HK1254739A1 - 从年长细胞群中富集和扩增高潜能人间充质干细胞 - Google Patents

从年长细胞群中富集和扩增高潜能人间充质干细胞 Download PDF

Info

Publication number
HK1254739A1
HK1254739A1 HK18113751.2A HK18113751A HK1254739A1 HK 1254739 A1 HK1254739 A1 HK 1254739A1 HK 18113751 A HK18113751 A HK 18113751A HK 1254739 A1 HK1254739 A1 HK 1254739A1
Authority
HK
Hong Kong
Prior art keywords
mscs
small
cells
msc
donor
Prior art date
Application number
HK18113751.2A
Other languages
English (en)
Chinese (zh)
Inventor
Travis Block
Milos MARINKOVIC
Xiao-Dong Chen
Original Assignee
The Board Of Regents Of The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Regents Of The University Of Texas System filed Critical The Board Of Regents Of The University Of Texas System
Publication of HK1254739A1 publication Critical patent/HK1254739A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
HK18113751.2A 2015-11-04 2016-11-04 从年长细胞群中富集和扩增高潜能人间充质干细胞 HK1254739A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562250664P 2015-11-04 2015-11-04
US62/250,664 2015-11-04
PCT/US2016/060624 WO2017079621A1 (en) 2015-11-04 2016-11-04 Enrich and amplify highly potent human mesenchymal stem cells from elderly cell populations

Publications (1)

Publication Number Publication Date
HK1254739A1 true HK1254739A1 (zh) 2019-07-26

Family

ID=58662777

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18113751.2A HK1254739A1 (zh) 2015-11-04 2016-11-04 从年长细胞群中富集和扩增高潜能人间充质干细胞

Country Status (8)

Country Link
US (1) US11802272B2 (enExample)
EP (1) EP3370740A4 (enExample)
JP (2) JP6871637B2 (enExample)
CN (1) CN108601799A (enExample)
AU (1) AU2016349701B2 (enExample)
CA (1) CA3004296A1 (enExample)
HK (1) HK1254739A1 (enExample)
WO (1) WO2017079621A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190153386A1 (en) * 2017-11-17 2019-05-23 James R. Musick Stem cell line for treatment of various medical conditions
CN113166722A (zh) 2018-10-03 2021-07-23 斯特姆生物系统有限公司 羊水细胞来源的细胞外基质及其用途
KR102639023B1 (ko) 2019-02-21 2024-02-20 스템바이오시스, 인크. 양수 세포-유래 ecm 상에서 심근세포 성숙을 위한 방법, 세포 구조, 및 약물 화합물의 심장 독성 및 전부정맥 스크리닝을 위한 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7807458B2 (en) * 2003-01-30 2010-10-05 The United States Of America As Represented By The Secretary Of The Department Of Veterans Affairs Multilineage-inducible cells and uses thereof
US9155762B2 (en) * 2005-12-08 2015-10-13 University Of Louisville Research Foundation, Inc. Uses and isolation of stem cells from bone marrow
EP2535403B1 (en) 2005-12-08 2019-06-19 University Of Louisville Research Foundation, Inc. Very small embryonic-like (VSEL) stem cells and methods of isolating and using the same
US8084023B2 (en) 2007-01-22 2011-12-27 The Board Of Trustees Of The University Of Arkansas Maintenance and propagation of mesenchymal stem cells
CN102333861A (zh) * 2008-09-30 2012-01-25 路易斯维尔大学研究基金会有限公司 用于分离非常小的胚胎样(vsel)干细胞的方法
BRPI0924921A2 (pt) 2009-03-31 2015-07-07 Univ Texas Métodos de isolar células-tronco mesequimais, de promover proliferação das referidas células e de produção de tecidos diferenciados
EP2614145B1 (en) 2010-09-07 2020-12-02 The Board of Regents of The University of Texas System Tissue-specific differentiation matrices and uses thereof
WO2012135838A1 (en) * 2011-04-01 2012-10-04 University Of Louisville Research Foundation, Inc. Methods and compositions for large-scale isolation of very small embryonic-like (vsel) stem cells
CA2857545A1 (en) * 2011-11-30 2013-06-06 Advanced Cell Technology, Inc. Mesenchymal stromal cells and uses related thereto
US20170335286A1 (en) 2014-10-30 2017-11-23 Stembiosys, Inc. Methods for maintaining and expanding mesenchymal stem cells on extracellular matrix coated microcarriers

