HRP20070062T3 - Formulacija otopine eritropoetina - Google Patents
Formulacija otopine eritropoetinaInfo
- Publication number
- HRP20070062T3 HRP20070062T3 HR20070062T HRP20070062T HRP20070062T3 HR P20070062 T3 HRP20070062 T3 HR P20070062T3 HR 20070062 T HR20070062 T HR 20070062T HR P20070062 T HRP20070062 T HR P20070062T HR P20070062 T3 HRP20070062 T3 HR P20070062T3
- Authority
- HR
- Croatia
- Prior art keywords
- solution formulation
- erythropoietin solution
- erythropoietin
- formulation
- aminomethane
- Prior art date
Links
- 102000003951 Erythropoietin Human genes 0.000 title abstract 2
- 108090000394 Erythropoietin Proteins 0.000 title abstract 2
- 229940105423 erythropoietin Drugs 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title abstract 2
- 102000008100 Human Serum Albumin Human genes 0.000 abstract 1
- 108091006905 Human Serum Albumin Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Stabilna farmaceutska formulacija eritropoetina naznačena time, da sadrži tris-(hidroksimetil)-aminometan kao stabilizator, pri čemu formulacija ne sadrži aminokiseline ili ljudski serumski albumin. Patent sadrži još 11 patentnih zahtjeva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03027460A EP1537876A1 (en) | 2003-12-01 | 2003-12-01 | Erythropoietin solution formulation |
| PCT/EP2004/013619 WO2005053745A1 (en) | 2003-12-01 | 2004-12-01 | Erythropoietin solution formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20070062T3 true HRP20070062T3 (hr) | 2008-05-31 |
Family
ID=34442909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20070062T HRP20070062T3 (hr) | 2003-12-01 | 2007-02-19 | Formulacija otopine eritropoetina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7468351B2 (hr) |
| EP (2) | EP1537876A1 (hr) |
| AT (1) | ATE355081T1 (hr) |
| AU (1) | AU2004294289B2 (hr) |
| BR (1) | BRPI0416679B8 (hr) |
| CA (1) | CA2545880C (hr) |
| DE (1) | DE602004005072T2 (hr) |
| DK (1) | DK1689437T3 (hr) |
| ES (1) | ES2280057T3 (hr) |
| HR (1) | HRP20070062T3 (hr) |
| NZ (1) | NZ546451A (hr) |
| PL (1) | PL1689437T3 (hr) |
| PT (1) | PT1689437E (hr) |
| RU (1) | RU2362581C2 (hr) |
| SI (1) | SI1689437T1 (hr) |
| WO (1) | WO2005053745A1 (hr) |
| ZA (1) | ZA200602340B (hr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2480569B1 (en) | 2009-09-23 | 2016-04-13 | ratiopharm GmbH | Process for the purification of recombinant human erythropoietin (epo) |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5978124A (ja) * | 1982-10-28 | 1984-05-04 | Green Cross Corp:The | エリスロポエチンの製法 |
| JPS6197229A (ja) * | 1984-10-18 | 1986-05-15 | Chugai Pharmaceut Co Ltd | 安定なエリトロポエチン製剤 |
| DE3729863A1 (de) * | 1987-09-05 | 1989-03-16 | Boehringer Mannheim Gmbh | Stabilisierte erythropoietin-lyophilisate |
| GB8822857D0 (en) * | 1988-09-29 | 1988-11-02 | Patralan Ltd | Pharmaceutical formulations |
| GB9001987D0 (en) * | 1990-01-29 | 1990-03-28 | Janssen Pharmaceutica Nv | Improved cyclodextrin based erythropietin formulation |
| DE4014654A1 (de) * | 1990-05-08 | 1991-11-14 | Behringwerke Ag | Galenische waessrige formulierungen von erythropoietin und ihre verwendung |
