HK1254739A1 - 從年長細胞群中富集和擴增高潛能人間充質幹細胞 - Google Patents

從年長細胞群中富集和擴增高潛能人間充質幹細胞

Info

Publication number
HK1254739A1
HK1254739A1 HK18113751.2A HK18113751A HK1254739A1 HK 1254739 A1 HK1254739 A1 HK 1254739A1 HK 18113751 A HK18113751 A HK 18113751A HK 1254739 A1 HK1254739 A1 HK 1254739A1
Authority
HK
Hong Kong
Prior art keywords
enrich
elderly
stem cells
mesenchymal stem
cell populations
Prior art date
Application number
HK18113751.2A
Other languages
English (en)
Inventor
Travis Block
Milos Marinkovic
Xiao-Dong Chen
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of HK1254739A1 publication Critical patent/HK1254739A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
HK18113751.2A 2015-11-04 2018-10-26 從年長細胞群中富集和擴增高潛能人間充質幹細胞 HK1254739A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562250664P 2015-11-04 2015-11-04
PCT/US2016/060624 WO2017079621A1 (en) 2015-11-04 2016-11-04 Enrich and amplify highly potent human mesenchymal stem cells from elderly cell populations

Publications (1)

Publication Number Publication Date
HK1254739A1 true HK1254739A1 (zh) 2019-07-26

Family

ID=58662777

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18113751.2A HK1254739A1 (zh) 2015-11-04 2018-10-26 從年長細胞群中富集和擴增高潛能人間充質幹細胞

Country Status (8)

Country Link
US (1) US11802272B2 (zh)
EP (1) EP3370740A4 (zh)
JP (2) JP6871637B2 (zh)
CN (1) CN108601799A (zh)
AU (1) AU2016349701B2 (zh)
CA (1) CA3004296A1 (zh)
HK (1) HK1254739A1 (zh)
WO (1) WO2017079621A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190153386A1 (en) * 2017-11-17 2019-05-23 James R. Musick Stem cell line for treatment of various medical conditions
CA3114426A1 (en) 2018-10-03 2020-04-09 Stembiosys, Inc. Amniotic fluid cell-derived extracellular matrix and uses thereof
CA3130860A1 (en) 2019-02-21 2020-08-27 Stembiosys, Inc. Methods for the maturation of cardiomyocytes on amniotic fluid cell-derived ecm, cellular constructs, and uses for cardiotoxicity and proarrhythmic screening of drug compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004069172A2 (en) * 2003-01-30 2004-08-19 The Government of the United States of America as represented by the Department of Veterans Affairs Multilineage-inducible cells and uses thereof
PL2535403T3 (pl) * 2005-12-08 2019-10-31 Univ Louisville Res Found Inc Bardzo małe komórki macierzyste typu embrionalnego (VSEL) oraz sposoby ich izolowania i zastosowania
US8084023B2 (en) 2007-01-22 2011-12-27 The Board Of Trustees Of The University Of Arkansas Maintenance and propagation of mesenchymal stem cells
CN102333861A (zh) * 2008-09-30 2012-01-25 路易斯维尔大学研究基金会有限公司 用于分离非常小的胚胎样(vsel)干细胞的方法
EP2414511B1 (en) 2009-03-31 2017-07-26 The Board of Regents of The University of Texas System Isolation of human umbilical cord blood-derived mesenchymal stem cells
WO2012033763A2 (en) 2010-09-07 2012-03-15 The Board Of Regents Of The University Of Texas System Tissue-specific differentiation matrices and uses thereof
US20140154219A1 (en) * 2011-04-01 2014-06-05 University Of Louisville Research Foundation, Inc. Methods and compositions for large-scale isolation of very small embryonic-like (vsel) stem cells
WO2016070057A1 (en) 2014-10-30 2016-05-06 Stembiosys, Inc. Methods for maintaining and expanding mesenchymal stem cells on extracellular matrix coated microcarriers

Also Published As

Publication number Publication date
AU2016349701A1 (en) 2018-05-24
US11802272B2 (en) 2023-10-31
WO2017079621A1 (en) 2017-05-11
US20180320140A1 (en) 2018-11-08
JP7153951B2 (ja) 2022-10-17
CA3004296A1 (en) 2017-05-11
JP2021105047A (ja) 2021-07-26
CN108601799A (zh) 2018-09-28
AU2016349701B2 (en) 2023-10-19
EP3370740A1 (en) 2018-09-12
JP2018537440A (ja) 2018-12-20
EP3370740A4 (en) 2019-05-22
JP6871637B2 (ja) 2021-05-12

Similar Documents

Publication Publication Date Title
IL272541A (en) Purified mesenchymal stem cell exosomes and uses thereof
EP3534921A4 (en) POPULATIONS OF MESENCHYMAL STEM CELLS, THEIR PRODUCTS AND THEIR USE
HK1254948A1 (zh) 源自間充質幹細胞的外泌體及其應用
IL267616A (en) Immunologically engineered pluripotent cells
IL259586A (en) Genetically modified stem cells and their uses
SG11201801549VA (en) Pluripotent stem cell production system
IL250689B (en) Rearrangement of multipurpose stem cells
SG11201609053YA (en) Multiplexed single cell gene expression analysis using template switch and tagmentation
HK1246342A1 (zh) 產生源自幹細胞的β細胞的方法及其用途
IL255480B (en) Preparations containing mesenchymal stem cells and their uses
IL263265A (en) Use of mesenchymal stem cells and their parts
IL270492B (en) Transdifferentiated cell populations and methods of use thereof
SG11201808567RA (en) Human stem cell derived endothelial cells, endothelial- hepatocyte co-culture system and uses thereof
EP3299023A4 (en) MESENCHYMAL SUBSTITUTE CELL CULTIVATED IN HYPOXIA AND USE THEREOF
IL254156A0 (en) Methods for producing neural stem cells and their use
IL275037A (en) CRISPR-CAS9-modified CD34+ human hematopoietic stem and progenitor cells and uses thereof
GB201701509D0 (en) Pluripotenet stem cells
HK1258172A1 (zh) 神經前體細胞群體及其用途
EP3362069A4 (en) INCREASING BETA CELL REPLICATION AND / OR SURVIVAL
HK1254739A1 (zh) 從年長細胞群中富集和擴增高潛能人間充質幹細胞
ZA202000574B (en) Mesenchymal stem cells as vaccine adjuvants and methods for using the same
HK1215786A1 (zh) 充氣墊氣室，及充氣墊
EP3321356A4 (en) Mesenchymal stem cell, clonogenic amplification method thereof, separation method thereof and uses thereof
EP3288570A4 (en) Modified stem cells and uses thereof
EP3160385A4 (en) STEM CELLS OF SUB-POPULATIONS DERIVED FROM GONADES