Also Published As

Publication number Publication date
JP6871637B2 (ja) 2021-05-12
AU2016349701A1 (en) 2018-05-24
CA3004296A1 (en) 2017-05-11
CN108601799A (zh) 2018-09-28
AU2016349701B2 (en) 2023-10-19
US20180320140A1 (en) 2018-11-08
EP3370740A4 (en) 2019-05-22
US11802272B2 (en) 2023-10-31
EP3370740A1 (en) 2018-09-12
WO2017079621A1 (en) 2017-05-11
JP2018537440A (ja) 2018-12-20
JP7153951B2 (ja) 2022-10-17
JP2021105047A (ja) 2021-07-26

Similar Documents

Publication Publication Date Title
Wu et al. Age-related decline in the matrix contents and functional properties of human periodontal ligament stem cell sheets
Hua et al. Comparison of different methods for the isolation of mesenchymal stem cells from umbilical cord matrix: proliferation and multilineage differentiation as compared to mesenchymal stem cells from umbilical cord blood and bone marrow
KR101507172B1 (ko) 동결된 제대조직으로부터 유래하는 생존가능한 세포
Tsagias et al. Isolation of mesenchymal stem cells using the total length of umbilical cord for transplantation purposes
Pievani et al. Comparative analysis of multilineage properties of mesenchymal stromal cells derived from fetal sources shows an advantage of mesenchymal stromal cells isolated from cord blood in chondrogenic differentiation potential
Tang et al. Coculture with monocytes/macrophages modulates osteogenic differentiation of adipose‐derived mesenchymal stromal cells on poly (lactic‐co‐glycolic) acid/polycaprolactone scaffolds
BR112014020119A2 (pt) cultura de células-tronco mesenquimais
Xu et al. Different angiogenic potentials of mesenchymal stem cells derived from umbilical artery, umbilical vein, and Wharton’s jelly
JPWO2005063967A1 (ja) 哺乳動物の骨髄細胞または臍帯血由来細胞と脂肪組織を利用した心筋細胞の誘導
S Choudhery et al. Utility of cryopreserved umbilical cord tissue for regenerative medicine
Alessio et al. Hybrid complexes of high and low molecular weight hyaluronan delay in vitro replicative senescence of mesenchymal stromal cells: a pilot study for future therapeutic application
Cavallo et al. Comparison of alternative mesenchymal stem cell sources for cell banking and musculoskeletal advanced therapies
Ennis et al. Isolation, characterization, and differentiation of human umbilical cord perivascular cells (HUCPVCs)
JP7153951B2 (ja) 高齢細胞集団由来の高い分化能を有するヒト間葉系幹細胞の濃縮および増幅
Ambrosi et al. Geriatric fragility fractures are associated with a human skeletal stem cell defect
Moniem et al. Optimizing a serum-free/xeno-free culture medium for culturing and promoting the proliferation of human dental pulp stem cells
KR20110095218A (ko) ＰＩ３Ｋ／ＡＫＴ／ＧＳＫ３ 경로를 통해 성체줄기세포의 증식, 다분화능 및 재프로그래밍을 촉진하는 ＣＤ４９ｆ
JP7475685B2 (ja) ヒト真皮線維芽細胞の単離方法
Soltero-Rivera et al. Distinctive characteristics of extracellular vesicles from feline adipose and placenta stromal cells unveil potential for regenerative medicine in cats
US20210269768A1 (en) Neonatal stromal cells having low mhc-i expression and uses therof
WO2016056653A1 (ja) 心筋細胞の製造方法、心室型心筋細胞及びその製造方法、並びにスクリーニング方法
Labusca et al. Isolation and phenotypic characterisation of stem cells from late stage osteoarthritic mesenchymal tissues
Zhao et al. The effect of a human acellular amniotic membrane loaded with mechanical stretch-stimulated bone marrow mesenchymal stem cells for the treatment of pelvic floor dysfunction
US20250152633A1 (en) Cells having improved proliferative capacity and reduced cellular senescence
Massidda et al. Mechanical Rejuvenation of Mesenchymal Stem Cells from Aged Patients