HRP20050689A2 - 4-aminopyrimidine-5-one - Google Patents
4-aminopyrimidine-5-oneInfo
- Publication number
- HRP20050689A2 HRP20050689A2 HR20050689A HRP20050689A HRP20050689A2 HR P20050689 A2 HRP20050689 A2 HR P20050689A2 HR 20050689 A HR20050689 A HR 20050689A HR P20050689 A HRP20050689 A HR P20050689A HR P20050689 A2 HRP20050689 A2 HR P20050689A2
- Authority
- HR
- Croatia
- Prior art keywords
- compounds
- dependent kinase
- cyclin
- cancer
- formula
- Prior art date
Links
- WYPGFVLAEWKLCO-UHFFFAOYSA-N 4-amino-4h-pyrimidin-5-one Chemical compound NC1N=CN=CC1=O WYPGFVLAEWKLCO-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 102000003903 Cyclin-dependent kinases Human genes 0.000 abstract 3
- 108090000266 Cyclin-dependent kinases Proteins 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 2
- 102000013701 Cyclin-Dependent Kinase 4 Human genes 0.000 abstract 1
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44627303P | 2003-02-10 | 2003-02-10 | |
| US51492603P | 2003-10-28 | 2003-10-28 | |
| PCT/EP2004/000971 WO2004069139A2 (en) | 2003-02-10 | 2004-02-03 | 4-aminopyrimidin-5-yl-methanone derivatives for inhibition of cdk4 activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20050689A2 true HRP20050689A2 (en) | 2006-08-31 |
Family
ID=32853425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20050689A HRP20050689A2 (en) | 2003-02-10 | 2005-08-01 | 4-aminopyrimidine-5-one |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7157455B2 (xx) |
| EP (1) | EP1628619A2 (xx) |
| JP (1) | JP2006523183A (xx) |
| KR (1) | KR100717099B1 (xx) |
| AR (1) | AR043693A1 (xx) |
| AU (1) | AU2004210408A1 (xx) |
| BR (1) | BRPI0407381A (xx) |
| CA (1) | CA2512915A1 (xx) |
| CL (1) | CL2004000226A1 (xx) |
| EA (1) | EA009412B1 (xx) |
| EC (1) | ECSP055958A (xx) |
| HR (1) | HRP20050689A2 (xx) |
| IL (1) | IL169626A0 (xx) |
| MA (1) | MA27716A1 (xx) |
| MX (1) | MXPA05008333A (xx) |
| MY (1) | MY137555A (xx) |
| NO (1) | NO20053410L (xx) |
| PL (1) | PL382309A1 (xx) |
| RS (1) | RS20050610A (xx) |
| TN (1) | TNSN05188A1 (xx) |
| TW (1) | TWI293881B (xx) |
| WO (1) | WO2004069139A2 (xx) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7211576B2 (en) * | 2004-04-20 | 2007-05-01 | Hoffmann-La Roche Inc. | Diaminothiazoles |
| US7405220B2 (en) | 2004-06-09 | 2008-07-29 | Hoffmann-La Roche Inc. | Pyrazolopyrimidines |
| ES2313556T3 (es) * | 2005-05-25 | 2009-03-01 | F. Hoffmann-La Roche Ag | Biomarcador para el control de la respuesta de los inhibidores de la cdk en la clinica. |
| US7705009B2 (en) * | 2005-11-22 | 2010-04-27 | Hoffman-La Roche Inc. | 4-aminopyrimidine-5-thione derivatives |
| BRPI0619236A2 (pt) | 2005-12-01 | 2011-09-20 | Hoffmann La Roche | derivados de 2,4,5-trifenil imidazolina, composição farmacêutica que os compreende, uso e processo para a sìntese dos mesmos |
| WO2007113005A2 (en) * | 2006-04-03 | 2007-10-11 | European Molecular Biology Laboratory (Embl) | 2-substituted 3-aminosulfonyl-thiophene derivatives as aurora kinase inhibitors |
| EP2343974A4 (en) | 2008-08-15 | 2015-07-15 | Univ Georgetown | SODIUM CHANNELS, DISEASE, AND ASSAYS AND RELATED COMPOSITIONS |
| US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| HUE045748T2 (hu) * | 2014-07-01 | 2020-01-28 | Millennium Pharm Inc | Heteroaril vegyületek mint SUMO aktiváló enzimek inhibitorai |
| CN113924293B (zh) | 2019-06-06 | 2024-07-09 | 北京泰德制药股份有限公司 | P2x3和/或p2x2/3受体拮抗剂、包含其的药物组合物及其用途 |
| EP4289835A4 (en) * | 2021-02-05 | 2024-08-28 | Shanghai Qilu Pharmaceutical Res And Development Centre Ltd | CDK INHIBITORS |
| WO2024063670A1 (ru) * | 2022-09-22 | 2024-03-28 | Акционерное общество "БИОКАД" | Ингибиторы циклинзависимой киназы 7 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9012592D0 (en) | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
| WO1998033798A2 (en) * | 1997-02-05 | 1998-08-06 | Warner Lambert Company | Pyrido[2,3-d]pyrimidines and 4-amino-pyrimidines as inhibitors of cell proliferation |
