HK1253863A1 - 含prrsv次要蛋白的重組病毒載體及其製造方法與用途 - Google Patents

含prrsv次要蛋白的重組病毒載體及其製造方法與用途

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Publication number
HK1253863A1
HK1253863A1 HK18112996.9A HK18112996A HK1253863A1 HK 1253863 A1 HK1253863 A1 HK 1253863A1 HK 18112996 A HK18112996 A HK 18112996A HK 1253863 A1 HK1253863 A1 HK 1253863A1
Authority
HK
Hong Kong
Prior art keywords
making
methods
viral vectors
recombinant viral
containing recombinant
Prior art date
Application number
HK18112996.9A
Other languages
English (en)
Inventor
Mebatsion Teshome
Kassa Aemro
Kim Taejoong
Original Assignee
Merial Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Inc filed Critical Merial Inc
Publication of HK1253863A1 publication Critical patent/HK1253863A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/082—Arteriviridae, e.g. EAV, PRRSV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK18112996.9A 2015-06-23 2018-10-11 含prrsv次要蛋白的重組病毒載體及其製造方法與用途 HK1253863A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562183410P 2015-06-23 2015-06-23
PCT/US2016/038964 WO2016210094A1 (en) 2015-06-23 2016-06-23 Prrsv minor protein-containing recombinant viral vectors and methods of making and use thereof

Publications (1)

Publication Number Publication Date
HK1253863A1 true HK1253863A1 (zh) 2019-07-05

Family

ID=56409166

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18112996.9A HK1253863A1 (zh) 2015-06-23 2018-10-11 含prrsv次要蛋白的重組病毒載體及其製造方法與用途

Country Status (20)

Country Link
US (2) US9981033B2 (zh)
EP (3) EP3313864B1 (zh)
JP (1) JP2018523993A (zh)
CN (1) CN107922462B (zh)
AR (1) AR105482A1 (zh)
AU (2) AU2016282772B2 (zh)
BR (1) BR112017027895A2 (zh)
CA (1) CA2990643C (zh)
CL (1) CL2017003341A1 (zh)
DK (1) DK3313864T3 (zh)
EA (1) EA201890110A1 (zh)
ES (1) ES2902491T3 (zh)
HK (1) HK1253863A1 (zh)
MX (2) MX2017016895A (zh)
NZ (1) NZ738957A (zh)
PH (1) PH12017502380A1 (zh)
PL (1) PL3313864T3 (zh)
TW (1) TWI737617B (zh)
WO (1) WO2016210094A1 (zh)
ZA (1) ZA201708638B (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3313864B1 (en) * 2015-06-23 2021-07-28 Boehringer Ingelheim Animal Health USA Inc. Prrsv minor protein-containing recombinant viral vectors and methods of making and use thereof
EP3554536B1 (en) * 2016-12-14 2022-10-26 Boehringer Ingelheim Animal Health USA Inc. Recombinant hvt vectors expressing multiple antigens of avian pathogens, and vaccines comprising them
MX2017008751A (es) * 2017-06-29 2019-02-08 Centro De Investig Y Asistencia En Tecnologia Y Diseno Del Estado De Jalisco A C Proteína quimérica para la prevención y el diagnóstico del síndrome respiratorio y reproductivo porciono (prss).
CN109395073B (zh) * 2018-11-07 2019-10-25 陕西诺威利华生物科技有限公司 一种免疫增强型重组prrsv病毒样颗粒亚单位疫苗
CN115043913B (zh) * 2022-06-30 2024-08-16 国药集团动物保健股份有限公司 一种蛋白组合物、其制备方法及其应用
CN115785286B (zh) * 2022-12-05 2023-07-14 北京标驰泽惠生物科技有限公司 一种猪繁殖与呼吸综合征病毒的融合蛋白及其应用
CN116948044B (zh) * 2023-07-27 2024-10-18 山西隆克尔生物制药有限公司 一种猪繁殖与呼吸综合症病毒基因工程亚单位疫苗

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AU2016282772B2 (en) 2019-09-05
US9981033B2 (en) 2018-05-29
WO2016210094A1 (en) 2016-12-29
EP3738975A1 (en) 2020-11-18
EP3313864B1 (en) 2021-07-28
AR105482A1 (es) 2017-10-11
CL2017003341A1 (es) 2018-07-13
TW201713358A (zh) 2017-04-16
EA201890110A1 (ru) 2018-05-31
MX2022000222A (es) 2022-02-03
ZA201708638B (en) 2019-08-28
US10751407B2 (en) 2020-08-25
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NZ738957A (en) 2019-09-27
CA2990643C (en) 2023-10-17
CN107922462B (zh) 2022-03-18
DK3313864T3 (da) 2021-11-01
US20160375122A1 (en) 2016-12-29
AU2019275585B2 (en) 2022-01-27
JP2018523993A (ja) 2018-08-30
US20180243398A1 (en) 2018-08-30
AU2019275585A1 (en) 2020-01-02
TWI737617B (zh) 2021-09-01
AU2016282772A1 (en) 2018-02-01
CN107922462A (zh) 2018-04-17
MX2017016895A (es) 2018-04-10
EP3889166A1 (en) 2021-10-06
PH12017502380A1 (en) 2018-06-25
ES2902491T3 (es) 2022-03-28
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BR112017027895A2 (pt) 2018-11-06
CA2990643A1 (en) 2016-12-29

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