HRP20050168A2 - Pyridyl substituted heterocycles useful for treating or preventing hcv infection - Google Patents
Pyridyl substituted heterocycles useful for treating or preventing hcv infection Download PDFInfo
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- HRP20050168A2 HRP20050168A2 HR20050168A HRP20050168A HRP20050168A2 HR P20050168 A2 HRP20050168 A2 HR P20050168A2 HR 20050168 A HR20050168 A HR 20050168A HR P20050168 A HRP20050168 A HR P20050168A HR P20050168 A2 HRP20050168 A2 HR P20050168A2
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- compound according
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- 208000015181 infectious disease Diseases 0.000 title claims description 27
- 125000000623 heterocyclic group Chemical group 0.000 title description 11
- 125000004076 pyridyl group Chemical group 0.000 title description 10
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- 125000000217 alkyl group Chemical group 0.000 claims description 32
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 32
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 31
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 22
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 claims description 21
- 239000000460 chlorine Substances 0.000 claims description 21
- 125000005843 halogen group Chemical group 0.000 claims description 21
- 125000001145 hydrido group Chemical class *[H] 0.000 claims description 21
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 20
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40546702P | 2002-08-23 | 2002-08-23 | |
| US41783702P | 2002-10-11 | 2002-10-11 | |
| US47137303P | 2003-05-15 | 2003-05-15 | |
| US10/646,348 US7157473B2 (en) | 2002-08-23 | 2003-08-22 | Pyridyl substituted heterocycles useful for treating or preventing HCV infection |
| PCT/US2003/026478 WO2004018463A2 (en) | 2002-08-23 | 2003-08-22 | Pyridyl substituted heterocycles useful for treating or preventing hcv infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20050168A2 true HRP20050168A2 (en) | 2005-10-31 |
Family
ID=31950772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20050168A HRP20050168A2 (en) | 2002-08-23 | 2005-02-22 | Pyridyl substituted heterocycles useful for treating or preventing hcv infection |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US7157473B2 (no) |
| EP (1) | EP1530569A2 (no) |
| JP (1) | JP2006501312A (no) |
| KR (1) | KR20050033653A (no) |
| AU (1) | AU2003262831A1 (no) |
| BR (1) | BR0313755A (no) |
| CA (1) | CA2494164A1 (no) |
| HR (1) | HRP20050168A2 (no) |
| IL (1) | IL166639A0 (no) |
| MX (1) | MXPA05002082A (no) |
| NO (1) | NO20051404L (no) |
| NZ (1) | NZ537980A (no) |
| PL (1) | PL374536A1 (no) |
| RS (1) | RS20050175A (no) |
| WO (1) | WO2004018463A2 (no) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY151199A (en) | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
| PL374536A1 (en) * | 2002-08-23 | 2005-10-31 | Rigel Pharmaceuticals, Inc. | Pyridyl substituted heterocycles useful for treating or preventing hcv infection |
| US7115642B2 (en) | 2003-05-02 | 2006-10-03 | Rigel Pharmaceuticals, Inc. | Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection |
| EP1620412A2 (en) * | 2003-05-02 | 2006-02-01 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds and hydro isomers thereof |
| US7220745B2 (en) * | 2003-05-15 | 2007-05-22 | Rigel Pharmaceuticals | Heterocyclic compounds useful to treat HCV |
| KR20060084845A (ko) | 2003-07-25 | 2006-07-25 | 이데닉스 (케이만) 리미티드 | Ｃ형 간염을 포함하는 플라비비리다에를 치료하기 위한퓨린 뉴클레오시드 유사체 |
| WO2005049065A2 (en) * | 2003-11-19 | 2005-06-02 | Rigel Pharmaceuticals, Inc. | Synergistic combinations of dihaloacetamide with interferon or ribavirin for treatment hcv infections |
| JP2007514763A (ja) * | 2003-12-19 | 2007-06-07 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｃ型肝炎ウイルス（ｈｃｖ）の感染を処置するための組成物および方法 |
| US7514434B2 (en) | 2004-02-23 | 2009-04-07 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof |
| JP2007530582A (ja) * | 2004-03-26 | 2007-11-01 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 代謝可能部分を含む複素環抗ウイルス化合物およびその使用 |
| JP2008540425A (ja) * | 2005-05-02 | 2008-11-20 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 代謝可能部分を含む複素環式抗ウイルス性化合物およびその使用 |
| EP2196153B1 (en) * | 2005-08-10 | 2015-07-01 | C.R.Bard, Inc. | Single-insertion, multiple sample biopsy device |
| KR100890862B1 (ko) * | 2005-11-07 | 2009-03-27 | 주식회사 엘지화학 | 유기 발광 소자 및 이의 제조 방법 |