| SK5212000A3 (en) | 1997-10-27 | 2001-04-09 | Agouron Pharmaceuticals Inc Ag | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases |
| US6262096B1 (en) * | 1997-11-12 | 2001-07-17 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
| EA200000840A1 (ru) | 1998-02-17 | 2001-02-26 | Туларик, Инк. | Антивирусные производные пиримидина |
| AU5438299A (en) | 1998-08-29 | 2000-03-21 | Astrazeneca Ab | Pyrimidine compounds |
| GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| MXPA02001108A (es) | 1999-09-15 | 2002-08-20 | Warner Lambert Co | Pieridinonas como inhibidores de la cinasa. |
| CA2386955A1 (en) | 1999-11-22 | 2001-05-31 | Warner-Lambert Company | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes |
| PE20011066A1 (es) * | 2000-01-25 | 2001-10-22 | Warner Lambert Co | PIRIDO [2,3-d] PIRIMIDIN-2,7-DIAMINAS INHIBIDORES DE CINASAS |
| SK10772002A3 (sk) * | 2000-01-27 | 2004-01-08 | Warner-Lambert Company | Pyridopyrimidinónové deriváty na liečbu neurodegeneratívnych ochorení |
| GB0004886D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| JP2004501083A (ja) | 2000-04-18 | 2004-01-15 | アゴーロン・ファーマシューティカルズ・インコーポレイテッド | プロテインキナーゼを阻害するためのピラゾール |
| JP4105948B2 (ja) | 2000-09-15 | 2008-06-25 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼインヒビターとして有用なピラゾール化合物 |
| KR100909665B1 (ko) | 2000-12-21 | 2009-07-29 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나제 억제제로서 유용한 피라졸 화합물 및 이를 포함하는 약제학적 조성물 |
| WO2002096888A1 (de) * | 2001-05-29 | 2002-12-05 | Schering Aktiengesellschaft | Cdk inhibitorische pyrimidine, deren herstellung und verwendung als arzneimittel |
| US7288547B2 (en) * | 2002-03-11 | 2007-10-30 | Schering Ag | CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents |
| EA200500721A1 (ru) | 2002-11-28 | 2005-12-29 | Шеринг Акциенгезельшафт | Пиримидины, ингибирующие chk, pdk и акт, их получение и применение в качестве лекарственных средств |
| CA2515095A1 (en) | 2003-02-10 | 2004-08-19 | Pfizer Inc. | Regimen of administration for nelfinavir |
| RU2373937C9 (ru) | 2003-02-10 | 2010-07-27 | Байер Шеринг Фарма Акциенгезельшафт | Лечение бактериальных заболеваний органов дыхания путем местного применения фторхинолонов |
| DE10349423A1 (de) | 2003-10-16 | 2005-06-16 | Schering Ag | Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
-
2004
- 2004-02-02 US US10/770,379 patent/US7157455B2/en not_active Expired - Fee Related
- 2004-02-03 KR KR1020057014717A patent/KR100717099B1/ko not_active IP Right Cessation
- 2004-02-03 BR BR0407381-9A patent/BRPI0407381A/pt not_active IP Right Cessation
- 2004-02-03 RS YUP-2005/0610A patent/RS20050610A/sr unknown
- 2004-02-03 CA CA002512915A patent/CA2512915A1/en not_active Abandoned
- 2004-02-03 WO PCT/EP2004/000971 patent/WO2004069139A2/en active Application Filing
- 2004-02-03 JP JP2006500021A patent/JP2006523183A/ja active Pending
- 2004-02-03 AU AU2004210408A patent/AU2004210408A1/en not_active Abandoned
- 2004-02-03 PL PL382309A patent/PL382309A1/pl not_active Application Discontinuation
- 2004-02-03 EP EP04707513A patent/EP1628619A2/en not_active Withdrawn
- 2004-02-03 MX MXPA05008333A patent/MXPA05008333A/es active IP Right Grant
- 2004-02-03 EA EA200501233A patent/EA009412B1/ru not_active IP Right Cessation
- 2004-02-06 MY MYPI20040366A patent/MY137555A/en unknown
- 2004-02-06 TW TW093102771A patent/TWI293881B/zh active
- 2004-02-06 AR ARP040100381A patent/AR043693A1/es not_active Application Discontinuation
- 2004-02-09 CL CL200400226A patent/CL2004000226A1/es unknown
-
2005
- 2005-07-11 IL IL169626A patent/IL169626A0/en unknown
- 2005-07-13 NO NO20053410A patent/NO20053410L/no not_active Application Discontinuation
- 2005-08-01 HR HR20050689A patent/HRP20050689A2/xx not_active Application Discontinuation
- 2005-08-02 TN TNP2005000188A patent/TNSN05188A1/en unknown
- 2005-08-09 EC EC2005005958A patent/ECSP055958A/es unknown
- 2005-08-30 MA MA28472A patent/MA27716A1/fr unknown
-
2006
- 2006-06-20 US US11/471,001 patent/US7615634B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EA009412B1 (ru) | 2007-12-28 |
| CA2512915A1 (en) | 2004-08-19 |
