HRP20000502B1 - NOVI KRISTALINIČNI OBLIK 6-HIDROKSI-3-(4-[2-(PIPERIDIN-1-IL)ETOKSI]FENOKSI)-2-(4-METOKSIFENIL)BENZO[b]TIOFEN HIDROKLORIDA - Google Patents

NOVI KRISTALINIČNI OBLIK 6-HIDROKSI-3-(4-[2-(PIPERIDIN-1-IL)ETOKSI]FENOKSI)-2-(4-METOKSIFENIL)BENZO[b]TIOFEN HIDROKLORIDA

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Publication number
HRP20000502B1
HRP20000502B1 HR20000502A HRP20000502A HRP20000502B1 HR P20000502 B1 HRP20000502 B1 HR P20000502B1 HR 20000502 A HR20000502 A HR 20000502A HR P20000502 A HRP20000502 A HR P20000502A HR P20000502 B1 HRP20000502 B1 HR P20000502B1
Authority
HR
Croatia
Prior art keywords
piperidin
benzo
methoxyphenyl
phenoxy
ethoxy
Prior art date
Application number
HR20000502A
Other languages
English (en)
Inventor
Kay Bush Julie
Charles Conrad Preston
Gerard Flom Merlyn
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of HRP20000502A2 publication Critical patent/HRP20000502A2/hr
Publication of HRP20000502B1 publication Critical patent/HRP20000502B1/hr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/09Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
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    • AHUMAN NECESSITIES
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    • A61P19/00Drugs for skeletal disorders
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    • AHUMAN NECESSITIES
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    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Abstract

Kristalinični 6-hidroksi-3-(4-[2-(piperidin-1-il)etoksi]fenoksi)-2-(4-metoksifenil)benzo[b]tiofen-hidroklorid hidrat (F-III), naznačen time što mu uzorak difrakcije rendgenskih zraka sadrži sljedeće reflekse: 4,6 ± 0,2; 7,8 ± 0,2; 9,3 ± 0,2; 14,0 ± 0,2; 17,6 ± 0,2; 20,8 ± 0,2 i 24,3 ± 0,2° u 2θ; dobivene na 25 ± 2 °C i 35 ± 10 % relativne vlage iz bakrenog izvora zračenja (CuK?; λ = 1,54056 A). Patent sadrži još 4 patentna zahtjeva.
HR20000502A 1999-07-29 2000-07-25 NOVI KRISTALINIČNI OBLIK 6-HIDROKSI-3-(4-[2-(PIPERIDIN-1-IL)ETOKSI]FENOKSI)-2-(4-METOKSIFENIL)BENZO[b]TIOFEN HIDROKLORIDA HRP20000502B1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14618499P 1999-07-29 1999-07-29
US14764299P 1999-08-06 1999-08-06
US14982099P 1999-08-19 1999-08-19

Publications (2)

Publication Number Publication Date
HRP20000502A2 HRP20000502A2 (en) 2001-06-30
HRP20000502B1 true HRP20000502B1 (hr) 2008-04-30

Family

ID=27386367

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000502A HRP20000502B1 (hr) 1999-07-29 2000-07-25 NOVI KRISTALINIČNI OBLIK 6-HIDROKSI-3-(4-[2-(PIPERIDIN-1-IL)ETOKSI]FENOKSI)-2-(4-METOKSIFENIL)BENZO[b]TIOFEN HIDROKLORIDA

Country Status (45)

