HRP20040402A2 - Use of 2-amino-4-pyridylmethyl-thiazoline derivatives as inhibitors of inducible no-synthase - Google Patents
Use of 2-amino-4-pyridylmethyl-thiazoline derivatives as inhibitors of inducible no-synthase Download PDFInfo
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- HRP20040402A2 HRP20040402A2 HR20040402A HRP20040402A HRP20040402A2 HR P20040402 A2 HRP20040402 A2 HR P20040402A2 HR 20040402 A HR20040402 A HR 20040402A HR P20040402 A HRP20040402 A HR P20040402A HR P20040402 A2 HRP20040402 A2 HR P20040402A2
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- pyridin
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- ylmethyl
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- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 title claims abstract description 11
- IKEKITJRHMNIAR-UHFFFAOYSA-N 4-(4,5-dihydro-1,3-thiazol-2-ylmethyl)pyridin-2-amine Chemical class C1=NC(N)=CC(CC=2SCCN=2)=C1 IKEKITJRHMNIAR-UHFFFAOYSA-N 0.000 title abstract description 7
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07—ORGANIC CHEMISTRY
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0114508A FR2832150B1 (fr) | 2001-11-09 | 2001-11-09 | Utilisation de derives de 2-amino-4-pyridylmethyl-thiazoline comme inhibiteurs de no-synthase inductible |
| US35297802P | 2002-01-30 | 2002-01-30 | |
| PCT/FR2002/003808 WO2003039446A2 (fr) | 2001-11-09 | 2002-11-07 | Derives de 2-amino-4-pyridylmethyl-thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20040402A2 true HRP20040402A2 (en) | 2004-10-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20040402A HRP20040402A2 (en) | 2001-11-09 | 2004-05-06 | Use of 2-amino-4-pyridylmethyl-thiazoline derivatives as inhibitors of inducible no-synthase |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6762196B2 (es) |
| EP (1) | EP1450750B1 (es) |
| JP (1) | JP4342309B2 (es) |
| CN (1) | CN1288153C (es) |
| AT (1) | ATE446295T1 (es) |
| BR (1) | BR0206368A (es) |
| CA (1) | CA2465877C (es) |
| CY (1) | CY1110284T1 (es) |
| DE (1) | DE60234117D1 (es) |
| DK (1) | DK1450750T3 (es) |
| ES (1) | ES2335090T3 (es) |
| HR (1) | HRP20040402A2 (es) |
| HU (1) | HUP0402033A2 (es) |
| IL (2) | IL161843A0 (es) |
| MA (1) | MA27143A1 (es) |
| MX (1) | MXPA04004213A (es) |
| NO (1) | NO20033131L (es) |
| PL (1) | PL370267A1 (es) |
| PT (1) | PT1450750E (es) |
| RU (1) | RU2004117531A (es) |
| SI (1) | SI1450750T1 (es) |
| WO (1) | WO2003039446A2 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10240735A1 (de) * | 2002-08-29 | 2004-03-18 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Verwendung von Modulatoren der NO-Signalkaskade und pharmazeutische Zusammensetzung |
| US8173642B2 (en) | 2005-10-25 | 2012-05-08 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives |
| JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
| AU2008245082B8 (en) | 2007-04-24 | 2012-09-13 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives substituted with a cyclic group |
| NZ589590A (en) | 2008-06-13 | 2012-05-25 | Shionogi & Co | Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity |
| EP2360155A4 (en) | 2008-10-22 | 2012-06-20 | Shionogi & Co | 2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT |
| MX2012006491A (es) | 2009-12-11 | 2012-07-03 | Shionogi & Co | Derivados de oxazina. |
| WO2012057247A1 (ja) | 2010-10-29 | 2012-05-03 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
| WO2012057248A1 (ja) | 2010-10-29 | 2012-05-03 | 塩野義製薬株式会社 | ナフチリジン誘導体 |
| CN103608345A (zh) | 2011-04-26 | 2014-02-26 | 盐野义制药株式会社 | 噁嗪衍生物和含有该噁嗪衍生物的bace1抑制剂 |