| TNSN05188A1 (en) | 2007-06-11 |
| EP1628619A2 (en) | 2006-03-01 |
| IL169626A0 (en) | 2007-07-04 |
| US7157455B2 (en) | 2007-01-02 |
| WO2004069139A3 (en) | 2007-04-26 |
| KR20050099544A (ko) | 2005-10-13 |
| CL2004000226A1 (es) | 2005-01-14 |
| AR043693A1 (es) | 2005-08-10 |
| MXPA05008333A (es) | 2005-09-30 |
| JP2006523183A (ja) | 2006-10-12 |
| MA27716A1 (fr) | 2006-01-02 |
| ECSP055958A (es) | 2006-01-16 |
| KR100717099B1 (ko) | 2007-05-10 |
| RS20050610A (xx) | 2007-12-31 |
| US20060229330A1 (en) | 2006-10-12 |
| MY137555A (en) | 2009-02-27 |
| WO2004069139A2 (en) | 2004-08-19 |
| NO20053410L (no) | 2005-09-08 |
| PL382309A1 (pl) | 2007-08-20 |
| TWI293881B (en) | 2008-03-01 |
| EA200501233A1 (ru) | 2006-04-28 |
| US20040162303A1 (en) | 2004-08-19 |
| TW200423940A (en) | 2004-11-16 |
| US7615634B2 (en) | 2009-11-10 |
| AU2004210408A1 (en) | 2004-08-19 |
| BRPI0407381A (pt) | 2006-02-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20050689A2 (en) | 4-aminopyrimidine-5-one | |
| BRPI0408068A (pt) | derivados de 5-feniltiazol e seus usos como inibidores de pi3 cinase | |
| MX2022013223A (es) | [1,3]diazino[5,4-d]pirimidinas como inhibidores de her2. | |
| BR112022012641A2 (pt) | Compostos tricíclicos substituídos | |
| MY156407A (en) | 5-phenylthiazole derivatives and use as p13 kinase inhibitors | |
| MX2010003927A (es) | Derivados de pirrolo [2,3-d] pirimidina como inhibidores de proteinas cinasas b. | |
| AR058780A1 (es) | Imidazopirazinas como inhibidores de quinasas dependientes de ciclina | |
| UA86614C2 (ru) | Соединение, которое имеет активность ингибитора киназ, фармацевтическая композиция, которая включает указанное соединение, и их применение для приготовления лекарственного препарата | |
| BRPI0618552B8 (pt) | compostos derivados de pirimidina ligados ao oxigênio,composição farmacêutica que inclui os ditos compostos,método de síntese dos compostos e usos terapêuticos dos mesmos | |
| MY147677A (en) | Piperazinyl derivatives useful in the treatment of gpr38 receptor mediated diseases | |
| AU2006273692A8 (en) | 1,4-Dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them | |
| CL2003002565A1 (es) | Compuestos derivados de 3h-quinazolin-4-ona, su proceso de preparacion, composicion farmaceutica que los contiene, y uso en el tratamiento y prevencion de enfermedades mediadas por inhibidores de mao-b, tales como la enfermedad de alzheimer y demenci | |
| SA522441965B1 (ar) | Trpa1 مشتقات تترازول كمثبطات لـ | |
| WO2007068473A3 (en) | Organic compounds | |
| BRPI0409818A (pt) | compostos, composições farmacêuticas, método para o tratamento ou profilaxia de doenças, e, usos de compostos e de um ou mais compostos em combinação com outros compostos farmacologicamente ativos | |
| MX2023011829A (es) | Derivados de uracilo como inhibidores de trpa1. | |
| MX2023014784A (es) | Preparacion de derivados de compuestos 1,2-diaminoheterociclicos sustituidos y su uso como agentes farmaceuticos. | |
| MX2023006881A (es) | Antagonistas del receptor de adenosina a2a. | |
| SA522441973B1 (ar) | Trpa1 مشتقات تترازول كمثبطات لـ | |
| MX2023003516A (es) | Inhibidores no covalentes de la cinasa dependiente de ciclina 7 (cdk7). | |
| WO2002059109A3 (en) | Naphthostyril derivatives and their use as inhibitors of cyclin- dependent kinases | |
| WO2004108094A3 (en) | Sulfonamide-substituted chalcone derivatives and their use to treat diseases | |
| SA523440367B1 (ar) | مشتقات تترازول كمثبطات لمستقبل عابر أنكيرين قوي 1 | |
| UA93878C2 (ru) | Производная бензилпиперазина, ee применение при лечении разных расстройств и фармацевтическая композиция, которая ee содержит | |
| BRPI0417895A (pt) | derivado de indeno (2,1a)indeno e isoindolo(2,1-a)indole, processo para a preparação de um composto, composições farmacêuticas, uso do derivado, uso de um rádiocomposto identificado e método para um tratamento de prevenção ou um tratamento de desordem |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20080125 Year of fee payment: 5 |
|
| OBST | Application withdrawn |