HRP20020305A8 - 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof - Google Patents
2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereofInfo
- Publication number
- HRP20020305A8 HRP20020305A8 HR20020305A HRP20020305A HRP20020305A8 HR P20020305 A8 HRP20020305 A8 HR P20020305A8 HR 20020305 A HR20020305 A HR 20020305A HR P20020305 A HRP20020305 A HR P20020305A HR P20020305 A8 HRP20020305 A8 HR P20020305A8
- Authority
- HR
- Croatia
- Prior art keywords
- necrosis factor
- thia
- intermediates
- preparation
- dibenzoazulenes
- Prior art date
Links
- ZOJHYZMNGGBPBV-UHFFFAOYSA-N 4-thiatetracyclo[12.4.0.02,6.08,13]octadeca-1(18),2,6,8,10,12,14,16-octaene Chemical class C1SC=C2C3=C(C4=C(C=C12)C=CC=C4)C=CC=C3 ZOJHYZMNGGBPBV-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 102000018594 Tumour necrosis factor Human genes 0.000 title 1
- 108050007852 Tumour necrosis factor Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000000589 Interleukin-1 Human genes 0.000 abstract 2
- 108010002352 Interleukin-1 Proteins 0.000 abstract 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- -1 forms Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 230000006433 tumor necrosis factor production Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C07D333/80—Seven-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Priority Applications (27)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR20020305A HRP20020305A8 (en) | 2002-04-10 | 2002-04-10 | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| JP2003582159A JP2005526828A (ja) | 2002-04-10 | 2003-04-09 | 腫瘍壊死因子産生の阻害剤としての２−チア−ジベンゾアズレン類及びその製造用中間体 |
| RU2004132868/04A RU2334749C2 (ru) | 2002-04-10 | 2003-04-09 | 2-тиадибензоазулены в качестве ингибиторов продуцирования фактора некроза опухоли и промежуточные продукты для их получения |
| AT03745849T ATE320433T1 (de) | 2002-04-10 | 2003-04-09 | 2-thia-dibenzoazulene als inhibitoren der produktion von tumornekrosefaktor und zwischenprodukte für deren herstellung |
| CNA038094932A CN1649875A (zh) | 2002-04-10 | 2003-04-09 | 作为肿瘤坏死因子产生抑制剂的2－硫杂－二苯并薁及用于其制备的中间体 |
| PCT/HR2003/000016 WO2003084962A1 (en) | 2002-04-10 | 2003-04-09 | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| IL16439603A IL164396A0 (en) | 2002-04-10 | 2003-04-09 | 2-Thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| EP03745849A EP1509530B1 (de) | 2002-04-10 | 2003-04-09 | 2-thia-dibenzoazulene als inhibitoren der produktion von tumornekrosefaktor und zwischenprodukte für deren herstellung |
| NZ535620A NZ535620A (en) | 2002-04-10 | 2003-04-09 | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| PL03372748A PL372748A1 (en) | 2002-04-10 | 2003-04-09 | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| MXPA04009943A MXPA04009943A (es) | 2002-04-10 | 2003-04-09 | 2-tiadibenzoazulenos como inhibidores de la produccion de factor de necrosis tumoral e intermediarios para su preparacion. |
| SI200330275T SI1509530T1 (sl) | 2002-04-10 | 2003-04-09 | 2-tia-dibenzoazuleni kot inhibitorji proizvodnje tumorje nekrotizirajocega faktorja in intermediatiza njihovo pripravo |
| DK03745849T DK1509530T3 (da) | 2002-04-10 | 2003-04-09 | 2-Thia-dibenzoazulener som inhibitorer af tumornekrosefaktorproduktion og mellemprodukter til fremstilling deraf |
| YU88304A YU88304A (sh) | 2002-04-10 | 2003-04-09 | 2-tia-dibenzoazuleni kao inhibitori stvaranja faktora tumorske nekroze i međuproizvodi za njihovo pripremanje |
| ES03745849T ES2260637T3 (es) | 2002-04-10 | 2003-04-09 | 2-tiadibenzoazuleno como inhibidores de la produccion del factor de necrosis tumoral e intermediarios para su preparacion. |
| DE60304048T DE60304048T2 (de) | 2002-04-10 | 2003-04-09 | 2-thia-dibenzoazulene als inhibitoren der produktion von tumornekrosefaktor und zwischenprodukte für deren herstellung |
| BR0309094-9A BR0309094A (pt) | 2002-04-10 | 2003-04-09 | 2-tia-dibenzoazulenos como inibidores da produção do fator de necrose de tumor e intermediários para a preparação dos mesmos |
| AU2003259963A AU2003259963A1 (en) | 2002-04-10 | 2003-04-09 | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| PT03745849T PT1509530E (pt) | 2002-04-10 | 2003-04-09 | 2-tia-dibenzoazulenos como inibidores da producao do factor de necrose tumoral e intermediarios para a producao destes |
