HRP20040412A2 - Anthranilic acid amides and pharmaceutical use thereof - Google Patents
Anthranilic acid amides and pharmaceutical use thereof Download PDFInfo
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- HRP20040412A2 HRP20040412A2 HR20040412A HRP20040412A HRP20040412A2 HR P20040412 A2 HRP20040412 A2 HR P20040412A2 HR 20040412 A HR20040412 A HR 20040412A HR P20040412 A HRP20040412 A HR P20040412A HR P20040412 A2 HRP20040412 A2 HR P20040412A2
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- Prior art keywords
- formula
- compound
- tautomer
- trifluoromethyl
- salt
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- PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical class NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 title claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 115
- 150000003839 salts Chemical class 0.000 claims description 44
- 125000000217 alkyl group Chemical group 0.000 claims description 27
- 150000001204 N-oxides Chemical class 0.000 claims description 26
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 claims description 20
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 20
- 229910052794 bromium Inorganic materials 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 20
- -1 perfluoro Chemical group 0.000 claims description 20
- 201000010099 disease Diseases 0.000 claims description 19
- 238000011282 treatment Methods 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 17
- 150000001408 amides Chemical class 0.000 claims description 16
- 229910052736 halogen Inorganic materials 0.000 claims description 14
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 13
- 125000000304 alkynyl group Chemical group 0.000 claims description 13
- 150000002367 halogens Chemical class 0.000 claims description 13
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 12
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- 125000001246 bromo group Chemical group Br* 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- 239000001257 hydrogen Substances 0.000 claims description 7
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- 206010064930 age-related macular degeneration Diseases 0.000 claims description 6
- 125000001153 fluoro group Chemical group F* 0.000 claims description 6
- XVJOUYLQGCSLGU-UHFFFAOYSA-N n-(4-bromophenyl)-2-(pyridin-4-ylmethylamino)benzamide Chemical compound C1=CC(Br)=CC=C1NC(=O)C1=CC=CC=C1NCC1=CC=NC=C1 XVJOUYLQGCSLGU-UHFFFAOYSA-N 0.000 claims description 6
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 6
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 claims description 6
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 claims description 6
- 125000003342 alkenyl group Chemical group 0.000 claims description 5
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- USVUTPQVJFNOFP-UHFFFAOYSA-N n-[4-prop-1-ynyl-3-(trifluoromethyl)phenyl]-2-(pyridin-4-ylmethylamino)benzamide Chemical compound C1=C(C(F)(F)F)C(C#CC)=CC=C1NC(=O)C1=CC=CC=C1NCC1=CC=NC=C1 USVUTPQVJFNOFP-UHFFFAOYSA-N 0.000 claims description 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 4
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- DAZIKVHZJQGBLZ-UHFFFAOYSA-N n-(4-prop-1-ynylphenyl)-2-(pyridin-4-ylmethylamino)benzamide Chemical compound C1=CC(C#CC)=CC=C1NC(=O)C1=CC=CC=C1NCC1=CC=NC=C1 DAZIKVHZJQGBLZ-UHFFFAOYSA-N 0.000 claims description 3
- UOMBFRPWZLSXSD-PVOKDAACSA-N n-[4-[(z)-prop-1-enyl]-3-(trifluoromethyl)phenyl]-2-(pyridin-4-ylmethylamino)benzamide;hydrochloride Chemical compound Cl.C1=C(C(F)(F)F)C(\C=C/C)=CC=C1NC(=O)C1=CC=CC=C1NCC1=CC=NC=C1 UOMBFRPWZLSXSD-PVOKDAACSA-N 0.000 claims description 3
- GXVUFJFHYMRVBU-UHFFFAOYSA-N 2-[[3-(methylcarbamoyl)phenyl]methylamino]-n-[3-(trifluoromethyl)phenyl]benzamide Chemical compound CNC(=O)C1=CC=CC(CNC=2C(=CC=CC=2)C(=O)NC=2C=C(C=CC=2)C(F)(F)F)=C1 GXVUFJFHYMRVBU-UHFFFAOYSA-N 0.000 claims description 2
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- ANNJRRWDKJXWBM-UHFFFAOYSA-N n-[4-propyl-3-(trifluoromethyl)phenyl]-2-(pyridin-4-ylmethylamino)benzamide Chemical compound C1=C(C(F)(F)F)C(CCC)=CC=C1NC(=O)C1=CC=CC=C1NCC1=CC=NC=C1 ANNJRRWDKJXWBM-UHFFFAOYSA-N 0.000 claims description 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0126901.8A GB0126901D0 (en) | 2001-11-08 | 2001-11-08 | Organic compounds |
GBGB0212917.9A GB0212917D0 (en) | 2001-11-08 | 2002-06-05 | Organic compounds |
PCT/EP2002/012445 WO2003040101A1 (en) | 2001-11-08 | 2002-11-07 | Anthranilic acid amides and pharmaceutical use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20040412A2 true HRP20040412A2 (en) | 2005-06-30 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20040412A HRP20040412A2 (en) | 2001-11-08 | 2004-05-07 | Anthranilic acid amides and pharmaceutical use thereof |
