HRP20040914A2 - Pharmaceutical and cosmetic compositions comprising plgf-1 - Google Patents
Pharmaceutical and cosmetic compositions comprising plgf-1Info
- Publication number
- HRP20040914A2 HRP20040914A2 HRP20040914A HRP20040914A2 HR P20040914 A2 HRP20040914 A2 HR P20040914A2 HR P20040914 A HRP20040914 A HR P20040914A HR P20040914 A2 HRP20040914 A2 HR P20040914A2
- Authority
- HR
- Croatia
- Prior art keywords
- plgf
- skin
- scleroderma
- treatment
- preparation
- Prior art date
Links
- 239000002537 cosmetic Substances 0.000 title claims description 16
- 239000000203 mixture Substances 0.000 title description 8
- 238000002360 preparation method Methods 0.000 claims description 36
- 101000595923 Homo sapiens Placenta growth factor Proteins 0.000 claims description 21
- 102100035194 Placenta growth factor Human genes 0.000 claims description 21
- 230000000699 topical effect Effects 0.000 claims description 19
- 239000000839 emulsion Substances 0.000 claims description 14
- 206010039710 Scleroderma Diseases 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 12
- 201000004384 Alopecia Diseases 0.000 claims description 11
- 210000002808 connective tissue Anatomy 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 11
- 238000007920 subcutaneous administration Methods 0.000 claims description 11
- 201000009594 Systemic Scleroderma Diseases 0.000 claims description 10
- 206010042953 Systemic sclerosis Diseases 0.000 claims description 10
- 230000033115 angiogenesis Effects 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 10
- 230000002265 prevention Effects 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 10
- 230000009885 systemic effect Effects 0.000 claims description 10
- 230000003676 hair loss Effects 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 230000001575 pathological effect Effects 0.000 claims description 8
- 239000000725 suspension Substances 0.000 claims description 8
- 239000000499 gel Substances 0.000 claims description 7
- 208000024963 hair loss Diseases 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- 208000000185 Localized scleroderma Diseases 0.000 claims description 5
- 230000000750 progressive effect Effects 0.000 claims description 5
- 230000005855 radiation Effects 0.000 claims description 5
- 210000004304 subcutaneous tissue Anatomy 0.000 claims description 5
- 230000032683 aging Effects 0.000 claims description 4
- 239000007943 implant Substances 0.000 claims description 4
- 231100000915 pathological change Toxicity 0.000 claims description 4
- 230000036285 pathological change Effects 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 3
- 238000007918 intramuscular administration Methods 0.000 claims description 3
- 239000002502 liposome Substances 0.000 claims description 3
- 230000007774 longterm Effects 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims description 3
- 206010033675 panniculitis Diseases 0.000 claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 3
- 230000001737 promoting effect Effects 0.000 claims description 3
- 231100000360 alopecia Toxicity 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 230000003054 hormonal effect Effects 0.000 claims description 2
- 230000002107 myocardial effect Effects 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 238000007911 parenteral administration Methods 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 239000002075 main ingredient Substances 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 210000003491 skin Anatomy 0.000 description 42
- 239000013543 active substance Substances 0.000 description 16
- 230000000694 effects Effects 0.000 description 15
- 239000000243 solution Substances 0.000 description 15
- 210000001519 tissue Anatomy 0.000 description 14
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 10