| CA002481514A CA2481514A1 (en) | 2002-04-10 | 2003-04-09 | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| US10/510,866 US7435834B2 (en) | 2002-04-10 | 2003-04-09 | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| UA20041008547A UA79277C2 (en) | 2002-04-10 | 2003-09-04 | 2-thia-dibenzoazulenes as inhibitors of tumors necrosis factor production, process for the preparation and use thereof |
| IS7474A IS7474A (is) | 2002-04-10 | 2004-09-27 | 1-Þía-bensónaftóasúlen sem hindrar fyrir æxlisdrepþáttar framleiðslu og milliefni til framleiðslu þeirra |
| ZA200408063A ZA200408063B (en) | 2002-04-10 | 2004-10-06 | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| US10/965,659 US20050131056A1 (en) | 2002-04-10 | 2004-10-12 | 2- thia-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof |
| NO20044506A NO20044506L (no) | 2002-04-10 | 2004-10-21 | 2-tia-dibenzoazulener som inhibitorer for tumornekrosefaktorproduksjon og mellomprodukter for fremstilling derav |
| CY20061100649T CY1105036T1 (el) | 2002-04-10 | 2006-05-18 | 2-θεια-διβενζοαζουλενια ως αναστολεις της παραγωγης του παραγοντα νεκρωσης ογκων και ενδιαμεσα για την παρασκευη αυτων |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR20020305A HRP20020305A8 (en) | 2002-04-10 | 2002-04-10 | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20020305A2 HRP20020305A2 (en) | 2003-10-31 |
| HRP20020305A8 true HRP20020305A8 (en) | 2009-03-31 |
Family
ID=28686903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20020305A HRP20020305A8 (en) | 2002-04-10 | 2002-04-10 | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7435834B2 (de) |
| EP (1) | EP1509530B1 (de) |
| JP (1) | JP2005526828A (de) |
| CN (1) | CN1649875A (de) |
| AT (1) | ATE320433T1 (de) |
| AU (1) | AU2003259963A1 (de) |
| BR (1) | BR0309094A (de) |
| CA (1) | CA2481514A1 (de) |
| CY (1) | CY1105036T1 (de) |
| DE (1) | DE60304048T2 (de) |
| DK (1) | DK1509530T3 (de) |
| ES (1) | ES2260637T3 (de) |
| HR (1) | HRP20020305A8 (de) |
| IL (1) | IL164396A0 (de) |
| IS (1) | IS7474A (de) |
| MX (1) | MXPA04009943A (de) |
| NO (1) | NO20044506L (de) |
| NZ (1) | NZ535620A (de) |
| PL (1) | PL372748A1 (de) |
| PT (1) | PT1509530E (de) |
| RU (1) | RU2334749C2 (de) |
| SI (1) | SI1509530T1 (de) |
| UA (1) | UA79277C2 (de) |
| WO (1) | WO2003084962A1 (de) |
| YU (1) | YU88304A (de) |
| ZA (1) | ZA200408063B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20020304B1 (en) * | 2002-04-10 | 2008-04-30 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof |
| HRP20020305A8 (en) | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| HRP20020452A2 (en) * | 2002-05-23 | 2004-02-29 | Pliva D D | 1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof |
| HRP20030885A2 (en) * | 2003-11-03 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS |
| HRP20030956A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU |
| WO2007075772A2 (en) * | 2005-12-20 | 2007-07-05 | President And Fellows Of Harvard College | Compounds, screens, and methods of treatment |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3711489A (en) * | 1971-03-31 | 1973-01-16 | Pfizer | Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles |
| CA967573A (en) | 1972-12-22 | 1975-05-13 | Joseph G. Lombardino | Tetracyclic anti-inflammatory agents |
| NL7605526A (nl) * | 1976-05-24 | 1977-11-28 | Akzo Nv | Nieuwe tetracyclische derivaten. |
| US4198421A (en) * | 1978-11-30 | 1980-04-15 | E. I. Du Pont De Nemours And Company | Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles |
| FR2504140A1 (fr) | 1981-04-16 | 1982-10-22 | Centre Nat Rech Scient | Nouveaux derives tetracycliques de la dibenzazepine, leur procede de preparation et les compositions pharmaceutiques en renfermant |
| EP0125484A1 (de) | 1983-04-12 | 1984-11-21 | Ciba-Geigy Ag | Polycyclische Carbonsäureverbindungen, Verfahren zu ihrer Herstellung und Präparate enthaltend solche Carbonsäureverbindungen, sowie deren Verwendung |
| IE62754B1 (en) | 1988-08-26 | 1995-02-22 | Akzo Nv | Tetracyclic antidepressants |
