HK1255215A1 - 用於成像和治療的尿素基前列腺特異性膜抗原(psma)抑制劑 - Google Patents
用於成像和治療的尿素基前列腺特異性膜抗原(psma)抑制劑Info
- Publication number
- HK1255215A1 HK1255215A1 HK18114343.5A HK18114343A HK1255215A1 HK 1255215 A1 HK1255215 A1 HK 1255215A1 HK 18114343 A HK18114343 A HK 18114343A HK 1255215 A1 HK1255215 A1 HK 1255215A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- psma
- urea
- inhibitors
- therapy
- imaging
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Nuclear Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562273786P | 2015-12-31 | 2015-12-31 | |
| US15/385,490 US10688200B2 (en) | 2015-12-31 | 2016-12-20 | Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy |
| PCT/US2016/068327 WO2017116994A1 (en) | 2015-12-31 | 2016-12-22 | Urea-based prostate specific membrane antigen (psma) inhibitors for imaging and therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1255215A1 true HK1255215A1 (zh) | 2019-08-09 |
Family
ID=59225798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18114343.5A HK1255215A1 (zh) | 2015-12-31 | 2018-11-09 | 用於成像和治療的尿素基前列腺特異性膜抗原(psma)抑制劑 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10688200B2 (zh) |
| EP (1) | EP3397968B1 (zh) |
| JP (1) | JP6850027B2 (zh) |
| KR (1) | KR20180098373A (zh) |
| CN (1) | CN108541302B (zh) |
| AU (2) | AU2016380151A1 (zh) |
| CA (1) | CA3010295C (zh) |
| DK (1) | DK3397968T3 (zh) |
| EA (1) | EA201891544A1 (zh) |
| HK (1) | HK1255215A1 (zh) |
| IL (1) | IL260342A (zh) |
| MX (1) | MX2018008168A (zh) |
| SG (1) | SG11201805380YA (zh) |
| WO (1) | WO2017116994A1 (zh) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| MX2016005013A (es) | 2013-10-18 | 2017-02-28 | Deutsches Krebsforsch | Inhibidores marcados de antigeno prostatico especifico de membrana (psma), su uso como agentes formadores de imagenes y agentes farmaceuticos para el tratamiento de cancer de prostata. |
| US10688200B2 (en) | 2015-12-31 | 2020-06-23 | Five Eleven Pharma Inc. | Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy |
| PT3925952T (pt) * | 2016-03-22 | 2023-12-13 | Univ Johns Hopkins | Agentes alvo de alta afinidade direcionados ao antigénio de membrana específica da próstata para endo radioterapia de cancro da próstata |
| WO2018204477A1 (en) | 2017-05-02 | 2018-11-08 | Cornell University | Methods and reagents for tumor targeting with greater efficacy and less toxicity |
| US11478558B2 (en) * | 2017-05-30 | 2022-10-25 | The Johns Hopkins University | Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer |
| IL274072B1 (en) | 2017-12-11 | 2024-07-01 | Univ Muenchen Tech | PSMA ligands for imaging and endoradiotherapy |
| US20190184040A1 (en) * | 2017-12-15 | 2019-06-20 | Wisconsin Alumni Research Foundation | Targeted Macrocyclic Agents for Dual Modality PET and MRI Imaging of Cancer |
| MX2018003175A (es) * | 2018-03-14 | 2019-09-16 | Instituto Nac De Investigaciones Nucleares | 177lu-dota-hynic-ipsma como un radiofarmaco terapeutico dirigido al antigeno prostatico especifico de membrana. |
| CN109438517B (zh) * | 2018-12-27 | 2021-01-08 | 北京久杰净化工程技术有限公司 | 一种与羰基金属核心配位的双功能连接剂的配合物及其制备方法 |
| KR20220004125A (ko) * | 2019-04-26 | 2022-01-11 | 파이브 일레븐 파마 인크. | 진단제 및 방사성핵종 치료제로서의 전립선-특이적 막 항원 (psma) 억제제 |
| WO2020252598A1 (en) | 2019-06-21 | 2020-12-24 | Provincial Health Services Authority | Radiolabeled compounds targeting the prostate-specific membrane antigen |
| CN115380117A (zh) * | 2020-02-18 | 2022-11-22 | 恩多塞特公司 | 治疗表达psma的癌症的方法 |
| AU2021352915A1 (en) * | 2020-10-01 | 2023-06-08 | Cornell University | Methods and compositions for increasing uptake, internalization, and/or retention of small molecule ligands |
| CN112358422B (zh) * | 2020-10-16 | 2023-06-23 | 中国辐射防护研究院 | 一种新型螯合剂nbed的制备方法 |
| US20240158420A1 (en) * | 2021-03-17 | 2024-05-16 | Five Eleven Pharma, Inc | [18f]a1f labeled psma targeting molecular probe and preparation method therefor |
| CN113372285B (zh) * | 2021-05-28 | 2024-06-18 | 西南医科大学附属医院 | 前列腺特异性膜抗原抑制剂、其放射性核素标记物及制法和应用 |
| CN114436905A (zh) * | 2022-01-24 | 2022-05-06 | 攀枝花学院 | 3-醛基-4-羟基苯乙酸甲酯的纯化方法 |
