HRP20020885B1 - SUPSTITUIRANI 9a-N-{N'-[4-(SULFONIL)FENILKARBAMOIL]}DERIVATI 9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A I 5-O-DESOZAMINIL-9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITRONOLIDA A - Google Patents

SUPSTITUIRANI 9a-N-{N'-[4-(SULFONIL)FENILKARBAMOIL]}DERIVATI 9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A I 5-O-DESOZAMINIL-9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITRONOLIDA A

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Publication number
HRP20020885B1
HRP20020885B1 HR20020885A HRP20020885A HRP20020885B1 HR P20020885 B1 HRP20020885 B1 HR P20020885B1 HR 20020885 A HR20020885 A HR 20020885A HR P20020885 A HRP20020885 A HR P20020885A HR P20020885 B1 HRP20020885 B1 HR P20020885B1
Authority
HR
Croatia
Prior art keywords
aza
dihydro
deoxo
phenylcarbamoyl
sulfonyl
Prior art date
Application number
HR20020885A
Other languages
English (en)
Inventor
Kujund�i� Nedjeljko
Bukvi� Kraja�i� Mirjana
Braj�a Karmen
Original Assignee
GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. filed Critical GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.
Priority to HR20020885A priority Critical patent/HRP20020885B1/hr
Priority to US10/534,628 priority patent/US7365056B2/en
Priority to PCT/HR2003/000058 priority patent/WO2004043985A1/en
Priority to AU2003282256A priority patent/AU2003282256A1/en
Priority to SI200330387T priority patent/SI1575969T1/sl
Priority to DK03773875T priority patent/DK1575969T3/da
Priority to EP03773875A priority patent/EP1575969B1/en
Priority to AT03773875T priority patent/ATE332908T1/de
Priority to PT03773875T priority patent/PT1575969E/pt
Priority to CL200302294A priority patent/CL2003002294A1/es
Priority to JP2004550854A priority patent/JP2006507315A/ja
Priority to DE60306807T priority patent/DE60306807T2/de
Priority to ES03773875T priority patent/ES2268446T3/es
Publication of HRP20020885A2 publication Critical patent/HRP20020885A2/hr
Priority to CY20061101461T priority patent/CY1106193T1/el
Publication of HRP20020885B1 publication Critical patent/HRP20020885B1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Supstituirani 9a-N-{N'-[4-(sulfonil)fenilkarbamoil]} derivati 9-deokso-9-dihidro-9a-aza-9a-homoeritromicina A i 5-O-desozaminil-9-deokso-9-dihidro-9a-aza-9a-homoeritronolida A opće formule 1, naznačen time, daR ima značenje H ili kladinozilnog ostatka, R1 ima značenje klor, amino, fenilamino, 2-piridilamino, 3,4-dimetil-5-izoksazolilamino i 5-metil-3-izoksazolilamino grupe, i njihove farmaceutskiprihvatljive adicione soli s anorganskim ili organskim kiselinama. Patent sadrži još 15 patentnih zahtjeva.
HR20020885A 2002-11-11 2002-11-11 SUPSTITUIRANI 9a-N-{N'-[4-(SULFONIL)FENILKARBAMOIL]}DERIVATI 9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A I 5-O-DESOZAMINIL-9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITRONOLIDA A HRP20020885B1 (hr)

Priority Applications (14)