- 230000001225 therapeutic effect Effects 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 108010006654 Bleomycin Proteins 0.000 description 6
- 102000008186 Collagen Human genes 0.000 description 6
- 108010035532 Collagen Proteins 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000000654 additive Substances 0.000 description 6
- 229960001561 bleomycin Drugs 0.000 description 6
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 6
- 229920001436 collagen Polymers 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 235000019198 oils Nutrition 0.000 description 6
- 230000009759 skin aging Effects 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 210000004204 blood vessel Anatomy 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 238000007491 morphometric analysis Methods 0.000 description 5
- 210000001835 viscera Anatomy 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 4
- 230000002491 angiogenic effect Effects 0.000 description 4
- 238000010171 animal model Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000007613 environmental effect Effects 0.000 description 4
- 210000004209 hair Anatomy 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 235000015112 vegetable and seed oil Nutrition 0.000 description 4
- 239000008158 vegetable oil Substances 0.000 description 4
- 238000011735 C3H mouse Methods 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 206010051246 Photodermatosis Diseases 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 230000002354 daily effect Effects 0.000 description 3
- 238000001493 electron microscopy Methods 0.000 description 3
- 238000004108 freeze drying Methods 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000007170 pathology Effects 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 229920001451 polypropylene glycol Polymers 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 102000016942 Elastin Human genes 0.000 description 2
- 108010014258 Elastin Proteins 0.000 description 2
- 206010016654 Fibrosis Diseases 0.000 description 2
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 206010040867 Skin hypertrophy Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000003698 anagen phase Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 description 2
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 2
- 229920002549 elastin Polymers 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 230000004761 fibrosis Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 210000003780 hair follicle Anatomy 0.000 description 2
- 230000003779 hair growth Effects 0.000 description 2
- 125000001475 halogen functional group Chemical group 0.000 description 2
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 229960002591 hydroxyproline Drugs 0.000 description 2
- 239000007951 isotonicity adjuster Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 230000008845 photoaging Effects 0.000 description 2
- 229920000193 polymethacrylate Polymers 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 230000026341 positive regulation of angiogenesis Effects 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 2
- 230000024883 vasodilation Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 239000007762 w/o emulsion Substances 0.000 description 2
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- SHBUUTHKGIVMJT-UHFFFAOYSA-N Hydroxystearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OO SHBUUTHKGIVMJT-UHFFFAOYSA-N 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010034576 Peripheral ischaemia Diseases 0.000 description 1