| IT1227527B (it) | 1988-12-05 | 1991-04-12 | Ciatti Maurizio | Spazzolino da denti a setole rotanti |
| US5552399A (en) | 1994-11-02 | 1996-09-03 | Janssen Pharmaceutica N.V. | Substituted tetracyclic azepine derivatives |
| CA2203664A1 (en) | 1994-11-02 | 1996-05-17 | Francisco Javier Fernandez-Gadea | Substituted tetracyclic oxazepine and thiazepine derivatives with 5-ht2 receptor affinity |
| PT892793E (pt) | 1996-04-12 | 2003-08-29 | Janssen Pharmaceutica Nv | Derivados 2-cianoiminoimidazolo inibidores da pde iv |
| UA52778C2 (uk) * | 1997-10-10 | 2003-01-15 | Янссен Фармацевтика Н.В. | Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі |
| HRP20000310A2 (en) * | 2000-05-17 | 2002-02-28 | Pliva Farmaceutska Ind Dioniko | New dibenzoazulene compounds as tumor necrosis factor inhibitors |
| HRP20020305A8 (en) | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| HRP20030957A2 (en) | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20040104A2 (en) | 2004-01-30 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders |
-
2002
- 2002-04-10 HR HR20020305A patent/HRP20020305A8/xx not_active Application Discontinuation
-
2003
- 2003-04-09 JP JP2003582159A patent/JP2005526828A/ja active Pending
- 2003-04-09 IL IL16439603A patent/IL164396A0/xx unknown
- 2003-04-09 YU YU88304A patent/YU88304A/sh unknown
- 2003-04-09 SI SI200330275T patent/SI1509530T1/sl unknown
- 2003-04-09 PL PL03372748A patent/PL372748A1/xx not_active Application Discontinuation
- 2003-04-09 PT PT03745849T patent/PT1509530E/pt unknown
- 2003-04-09 ES ES03745849T patent/ES2260637T3/es not_active Expired - Lifetime
- 2003-04-09 AT AT03745849T patent/ATE320433T1/de not_active IP Right Cessation
- 2003-04-09 RU RU2004132868/04A patent/RU2334749C2/ru not_active IP Right Cessation
- 2003-04-09 US US10/510,866 patent/US7435834B2/en not_active Expired - Fee Related
- 2003-04-09 BR BR0309094-9A patent/BR0309094A/pt not_active IP Right Cessation
- 2003-04-09 AU AU2003259963A patent/AU2003259963A1/en not_active Abandoned
- 2003-04-09 CA CA002481514A patent/CA2481514A1/en not_active Abandoned
- 2003-04-09 MX MXPA04009943A patent/MXPA04009943A/es active IP Right Grant
- 2003-04-09 NZ NZ535620A patent/NZ535620A/xx unknown
- 2003-04-09 WO PCT/HR2003/000016 patent/WO2003084962A1/en active IP Right Grant
- 2003-04-09 DE DE60304048T patent/DE60304048T2/de not_active Expired - Fee Related
- 2003-04-09 DK DK03745849T patent/DK1509530T3/da active
- 2003-04-09 EP EP03745849A patent/EP1509530B1/de not_active Expired - Lifetime
- 2003-04-09 CN CNA038094932A patent/CN1649875A/zh active Pending
- 2003-09-04 UA UA20041008547A patent/UA79277C2/uk unknown
-
2004
- 2004-09-27 IS IS7474A patent/IS7474A/is unknown
- 2004-10-06 ZA ZA200408063A patent/ZA200408063B/en unknown
- 2004-10-21 NO NO20044506A patent/NO20044506L/no not_active Application Discontinuation
-
2006
- 2006-05-18 CY CY20061100649T patent/CY1105036T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20020305A2 (en) | 2003-10-31 |
| DK1509530T3 (da) | 2006-07-17 |
| CY1105036T1 (el) | 2010-03-03 |
| BR0309094A (pt) | 2005-02-09 |
| IS7474A (is) | 2004-09-27 |
| EP1509530A1 (de) | 2005-03-02 |
| US7435834B2 (en) | 2008-10-14 |
| NO20044506L (no) | 2004-11-09 |
| ES2260637T3 (es) | 2006-11-01 |
| ATE320433T1 (de) | 2006-04-15 |
| ZA200408063B (en) | 2006-07-26 |
| JP2005526828A (ja) | 2005-09-08 |
| RU2334749C2 (ru) | 2008-09-27 |
| DE60304048D1 (de) | 2006-05-11 |
| DE60304048T2 (de) | 2006-10-19 |
| SI1509530T1 (sl) | 2006-08-31 |
| UA79277C2 (en) | 2007-06-11 |
| NZ535620A (en) | 2006-03-31 |
| CA2481514A1 (en) | 2003-10-16 |
| PT1509530E (pt) | 2006-07-31 |
| PL372748A1 (en) | 2005-08-08 |
| CN1649875A (zh) | 2005-08-03 |
| US20050182126A1 (en) | 2005-08-18 |
| IL164396A0 (en) | 2005-12-18 |
| EP1509530B1 (de) | 2006-03-15 |
| MXPA04009943A (es) | 2005-09-30 |
| RU2004132868A (ru) | 2005-06-10 |
| YU88304A (sh) | 2006-08-17 |
| WO2003084962A1 (en) | 2003-10-16 |
| AU2003259963A1 (en) | 2003-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| PPPP | Transfer of rights |
Owner name: PLIVA-ISTRAZIVACKI INSTITUT D.O.O., HR |
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