HRP20040744A2 - Preparation of n-methyl-3-hydroxy-3-(2-thienyl)propylamine via novel thiophene derivatives containing carbamate groups as intermediates - Google Patents

Preparation of n-methyl-3-hydroxy-3-(2-thienyl)propylamine via novel thiophene derivatives containing carbamate groups as intermediates

Info

Publication number
HRP20040744A2
HRP20040744A2 HRP20040744A HRP20040744A2 HR P20040744 A2 HRP20040744 A2 HR P20040744A2 HR P20040744 A HRP20040744 A HR P20040744A HR P20040744 A2 HRP20040744 A2 HR P20040744A2
Authority
HR
Croatia
Prior art keywords
thienyl
intermediates
hydroxy
methyl
preparation
Prior art date
Application number
Other languages
English (en)
Inventor
Dietmar Reichert
Juan Josu Almena Perea
Michael Schwarm
Karlheinz Drauz
Hans-Peter Krimmer
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of HRP20040744A2 publication Critical patent/HRP20040744A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HRP20040744 2002-02-22 2004-08-18 Preparation of n-methyl-3-hydroxy-3-(2-thienyl)propylamine via novel thiophene derivatives containing carbamate groups as intermediates HRP20040744A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10207586A DE10207586A1 (de) 2002-02-22 2002-02-22 Herstellung von N-Methyl-3-hydroxy-3-(2-thienyl)propanamin über neue carbamatgruppenhaltige Thiophenderivate als Zwischenprodukte
PCT/EP2003/000910 WO2003070720A1 (en) 2002-02-22 2003-01-30 Preparation of n-methyl-3-hydroxy- 3-(2-thienyl)propylamine via novel thiophene derivatives containing carbamate groups as intermediates

Publications (1)

Publication Number Publication Date
HRP20040744A2 true HRP20040744A2 (en) 2004-12-31

Family

ID=27740334

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20040744 HRP20040744A2 (en) 2002-02-22 2004-08-18 Preparation of n-methyl-3-hydroxy-3-(2-thienyl)propylamine via novel thiophene derivatives containing carbamate groups as intermediates

Country Status (11)

Country Link
US (1) US20050171360A1 (xx)
EP (1) EP1476439A1 (xx)
JP (1) JP2005519077A (xx)
KR (1) KR20040096593A (xx)
AU (1) AU2003206800A1 (xx)
CA (1) CA2477082A1 (xx)
DE (1) DE10207586A1 (xx)
HR (1) HRP20040744A2 (xx)
IL (1) IL163611A0 (xx)
PL (1) PL370432A1 (xx)
WO (1) WO2003070720A1 (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2003097632A1 (ja) * 2002-05-20 2005-09-15 三菱レイヨン株式会社 プロパノールアミン誘導体、及び３−ｎ−メチルアミノ−１−（２−チエニル）−１−プロパノールの製造方法、並びにプロパノールアミン誘導体の製造方法
KR101160502B1 (ko) * 2004-02-19 2012-06-28 론자 아게 거울상 이성질체적으로 순수한 1-치환된-3-아미노알콜의제조 방법
EP1566383A1 (en) * 2004-02-19 2005-08-24 Lonza AG Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
CZ297560B6 (cs) * 2004-10-26 2007-02-07 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu)
TW200639162A (en) 2005-03-14 2006-11-16 Teva Pharma Pure duloxetine hydrochloride
JPWO2006104249A1 (ja) * 2005-03-29 2008-09-11 日本ゼオン株式会社 １−（２−チエニル）−３−アルキルアミノプロピルアルコールの製造方法
MY148074A (en) 2005-05-10 2013-02-28 Novartis Ag Pharmaceutical compositions comprising imatinib and a release retardant
US20070281989A1 (en) * 2006-05-31 2007-12-06 Santiago Ini Process for preparing duloxetine and intermediates thereof
EP1838692A2 (en) 2005-09-22 2007-10-03 Teva Pharmaceutical Industries Ltd Dnt-maleate and methods of preparation thereof
EP1899317A2 (en) * 2006-04-17 2008-03-19 Teva Pharmaceutical Industries Ltd Enantiomers of n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine borane as intermediates in the synthesis of duloxetine
CA2656128A1 (en) 2006-07-03 2008-01-10 Ranbaxy Laboratories Limited Process for the preparation of enantiomerically pure salts of n-methyl-3(1-naphthaleneoxy)-3-(2-thienyl)propanamine
WO2008077645A1 (en) * 2006-12-22 2008-07-03 Synthon B.V. Process for making duloxetine and related compounds
US8148549B2 (en) * 2009-03-12 2012-04-03 Sci Pharmtech, Inc. Preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl) propylamine using optically active methylhydroxylaminopropanol compound as an intermediate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI912280A (fi) * 1990-05-17 1991-11-18 Lilly Co Eli Kiral syntes av 1-aryl-3-aminopropan-1 -oler.

Also Published As

Publication number Publication date
US20050171360A1 (en) 2005-08-04
EP1476439A1 (en) 2004-11-17
JP2005519077A (ja) 2005-06-30
AU2003206800A1 (en) 2003-09-09
IL163611A0 (en) 2005-12-18
DE10207586A1 (de) 2003-09-11
KR20040096593A (ko) 2004-11-16
CA2477082A1 (en) 2003-08-28
PL370432A1 (en) 2005-05-30
WO2003070720A1 (en) 2003-08-28

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