| CN103463084A (zh) * | 2008-03-14 | 2013-12-25 | 大塚制药株式会社 | 制剂组合物在制备治疗以mmp-2及/或mmp-9为起因的肺气肿的药物中的应用 |
| US8362020B2 (en) * | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| BR112017028125A2 (pt) | 2015-06-23 | 2018-08-28 | Kissei Pharmaceutical Co., Ltd. | derivado de pirazola ou sal farmaceuticamente aceitável do mesmo |
| CN116535399B (zh) * | 2022-01-25 | 2024-02-27 | 中国药科大学 | 3-羟基-5-(异噁唑-5-基)吡啶甲酰甘氨酸类化合物、制法、药物组合物和应用 |
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| DE2721955A1 (de) | 1977-05-14 | 1978-11-23 | Basf Ag | Azofarbstoffe |
| DE3623302A1 (de) | 1985-11-09 | 1987-05-14 | Bayer Ag | Nicotinsaeurederivate |
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| DE4124942A1 (de) | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE4137940A1 (de) | 1991-11-18 | 1993-05-19 | Basf Ag | 3-isoxazolylphenylverbindungen, ihre herstellung und ihre verwendung |
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| DE4210502A1 (de) | 1992-03-31 | 1993-10-07 | Bayer Ag | Verwendung von 3-aminosubstituierten Isoxazolderivaten zur Bekämpfung von Endoparasiten, neue 3-aminosubstituierte Isoxazolderivate und Verfahren zu ihrer Herstellung |
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| DE10032874A1 (de) | 2000-07-06 | 2002-01-17 | Bayer Ag | Arzneimittelkombinationen gegen virale Erkrankungen |
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| GB0017676D0 (en) * | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
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| US20030199521A1 (en) | 2001-01-13 | 2003-10-23 | Dykstra Christine C. | Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection |
| DE10148598A1 (de) * | 2001-04-19 | 2002-10-24 | Bayer Ag | Neue Arylsulfonamide als antivirale Mittel |
| CN1516695A (zh) * | 2001-04-19 | 2004-07-28 | 用作抗病毒剂的芳基磺酰胺类化合物 | |
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| MY151199A (en) | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
| PL374536A1 (en) | 2002-08-23 | 2005-10-31 | Rigel Pharmaceuticals, Inc. | Pyridyl substituted heterocycles useful for treating or preventing hcv infection |
| US7220745B2 (en) | 2003-05-15 | 2007-05-22 | Rigel Pharmaceuticals | Heterocyclic compounds useful to treat HCV |
-
2003
- 2003-08-22 PL PL03374536A patent/PL374536A1/xx not_active Application Discontinuation
- 2003-08-22 WO PCT/US2003/026478 patent/WO2004018463A2/en active Application Filing
- 2003-08-22 MX MXPA05002082A patent/MXPA05002082A/es unknown
- 2003-08-22 NZ NZ537980A patent/NZ537980A/en not_active IP Right Cessation
- 2003-08-22 KR KR1020057003019A patent/KR20050033653A/ko not_active Application Discontinuation
- 2003-08-22 RS YUP-2005/0175A patent/RS20050175A/sr unknown
- 2003-08-22 BR BR0313755-4A patent/BR0313755A/pt not_active IP Right Cessation
- 2003-08-22 US US10/646,348 patent/US7157473B2/en active Active
- 2003-08-22 EP EP03793349A patent/EP1530569A2/en not_active Withdrawn
- 2003-08-22 JP JP2005501778A patent/JP2006501312A/ja active Pending
- 2003-08-22 CA CA002494164A patent/CA2494164A1/en not_active Abandoned
- 2003-08-22 AU AU2003262831A patent/AU2003262831A1/en not_active Abandoned
-
2005
- 2005-02-01 IL IL16663905A patent/IL166639A0/xx unknown
- 2005-02-22 HR HR20050168A patent/HRP20050168A2/hr not_active Application Discontinuation
- 2005-03-17 NO NO20051404A patent/NO20051404L/no not_active Application Discontinuation
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2006
- 2006-11-21 US US11/561,991 patent/US7332602B2/en not_active Expired - Lifetime
-
2007
- 2007-12-20 US US11/960,990 patent/US7714137B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA05002082A (es) | 2005-06-08 |
| US7157473B2 (en) | 2007-01-02 |
| NO20051404L (no) | 2005-05-10 |
| US20080171871A1 (en) | 2008-07-17 |
| WO2004018463A2 (en) | 2004-03-04 |
| BR0313755A (pt) | 2005-06-21 |
| WO2004018463A3 (en) | 2004-05-06 |
| JP2006501312A (ja) | 2006-01-12 |
| PL374536A1 (en) | 2005-10-31 |
| US7332602B2 (en) | 2008-02-19 |
| US20070155966A1 (en) | 2007-07-05 |
| US7714137B2 (en) | 2010-05-11 |
| IL166639A0 (en) | 2006-01-15 |
| NZ537980A (en) | 2007-08-31 |
| US20040127497A1 (en) | 2004-07-01 |
| KR20050033653A (ko) | 2005-04-12 |
| EP1530569A2 (en) | 2005-05-18 |
| AU2003262831A1 (en) | 2004-03-11 |
| RS20050175A (en) | 2007-09-21 |
| CA2494164A1 (en) | 2004-03-04 |
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