Country Link
EP (1) EP1204655B1 (hr)
JP (1) JP2001048880A (hr)
KR (1) KR100733094B1 (hr)
CN (1) CN1138771C (hr)
AR (1) AR029176A1 (hr)
AT (2) ATE251151T1 (hr)
AU (2) AU6335500A (hr)
BE (1) BE1013410A3 (hr)
BR (1) BR0003211A (hr)
CA (1) CA2314685C (hr)
CO (1) CO5180572A1 (hr)
CZ (1) CZ300356B6 (hr)
DE (2) DE60005693T2 (hr)
DK (1) DK176771B1 (hr)
EG (1) EG24196A (hr)
ES (1) ES2208384T3 (hr)
FI (1) FI20001721A (hr)
FR (1) FR2798384B1 (hr)
GB (1) GB2352716A (hr)
GR (1) GR20000100264A (hr)
HK (1) HK1034962A1 (hr)
HR (1) HRP20000502B1 (hr)
HU (1) HUP0003005A2 (hr)
ID (1) ID26679A (hr)
IL (1) IL137552A (hr)
IT (1) IT1318659B1 (hr)
LT (1) LT4789B (hr)
LU (1) LU90616B1 (hr)
LV (1) LV12733B (hr)
MD (1) MD2335G2 (hr)
MX (1) MXPA00007462A (hr)
MY (1) MY120393A (hr)
NL (1) NL1015822C2 (hr)
NO (1) NO325594B1 (hr)
NZ (1) NZ506045A (hr)
PE (1) PE20010383A1 (hr)
PL (1) PL341748A1 (hr)
PT (1) PT102501A (hr)
SE (1) SE0002793L (hr)
SG (1) SG90737A1 (hr)
SI (1) SI20427B (hr)
SV (1) SV2002000134A (hr)
TR (1) TR200002205A2 (hr)
TW (1) TWI271403B (hr)
WO (1) WO2001009115A2 (hr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122203B2 (en) 2000-05-08 2006-10-17 Eli Lilly And Company Stabilized formulations of 6-hydroxy-3-(-4-[2-(piperidin-1-yl) ethoxy]phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene and salts thereof
SK286346B6 (en) * 2000-05-08 2008-07-07 Lilly Co Eli Stabilized formulations of 6-hydroxy-3-(4-[2-(piperidin-1-yl) ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene and salts thereof
AU2005200809B2 (en) * 2000-05-08 2006-05-11 Eli Lilly And Company Stabilized Formulations of 6-hydroxy-3-(4-[2-(piperidin-1-yl) Ethoxy]phenoxy)-2-(4-methoxyphenyl) Benzo[b]thiophene and Salts Thereof
EP1757291A3 (en) * 2000-05-08 2009-07-15 Eli Lilly & Company Stabilized formulations of 6-hydroxy-3-(4-[2-(piperidin-1-YL)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene and salts thereof
CN1268624C (zh) * 2000-10-20 2006-08-09 伊莱利利公司 6-羟基-3-(4-[2-(哌啶-1-基)乙氧基]苯氧基)-2-(4-甲氧基苯基)苯并[b]噻吩盐酸盐的新晶形
US6921827B2 (en) 2000-11-27 2005-07-26 Eli Lilly And Company Process for preparing 3-aryl-benzo{b} thiophenes
ATE480534T1 (de) * 2004-07-22 2010-09-15 Lilly Co Eli Kristallines variables hydrat von (s)-6-(4-(2-((3-(9h-carbazol-4-yloxy)-2-hydroxy ropyl)amino)-2- methylpropyl)phenoxy)-3-pyridincarbonsäureamid- hemisuccinatsalz
EP2425846A1 (en) * 2004-12-23 2012-03-07 Voyager Pharmaceutical Corporation Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease
WO2006088648A1 (en) * 2005-02-11 2006-08-24 Eli Lilly And Company Compositions and methods for treating dyslipidemia
DE102008057230A1 (de) * 2008-11-11 2010-05-12 Bayer Schering Pharma Aktiengesellschaft Synergistische pharmazeutische Kombination mit einem Estrogenrezeptorantagonisten und einem Progestin
CN113325183B (zh) * 2021-06-01 2022-11-15 中国医学科学院北京协和医院 一种用于鉴别诊断em/fem的试剂盒