| WO2014065434A1 (en) | 2012-10-24 | 2014-05-01 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0670720A1 (en) * | 1992-11-27 | 1995-09-13 | The Wellcome Foundation Limited | Enzyme inhibitors |
| AU688811B2 (en) * | 1993-10-21 | 1998-03-19 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
| AU4149696A (en) * | 1994-11-15 | 1996-06-06 | Merck & Co., Inc. | Substituted heterocycles as inhibitors of nitric oxide synthase |
| FR2810037B1 (fr) * | 2000-06-09 | 2004-04-23 | Aventis Pharma Sa | Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible |
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2002
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- 2002-11-07 DE DE60234117T patent/DE60234117D1/de not_active Expired - Lifetime
- 2002-11-07 ES ES02793210T patent/ES2335090T3/es not_active Expired - Lifetime
- 2002-11-07 AT AT02793210T patent/ATE446295T1/de active
- 2002-11-07 CA CA002465877A patent/CA2465877C/fr not_active Expired - Fee Related
- 2002-11-07 CN CNB028246934A patent/CN1288153C/zh not_active Expired - Fee Related
- 2002-11-07 PL PL02370267A patent/PL370267A1/xx unknown
- 2002-11-07 EP EP02793210A patent/EP1450750B1/fr not_active Expired - Lifetime
- 2002-11-07 SI SI200230869T patent/SI1450750T1/sl unknown
- 2002-11-07 BR BR0206368-9A patent/BR0206368A/pt not_active Application Discontinuation
- 2002-11-07 HU HU0402033A patent/HUP0402033A2/hu unknown
- 2002-11-07 RU RU2004117531/04A patent/RU2004117531A/ru not_active Application Discontinuation
- 2002-11-07 MX MXPA04004213A patent/MXPA04004213A/es active IP Right Grant
- 2002-11-07 WO PCT/FR2002/003808 patent/WO2003039446A2/fr active Application Filing
- 2002-11-07 IL IL16184302A patent/IL161843A0/xx unknown
- 2002-11-07 DK DK02793210.2T patent/DK1450750T3/da active
- 2002-11-07 PT PT02793210T patent/PT1450750E/pt unknown
- 2002-11-08 US US10/290,624 patent/US6762196B2/en not_active Expired - Fee Related
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2003
- 2003-07-08 NO NO20033131A patent/NO20033131L/no unknown
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2004
- 2004-04-22 MA MA27644A patent/MA27143A1/fr unknown
- 2004-05-06 HR HR20040402A patent/HRP20040402A2/hr not_active Application Discontinuation
- 2004-05-06 IL IL161843A patent/IL161843A/en not_active IP Right Cessation
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2010
- 2010-01-20 CY CY20101100056T patent/CY1110284T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2335090T3 (es) | 2010-03-22 |
| WO2003039446A2 (fr) | 2003-05-15 |
| PL370267A1 (en) | 2005-05-16 |
| JP4342309B2 (ja) | 2009-10-14 |
| BR0206368A (pt) | 2004-02-10 |
| JP2005517634A (ja) | 2005-06-16 |
| DK1450750T3 (da) | 2010-03-08 |
| IL161843A0 (en) | 2005-11-20 |
| PT1450750E (pt) | 2010-01-18 |
| CA2465877A1 (fr) | 2003-05-15 |
| WO2003039446A3 (fr) | 2003-11-27 |
| MA27143A1 (fr) | 2005-01-03 |
| SI1450750T1 (sl) | 2010-02-26 |
| NO20033131D0 (no) | 2003-07-08 |
| CN1288153C (zh) | 2006-12-06 |
| NO20033131L (no) | 2003-08-27 |
| HUP0402033A2 (hu) | 2005-02-28 |
| RU2004117531A (ru) | 2005-04-10 |
| CN1602311A (zh) | 2005-03-30 |
| DE60234117D1 (de) | 2009-12-03 |
| EP1450750A2 (fr) | 2004-09-01 |
| CA2465877C (fr) | 2009-12-29 |
| MXPA04004213A (es) | 2004-07-08 |
| US20030153605A1 (en) | 2003-08-14 |
| ATE446295T1 (de) | 2009-11-15 |
| CY1110284T1 (el) | 2015-01-14 |
| US6762196B2 (en) | 2004-07-13 |
| IL161843A (en) | 2011-08-31 |
| EP1450750B1 (fr) | 2009-10-21 |
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