HRP20000726B1 - Quinoline derivatives - Google Patents

Quinoline derivatives

Info

Publication number
HRP20000726B1
HRP20000726B1 HR20000726A HRP20000726A HRP20000726B1 HR P20000726 B1 HRP20000726 B1 HR P20000726B1 HR 20000726 A HR20000726 A HR 20000726A HR P20000726 A HRP20000726 A HR P20000726A HR P20000726 B1 HRP20000726 B1 HR P20000726B1
Authority
HR
Croatia
Prior art keywords
propyl
iso
butyl
ethyl
quinoline derivatives
Prior art date
Application number
HR20000726A
Other languages
English (en)
Croatian (hr)
Inventor
Bj�rk Anders
J�nsson Stig
Fex Tomas
Hedlund Gunnar
Original Assignee
Active Biotech Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Active Biotech Ab filed Critical Active Biotech Ab
Publication of HRP20000726A2 publication Critical patent/HRP20000726A2/hr
Publication of HRP20000726B1 publication Critical patent/HRP20000726B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR20000726A 1998-04-27 2000-10-26 Quinoline derivatives HRP20000726B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9801474A SE9801474D0 (sv) 1998-04-27 1998-04-27 Quinoline Derivatives
PCT/SE1999/000676 WO1999055678A1 (en) 1998-04-27 1999-04-26 Quinoline derivatives

Publications (2)

Publication Number Publication Date
HRP20000726A2 HRP20000726A2 (en) 2001-04-30
HRP20000726B1 true HRP20000726B1 (en) 2009-04-30

Family

ID=20411103

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000726A HRP20000726B1 (en) 1998-04-27 2000-10-26 Quinoline derivatives

Country Status (33)

