HN2011000876A - Inhibidores de las enzimas de proteina cinaza activadas por mitogeno p38 - Google Patents
Inhibidores de las enzimas de proteina cinaza activadas por mitogeno p38Info
- Publication number
- HN2011000876A HN2011000876A HN2011000876A HN2011000876A HN2011000876A HN 2011000876 A HN2011000876 A HN 2011000876A HN 2011000876 A HN2011000876 A HN 2011000876A HN 2011000876 A HN2011000876 A HN 2011000876A HN 2011000876 A HN2011000876 A HN 2011000876A
- Authority
- HN
- Honduras
- Prior art keywords
- cinaza
- mitogen
- inhibitors
- protein
- enzymes activated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
ESTA INVENCION PROPORCIONA, ENTRE OTROS, COMPUESTOS DE LA FORMULA (I) EN DONDE R1,AR,L,X,R3 Y Q SON COMO SE DEFINEN EN LA ESPECIFICACION, PARA USARLOS EN TERAPIA, ESPECIALMENTE EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0818033.3A GB0818033D0 (en) | 2008-10-02 | 2008-10-02 | Novel compound |
GB0822609A GB0822609D0 (en) | 2008-12-11 | 2008-12-11 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
HN2011000876A true HN2011000876A (es) | 2014-01-20 |
Family
ID=42027990
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HN2011000876A HN2011000876A (es) | 2008-10-02 | 2011-04-01 | Inhibidores de las enzimas de proteina cinaza activadas por mitogeno p38 |
Country Status (23)
Country | Link |
---|---|
US (3) | US8293748B2 (es) |
EP (1) | EP2350049B1 (es) |
JP (1) | JP2012504591A (es) |
KR (1) | KR20110070887A (es) |
CN (1) | CN102256964A (es) |
AU (1) | AU2009299555B2 (es) |
BR (1) | BRPI0920707A2 (es) |
CA (1) | CA2738828A1 (es) |
CL (1) | CL2011000737A1 (es) |
CO (1) | CO6351786A2 (es) |
CR (1) | CR20110477A (es) |
EA (1) | EA020641B1 (es) |
EC (1) | ECSP11010949A (es) |
ES (1) | ES2461496T3 (es) |
HK (1) | HK1160129A1 (es) |
HN (1) | HN2011000876A (es) |
MX (1) | MX2011003553A (es) |
MY (1) | MY159230A (es) |
NI (1) | NI201100063A (es) |
NZ (1) | NZ591427A (es) |
PE (1) | PE20110598A1 (es) |
WO (1) | WO2010038086A2 (es) |
ZA (1) | ZA201103180B (es) |
Families Citing this family (52)
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NZ586418A (en) | 2007-12-19 | 2012-09-28 | Cancer Rec Tech Ltd | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
PE20110598A1 (es) | 2008-10-02 | 2011-08-31 | Respivert Ltd | Inhibidores de las enzimas de proteina cinasa activadas por mitogeno p38 |
GB0818033D0 (en) * | 2008-10-02 | 2008-11-05 | Respivert Ltd | Novel compound |
CA2746354A1 (en) | 2008-12-11 | 2010-06-17 | Respivert Limited | P38 map kinase inhibitors |
WO2010097115A1 (en) | 2009-02-26 | 2010-09-02 | Glaxo Group Limited | Pharmaceutical formulations comprising 4-{(1r)-2- [(6-{2-[(2,6-dichlorobenzyl)oxy] ethoxy}hexyl)amino]-1-hydroxyethyl}-2- (hydroxymethyl)phenol |
GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
GB0921075D0 (en) | 2009-12-01 | 2010-01-13 | Glaxo Group Ltd | Novel combination of the therapeutic agents |
GB0921730D0 (en) * | 2009-12-11 | 2010-01-27 | Respivert Ltd | Method of treatment |