Application Number Priority Date Filing Date Title
HR20020885A HRP20020885B1 (hr) 2002-11-11 2002-11-11 SUPSTITUIRANI 9a-N-{N'-[4-(SULFONIL)FENILKARBAMOIL]}DERIVATI 9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A I 5-O-DESOZAMINIL-9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITRONOLIDA A
AT03773875T ATE332908T1 (de) 2002-11-11 2003-11-10 Substituierte 9a-n-(n' 4- (sulfonyl)phenylcarbamoyl) derivate von 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin a und 5-0- desosaminyl-9-deoxo-9-di-hydro-9a-aza-9a- homoerithronolide a
PT03773875T PT1575969E (pt) 2002-11-11 2003-11-10 Derivados com substituicao 9a-n- (n'-4- ( sulfonil )fenil ) carbamoilo ) de 9-desoxo-9-dihidro-9a-aza-9a-homoeritromicina a e 5-0-desosaminil-9-desoxo-9-di-hidro-9a-aza-9a-homoeritronilida a
AU2003282256A AU2003282256A1 (en) 2002-11-11 2003-11-10 Substituted 9a-n-{n'-(4-(sulfonyl)phenyl)carbamoyl} derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin a and 5-0-desosaminyl--9-deoxo-9-di-hydro-9a-aza-9a-homoerithronolide a
SI200330387T SI1575969T1 (sl) 2002-11-11 2003-11-10 Substituirani 9a-n-(n'-4-(sulfonil)fenil karbamoil) derivati 9-deokso-9-dihidro-9a-aza-9a-homoeritromicina a in 5-o-desozaminil-9-deokso-9-dihidro-9a-aza-9a-homoeritronolida a
DK03773875T DK1575969T3 (da) 2002-11-11 2003-11-10 Substituerede 9a-N-(N'-4(sulfonyl)phenylcarbamoyl)-derivater af 9 deoxo-9-dihydro-9a-aza-9a-homoerithromycin A og 5-O-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerithronolid A
EP03773875A EP1575969B1 (en) 2002-11-11 2003-11-10 SUBSTITUTED 9a-N-(N'- 4-(SULFONYL)PHENYL CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-0-DESOSAMINYL-9-DEOXO-9-DI-HYDRO-9A-AZA-9A-HOMOERITHRONOLIDE A
US10/534,628 US7365056B2 (en) 2002-11-11 2003-11-10 Substituted 9a-N-(N′-(sulfonyl)phenylcarbamoyl)derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithomycin A and 5-0-desosaminyl-9-deoxo-9-dihydro-9-a-aza-9a-homoerithronolide A
PCT/HR2003/000058 WO2004043985A1 (en) 2002-11-11 2003-11-10 Substituted 9a-n-{n'-[4-(sulfonyl)phenyl]carbamoyl} derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin a and 5-0-desosaminyl­-9-deoxo-9-di-hydro-9a-aza-9a-homoerithronolide a
CL200302294A CL2003002294A1 (es) 2002-11-11 2003-11-10 Derivados de sulfonilfenilcarbamoil sustituidos de 9-deoxo-9-dihidro-9a-aza-9a-homoertitromicina a y 5-o- desosaminil-9-deoxo-9-dihidro-9a-aza-9a-homoeritromnolida a, composicion farmaceutica, procedimiento de preparacion, util para esterilizar salas
JP2004550854A JP2006507315A (ja) 2002-11-11 2003-11-10 ９−デオキソ−９−ジヒドロ−９ａ−アザ−９ａ−ホモエリスロマイシンＡ及び５−Ｏ−デソサミニル−９−デオキソ−９−ジヒドロ−９ａ−アザ−９ａ−ホモエリスロノリドＡの置換した９ａ−Ｎ−｛Ｎ’−［４−（スルホニル）フェニルカルバモイル］｝誘導体
DE60306807T DE60306807T2 (de) 2002-11-11 2003-11-10 SUBSTITUIERTE 9a-N-(N'[4-(SULFONYL)PHENYLCARBAMOYL])-DERIVATE VON 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A UND 5-0-DESOSAMINYL-9-DEOXO-9-DI-HYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
ES03773875T ES2268446T3 (es) 2002-11-11 2003-11-10 Derivados 9a-n-(n'-(4-(sulfonil)fenilcarbamoil)) sustituidos de 9-desoxo-9-dihidro-9a-aza-9a-homoeritromicina a y de 5-o-desosaminil-9-desoxo-9-dihidro-9a-aza-9a-homoeritronolido a.
CY20061101461T CY1106193T1 (el) 2002-11-11 2006-10-12 YΠΟΚΑΤΕΣΤΗΜΕΝΑ ΠΑΡΑΓΩΓΑ 9α-Ν-(Ν’-4-(ΣΟΥΛΦΟΝΥΛΟ) ΦΑΙΝΥΛΟΚΑΡΒΑΜΟΫΛΟ) ΤΗΣ 9-ΔΕΟΞΟ-9-ΔΙΥΔΡΟ-9α-ΑΖΑ-9α-ΟΜΟEPΥΘΡΟΜΥΚΙΝΗΣ Α ΚΑΙ ΤΗΣ 5-0-ΔΕΣΟΣΑΜΙΝΥΛΟ-9-ΔΕΟΞΟ-9-ΔΙΥΔΡΟ-9α-ΑΖΑ-9α-ΟΜΟEPΥΘΡΟΝΟΛΙΔΗΣ Α

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR20020885A HRP20020885B1 (hr) 2002-11-11 2002-11-11 SUPSTITUIRANI 9a-N-{N'-[4-(SULFONIL)FENILKARBAMOIL]}DERIVATI 9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A I 5-O-DESOZAMINIL-9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITRONOLIDA A

Publications (2)

Publication Number Publication Date
HRP20020885A2 HRP20020885A2 (en) 2005-04-30
HRP20020885B1 true HRP20020885B1 (hr) 2007-05-31

Family

ID=32310061

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020885A HRP20020885B1 (hr) 2002-11-11 2002-11-11 SUPSTITUIRANI 9a-N-{N'-[4-(SULFONIL)FENILKARBAMOIL]}DERIVATI 9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A I 5-O-DESOZAMINIL-9-DEOKSO-9-DIHIDRO-9a-AZA-9a-HOMOERITRONOLIDA A

Country Status (13)

Country Link
US (1) US7365056B2 (hr)
EP (1) EP1575969B1 (hr)
JP (1) JP2006507315A (hr)
AT (1) ATE332908T1 (hr)
AU (1) AU2003282256A1 (hr)
CL (1) CL2003002294A1 (hr)
CY (1) CY1106193T1 (hr)
DE (1) DE60306807T2 (hr)
DK (1) DK1575969T3 (hr)
ES (1) ES2268446T3 (hr)
HR (1) HRP20020885B1 (hr)
PT (1) PT1575969E (hr)
WO (1) WO2004043985A1 (hr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020991A2 (en) 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
EP1841437B1 (en) * 2005-01-14 2009-04-29 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. 9a-carbamoyl and thiocarbamoyl azalides with antimalarial activity
CN104119413B (zh) * 2014-07-29 2016-08-24 华中农业大学 一种土拉霉素残留标示物的合成方法

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FR2473525A1 (fr) 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
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Also Published As

Publication number Publication date
WO2004043985A1 (en) 2004-05-27
EP1575969B1 (en) 2006-07-12
AU2003282256A1 (en) 2004-06-03
HRP20020885A2 (en) 2005-04-30
DK1575969T3 (da) 2006-10-30
PT1575969E (pt) 2006-10-31
US7365056B2 (en) 2008-04-29
JP2006507315A (ja) 2006-03-02
US20060084795A1 (en) 2006-04-20
EP1575969A1 (en) 2005-09-21
ATE332908T1 (de) 2006-08-15
CL2003002294A1 (es) 2005-01-28
DE60306807D1 (de) 2006-08-24
DE60306807T2 (de) 2007-01-18
CY1106193T1 (el) 2011-06-08
ES2268446T3 (es) 2007-03-16

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