Country Link
EP (1) EP1073639B1 (pt)
JP (1) JP4045069B2 (pt)
KR (1) KR100571534B1 (pt)
CN (1) CN1113057C (pt)
AP (1) AP1293A (pt)
AT (1) ATE228505T1 (pt)
AU (1) AU747550B2 (pt)
BR (1) BR9909925B1 (pt)
CA (1) CA2329788C (pt)
CZ (1) CZ297439B6 (pt)
DE (1) DE69904162T2 (pt)
DK (1) DK1073639T3 (pt)
EE (1) EE04275B1 (pt)
ES (1) ES2188242T3 (pt)
HK (1) HK1036618A1 (pt)
HR (1) HRP20000726B1 (pt)
HU (1) HU227709B1 (pt)
ID (1) ID26277A (pt)
IL (2) IL138160A0 (pt)
IS (1) IS2082B (pt)
ME (1) ME00870B (pt)
NO (1) NO315606B1 (pt)
NZ (1) NZ506641A (pt)
OA (1) OA11547A (pt)
PL (1) PL190441B1 (pt)
PT (1) PT1073639E (pt)
RS (1) RS50029B (pt)
RU (1) RU2197481C2 (pt)
SE (1) SE9801474D0 (pt)
TR (1) TR200003061T2 (pt)
UA (1) UA60354C2 (pt)
WO (1) WO1999055678A1 (pt)
ZA (1) ZA200004601B (pt)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0002320D0 (sv) * 1999-10-25 2000-06-21 Active Biotech Ab Malignant tumors
SE0201778D0 (sv) * 2002-06-12 2002-06-12 Active Biotech Ab Process for the manufacture of quinoline derivatives
KR100908655B1 (ko) 2002-11-27 2009-07-21 엘지디스플레이 주식회사 데이터 공급시간의 변조방법과 이를 이용한액정표시장치의 구동방법 및 장치
SE0400235D0 (sv) * 2004-02-06 2004-02-06 Active Biotech Ab New composition containing quinoline compounds
SE0401578D0 (sv) * 2004-06-18 2004-06-18 Active Biotech Ab Novel compounds
US7838522B2 (en) 2004-11-17 2010-11-23 Ares Trading S.A. Benzothiazole formulations and use thereof
CA2589367C (en) 2004-12-21 2015-02-03 Laboratoires Serono S.A. Sulfonyl amino cyclic derivatives and use thereof
RS51957B (en) 2005-01-31 2012-02-29 Merck Serono Sa. N-HYDROXIAMIDE DERIVATIVES AND THEIR USE
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 jnk 억제제
WO2007025991A2 (en) 2005-09-01 2007-03-08 Ares Trading S.A. Treatment of optic neuritis
US7884208B2 (en) 2005-10-19 2011-02-08 Teva Pharmaceutical Industries, Ltd. Crystals of laquinimod sodium, and process for the manufacture thereof
AR061348A1 (es) * 2006-06-12 2008-08-20 Teva Pharma Preparados estables de laquinimod
DK2234485T3 (da) 2007-12-20 2014-02-10 Teva Pharma Stabile laquinimod-præparater
AU2009288108B2 (en) 2008-09-03 2013-10-17 Teva Pharmaceutical Industries, Ltd. 2-oxo-1,2-dihydro-quinoline modulators of immune function
KR20120045032A (ko) * 2009-07-30 2012-05-08 테바 파마슈티컬 인더스트리즈 리미티드 라퀴니모드를 이용한 크론병의 치료
JP5859438B2 (ja) * 2009-08-10 2016-02-10 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドを用いたbdnf関連疾患の治療
JP5819328B2 (ja) 2010-03-03 2015-11-24 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドとメトトレキセートとの組合せによる関節リウマチの治療
AU2011223692A1 (en) * 2010-03-03 2012-10-25 Teva Pharmaceutical Industries Ltd. Treatment of lupus nephritis using laquinimod
KR20130036217A (ko) * 2010-03-03 2013-04-11 테바 파마슈티컬 인더스트리즈 리미티드 라퀴니모드를 이용한 루푸스 관절염의 치료
WO2011116091A1 (en) 2010-03-17 2011-09-22 Novartis Ag Dispenser
BR112013000607A2 (pt) * 2010-07-09 2016-06-28 Teva Pharma 5-cloro-4-hidroxi-1-metil-2-oxo-n-fenil-1,2-di-hidroquinolina-3-carboxamida, os sais e suas utilizações
EA025377B1 (ru) 2010-07-09 2016-12-30 Тева Фармасьютикал Индастриз Лтд. Дейтерированный n-этил-n-фенил-1,2-дигидро-4-гидрокси-5-хлор-1-метил-2-оксохинолин-3-карбоксамид, его соли и их применение
CA2802006C (en) 2010-07-09 2018-09-25 Active Biotech Ab Method for manufacturing of quinoline-3-carboxamides
EP2444086A1 (en) 2010-10-22 2012-04-25 Almirall, S.A. Combinations comprising DHODH inhibitors and COX inhibitors
SG11201401330YA (en) 2011-10-12 2014-05-29 Teva Pharma Treatment of multiple sclerosis with combination of laquinimod and fingolimod
CN106063787A (zh) 2012-02-03 2016-11-02 泰华制药工业有限公司 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途
EP3225617A1 (en) 2012-02-16 2017-10-04 Teva Pharmaceutical Industries Ltd N-ethyl-n-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinoline carboxamide, preparation and uses thereof
TW201350467A (zh) 2012-05-08 2013-12-16 Teva Pharma N-乙基-4-羥基-1-甲基-5-(甲基(2,3,4,5,6-五羥基己基)胺基)-2-側氧-n-苯基-1,2-二氫喹啉-3-甲醯胺
TW201400117A (zh) * 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療gaba媒介之疾病之拉喹莫德(laquinimod)
WO2014074381A1 (en) * 2012-11-07 2014-05-15 Teva Pharmaceutical Industries Ltd. Amine salts of laquinimod
RU2545056C2 (ru) * 2012-12-10 2015-03-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здавоохранения и социального развития Российской Федерации (ГБОУ ВПО ПГФА Минздравсоцразвития России) Противовоспалительное и анальгетическое средство на основе изопропиламида 1,2-дигидро-1н-2-оксоцинхониновой кислоты
JP2016510343A (ja) * 2013-02-15 2016-04-07 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドを用いる多発性硬化症の治療
US9233927B2 (en) 2013-03-14 2016-01-12 Teva Pharmaceutical Industries, Ltd. Crystals of laquinimod sodium and improved process for the manufacture thereof
CA2945978A1 (en) 2014-04-29 2015-11-05 Teva Pharmaceutical Industries Ltd. Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status
ES2631194T3 (es) 2014-09-23 2017-08-29 Active Biotech Ab Quinolincarboxamidas para usar en el tratamiento del mieloma múltiple
AU2015348778B2 (en) 2014-11-19 2020-12-24 Active Biotech Ab Quinoline carboxamides for use in the treatment of leukemia
MX2022006439A (es) 2019-12-19 2022-07-19 Active Biotech Ab Compuestos para el tratamiento de enfermedades oculares asociadas con la vascularizacion excesiva.
JP2023519153A (ja) 2020-03-03 2023-05-10 アクティブ バイオテック エイビー 組合せ療法における使用のためのタスキニモドまたはその薬学的に許容される塩
US20230203003A1 (en) * 2020-05-21 2023-06-29 Stemsynergy Therapeutics, Inc. Notch Inhibitors and Uses Thereof
WO2022018240A1 (en) 2020-07-23 2022-01-27 Erasmus University Medical Center Rotterdam S100 proteins as novel therapeutic targets in myeloproliferative neoplasms
US20240091215A1 (en) 2021-01-18 2024-03-21 Active Biotech Ab Tasquinimod or a pharmaceutically acceptable salt thereof for use in the treatment of myelodysplastic syndrome
CA3218977A1 (en) 2021-05-25 2022-12-01 Hans Wannman A plurality of tasquinimod particles and use thereof
AU2022303084A1 (en) 2021-07-02 2024-01-25 Active Biotech Ab A pharmaceutical product containing tasquinimod and a method for assessing the purity of said product

