HK86679A - Dethiacephalosporanic acid derivatives and their preparation and use - Google Patents

Dethiacephalosporanic acid derivatives and their preparation and use

Info

Publication number
HK86679A
HK86679A HK866/79A HK86679A HK86679A HK 86679 A HK86679 A HK 86679A HK 866/79 A HK866/79 A HK 866/79A HK 86679 A HK86679 A HK 86679A HK 86679 A HK86679 A HK 86679A
Authority
HK
Hong Kong
Prior art keywords
dethiacephalosporanic
preparation
acid derivatives
derivatives
acid
Prior art date
Application number
HK866/79A
Inventor
R Ratcliffe
B G Christensen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HK86679A publication Critical patent/HK86679A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/02—Preparation
    • C07D463/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
HK866/79A 1972-11-06 1979-12-20 Dethiacephalosporanic acid derivatives and their preparation and use HK86679A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30390572A 1972-11-06 1972-11-06
US39566273A 1973-09-18 1973-09-18

Publications (1)

Publication Number Publication Date
HK86679A true HK86679A (en) 1979-12-28

Family

ID=26973713

Family Applications (1)

Application Number Title Priority Date Filing Date
HK866/79A HK86679A (en) 1972-11-06 1979-12-20 Dethiacephalosporanic acid derivatives and their preparation and use

Country Status (11)