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510357A (en) 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
PL182493B1 (pl) * 1995-02-28 2002-01-31 Lilly Co Eli Nowe pochodne benzotiofenu, nowe związki pośrednie i sposób wytwarzania nowych pochodnych benzotiofenu oraz środek farmaceutyczny
ZA982877B (en) * 1997-04-09 1999-10-04 Lilly Co Eli Treatment of central nervous system disorders with selective estrogen receptor modulators.
AU6335600A (en) * 1999-07-29 2001-02-19 Eli Lilly And Company A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-metho yphenyl)benzo[b]thiophene hydrochloride

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CN1283622A (zh) 2001-02-14
AU4891100A (en) 2001-02-01
ES2208384T3 (es) 2004-06-16
EP1204655B1 (en) 2003-10-01
CN1138771C (zh) 2004-02-18
SG90737A1 (en) 2002-08-20
CO5180572A1 (es) 2002-07-30
ITMI20001758A1 (it) 2002-01-28
KR100733094B1 (ko) 2007-06-27
GR20000100264A (el) 2001-03-30
SI20427B (sl) 2009-04-30
TWI271403B (en) 2007-01-21
PL341748A1 (en) 2001-02-12
TR200002205A2 (tr) 2001-03-21
EP1204655A2 (en) 2002-05-15
AR029176A1 (es) 2003-06-18
NL1015822C2 (nl) 2004-08-04
MD20000161A (en) 2001-04-30
KR20010049911A (ko) 2001-06-15
WO2001009115A3 (en) 2001-08-16
HUP0003005A2 (hu) 2002-04-29
IT1318659B1 (it) 2003-08-27
MD2335F2 (en) 2003-12-31
DE60005693T2 (de) 2004-07-29
HK1034962A1 (en) 2001-11-09
GB2352716A (en) 2001-02-07
ATE251151T1 (de) 2003-10-15
NZ506045A (en) 2002-02-01
ID26679A (id) 2001-02-01
IL137552A0 (en) 2001-07-24
FI20001721A (fi) 2001-01-30
MXPA00007462A (es) 2002-06-04
HU0003005D0 (en) 2000-10-28
MD2335G2 (ro) 2004-06-30
CZ20002717A3 (en) 2001-05-16
CA2314685A1 (en) 2001-01-29
WO2001009115A2 (en) 2001-02-08
FR2798384B1 (fr) 2004-09-24
SV2002000134A (es) 2002-06-07
EG24196A (en) 2008-10-14
PT102501A (pt) 2001-01-31
BR0003211A (pt) 2001-03-13
MY120393A (en) 2005-10-31
GB0018636D0 (en) 2000-09-13
DK200001150A (da) 2001-01-30
IL137552A (en) 2009-06-15
PE20010383A1 (es) 2001-04-05
NL1015822A1 (nl) 2001-01-30
ITMI20001758A0 (it) 2000-07-28
LT4789B (lt) 2001-05-25
DK176771B1 (da) 2009-08-03
JP2001048880A (ja) 2001-02-20
LT2000075A (lt) 2001-02-26
SE0002793L (sv) 2001-01-30
NO20003876D0 (no) 2000-07-28
CZ300356B6 (cs) 2009-04-29
LV12733B (lv) 2002-02-20
FR2798384A1 (fr) 2001-03-16
DE10036855A1 (de) 2001-03-22
FI20001721A0 (fi) 2000-07-28
AU6335500A (en) 2001-02-19
SI20427A (sl) 2001-06-30
AU779559B2 (en) 2005-01-27
HRP20000502A2 (en) 2001-06-30
BE1013410A3 (fr) 2001-12-04
DE60005693D1 (de) 2003-11-06
CA2314685C (en) 2009-10-20
NO20003876L (no) 2001-01-30
AT502317A1 (de) 2007-02-15
SE0002793D0 (sv) 2000-07-28
IE20000604A1 (en) 2001-04-04
LV12733A (lv) 2001-10-20
LU90616B1 (fr) 2007-06-08
NO325594B1 (no) 2008-06-23

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