HK1256411A1 - 苯並二氮雜䓬衍生物的合成 - Google Patents

苯並二氮雜䓬衍生物的合成

Info

Publication number
HK1256411A1
HK1256411A1 HK18115543.0A HK18115543A HK1256411A1 HK 1256411 A1 HK1256411 A1 HK 1256411A1 HK 18115543 A HK18115543 A HK 18115543A HK 1256411 A1 HK1256411 A1 HK 1256411A1
Authority
HK
Hong Kong
Prior art keywords
synthesis
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
HK18115543.0A
Other languages
English (en)
Inventor
Malcolm James Boyce
Liv Thomsen
Donald Alan Gilbert
David Wood
Original Assignee
Trio Medicines Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2015/052291 external-priority patent/WO2016020698A1/en
Application filed by Trio Medicines Ltd filed Critical Trio Medicines Ltd
Publication of HK1256411A1 publication Critical patent/HK1256411A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK18115543.0A 2015-08-07 2018-12-05 苯並二氮雜䓬衍生物的合成 HK1256411A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1513979.3A GB201513979D0 (en) 2015-08-07 2015-08-07 Synthesis of benzodiazepine derivatives
PCT/GB2015/052291 WO2016020698A1 (en) 2014-08-08 2015-08-07 Benzodiazepine derivatives as cck2/gastrin receptor antagonists
PCT/GB2016/052442 WO2017025727A1 (en) 2015-08-07 2016-08-05 Synthesis of benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
HK1256411A1 true HK1256411A1 (zh) 2019-09-20

Family

ID=54200391

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18115543.0A HK1256411A1 (zh) 2015-08-07 2018-12-05 苯並二氮雜䓬衍生物的合成

Country Status (7)

Country Link
US (3) US10570102B2 (zh)
EP (2) EP3331865B1 (zh)
JP (1) JP6979398B2 (zh)
CN (1) CN108055843A (zh)
GB (1) GB201513979D0 (zh)
HK (1) HK1256411A1 (zh)
WO (1) WO2017025727A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107162923B (zh) * 2017-06-12 2019-04-23 浙江新三和医药化工股份有限公司 一种邻氨基苯乙酮的制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA2032226A1 (en) 1989-12-18 1991-06-19 Mark G. Bock Benzodiazepine analogs
US4994258A (en) 1990-03-05 1991-02-19 Merck & Co., Inc. Gamma emitting, CCK-A antagonists for pancreatic imaging
CA2056809A1 (en) 1990-12-07 1992-06-08 Mark G. Bock Benzodiazepine analogs
US5218114A (en) 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
FR2682381B1 (fr) * 1991-10-10 1995-04-07 Rhone Poulenc Rorer Sa Derives de benzodiazepine, leur preparation et les medicaments les contenant.
CN1074216A (zh) * 1991-10-24 1993-07-14 格拉克索公司 尿素衍生物
AU2759692A (en) * 1991-10-24 1993-05-21 Glaxo Group Limited Benzodiazepine derivatives as antagonists of gastrin and/or cholecystokinin
GB2264492B (en) 1992-02-27 1996-09-25 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives
IL104853A (en) * 1992-02-27 1997-11-20 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them
EP0637308A1 (en) 1992-03-16 1995-02-08 MERCK SHARP & DOHME LTD. Benzodiazepine derivatives, compositions containing them and their use in therapy
AU688316B2 (en) 1993-04-15 1998-03-12 Glaxo Wellcome Inc. 1,5 benzodiazepine derivatives having CCK and/or gastrin antagonistic activity
GB2282595A (en) 1993-08-25 1995-04-12 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives
GB2282594A (en) 1993-08-25 1995-04-12 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives
AUPO284396A0 (en) 1996-10-08 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
CN100348196C (zh) 2001-11-13 2007-11-14 詹姆士布莱克基金会有限公司 作为胃泌激素和缩胆囊肽受体配体的苯并三氮杂䓬
US7524837B2 (en) 2003-05-12 2009-04-28 Janssen Pharmaceutica N.V. Benzotriazapinone salts and methods for using same
WO2005090319A1 (en) 2004-03-19 2005-09-29 Arrow Therapeutics Limited Process for preparing benzodiazepines
GB201414116D0 (en) 2014-08-08 2014-09-24 Trio Medicines Ltd Benzodiazepine derivatives

Also Published As

Publication number Publication date
WO2017025727A1 (en) 2017-02-16
US20200223807A1 (en) 2020-07-16
US11447454B2 (en) 2022-09-20
CN108055843A (zh) 2018-05-18
EP3331865A1 (en) 2018-06-13
EP3868746A1 (en) 2021-08-25
EP3331865B1 (en) 2021-05-12
GB201513979D0 (en) 2015-09-23
US20230055040A1 (en) 2023-02-23
JP2018523660A (ja) 2018-08-23
US10570102B2 (en) 2020-02-25
US20180237400A1 (en) 2018-08-23
JP6979398B2 (ja) 2021-12-15

Similar Documents

Publication Publication Date Title
IL255817A (en) Synthesis of heterocyclic compounds
IL260675B (en) Preparation of carbamoylpyridone-polycyclic compounds
SG11201706729SA (en) Derivatives of sobetirome
ZA201808057B (en) Synthesis of indazoles
IL263050B (en) History of Subtirum
IL262413B (en) Synthesis of indazoles
SG10202111790YA (en) Synthesis of omecamtiv mecarbil
HK1250719A1 (zh) 脫氧糖胺的合成
HK1256411A1 (zh) 苯並二氮雜䓬衍生物的合成
HRP20181918T1 (hr) Postupak za sintezu derivata benzazepina
PL3174849T3 (pl) Synteza pochodnych pirolidyny
HK1208220A1 (zh) 種 -烯丙基喜樹鹼衍生物的合成方法