PL2531502T3 (pl) | 2010-02-01 | 2014-08-29 | Cancer Research Tech Ltd | 1-(5-tert-Butylo-2-fenylo-2H-pirazol-3-ilo)-3-[2-fluoro-4-(1-metylo-2-okso-2,3-dihydro-1H-imidazo[4,5-b]pirydyn-7-yloksy)-fenylo]-mocznik i związki pokrewne oraz ich zastosowanie w terapii |
GB201005589D0 (en) | 2010-04-01 | 2010-05-19 | Respivert Ltd | Novel compounds |
JP5787977B2 (ja) | 2010-04-08 | 2015-09-30 | レスピバート・リミテツド | P38mapキナーゼ阻害剤 |
EP2556067B1 (en) | 2010-04-08 | 2016-02-24 | Respivert Limited | Pyrazolyl ureas as p38 map kinase inhibitors |
GB201010193D0 (en) * | 2010-06-17 | 2010-07-21 | Respivert Ltd | Medicinal use |
GB201010196D0 (en) * | 2010-06-17 | 2010-07-21 | Respivert Ltd | Methods |
JP5973426B2 (ja) | 2010-06-17 | 2016-08-23 | レスピバート・リミテツド | P38mapk阻害剤を含む呼吸器用製剤 |
WO2013050757A1 (en) | 2011-10-03 | 2013-04-11 | Respivert Limited | 1-pyrazolyl-3- (4- ( (2 -anilinopyrimidin- 4 - yl) oxy) napththalen- 1 - yl) ureas as p38 map kinase inhibitors |
EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
ES2814336T3 (es) | 2012-04-13 | 2021-03-26 | Glaxosmithkline Ip Dev Ltd | Partículas de agregado |
GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
GB201215357D0 (en) | 2012-08-29 | 2012-10-10 | Respivert Ltd | Compounds |
EP2890701B1 (en) | 2012-08-29 | 2017-03-29 | Respivert Limited | Kinase inhibitors |
US20150210722A1 (en) | 2012-08-29 | 2015-07-30 | Respivert Limited | Kinase inhibitors |
US20150225373A1 (en) | 2012-08-29 | 2015-08-13 | Respivert Limited | Kinase inhibitors |
US9732063B2 (en) | 2012-11-16 | 2017-08-15 | Respivert Limited | Kinase inhibitors |
GB201222679D0 (en) | 2012-12-17 | 2013-01-30 | Glaxo Group Ltd | Pharmaceutical combination products |
WO2014140582A1 (en) | 2013-03-14 | 2014-09-18 | Respivert Limited | Kinase inhibitors |
WO2014162121A1 (en) | 2013-04-02 | 2014-10-09 | Topivert Pharma Limited | Kinase inhibitors based upon n-alkyl pyrazoles |
CN105246884B (zh) | 2013-04-02 | 2018-05-22 | 瑞斯比维特有限公司 | 用作激酶抑制剂的脲衍生物 |
SG11201510064WA (en) | 2013-06-14 | 2016-01-28 | Psioxus Theraupeutics Ltd | A dosing regime and formulations for type b adenoviruses |
GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
CN113717162A (zh) | 2013-12-20 | 2021-11-30 | 奥苏拉收购有限公司 | 用作激酶抑制剂的脲衍生物 |
BR112016015838B1 (pt) | 2014-02-14 | 2023-05-09 | Respivert Limited | Compostos heterocíclicos aromáticos, composição farmacêutica e formulação farmacêutica em pó seco compreendendo os referidos compostos, produto de combinação e usos dos mesmos |
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US10072034B2 (en) | 2016-04-06 | 2018-09-11 | Respivert Limited | Kinase inhibitors |
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BR112020004319A2 (pt) | 2017-09-05 | 2020-09-08 | GLAdiator Biosciences, Inc. | método de alvejamento de exossomas |
WO2019083455A1 (en) | 2017-10-25 | 2019-05-02 | Aslan Pharmaceuticals Pte Ltd | VARLITINIB FOR USE IN THE TREATMENT OF CANCER IN A PATIENT IDENTIFIED AS PRESENTING HER1, HER2 AND / OR HER3-ACTIVATED HERC-RECEPTOR CANCER CELLS |
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-
2009
- 2009-10-02 PE PE2011000797A patent/PE20110598A1/es not_active Application Discontinuation