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0059698A1 (en) * 1981-03-03 1982-09-08 Ab Leo Heterocyclic carboxamides, compositions containing such compounds, processes for their preparation and methods of treatment therewith
WO1992018483A1 (en) * 1991-04-22 1992-10-29 Fujisawa Pharmaceutical Co., Ltd. Quinoline derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0059698A1 (en) * 1981-03-03 1982-09-08 Ab Leo Heterocyclic carboxamides, compositions containing such compounds, processes for their preparation and methods of treatment therewith
WO1992018483A1 (en) * 1991-04-22 1992-10-29 Fujisawa Pharmaceutical Co., Ltd. Quinoline derivatives

Also Published As

Publication number Publication date
IS5615A (is) 2000-08-31
BR9909925A (pt) 2001-01-09
UA60354C2 (uk) 2003-10-15
ID26277A (id) 2000-12-14
SE9801474D0 (sv) 1998-04-27
AU4301399A (en) 1999-11-16
IL138160A (en) 2006-04-10
CZ20003849A3 (cs) 2001-03-14
EE04275B1 (et) 2004-04-15
HU227709B1 (en) 2011-12-28
NZ506641A (en) 2002-03-28
AU747550B2 (en) 2002-05-16
YU61200A (sh) 2003-07-07
CA2329788A1 (en) 1999-11-04
PL190441B1 (pl) 2005-12-30
EE200000613A (et) 2002-04-15
IL138160A0 (en) 2001-10-31
IS2082B (is) 2006-02-15
CZ297439B6 (cs) 2006-12-13
WO1999055678A1 (en) 1999-11-04
EP1073639A1 (en) 2001-02-07
NO315606B1 (no) 2003-09-29
EP1073639B1 (en) 2002-11-27
ES2188242T3 (es) 2003-06-16
HUP0102084A3 (en) 2002-12-28
HRP20000726A2 (en) 2001-04-30
CA2329788C (en) 2004-11-23
ME00870B (me) 2008-11-28
BR9909925B1 (pt) 2010-09-21
HK1036618A1 (en) 2002-01-11
JP4045069B2 (ja) 2008-02-13
NO20005254D0 (no) 2000-10-19
PT1073639E (pt) 2003-04-30
AP2000001933A0 (en) 2000-12-31
ZA200004601B (en) 2002-02-27
HUP0102084A2 (hu) 2001-11-28
OA11547A (en) 2004-05-24
DE69904162D1 (de) 2003-01-09
PL343420A1 (en) 2001-08-13
ATE228505T1 (de) 2002-12-15
DK1073639T3 (da) 2003-03-24
JP2002513006A (ja) 2002-05-08
AP1293A (en) 2004-08-30
CN1113057C (zh) 2003-07-02
TR200003061T2 (tr) 2001-01-22
DE69904162T2 (de) 2003-08-21
NO20005254L (no) 2000-12-27
CN1298393A (zh) 2001-06-06
RU2197481C2 (ru) 2003-01-27
KR100571534B1 (ko) 2006-04-14
RS50029B (sr) 2008-11-28

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