| TW518219B (en) * | 1996-04-26 | 2003-01-21 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
| ES2224299T3 (es) * | 1998-02-23 | 2005-03-01 | Cilag Ag International | Dispersion liposomal de eritroyetina. |
| DE69915204T2 (de) * | 1998-08-17 | 2004-07-29 | Pfizer Products Inc., Groton | Stabilisierte Proteinzusammensetzung |
| US6979442B1 (en) * | 1998-08-17 | 2005-12-27 | Pfizer Inc. | Stabilized protein compositions |
| US20040022861A1 (en) * | 2001-01-30 | 2004-02-05 | Williams Robert O. | Process for production of nanoparticles and microparticles by spray freezing into liquid |
| US6818613B2 (en) * | 2001-11-07 | 2004-11-16 | Ortho-Mcneil Pharmaceutical, Inc. | Aqueous sustained-release formulations of proteins |
| DE10161577B4 (de) * | 2001-12-14 | 2008-01-10 | Scil Proteins Gmbh | Verfahren zur Renaturierung von Proteinen |
-
2003
- 2003-12-01 EP EP03027460A patent/EP1537876A1/en not_active Withdrawn
-
2004
- 2004-12-01 WO PCT/EP2004/013619 patent/WO2005053745A1/en active IP Right Grant
- 2004-12-01 DK DK04803390T patent/DK1689437T3/da active
- 2004-12-01 AU AU2004294289A patent/AU2004294289B2/en active Active
- 2004-12-01 ES ES04803390T patent/ES2280057T3/es active Active
- 2004-12-01 RU RU2006123317/15A patent/RU2362581C2/ru active
- 2004-12-01 US US10/581,269 patent/US7468351B2/en active Active
- 2004-12-01 EP EP04803390A patent/EP1689437B1/en active Active
- 2004-12-01 DE DE602004005072T patent/DE602004005072T2/de active Active
- 2004-12-01 NZ NZ546451A patent/NZ546451A/en unknown
- 2004-12-01 PL PL04803390T patent/PL1689437T3/pl unknown
- 2004-12-01 BR BRPI0416679A patent/BRPI0416679B8/pt active IP Right Grant
- 2004-12-01 CA CA2545880A patent/CA2545880C/en active Active
- 2004-12-01 PT PT04803390T patent/PT1689437E/pt unknown
- 2004-12-01 SI SI200430243T patent/SI1689437T1/sl unknown
- 2004-12-01 AT AT04803390T patent/ATE355081T1/de active
-
2006
- 2006-03-22 ZA ZA200602340A patent/ZA200602340B/xx unknown
-
2007
- 2007-02-19 HR HR20070062T patent/HRP20070062T3/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE355081T1 (de) | 2006-03-15 |
| NZ546451A (en) | 2008-08-29 |
| RU2006123317A (ru) | 2008-01-20 |
| AU2004294289A1 (en) | 2005-06-16 |
| CA2545880A1 (en) | 2005-06-16 |
| DE602004005072D1 (de) | 2007-04-12 |
| RU2362581C2 (ru) | 2009-07-27 |
| BRPI0416679A (pt) | 2007-02-13 |
| EP1537876A1 (en) | 2005-06-08 |
| EP1689437A1 (en) | 2006-08-16 |
| PT1689437E (pt) | 2007-03-30 |
| DK1689437T3 (da) | 2007-05-21 |
| BRPI0416679B1 (pt) | 2018-02-06 |
| CA2545880C (en) | 2011-08-30 |
| US20070128231A1 (en) | 2007-06-07 |
| EP1689437B1 (en) | 2007-02-28 |
| AU2004294289B2 (en) | 2010-07-22 |
| US7468351B2 (en) | 2008-12-23 |
| SI1689437T1 (sl) | 2007-06-30 |
| WO2005053745A1 (en) | 2005-06-16 |
| DE602004005072T2 (de) | 2007-06-21 |
| BRPI0416679B8 (pt) | 2021-05-25 |
| PL1689437T3 (pl) | 2007-06-29 |
| ZA200602340B (en) | 2007-08-29 |
| ES2280057T3 (es) | 2007-09-01 |
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