuticals, Inc. 2',4'-fluoro nucleosides for the treatment of hcv
EP3004130B1 (en) 2013-06-05 2019-08-07 Idenix Pharmaceuticals LLC. 1',4'-thio nucleosides for the treatment of hcv
US20150037282A1 (en) 2013-08-01 2015-02-05 Idenix Pharmaceuticals, Inc. D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
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Also Published As

Publication number Publication date
US20060194749A1 (en) 2006-08-31
HRP20070435A2 (en) 2008-02-29
ZA200707410B (en) 2008-10-29
WO2006093986A1 (en) 2006-09-08
AU2006218704A1 (en) 2006-09-08
TW200640474A (en) 2006-12-01
US7524825B2 (en) 2009-04-28
JP2008531704A (ja) 2008-08-14
AP2007004128A0 (en) 2007-08-31
BRPI0607769A2 (pt) 2009-10-06
BRPI0607770A2 (pt) 2009-06-13
KR20070106767A (ko) 2007-11-05
EP1853618A1 (en) 2007-11-14
AU2006218705A1 (en) 2006-09-08
HRP20070435A9 (en) 2008-09-30
MX2007010460A (es) 2007-11-08
EA200701849A1 (ru) 2008-02-28
MX2007010463A (es) 2007-11-08
AP2007004118A0 (en) 2007-08-31
NO20074915L (no) 2007-11-20
CA2597683A1 (en) 2006-09-08
CN101128474A (zh) 2008-02-20
NO20074613L (no) 2007-11-27
CN101142226A (zh) 2008-03-12
IL184954A0 (en) 2007-12-03
EP1853617A1 (en) 2007-11-14
AR058419A1 (es) 2008-02-06
US7534771B2 (en) 2009-05-19
KR20070106781A (ko) 2007-11-05
CA2597685A1 (en) 2006-09-08
JP2008531703A (ja) 2008-08-14
US20090208457A1 (en) 2009-08-20
IL184955A0 (en) 2007-12-03
WO2006093987A1 (en) 2006-09-08
US20060252715A1 (en) 2006-11-09
EA200701850A1 (ru) 2008-02-28
US20090253648A1 (en) 2009-10-08

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