- 2009-10-02 MY MYPI2011001435A patent/MY159230A/en unknown
- 2009-10-02 BR BRPI0920707A patent/BRPI0920707A2/pt not_active IP Right Cessation
- 2009-10-02 NZ NZ591427A patent/NZ591427A/xx unknown
- 2009-10-02 US US13/121,999 patent/US8293748B2/en active Active
- 2009-10-02 ES ES09785724.7T patent/ES2461496T3/es active Active
- 2009-10-02 CA CA2738828A patent/CA2738828A1/en not_active Abandoned
- 2009-10-02 KR KR1020117009977A patent/KR20110070887A/ko not_active Application Discontinuation
- 2009-10-02 MX MX2011003553A patent/MX2011003553A/es active IP Right Grant
- 2009-10-02 EA EA201170521A patent/EA020641B1/ru not_active IP Right Cessation
- 2009-10-02 WO PCT/GB2009/051304 patent/WO2010038086A2/en active Application Filing
- 2009-10-02 EP EP09785724.7A patent/EP2350049B1/en active Active
- 2009-10-02 AU AU2009299555A patent/AU2009299555B2/en not_active Ceased
- 2009-10-02 JP JP2011529637A patent/JP2012504591A/ja not_active Withdrawn
- 2009-10-02 CN CN2009801395551A patent/CN102256964A/zh active Pending
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2011
- 2011-03-25 CO CO11037018A patent/CO6351786A2/es active IP Right Grant
- 2011-04-01 CL CL2011000737A patent/CL2011000737A1/es unknown
- 2011-04-01 NI NI201100063A patent/NI201100063A/es unknown
- 2011-04-01 HN HN2011000876A patent/HN2011000876A/es unknown
- 2011-04-01 EC EC2011010949A patent/ECSP11010949A/es unknown
- 2011-04-29 ZA ZA2011/03180A patent/ZA201103180B/en unknown
- 2011-09-06 CR CR20110477A patent/CR20110477A/es not_active Application Discontinuation
-
2012
- 2012-01-18 HK HK12100606.2A patent/HK1160129A1/xx not_active IP Right Cessation
- 2012-09-14 US US13/616,696 patent/US8618140B2/en active Active
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2013
- 2013-12-24 US US14/139,982 patent/US8975285B2/en active Active
Also Published As
Publication number | Publication date |
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US20110212962A1 (en) | 2011-09-01 |
JP2012504591A (ja) | 2012-02-23 |
EA201170521A1 (ru) | 2011-12-30 |
KR20110070887A (ko) | 2011-06-24 |
EP2350049B1 (en) | 2014-02-26 |
CA2738828A1 (en) | 2010-04-08 |
PE20110598A1 (es) | 2011-08-31 |
AU2009299555B2 (en) | 2014-01-16 |
WO2010038086A8 (en) | 2011-04-28 |
ES2461496T3 (es) | 2014-05-20 |
MY159230A (en) | 2016-12-30 |
WO2010038086A3 (en) | 2010-06-24 |
HK1160129A1 (en) | 2012-08-10 |
EP2350049A2 (en) | 2011-08-03 |
US8975285B2 (en) | 2015-03-10 |
CO6351786A2 (es) | 2011-12-20 |
US20140114064A1 (en) | 2014-04-24 |
US8293748B2 (en) | 2012-10-23 |
CN102256964A (zh) | 2011-11-23 |
BRPI0920707A2 (pt) | 2015-12-29 |
US20130012512A1 (en) | 2013-01-10 |
CR20110477A (es) | 2012-06-04 |
ZA201103180B (en) | 2012-10-31 |
US8618140B2 (en) | 2013-12-31 |
ECSP11010949A (es) | 2011-06-30 |
AU2009299555A1 (en) | 2010-04-08 |
NI201100063A (es) | 2011-10-21 |
EA020641B1 (ru) | 2014-12-30 |
WO2010038086A2 (en) | 2010-04-08 |
CL2011000737A1 (es) | 2011-10-14 |
MX2011003553A (es) | 2011-05-25 |
NZ591427A (en) | 2012-12-21 |
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