HRP20030448B1 - Ortho-substituted nitrogen-containing bisaryl compounds used as potassium channel inhibitors - Google Patents
Ortho-substituted nitrogen-containing bisaryl compounds used as potassium channel inhibitorsInfo
- Publication number
- HRP20030448B1 HRP20030448B1 HR20030448A HRP20030448A HRP20030448B1 HR P20030448 B1 HRP20030448 B1 HR P20030448B1 HR 20030448 A HR20030448 A HR 20030448A HR P20030448 A HRP20030448 A HR P20030448A HR P20030448 B1 HRP20030448 B1 HR P20030448B1
- Authority
- HR
- Croatia
- Prior art keywords
- carbon atoms
- alkyl
- phenyl
- methylsulfonyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10060807A DE10060807A1 (de) | 2000-12-07 | 2000-12-07 | Ortho, ortho-substituierte stickstoffhaltige Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| PCT/EP2001/013680 WO2002046162A1 (de) | 2000-12-07 | 2001-11-24 | Ortho-substituierte stickstoffhaltige bisarylverbindungen zur verwendung als kalium-kanal-inhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20030448A2 HRP20030448A2 (en) | 2005-04-30 |
| HRP20030448B1 true HRP20030448B1 (en) | 2006-06-30 |
Family
ID=7666129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20030448A HRP20030448B1 (en) | 2000-12-07 | 2001-11-24 | Ortho-substituted nitrogen-containing bisaryl compounds used as potassium channel inhibitors |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6794377B2 (cs) |
| EP (1) | EP1341764B1 (cs) |
| JP (1) | JP4445198B2 (cs) |
| KR (1) | KR100815070B1 (cs) |
| CN (1) | CN1237052C (cs) |
| AR (1) | AR033408A1 (cs) |
| AT (1) | ATE297897T1 (cs) |
| AU (2) | AU2189202A (cs) |
| BR (1) | BR0116005A (cs) |
| CA (1) | CA2436891C (cs) |
| CZ (1) | CZ301923B6 (cs) |
| DE (2) | DE10060807A1 (cs) |
| DK (1) | DK1341764T3 (cs) |
| EE (1) | EE05220B1 (cs) |
| ES (1) | ES2242792T3 (cs) |
| HR (1) | HRP20030448B1 (cs) |
| HU (1) | HUP0302762A3 (cs) |
| IL (2) | IL156312A0 (cs) |
| MX (1) | MXPA03004966A (cs) |
| NO (1) | NO325297B1 (cs) |
| NZ (1) | NZ526294A (cs) |
| PL (1) | PL207057B1 (cs) |
| PT (1) | PT1341764E (cs) |
| RU (1) | RU2275360C2 (cs) |
| SI (1) | SI1341764T1 (cs) |
| SK (1) | SK286056B6 (cs) |
| TW (1) | TWI242005B (cs) |
| WO (1) | WO2002046162A1 (cs) |
| YU (1) | YU40203A (cs) |
| ZA (1) | ZA200303931B (cs) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0124938D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124934D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124941D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124936D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124939D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124933D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| PT1474395E (pt) | 2002-02-12 | 2008-01-02 | Smithkline Beecham Corp | Derivados de nicotinamida úteis como inibidores de p38 |
| GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
| GB0308185D0 (en) * | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| DE10341233A1 (de) * | 2003-09-08 | 2005-03-24 | Aventis Pharma Deutschland Gmbh | Kombination von Phenylcarbonsäureamiden mit beta-Adrenozeptoren-Blockern und deren Verwendung zur Behandlung von Vorhofarrhythmien |
| US20050054673A1 (en) * | 2003-09-08 | 2005-03-10 | Aventis Pharma Deutschland Gmbh | Combination of phenylcarboxylic acid amides with beta-adrenoreceptor blockers and their use for the treatment of atrial arrhythmias |
| GB0402143D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
| GB0412986D0 (en) | 2004-06-10 | 2004-07-14 | Xention Discovery Ltd | Compounds |
| US7569589B2 (en) | 2004-07-29 | 2009-08-04 | Merck & Co., Inc. | Potassium channel inhibitors |
| US20080051416A1 (en) * | 2004-10-05 | 2008-02-28 | Smithkline Beecham Corporation | Novel Compounds |
| US7419962B2 (en) * | 2004-12-07 | 2008-09-02 | Enanta Pharmaceuticals, Inc. | 3,6-bicyclolides |
| US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| GB0512429D0 (en) * | 2005-06-17 | 2005-07-27 | Smithkline Beecham Corp | Novel compound |
| JP4943429B2 (ja) * | 2005-07-22 | 2012-05-30 | メルク・シャープ・エンド・ドーム・コーポレイション | カリウムチャネル阻害剤 |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| SG163543A1 (en) * | 2006-04-27 | 2010-08-30 | Sanofi Aventis Deutschland | Inhibitors of the task-1 and task-3 ion channel |
| GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| JP5485391B2 (ja) | 2009-07-30 | 2014-05-07 | エフ．ホフマン−ラ ロシュ アーゲー | Ｐ２ｘ７調節薬としてのジヒドロピリミドンアミド類 |
| GB201105659D0 (en) | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
| NO3175985T3 (cs) | 2011-07-01 | 2018-04-28 | ||
| CA2862670A1 (en) | 2012-01-27 | 2013-08-01 | Gilead Sciences, Inc. | Combination therapies using late sodium ion channel blockers and potassium ion channel blockers |
| EP3263559A1 (en) * | 2013-01-22 | 2018-01-03 | Technische Universität Graz | Lipase inhibitors |
| WO2014183221A1 (en) * | 2013-05-17 | 2014-11-20 | The Centre For Drug Research And Development | Resveratrol analogs and therapeutic uses thereof |
| TWI773657B (zh) | 2015-12-18 | 2022-08-11 | 美商亞德利克斯公司 | 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物 |
| US12084472B2 (en) | 2015-12-18 | 2024-09-10 | Ardelyx, Inc. | Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists |
| JP7120549B2 (ja) * | 2016-12-15 | 2022-08-17 | 小野薬品工業株式会社 | Ｔｒｅｋ（ｔｗｉｋ関連ｋチャネル）チャネルのアクチベータ |
| SMT202200134T1 (it) | 2018-03-08 | 2022-05-12 | Incyte Corp | Composti di amminopirazindiolo come inibitori di pi3k-y |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4616002A (en) * | 1984-11-09 | 1986-10-07 | Ciba-Geigy Corporation | Dihydro pyridine compounds, compositions and use |
| US5196537A (en) * | 1991-03-21 | 1993-03-23 | G. D. Searle & Co. | 5-apylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders |
| GB9307527D0 (en) * | 1993-04-13 | 1993-06-02 | Fujisawa Pharmaceutical Co | New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
| DE4430638A1 (de) * | 1994-08-29 | 1996-03-07 | Bayer Ag | Verwendung von substituierten 4-Phenyl-6-amino-nicotinsäurederivaten als Arzneimittel |
| US5670504A (en) | 1995-02-23 | 1997-09-23 | Merck & Co. Inc. | 2,6-diaryl pyridazinones with immunosuppressant activity |
| US6083986A (en) * | 1996-07-26 | 2000-07-04 | Icagen, Inc. | Potassium channel inhibitors |
| US5935945A (en) | 1996-10-31 | 1999-08-10 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| US5969017A (en) | 1996-10-31 | 1999-10-19 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| US6333337B1 (en) * | 1998-01-27 | 2001-12-25 | Icagen, Inc. | Potassium channel inhibitors |
| EP1082315A1 (en) | 1998-06-05 | 2001-03-14 | Icagen, Inc. | Potassium channel inhibitors |
| EP1109544A4 (en) * | 1998-09-01 | 2004-10-27 | Bristol Myers Squibb Co | POTASSIUM CHANNEL INHIBITORS AND THEIR METHOD OF USE |
| DE19947457A1 (de) * | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | 2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen |
| DE10059418A1 (de) * | 2000-11-30 | 2002-06-20 | Aventis Pharma Gmbh | Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
-
2000
- 2000-12-07 DE DE10060807A patent/DE10060807A1/de not_active Withdrawn
-
2001
- 2001-11-24 JP JP2002547901A patent/JP4445198B2/ja not_active Expired - Fee Related
- 2001-11-24 IL IL15631201A patent/IL156312A0/xx unknown
- 2001-11-24 MX MXPA03004966A patent/MXPA03004966A/es active IP Right Grant
- 2001-11-24 AU AU2189202A patent/AU2189202A/xx active Pending
- 2001-11-24 PL PL365318A patent/PL207057B1/pl not_active IP Right Cessation
- 2001-11-24 AT AT01999558T patent/ATE297897T1/de active
- 2001-11-24 CN CNB018201814A patent/CN1237052C/zh not_active Expired - Fee Related
- 2001-11-24 SK SK687-2003A patent/SK286056B6/sk not_active IP Right Cessation
- 2001-11-24 WO PCT/EP2001/013680 patent/WO2002046162A1/de not_active Ceased
- 2001-11-24 YU YU40203A patent/YU40203A/sh unknown
- 2001-11-24 DE DE50106549T patent/DE50106549D1/de not_active Expired - Lifetime
- 2001-11-24 SI SI200130385T patent/SI1341764T1/xx unknown
- 2001-11-24 ES ES01999558T patent/ES2242792T3/es not_active Expired - Lifetime
- 2001-11-24 HU HU0302762A patent/HUP0302762A3/hu unknown
- 2001-11-24 KR KR1020037007552A patent/KR100815070B1/ko not_active Expired - Fee Related
- 2001-11-24 DK DK01999558T patent/DK1341764T3/da active