Country Status (25)
Country | Link |
---|---|
US (1) | US7067543B2 (de) |
EP (2) | EP2269988B1 (de) |
JP (1) | JP4179989B2 (de) |
KR (1) | KR100633814B1 (de) |
CN (1) | CN100467450C (de) |
AR (1) | AR037261A1 (de) |
AT (1) | ATE494278T1 (de) |
AU (1) | AU2002342889B2 (de) |
BR (1) | BR0213939A (de) |
CA (1) | CA2462390C (de) |
DE (1) | DE60238856D1 (de) |
GB (2) | GB0126901D0 (de) |
HR (1) | HRP20040412A2 (de) |
IL (1) | IL161163A0 (de) |
MX (1) | MXPA04004390A (de) |
MY (1) | MY136322A (de) |
NO (1) | NO326986B1 (de) |
NZ (1) | NZ532587A (de) |
PE (1) | PE20030540A1 (de) |
PL (1) | PL368417A1 (de) |
PT (1) | PT1446381E (de) |
RS (1) | RS29404A (de) |
RU (1) | RU2315756C2 (de) |
TW (1) | TWI260985B (de) |
WO (1) | WO2003040101A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7307088B2 (en) * | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
GB0229022D0 (en) * | 2002-12-12 | 2003-01-15 | Novartis Ag | Organic Compounds |
UA89035C2 (ru) | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Эфиры гидроксамовых кислот и их фармацевтическое применение |
JP4673748B2 (ja) | 2004-01-28 | 2011-04-20 | 三井化学アグロ株式会社 | アミド誘導体及びその製造方法ならびにその殺虫剤としての使用方法 |
DE102004009238A1 (de) * | 2004-02-26 | 2005-09-08 | Merck Patent Gmbh | Arylamid-Derivate |
JPWO2006070878A1 (ja) * | 2004-12-28 | 2008-06-12 | アステラス製薬株式会社 | カルボン酸誘導体またはその塩 |
EP2145873A1 (de) * | 2008-06-17 | 2010-01-20 | Commissariat A L'energie Atomique | Neue Verbindungen, die eine Schutzaktivität gegen die Wirkung von Toxinen und Viren über einen intrazellulären Wirkungsmechanismus entfalten |
NZ591820A (en) | 2008-08-27 | 2012-12-21 | Leo Pharma As | Pyridine derivatives as vegfr-2 receptor and protein tyrosine kinase inhibitors |
JP2011057661A (ja) * | 2009-08-14 | 2011-03-24 | Bayer Cropscience Ag | 殺虫性カルボキサミド類 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US3226394A (en) * | 1964-06-16 | 1965-12-28 | Shulton Inc | Pyridylethylated anthranilamides and derivatives thereof |
WO1998014449A1 (en) | 1996-10-02 | 1998-04-09 | Novartis Ag | Fused pyrazole derivatives and processes for their preparation |
GB9824579D0 (en) * | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
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2001
- 2001-11-08 GB GBGB0126901.8A patent/GB0126901D0/en not_active Ceased
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2002
- 2002-06-05 GB GBGB0212917.9A patent/GB0212917D0/en not_active Ceased
- 2002-11-06 TW TW091132668A patent/TWI260985B/zh active
- 2002-11-06 PE PE2002001081A patent/PE20030540A1/es not_active Application Discontinuation
- 2002-11-06 AR ARP020104236A patent/AR037261A1/es not_active Application Discontinuation
- 2002-11-07 WO PCT/EP2002/012445 patent/WO2003040101A1/en active IP Right Grant
- 2002-11-07 BR BR0213939-1A patent/BR0213939A/pt not_active IP Right Cessation
- 2002-11-07 CN CNB028214307A patent/CN100467450C/zh not_active Expired - Fee Related
- 2002-11-07 PL PL02368417A patent/PL368417A1/xx not_active Application Discontinuation
- 2002-11-07 EP EP10180423A patent/EP2269988B1/de not_active Expired - Lifetime
- 2002-11-07 AT AT02779536T patent/ATE494278T1/de active
- 2002-11-07 RS YUP-294/04A patent/RS29404A/sr unknown
- 2002-11-07 CA CA2462390A patent/CA2462390C/en not_active Expired - Fee Related
- 2002-11-07 KR KR1020047007000A patent/KR100633814B1/ko not_active IP Right Cessation
- 2002-11-07 US US10/494,222 patent/US7067543B2/en not_active Expired - Fee Related
- 2002-11-07 NZ NZ532587A patent/NZ532587A/en not_active IP Right Cessation
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- 2002-11-07 JP JP2003542147A patent/JP4179989B2/ja not_active Expired - Fee Related
- 2002-11-07 MY MYPI20024160A patent/MY136322A/en unknown
- 2002-11-07 EP EP02779536A patent/EP1446381B1/de not_active Expired - Lifetime
- 2002-11-07 PT PT02779536T patent/PT1446381E/pt unknown
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- 2002-11-07 RU RU2004117548/04A patent/RU2315756C2/ru not_active IP Right Cessation
- 2002-11-07 DE DE60238856T patent/DE60238856D1/de not_active Expired - Lifetime
- 2002-11-07 AU AU2002342889A patent/AU2002342889B2/en not_active Ceased
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2004
- 2004-05-07 HR HR20040412A patent/HRP20040412A2/hr not_active Application Discontinuation
- 2004-05-25 NO NO20042137A patent/NO326986B1/no not_active IP Right Cessation
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