HRP20010797A2 - eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING - Google Patents
eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING Download PDFInfo
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- HRP20010797A2 HRP20010797A2 HR20010797A HRP20010797A HRP20010797A2 HR P20010797 A2 HRP20010797 A2 HR P20010797A2 HR 20010797 A HR20010797 A HR 20010797A HR P20010797 A HRP20010797 A HR P20010797A HR P20010797 A2 HRP20010797 A2 HR P20010797A2
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Physics & Mathematics (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12955099P | 1999-04-16 | 1999-04-16 | |
| PCT/US2000/009913 WO2000062605A1 (en) | 1999-04-16 | 2000-04-14 | eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20010797A2 true HRP20010797A2 (en) | 2003-02-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20010797A HRP20010797A2 (en) | 1999-04-16 | 2001-10-29 | eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US6900038B2 (zh) |
| EP (1) | EP1178722A4 (zh) |
| JP (1) | JP2002541829A (zh) |
| KR (1) | KR100737945B1 (zh) |
| CN (1) | CN100357433C (zh) |
| AU (2) | AU774010B2 (zh) |
| BG (1) | BG106051A (zh) |
| BR (1) | BR0009805A (zh) |
| CA (1) | CA2369764A1 (zh) |
| CZ (1) | CZ20013427A3 (zh) |
| EE (1) | EE200100538A (zh) |
| HK (1) | HK1046081B (zh) |
| HR (1) | HRP20010797A2 (zh) |
| HU (1) | HUP0200799A3 (zh) |
| IL (1) | IL145760A0 (zh) |
| MX (1) | MXPA01010459A (zh) |
| NO (1) | NO20015008L (zh) |
| NZ (1) | NZ514305A (zh) |
| PL (1) | PL351087A1 (zh) |
| RU (1) | RU2257226C2 (zh) |
| SK (1) | SK14692001A3 (zh) |
| UA (1) | UA76939C2 (zh) |
| WO (1) | WO2000062605A1 (zh) |
| YU (1) | YU73301A (zh) |
| ZA (1) | ZA200108463B (zh) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL145760A0 (en) * | 1999-04-16 | 2002-07-25 | Univ Yale | eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING |
| US7098016B2 (en) | 2002-06-14 | 2006-08-29 | Wisconsin Alumni Research Foundation | Ribonuclease zymogen design |
| US20040120930A1 (en) * | 2002-08-16 | 2004-06-24 | Schering Aktiengesellschaft | Gene therapy for critical limb ischemia with wild type or mutant eNOS |
| MXPA05001906A (es) * | 2002-08-16 | 2005-04-28 | Schering Ag | Mutantes de enos utiles para genoterapia. |
| GB0226463D0 (en) * | 2002-11-13 | 2002-12-18 | Isis Innovation | Mimicking the athletic heart |
| CN1717254A (zh) * | 2002-12-02 | 2006-01-04 | 安增子摩祺株式会社 | 用于治疗或预防血管生成－依赖性症状的组合物 |
| WO2006023879A1 (en) * | 2004-08-20 | 2006-03-02 | Board Of Regents, The University Of Texas System | Screening of agents for activity against ischemic myocardial insults |
| MX2007003522A (es) * | 2004-09-24 | 2007-06-11 | Beth Israel Hospital | Complicaciones del embarazo. |
| US7740849B2 (en) * | 2004-09-24 | 2010-06-22 | Beth Israel Deaconess Medical Center | Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders |
| US20090286271A1 (en) * | 2006-05-31 | 2009-11-19 | Karumanchi Ananth S | Methods of Diagnosing and Treating Complications of Pregnancy |
| CA2654283A1 (en) * | 2006-05-31 | 2008-03-13 | Beth Israel Deaconess Medical Center, Inc. | Methods of diagnosing and treating complications of pregnancy |
| US8183007B2 (en) | 2008-07-22 | 2012-05-22 | Promega Corporation | ADP detection based methods using adenylate cyclase and bioluminescence |
| US8652785B2 (en) * | 2008-12-04 | 2014-02-18 | Sanofi | Method of screening a modulator of endothelial NO synthase comprising the use of heme binding protein 1 |
| RU2526575C2 (ru) * | 2012-11-02 | 2014-08-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ повышения иммуносупрессивных свойств мезенхимальных стромальных клеток жировой ткани |
| JP6510041B2 (ja) | 2014-10-08 | 2019-05-08 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 生物発光サクシネート検出アッセイ |
| CN107802826B (zh) * | 2017-10-26 | 2020-02-18 | 首都医科大学宣武医院 | eNOS突变体在促进血管生成中的应用 |
| CN116790603B (zh) * | 2023-08-18 | 2023-10-31 | 成都中科奥格生物科技有限公司 | 一种sgRNA、CRISPR/Cas9载体及其构建方法和用途 |
Family Cites Families (10)
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| US5498539A (en) * | 1992-07-02 | 1996-03-12 | Daiichi Pharmaceutical Co., Ltd. | Bovine endothelial nitric oxide synthase nucleic acids |
| US5658565A (en) * | 1994-06-24 | 1997-08-19 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Inducible nitric oxide synthase gene for treatment of disease |
| DE4411402A1 (de) * | 1994-03-31 | 1995-10-05 | Juergen Schrader | DNA-Expressionsvektoren zur Verwendung in der gentherapeutischen Behandlung von Gefäßerkrankungen |
| FR2722507B1 (fr) * | 1994-07-12 | 1996-08-14 | Rhone Poulenc Rorer Sa | Adenovirus comportant un gene codant pour une no synthase |
| US5968983A (en) * | 1994-10-05 | 1999-10-19 | Nitrosystems, Inc | Method and formulation for treating vascular disease |
| US5837534A (en) * | 1995-11-14 | 1998-11-17 | The Board Of Regents Of The University Of Texas System | Smooth muscle 22α promoter, gene transfer vectors containing the same, and method of use of the same to target gene expression in arterial smooth muscle cells |
| WO2000020025A2 (en) * | 1998-10-02 | 2000-04-13 | St. Elizabeth's Medical Center, Inc. | Akt compositions for enhancing survival of cells |
| ATE402995T1 (de) * | 1999-03-19 | 2008-08-15 | Aventis Pharma Inc | Akt-3 nukleinsäure, polypeptide und deren verwendung |
| IL145760A0 (en) * | 1999-04-16 | 2002-07-25 | Univ Yale | eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING |
| SI20978A (sl) * | 1999-06-11 | 2003-02-28 | Aventis Pharmaceuticals Products Inc. | Indukcija vaskularnega endotelnega rastnega faktorja (VEGF) s serin/treonin protein kinazo Akt |
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- 2000-04-14 EE EEP200100538A patent/EE200100538A/xx unknown
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- 2000-04-14 JP JP2000611751A patent/JP2002541829A/ja active Pending
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2011
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