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 238000011804 SKH1 hairless mouse Methods 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 206010050207 Skin fibrosis Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000002870 angiogenesis inducing agent Substances 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 208000004267 erosive arthropathy Diseases 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229940072106 hydroxystearate Drugs 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 230000004968 inflammatory condition Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229960003151 mercaptamine Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 230000000897 modulatory effect Effects 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000003114 pinocytic effect Effects 0.000 description 1
- -1 polylactate Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000003658 preventing hair loss Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 230000036558 skin tension Effects 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000004906 toe nail Anatomy 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Birds (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002RM000119A ITRM20020119A1 (it) | 2002-03-05 | 2002-03-05 | Composizioni contenenti plgf ad uso farmaceutico e cosmetico. |
| PCT/IT2003/000132 WO2003074075A1 (en) | 2002-03-05 | 2003-03-05 | Pharmaceutical and cosmetic compositions comprising plgf-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20040914A2 true HRP20040914A2 (en) | 2004-12-31 |
Family
ID=11456138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20040914 HRP20040914A2 (en) | 2002-03-05 | 2004-10-05 | Pharmaceutical and cosmetic compositions comprising plgf-1 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7364722B2 (ja) |
| EP (1) | EP1482967B1 (ja) |
| JP (2) | JP5010093B2 (ja) |
| KR (1) | KR100988656B1 (ja) |
| CN (1) | CN100467058C (ja) |
| AU (1) | AU2003217464B2 (ja) |
| BR (1) | BR0308040A (ja) |
| CA (1) | CA2477075C (ja) |
| CY (1) | CY1114209T1 (ja) |
| DK (1) | DK1482967T3 (ja) |
| ES (1) | ES2424827T3 (ja) |
| HK (1) | HK1078469A1 (ja) |
| HR (1) | HRP20040914A2 (ja) |
| IT (1) | ITRM20020119A1 (ja) |
| MX (1) | MXPA04008486A (ja) |
| PL (1) | PL371788A1 (ja) |
| PT (1) | PT1482967E (ja) |
| RU (1) | RU2292906C2 (ja) |
| SI (1) | SI1482967T1 (ja) |
| WO (1) | WO2003074075A1 (ja) |
| ZA (1) | ZA200407707B (ja) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2872040B1 (fr) * | 2004-06-23 | 2006-09-22 | Centre Nat Rech Scient Cnrse | Utilisation cosmetique d'au moins un tetrapeptide naturel ac-n-ser-asp-lys-pro- ou un de ses analogues en tant qu'agent antivieillissement et restructurant de la peau |
| US8057458B2 (en) * | 2006-10-30 | 2011-11-15 | Warsaw Orthopedic, Inc. | Method for treating facet pain |
| BRPI1008815A2 (pt) * | 2009-02-05 | 2018-02-14 | Digna Biotech, S.L | composições farmacêuticas compreendendo peptídeos inibidores de tgf-beta1 |
| US8741850B2 (en) | 2009-07-24 | 2014-06-03 | Advanced Accelerator Applications S.A. | Compounds modulators of VEGF activity and uses thereof |
| EP3586867A3 (en) * | 2013-01-28 | 2020-04-08 | Shire Human Genetic Therapies, Inc. | Placenta growth factor in treating duchenne muscular dystrophy |
| AU2015206236B2 (en) | 2014-01-17 | 2020-02-20 | Mimedx Group, Inc. | Method for inducing angiogenesis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1242149B (it) | 1990-09-27 | 1994-02-16 | Consiglio Nazionale Ricerche | Sequenza di nucleotidi codificante per una proteina umana con proprieta' regolative dell'angiogenesi |
| US6211147B1 (en) * | 1995-08-15 | 2001-04-03 | Connetics Corporation | Method of promoting angiogenesis using relaxin |
| DE69839529D1 (de) * | 1997-12-24 | 2008-07-03 | Ludwig Inst Cancer Res | Expressionsvektoren und zellinien zur expression von vaskulärem wachstumsfaktor d, sowie verfahren zur behandlung von melanomen |
| AU782394B2 (en) * | 1999-06-29 | 2005-07-21 | J. Alexander Marchosky | Compositions and methods for forming and strengthening bone |
| WO2001057181A2 (en) * | 2000-02-04 | 2001-08-09 | Carmeliet, Peter | Use of vascular endothelial growth factor, placenta growth factor or both for preventing or treating ischemic diseases or stroke |