- 2001-11-24 CA CA2436891A patent/CA2436891C/en not_active Expired - Fee Related
- 2001-11-24 BR BR0116005-2A patent/BR0116005A/pt not_active Application Discontinuation
- 2001-11-24 EP EP01999558A patent/EP1341764B1/de not_active Expired - Lifetime
- 2001-11-24 CZ CZ20031564A patent/CZ301923B6/cs not_active IP Right Cessation
- 2001-11-24 EE EEP200300225A patent/EE05220B1/xx not_active IP Right Cessation
- 2001-11-24 RU RU2003120080/04A patent/RU2275360C2/ru not_active IP Right Cessation
- 2001-11-24 HR HR20030448A patent/HRP20030448B1/xx not_active IP Right Cessation
- 2001-11-24 AU AU2002221892A patent/AU2002221892B2/en not_active Ceased
- 2001-11-24 NZ NZ526294A patent/NZ526294A/en unknown
- 2001-11-24 PT PT01999558T patent/PT1341764E/pt unknown
- 2001-12-05 AR ARP010105665A patent/AR033408A1/es active IP Right Grant
- 2001-12-05 US US10/002,326 patent/US6794377B2/en not_active Expired - Fee Related
- 2001-12-05 TW TW090130040A patent/TWI242005B/zh active
-
2003
- 2003-05-21 ZA ZA200303931A patent/ZA200303931B/en unknown
- 2003-06-02 NO NO20032488A patent/NO325297B1/no not_active IP Right Cessation
- 2003-06-04 IL IL156312A patent/IL156312A/en not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20030448B1 (en) | Ortho-substituted nitrogen-containing bisaryl compounds used as potassium channel inhibitors | |
| HRP20030436B1 (en) | Ortho-substituted and meta-substituted bis-aryl compounds, method for the production thereof, their use as a medicament, and pharmaceutical preparations containing these compounds | |
| HRP20020264B1 (hr) | 2'-supstituirani 1,1'-bifenil-2-karbonamidi, postupci za njihovu proizvodnju, njihova upotreba kao lijeka, kao i farmaceutski pripravci koji ih sadrže | |
| TWI266761B (en) | Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents | |
| HRP20080063T3 (en) | Capsaicin derivates and the production and use thereof | |
| RU2003120080A (ru) | Орто-замещенные азотсодержащие бисарильные соединения для применения в качестве ингибиторов калиевого канала, а также содержащие их фармацевтические композиции | |
| HUP0301607A2 (hu) | Szelektív neurokinin antagonista hatású nitrogéntartalmú heterociklusos vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| HRP20090005T3 (hr) | Biciklički heterociklički spojevi kao inhibitori hiv integraze | |
| DE602004017126D1 (de) | Acylsulfonamid-verbindungen als inhibitoren der rna-abhängigen rna-polymerase | |
| HUP0402026A2 (hu) | 5,6-Diaril-pirazin-2-amid-származékok mint CB1 antagonisták, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| CA2457054A1 (en) | Activator of peroxisome proliferator-activated receptor .delta. | |
| DK1260512T3 (da) | Hidtil ukendte, cykliske amidderivater | |
| WO2003106428A8 (fr) | Derives d'arylsulfonamides et leur utilisation en tant que antagonistes au recepteur b1 de la bradykinine | |
| HRP20021038B1 (hr) | Spojevi sa sulfonamidnom grupom i farmaceutske smjese koje sadrže te spojeve | |
| WO2002038565A3 (de) | 7-(r)-amino-triazolopyrimidine, deren herstellung und verwendung zur bekämpfung von pflanzenpathogenen pilzen | |
| NO20070457L (no) | Pyrazolderivater | |
| DE69012486D1 (de) | Überzugszusammensetzungen. | |
| YU48030B (sh) | Postupak za dobijanje supstituisanih piperidina i supstituisani piperidini | |
| PT1114076E (pt) | Aceleradores para sistemas endureciveis | |
| NO20021294D0 (no) | Benzopyranderivat | |
| TW200612920A (en) | Novel imidazolidine derivatives | |
| CA2423007A1 (en) | Spiro derivatives and adhesion molecule inhibitors containing the same as effective ingredients | |
| TW200420292A (en) | Benzofuran derivative | |
| NZ334439A (en) | Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa-receptor agonists | |
| TW325477B (en) | Thermochromic compounds, their preparation and the use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| PNAN | Change of the applicant name, address/residence |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, DE |
|
| B1PR | Patent granted | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20101122 Year of fee payment: 10 |
|
| PBON | Lapse due to non-payment of renewal fee |
Effective date: 20111125 |