HK86679A - Dethiacephalosporanic acid derivatives and their preparation and use - Google Patents

Dethiacephalosporanic acid derivatives and their preparation and use

Info

Publication number
HK86679A
HK86679A HK866/79A HK86679A HK86679A HK 86679 A HK86679 A HK 86679A HK 866/79 A HK866/79 A HK 866/79A HK 86679 A HK86679 A HK 86679A HK 86679 A HK86679 A HK 86679A
Authority
HK
Hong Kong
Prior art keywords
dethiacephalosporanic
preparation
acid derivatives
derivatives
acid
Prior art date
Application number
HK866/79A
Other languages
English (en)
Inventor
R Ratcliffe
B G Christensen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HK86679A publication Critical patent/HK86679A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/02—Preparation
    • C07D463/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK866/79A 1972-11-06 1979-12-20 Dethiacephalosporanic acid derivatives and their preparation and use HK86679A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30390572A 1972-11-06 1972-11-06
US39566273A 1973-09-18 1973-09-18

Publications (1)

Publication Number Publication Date
HK86679A true HK86679A (en) 1979-12-28

Family

ID=26973713

Family Applications (1)

Application Number Title Priority Date Filing Date
HK866/79A HK86679A (en) 1972-11-06 1979-12-20 Dethiacephalosporanic acid derivatives and their preparation and use

Country Status (11)