Country Link
JP (1) JPS5632993B2 (en)
AT (1) AT340590B (en)
BE (1) BE806921A (en)
CH (1) CH602723A5 (en)
DE (1) DE2355209A1 (en)
ES (1) ES420271A1 (en)
FR (1) FR2205313B1 (en)
GB (1) GB1455016A (en)
HK (1) HK86679A (en)
NL (1) NL178005C (en)
SE (1) SE417205B (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226866A (en) * 1972-11-06 1980-10-07 Merck & Co., Inc. Novel antibiotic analogues of cephalosporins
US4172199A (en) * 1975-01-02 1979-10-23 Bristol-Myers Company O-2-isocephem-4-carboxylic acid derivatives as antibacterial agents
US4012383A (en) * 1975-01-02 1977-03-15 Bristol-Myers Company Δ2,3 -1,4-morpholine-2-carboxylic acids and derivatives thereof useful in preparation of antibacteria agents
US4166906A (en) * 1975-04-11 1979-09-04 Bristol-Myers Company 0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
US4166905A (en) * 1975-04-11 1979-09-04 Bristol-Myers Company O-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
US4011216A (en) * 1975-04-11 1977-03-08 Bristol-Myers Company Δ2,3-0-2-Isocephem-4-carboxylic acid and derivatives thereof as antibacterial agents
US4171439A (en) * 1975-04-11 1979-10-16 Bristol-Myers Company Antibacterial analogs of isocephalosporins
US4108992A (en) 1975-05-10 1978-08-22 Beecham Group Limited Cephalosporin analogues and compositions
US4171438A (en) * 1975-07-23 1979-10-16 Bristol-Myers Company 0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
US4013648A (en) * 1975-07-23 1977-03-22 Bristol-Myers Company Δ2,3 -0-2-Isocephem-4-carboxylic acid and derivatives as antibacterial agents
NO158505C (en) * 1976-03-25 1988-09-21 Shionogi & Co ANALOGY PROCEDURE FOR THE PREPARATION OF A THERAPEUTIC ACTIVE 7BETA-SUBSTITUTED MALONAMIDO-1-OXADADIA 7ALFA-METOXY-3- (1-METHYLTETRAZOL-5-YL) -TYOMETHYL CEPHALOSPORIN.
US4180571A (en) * 1976-03-25 1979-12-25 Shionogi & Co., Ltd. Arylmalonamido-1-oxadethiacephalosporins
CA1085392A (en) 1976-03-25 1980-09-09 Masayuki Narisada Arylmalonamido-1-oxadethiacephalosporins
JPS607635B2 (en) * 1976-04-27 1985-02-26 塩野義製薬株式会社 Oxazolidine compounds
JPS604811B2 (en) * 1976-07-28 1985-02-06 塩野義製薬株式会社 Halogenation of methyl ketones
JPS609515B2 (en) * 1976-08-09 1985-03-11 塩野義製薬株式会社 3'-Noroxacephalosporins
CA1076125A (en) * 1976-08-09 1980-04-22 Masayuki Narisada Intermediates for cephalosporin analogues
JPS5331690A (en) * 1976-09-01 1978-03-25 Shionogi & Co Ltd Oxadithiacephalosporins
US4089956A (en) * 1976-09-08 1978-05-16 Smithkline Corporation 7-Acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives and bactericidal compositions and use thereof
JPS5398951A (en) 1977-02-08 1978-08-29 Shionogi & Co Ltd Azetidinone derivatives and process for their preparation
GB1557552A (en) * 1977-02-15 1979-12-12 Shionogi & Co 1 oxadethiacepham compounds
JPS53105491A (en) 1977-02-25 1978-09-13 Shionogi & Co Ltd Oxazolinoazethidinylbutyrylic acid derivatives
CA1100962A (en) * 1977-04-28 1981-05-12 Yoshio Hamashima Haloarylmalonamidooxacephalosporins
JPS53149991A (en) * 1977-06-01 1978-12-27 Shionogi & Co Ltd Preparation of 3-heterothiomethyl-1-oxadethia-3-cephem-4-carboxylic acid
JPS5419990A (en) * 1977-07-14 1979-02-15 Shionogi & Co Ltd Dihydrotriazinylthioxacephalosporin
JPS609718B2 (en) * 1977-08-25 1985-03-12 塩野義製薬株式会社 Thiadiazolylthiosephalosporin related antibiotics
IT1102408B (en) * 1977-12-23 1985-10-07 Fujisawa Pharmaceutical Co ANALOGUE COMPOUNDS OF CEPHALOSPHORINE AND PROCEDURES FOR THEIR PREPARATION
EP0004134B1 (en) * 1978-03-04 1981-12-30 Beecham Group Plc Beta-lactam antibacterial agents, their pharmaceutical compositions and process for their preparation
JPS5936914B2 (en) * 1978-06-24 1984-09-06 協和醗酵工業株式会社 Cephalosporin analogs
US4327093A (en) * 1978-10-24 1982-04-27 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds
JPS5616491A (en) * 1979-07-19 1981-02-17 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
JPS5671092A (en) * 1979-11-14 1981-06-13 Kyowa Hakko Kogyo Co Ltd Optical active cephalosporin analogous derivative
DE3069524D1 (en) * 1979-12-20 1984-11-29 Hoechst Uk Ltd Penem derivatives
JPS56103185A (en) * 1980-01-22 1981-08-18 Shionogi & Co Ltd Malonamidoxa-dethia-cephem compound
US4304774A (en) * 1980-09-17 1981-12-08 Eli Lilly And Company Bis-tetrazolmethyl substituted β-lactam antibiotics
DE3225269A1 (en) * 1982-07-06 1984-01-12 Bayer Ag, 5090 Leverkusen METHOD FOR PRODUCING 7-AMINO-1-DETHIA-1-OXA-3-HYDROXYMETHYL-CEPHEM-4-CARBONIC ACIDS
JPS59104389A (en) * 1982-12-06 1984-06-16 Shionogi & Co Ltd Oxacephem derivative
US4717722A (en) * 1984-05-07 1988-01-05 Merck & Co., Inc. Substituted 1-oxa-dethiacephalosporins as anti-inflammatory and antidegenerative agents
US4708956A (en) * 1985-12-12 1987-11-24 Kyowa Hakko Kogyo Co., Ltd. 3-position halogenated cephalosporin analogs and pharmaceutical compositions
US5019571A (en) * 1988-01-25 1991-05-28 Eli Lilly And Company 1-carbacephalosporin antibiotics
JP2004168775A (en) * 2002-11-08 2004-06-17 Orchid Chemicals & Pharmaceuticals Ltd Improving synthetic method of oxacephalosporin
JP6006201B2 (en) * 2011-04-28 2016-10-12 塩野義製薬株式会社 Novel cephem compounds having catechol or pseudo-catechol structure
CN103254215B (en) * 2013-05-24 2015-06-03 浙江东邦药业有限公司 Preparation method of allyl chlorooxyl cephalosporin compound

Also Published As

Publication number Publication date
CH602723A5 (en) 1978-07-31
BE806921A (en) 1974-05-06
SE417205B (en) 1981-03-02
JPS49133594A (en) 1974-12-21
NL178005B (en) 1985-08-01
ATA491775A (en) 1977-04-15
GB1455016A (en) 1976-11-10
FR2205313B1 (en) 1976-07-02
FR2205313A1 (en) 1974-05-31
NL178005C (en) 1986-01-02
ES420271A1 (en) 1976-07-01
AT340590B (en) 1977-12-27
DE2355209A1 (en) 1974-05-16
NL7314711A (en) 1974-05-08
JPS5632993B2 (en) 1981-07-31

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