HRP20050681A2 - Triazole compounds useful in therapy - Google Patents

Triazole compounds useful in therapy Download PDF

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Publication number
HRP20050681A2
HRP20050681A2 HR20050681A HRP20050681A HRP20050681A2 HR P20050681 A2 HRP20050681 A2 HR P20050681A2 HR 20050681 A HR20050681 A HR 20050681A HR P20050681 A HRP20050681 A HR P20050681A HR P20050681 A2 HRP20050681 A2 HR P20050681A2
Authority
HR
Croatia
Prior art keywords
image
mmol
compound
chloro
tetrahydro
Prior art date
Application number
HR20050681A
Other languages
English (en)
Croatian (hr)
Inventor
Stephen Bryans Justin
Stephen Johnson Patrick
Jane Russell Rachel
Ryckmans Thomas
Stobie Alan
Peter Wayman Christopher
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0303852.8A external-priority patent/GB0303852D0/en
Priority claimed from GBGB0317227.7A external-priority patent/GB0317227D0/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of HRP20050681A2 publication Critical patent/HRP20050681A2/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Pregnancy & Childbirth (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Anesthesiology (AREA)
  • Communicable Diseases (AREA)
HR20050681A 2003-02-19 2004-02-09 Triazole compounds useful in therapy HRP20050681A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0303852.8A GB0303852D0 (en) 2003-02-19 2003-02-19 Triazole compounds useful in therapy
GBGB0317227.7A GB0317227D0 (en) 2003-07-23 2003-07-23 Treatment of male sexual dysfunction
PCT/IB2004/000432 WO2004074291A1 (en) 2003-02-19 2004-02-09 Triazole compounds useful in therapy

Publications (1)

Publication Number Publication Date
HRP20050681A2 true HRP20050681A2 (en) 2005-12-31

Family

ID=34889119

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20050681A HRP20050681A2 (en) 2003-02-19 2004-02-09 Triazole compounds useful in therapy

Country Status (25)

Country Link
EP (1) EP1597260B1 (enExample)
JP (2) JP4033886B2 (enExample)
KR (1) KR100750028B1 (enExample)
AP (1) AP2005003376A0 (enExample)
AT (1) ATE349449T1 (enExample)
AU (1) AU2004213242B2 (enExample)
BR (1) BRPI0407676A (enExample)
CA (1) CA2516557C (enExample)
DE (1) DE602004003914T2 (enExample)
DK (1) DK1597260T3 (enExample)
EA (1) EA009460B1 (enExample)
EC (1) ECSP055973A (enExample)
ES (1) ES2277237T3 (enExample)
GE (1) GEP20074089B (enExample)
HR (1) HRP20050681A2 (enExample)
IS (1) IS2450B (enExample)
MA (1) MA27712A1 (enExample)
MX (1) MXPA05008923A (enExample)
NO (1) NO20054053L (enExample)
OA (1) OA13029A (enExample)
PL (1) PL378747A1 (enExample)
PT (1) PT1597260E (enExample)
RS (1) RS20050638A (enExample)
SI (1) SI1597260T1 (enExample)
TN (1) TNSN05200A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008133288A1 (ja) * 2007-04-25 2008-11-06 Daiichi Sankyo Company, Limited 三環性アリール化合物
JP2013510834A (ja) * 2009-11-16 2013-03-28 メリテク ［１，５］‐ジアゾシン誘導体
US8420633B2 (en) * 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) * 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) * 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) * 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US9006450B2 (en) * 2010-07-01 2015-04-14 Boehringer Ingelheim International Gmbh Compounds, pharmaceutical compositions and uses thereof
JP6454707B2 (ja) * 2013-12-05 2019-01-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ｔｒａｎｓ−８−クロロ−５−メチル−１−［４−（ピリジン−２−イルオキシ）−シクロヘキシル］−５，６−ジヒドロ−４Ｈ−２，３，５，１０ｂ−テトラアザ−ベンゾ［ｅ］アズレン及びその結晶形態の合成
HU231206B1 (hu) * 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek

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GB8823475D0 (en) * 1988-10-06 1988-11-16 Merck Sharp & Dohme Chemical compounds
US5438035A (en) * 1994-06-24 1995-08-01 American Cyanamid Company Methods for controlling undesirable plant species with benzodiazepine compounds
US5753648A (en) * 1995-01-17 1998-05-19 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
HUP9904514A3 (en) * 1996-11-01 2000-10-30 Wyeth Corp 5h-pyrrolo[2,1-c][1,4]-benzodiazepin 3-carboxamide derivatives, process for their preparation, their use and pharmaceutical compositions containing them
TR200102069T2 (tr) * 1999-01-19 2001-11-21 Ortho-Mcneil Pharmaceutical, Inc. Vasopresin reseptörü antagonistleri olarak trisiklik benzodiazepinler.
US7109193B2 (en) * 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
GB0224919D0 (en) * 2002-10-25 2002-12-04 Pfizer Ltd Triazole compounds useful in therapy

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Publication number Publication date
EA009460B1 (ru) 2007-12-28
NO20054053D0 (no) 2005-08-31
DE602004003914T2 (de) 2007-05-31
KR100750028B1 (ko) 2007-08-16
ES2277237T3 (es) 2007-07-01
AP2005003376A0 (en) 2005-09-30
EP1597260A1 (en) 2005-11-23
PL378747A1 (pl) 2006-05-15
KR20050106443A (ko) 2005-11-09
BRPI0407676A (pt) 2006-03-01
GEP20074089B (en) 2007-04-10
TNSN05200A1 (fr) 2007-06-11
DK1597260T3 (da) 2007-04-02
EA200501136A1 (ru) 2006-06-30
IS7957A (is) 2005-07-25
AU2004213242B2 (en) 2007-04-19
CA2516557A1 (en) 2004-09-02
EP1597260B1 (en) 2006-12-27
ECSP055973A (es) 2006-01-16
MXPA05008923A (es) 2006-03-09
JP2006517921A (ja) 2006-08-03
JP2007045838A (ja) 2007-02-22
CA2516557C (en) 2008-11-18
PT1597260E (pt) 2007-01-31
DE602004003914D1 (de) 2007-02-08
NO20054053L (no) 2005-10-31
JP4033886B2 (ja) 2008-01-16
MA27712A1 (fr) 2006-01-02
SI1597260T1 (sl) 2007-04-30
OA13029A (en) 2006-11-10
ATE349449T1 (de) 2007-01-15
AU2004213242A1 (en) 2004-09-02
RS20050638A (sr) 2007-12-31
IS2450B (is) 2008-11-15

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