| CN116514735A (zh) * | 2022-01-30 | 2023-08-01 | 晶核生物医药科技(南京)有限公司 | 一种肽脲素衍生物、含其的药物组合物及其应用 |
| CN114874122A (zh) * | 2022-05-31 | 2022-08-09 | 南京航空航天大学 | 一种新的小分子抑制剂及其制备方法和应用 |
| WO2024021556A1 (zh) * | 2023-02-02 | 2024-02-01 | 北京师范大学 | 一种靶向前列腺特异性膜抗原的放射性金属配合物及其标记配体 |
| CN116507630A (zh) * | 2023-02-14 | 2023-07-28 | 北京师范大学 | 含硝基芳香杂环基团的psma靶向放射性金属配合物及其制备 |
| CN118496299A (zh) * | 2023-02-16 | 2024-08-16 | 无锡诺宇医药科技有限公司 | Psma靶向放射性诊疗一体化药物及其合成和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1472541T1 (sl) | 2002-01-10 | 2010-12-31 | Univ Johns Hopkins | Prikazovalni agensi in postopek prikazovanja naaladase ali psma |
| US8338565B2 (en) | 2008-08-20 | 2012-12-25 | Ensemble Therapeutics Corporation | Macrocyclic compounds for inhibition of tumor necrosis factor alpha |
| CN107325127B (zh) * | 2011-06-15 | 2020-09-01 | 癌靶技术有限责任公司 | 螯合的psma抑制剂 |
| WO2013022797A1 (en) | 2011-08-05 | 2013-02-14 | Molecular Insight Pharmaceuticals | Radiolabeled prostate specific membrane antigen inhibitors |
| CN104203942B (zh) * | 2011-11-30 | 2017-04-12 | 约翰霍普金斯大学 | 前列腺特异性膜抗原(psma)的同源多价抑制剂和异源多价抑制剂以及其用途 |
| US9636413B2 (en) * | 2012-11-15 | 2017-05-02 | Endocyte, Inc. | Conjugates for treating diseases caused by PSMA expressing cells |
| WO2014110372A1 (en) * | 2013-01-14 | 2014-07-17 | Molecular Insight Pharmaceuticals | Triazine based radiopharmaceuticals and radioimaging agents |
| US10406246B2 (en) | 2013-10-17 | 2019-09-10 | Deutsches Kresbsforschungszentrum | Double-labeled probe for molecular imaging and use thereof |
| EP2862857A1 (en) * | 2013-10-18 | 2015-04-22 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| MX2016005013A (es) * | 2013-10-18 | 2017-02-28 | Deutsches Krebsforsch | Inhibidores marcados de antigeno prostatico especifico de membrana (psma), su uso como agentes formadores de imagenes y agentes farmaceuticos para el tratamiento de cancer de prostata. |
| KR102457827B1 (ko) * | 2013-11-14 | 2022-10-24 | 엔도사이트, 인코포레이티드 | 양전자 방출 단층 촬영용 화합물 |
| CA3215134A1 (en) * | 2014-05-06 | 2015-11-12 | The Johns Hopkins University | Metal/radiometal-labeled psma inhibitors for psma-targeted imaging and radiotherapy |
| US10688200B2 (en) | 2015-12-31 | 2020-06-23 | Five Eleven Pharma Inc. | Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy |
-
2016
- 2016-12-20 US US15/385,490 patent/US10688200B2/en active Active - Reinstated
- 2016-12-22 JP JP2018534552A patent/JP6850027B2/ja active Active
- 2016-12-22 AU AU2016380151A patent/AU2016380151A1/en not_active Abandoned
- 2016-12-22 WO PCT/US2016/068327 patent/WO2017116994A1/en active Application Filing
- 2016-12-22 MX MX2018008168A patent/MX2018008168A/es unknown
- 2016-12-22 EA EA201891544A patent/EA201891544A1/ru unknown
- 2016-12-22 SG SG11201805380YA patent/SG11201805380YA/en unknown
- 2016-12-22 KR KR1020187021593A patent/KR20180098373A/ko not_active Application Discontinuation
- 2016-12-22 DK DK16882430.8T patent/DK3397968T3/da active
- 2016-12-22 CA CA3010295A patent/CA3010295C/en active Active
- 2016-12-22 EP EP16882430.8A patent/EP3397968B1/en active Active
- 2016-12-22 CN CN201680079844.7A patent/CN108541302B/zh active Active
-
2018
- 2018-06-28 IL IL260342A patent/IL260342A/en unknown
- 2018-11-09 HK HK18114343.5A patent/HK1255215A1/zh unknown
-
2023
- 2023-06-13 AU AU2023203682A patent/AU2023203682A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK3397968T3 (da) | 2021-11-01 |
| CA3010295C (en) | 2023-09-26 |
| EP3397968A4 (en) | 2019-11-27 |
| US10688200B2 (en) | 2020-06-23 |
| IL260342A (en) | 2018-08-30 |
| CN108541302B (zh) | 2023-02-14 |
| EP3397968B1 (en) | 2021-09-29 |
| US20170189568A1 (en) | 2017-07-06 |
| AU2016380151A1 (en) | 2018-07-19 |
| CA3010295A1 (en) | 2017-07-06 |
| JP6850027B2 (ja) | 2021-03-31 |
| JP2019508374A (ja) | 2019-03-28 |
| WO2017116994A1 (en) | 2017-07-06 |
| SG11201805380YA (en) | 2018-07-30 |
| CN108541302A (zh) | 2018-09-14 |
| EP3397968A1 (en) | 2018-11-07 |
| MX2018008168A (es) | 2019-02-20 |
| AU2023203682A1 (en) | 2023-07-06 |
| KR20180098373A (ko) | 2018-09-03 |
| EA201891544A1 (ru) | 2018-11-30 |
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