Country Link
JP (1) JPS5632993B2 (enrdf_load_html_response)
AT (1) AT340590B (enrdf_load_html_response)
BE (1) BE806921A (enrdf_load_html_response)
CH (1) CH602723A5 (enrdf_load_html_response)
DE (1) DE2355209A1 (enrdf_load_html_response)
ES (1) ES420271A1 (enrdf_load_html_response)
FR (1) FR2205313B1 (enrdf_load_html_response)
GB (1) GB1455016A (enrdf_load_html_response)
HK (1) HK86679A (enrdf_load_html_response)
NL (1) NL178005C (enrdf_load_html_response)
SE (1) SE417205B (enrdf_load_html_response)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226866A (en) * 1972-11-06 1980-10-07 Merck & Co., Inc. Novel antibiotic analogues of cephalosporins
US4172199A (en) * 1975-01-02 1979-10-23 Bristol-Myers Company O-2-isocephem-4-carboxylic acid derivatives as antibacterial agents
US4012383A (en) * 1975-01-02 1977-03-15 Bristol-Myers Company Δ2,3 -1,4-morpholine-2-carboxylic acids and derivatives thereof useful in preparation of antibacteria agents
US4011216A (en) * 1975-04-11 1977-03-08 Bristol-Myers Company Δ2,3-0-2-Isocephem-4-carboxylic acid and derivatives thereof as antibacterial agents
US4166905A (en) * 1975-04-11 1979-09-04 Bristol-Myers Company O-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
US4166906A (en) * 1975-04-11 1979-09-04 Bristol-Myers Company 0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
US4171439A (en) * 1975-04-11 1979-10-16 Bristol-Myers Company Antibacterial analogs of isocephalosporins
US4108992A (en) 1975-05-10 1978-08-22 Beecham Group Limited Cephalosporin analogues and compositions
US4171438A (en) * 1975-07-23 1979-10-16 Bristol-Myers Company 0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
US4013648A (en) * 1975-07-23 1977-03-22 Bristol-Myers Company Δ2,3 -0-2-Isocephem-4-carboxylic acid and derivatives as antibacterial agents
US4180571A (en) * 1976-03-25 1979-12-25 Shionogi & Co., Ltd. Arylmalonamido-1-oxadethiacephalosporins
CY1158A (en) * 1976-03-25 1983-01-28 Shionogi & Co Arylmalonamido-1-oxadethiacephalosporins
CA1085392A (en) 1976-03-25 1980-09-09 Masayuki Narisada Arylmalonamido-1-oxadethiacephalosporins
JPS607635B2 (ja) * 1976-04-27 1985-02-26 塩野義製薬株式会社 オキサゾリジン化合物
JPS604811B2 (ja) * 1976-07-28 1985-02-06 塩野義製薬株式会社 メチルケトンのハロゲン化
IE45650B1 (en) * 1976-08-09 1982-10-20 Shionogi & Co Intermediates for cephalosporin analogues
JPS609515B2 (ja) * 1976-08-09 1985-03-11 塩野義製薬株式会社 ３′−ノルオキサセファロスポリン類
JPS5331690A (en) * 1976-09-01 1978-03-25 Shionogi & Co Ltd Oxadithiacephalosporins
US4089956A (en) * 1976-09-08 1978-05-16 Smithkline Corporation 7-Acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives and bactericidal compositions and use thereof
JPS5398951A (en) 1977-02-08 1978-08-29 Shionogi & Co Ltd Azetidinone derivatives and process for their preparation
GB1557552A (en) * 1977-02-15 1979-12-12 Shionogi & Co 1 oxadethiacepham compounds
JPS53105491A (en) 1977-02-25 1978-09-13 Shionogi & Co Ltd Oxazolinoazethidinylbutyrylic acid derivatives
CA1100962A (en) * 1977-04-28 1981-05-12 Yoshio Hamashima Haloarylmalonamidooxacephalosporins
JPS53149991A (en) * 1977-06-01 1978-12-27 Shionogi & Co Ltd Preparation of 3-heterothiomethyl-1-oxadethia-3-cephem-4-carboxylic acid
JPS5419990A (en) * 1977-07-14 1979-02-15 Shionogi & Co Ltd Dihydrotriazinylthioxacephalosporin
JPS609718B2 (ja) * 1977-08-25 1985-03-12 塩野義製薬株式会社 チアジアゾリルチオセフアロスポリン類縁抗生物質
IT1102408B (it) * 1977-12-23 1985-10-07 Fujisawa Pharmaceutical Co Composti analoghi della cefalosforina e procedimenti per la loro preparazione
EP0004134B1 (en) * 1978-03-04 1981-12-30 Beecham Group Plc Beta-lactam antibacterial agents, their pharmaceutical compositions and process for their preparation
JPS5936914B2 (ja) * 1978-06-24 1984-09-06 協和醗酵工業株式会社 セフアロスポリン類縁体
US4327093A (en) * 1978-10-24 1982-04-27 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds
JPS5616491A (en) * 1979-07-19 1981-02-17 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
JPS5671092A (en) * 1979-11-14 1981-06-13 Kyowa Hakko Kogyo Co Ltd Optical active cephalosporin analogous derivative
EP0031509B1 (en) * 1979-12-20 1984-10-24 Hoechst Uk Limited Penem derivatives
JPS56103185A (en) * 1980-01-22 1981-08-18 Shionogi & Co Ltd Malonamidoxa-dethia-cephem compound
US4304774A (en) * 1980-09-17 1981-12-08 Eli Lilly And Company Bis-tetrazolmethyl substituted β-lactam antibiotics
US4347183A (en) 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
DE3225269A1 (de) * 1982-07-06 1984-01-12 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 7-amino-1-dethia-1-oxa-3-hydroxymethyl-cephem-4-carbonsaeuren
JPS59104389A (ja) * 1982-12-06 1984-06-16 Shionogi & Co Ltd オキサセファム誘導体
US4717722A (en) * 1984-05-07 1988-01-05 Merck & Co., Inc. Substituted 1-oxa-dethiacephalosporins as anti-inflammatory and antidegenerative agents
US4708956A (en) * 1985-12-12 1987-11-24 Kyowa Hakko Kogyo Co., Ltd. 3-position halogenated cephalosporin analogs and pharmaceutical compositions
US5019571A (en) * 1988-01-25 1991-05-28 Eli Lilly And Company 1-carbacephalosporin antibiotics
JP2004168775A (ja) * 2002-11-08 2004-06-17 Orchid Chemicals & Pharmaceuticals Ltd オキサセファロスポリンの改良合成法
KR20140039202A (ko) * 2011-04-28 2014-04-01 시오노기세야쿠 가부시키가이샤 카테콜 또는 의사 카테콜 구조를 갖는 신규 세펨 화합물
CN103254215B (zh) * 2013-05-24 2015-06-03 浙江东邦药业有限公司 一种烯丙基氯代氧头孢化合物的制备方法

Also Published As

Publication number Publication date
ES420271A1 (es) 1976-07-01
NL178005B (nl) 1985-08-01
CH602723A5 (enrdf_load_html_response) 1978-07-31
NL178005C (nl) 1986-01-02
ATA491775A (de) 1977-04-15
BE806921A (fr) 1974-05-06
DE2355209A1 (de) 1974-05-16
JPS5632993B2 (enrdf_load_html_response) 1981-07-31
AT340590B (de) 1977-12-27
NL7314711A (enrdf_load_html_response) 1974-05-08
GB1455016A (en) 1976-11-10
JPS49133594A (enrdf_load_html_response) 1974-12-21
FR2205313A1 (enrdf_load_html_response) 1974-05-31
SE417205B (sv) 1981-03-02
FR2205313B1 (enrdf_load_html_response) 1976-07-02

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