| US6773881B2 (en) * | 2000-03-31 | 2004-08-10 | The General Hospital Corporation | Methods of modulating hair growth |
-
2002
- 2002-03-05 IT IT2002RM000119A patent/ITRM20020119A1/it unknown
-
2003
- 2003-03-05 AU AU2003217464A patent/AU2003217464B2/en not_active Ceased
- 2003-03-05 ES ES03712652T patent/ES2424827T3/es not_active Expired - Lifetime
- 2003-03-05 PL PL03371788A patent/PL371788A1/xx unknown
- 2003-03-05 CN CNB038051532A patent/CN100467058C/zh not_active Expired - Fee Related
- 2003-03-05 KR KR1020047013804A patent/KR100988656B1/ko not_active IP Right Cessation
- 2003-03-05 CA CA2477075A patent/CA2477075C/en not_active Expired - Fee Related
- 2003-03-05 US US10/507,272 patent/US7364722B2/en not_active Expired - Fee Related
- 2003-03-05 BR BR0308040-4A patent/BR0308040A/pt active Search and Examination
- 2003-03-05 PT PT37126521T patent/PT1482967E/pt unknown
- 2003-03-05 WO PCT/IT2003/000132 patent/WO2003074075A1/en active Application Filing
- 2003-03-05 DK DK03712652.1T patent/DK1482967T3/da active
- 2003-03-05 RU RU2004129586/15A patent/RU2292906C2/ru not_active IP Right Cessation
- 2003-03-05 MX MXPA04008486A patent/MXPA04008486A/es active IP Right Grant
- 2003-03-05 EP EP03712652.1A patent/EP1482967B1/en not_active Expired - Lifetime
- 2003-03-05 SI SI200332290T patent/SI1482967T1/sl unknown
- 2003-03-05 JP JP2003572591A patent/JP5010093B2/ja not_active Expired - Fee Related
-
2004
- 2004-09-23 ZA ZA2004/07707A patent/ZA200407707B/en unknown
- 2004-10-05 HR HRP20040914 patent/HRP20040914A2/hr not_active Application Discontinuation
-
2005
- 2005-11-18 HK HK05110410.6A patent/HK1078469A1/xx not_active IP Right Cessation
-
2010
- 2010-01-18 JP JP2010007759A patent/JP5144690B2/ja not_active Expired - Fee Related
-
2013
- 2013-08-13 CY CY20131100692T patent/CY1114209T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1482967A1 (en) | 2004-12-08 |
| DK1482967T3 (da) | 2013-08-26 |
| US7364722B2 (en) | 2008-04-29 |
| ES2424827T3 (es) | 2013-10-08 |
| JP5010093B2 (ja) | 2012-08-29 |
| HK1078469A1 (en) | 2006-03-17 |
| JP2010116405A (ja) | 2010-05-27 |
| ITRM20020119A1 (it) | 2003-09-05 |
| US20050239698A2 (en) | 2005-10-27 |
| AU2003217464A1 (en) | 2003-09-16 |
| BR0308040A (pt) | 2004-12-14 |
| SI1482967T1 (sl) | 2013-10-30 |
| CA2477075C (en) | 2013-08-06 |
| AU2003217464B2 (en) | 2007-08-30 |
| JP5144690B2 (ja) | 2013-02-13 |
| RU2004129586A (ru) | 2005-06-10 |
| CN1638793A (zh) | 2005-07-13 |
| CN100467058C (zh) | 2009-03-11 |
| JP2005519101A (ja) | 2005-06-30 |
| KR100988656B1 (ko) | 2010-10-18 |
| KR20040111379A (ko) | 2004-12-31 |
| PL371788A1 (en) | 2005-06-27 |
| MXPA04008486A (es) | 2005-04-19 |
| WO2003074075A1 (en) | 2003-09-12 |
| CY1114209T1 (el) | 2016-08-31 |
| ZA200407707B (en) | 2005-07-27 |
| US20050075288A1 (en) | 2005-04-07 |
| RU2292906C2 (ru) | 2007-02-10 |
| PT1482967E (pt) | 2013-08-27 |
| EP1482967B1 (en) | 2013-05-15 |
| ITRM20020119A0 (it) | 2002-03-05 |
| CA2477075A1 (en) | 2003-09-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6337071B2 (ja) | 皮膚外用剤組成物 | |
| JPH04224522A (ja) | 繊維芽細胞増殖因子含有組成物による禿頭症の治療又は予防方法 | |
| US8685391B2 (en) | Skin care compositions | |
| AU2017274069B2 (en) | Skin care formulation | |
| JP5144690B2 (ja) | Ｐｌｇｆ−１を含む医薬品及び化粧品組成物 | |
| JP2010116405A6 (ja) | Ｐｌｇｆ−１を含む医薬品及び化粧品組成物 | |
| AU1077895A (en) | Medicaments comprising relaxin and their use | |
| JPWO2009119073A1 (ja) | 皮膚の老化や瘢痕の治療剤 | |
| HRP20041178A2 (en) | Muteins of placental growth factor type 1, prepèaration method and application thereof | |
| KR20210114646A (ko) | 성장인자를 함유하는 탈모 치료 또는 모발 성장 촉진용 조성물 | |
| EP3888625A1 (en) | Composition for scalp and hair |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20120228 Year of fee payment: 10 |
|
| OBST | Application withdrawn |