HK1249919A1 - 上皮細胞的離體增殖 - Google Patents

上皮細胞的離體增殖

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Publication number
HK1249919A1
HK1249919A1 HK18109288.2A HK18109288A HK1249919A1 HK 1249919 A1 HK1249919 A1 HK 1249919A1 HK 18109288 A HK18109288 A HK 18109288A HK 1249919 A1 HK1249919 A1 HK 1249919A1
Authority
HK
Hong Kong
Prior art keywords
epithelial cells
vivo proliferation
proliferation
vivo
epithelial
Prior art date
Application number
HK18109288.2A
Other languages
English (en)
Inventor
Chengkang Zhang
Original Assignee
Propagenix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Propagenix Inc filed Critical Propagenix Inc
Publication of HK1249919A1 publication Critical patent/HK1249919A1/zh

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0688—Cells from the lungs or the respiratory tract
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0683—Cells of the male genital tract, e.g. prostate, epididymis; Non-germinal cells from testis, e.g. Leydig cells, Sertoli cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C12N2500/14—Calcium; Ca chelators; Calcitonin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK18109288.2A 2015-04-03 2018-07-18 上皮細胞的離體增殖 HK1249919A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562142851P 2015-04-03 2015-04-03
US201562217406P 2015-09-11 2015-09-11
US201662294896P 2016-02-12 2016-02-12
PCT/US2016/025396 WO2016161192A1 (en) 2015-04-03 2016-03-31 Ex vivo proliferation of epithelial cells

Publications (1)

Publication Number Publication Date
HK1249919A1 true HK1249919A1 (zh) 2018-11-16

Family

ID=55806770

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18109288.2A HK1249919A1 (zh) 2015-04-03 2018-07-18 上皮細胞的離體增殖

Country Status (13)

Country Link
US (7) US9790471B2 (zh)
EP (2) EP3822339A1 (zh)
JP (2) JP6964068B2 (zh)
KR (1) KR102598772B1 (zh)
CN (1) CN107636149A (zh)
AU (1) AU2016243750B2 (zh)
CA (1) CA2981708A1 (zh)
DK (1) DK3277799T3 (zh)
HK (1) HK1249919A1 (zh)
IL (1) IL254588B (zh)
MX (1) MX2017012206A (zh)
SG (2) SG10201902872YA (zh)
WO (1) WO2016161192A1 (zh)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107636149A (zh) 2015-04-03 2018-01-26 普罗帕格尼克斯公司 上皮细胞的离体增殖
US10100285B2 (en) 2015-04-03 2018-10-16 Propagenix Inc. Ex vivo proliferation of epithelial cells
EP3892718A1 (en) 2015-09-11 2021-10-13 Propagenix Inc. Ex vivo proliferation of epithelial cells
AU2017421792B2 (en) * 2017-06-30 2022-03-10 Stemlab Inc. Method for directly reprogramming cells in urine into keratinocyte stem cells and method for preparing composition for promoting skin regeneration by using reprogrammed keratinocyte stem cells
JP2021517574A (ja) * 2018-03-23 2021-07-26 サイトーＣｙｔｏｏ 骨格筋肥大誘発剤としてのａｌｋ５阻害剤
HU231285B1 (hu) 2018-04-18 2022-08-28 Printnet Kereskedelmi És Szolgáltató Kft. A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek
US20210189351A1 (en) 2018-08-20 2021-06-24 Propagenix Inc. Epithelial cell spheroids
KR20200032830A (ko) * 2018-09-19 2020-03-27 메디칸(주) 자가 줄기세포의 자가 배양 방법 및 장치
CN113166722A (zh) 2018-10-03 2021-07-23 斯特姆生物系统有限公司 羊水细胞来源的细胞外基质及其用途
US11047849B2 (en) * 2018-10-17 2021-06-29 Mandom Corporation Method for observing sebaceous gland and use thereof
CN109294972A (zh) * 2018-10-17 2019-02-01 南京农业大学 一种羔羊小肠上皮细胞体外培养方法
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
EP3927814A1 (en) 2019-02-21 2021-12-29 Stembiosys, Inc. Methods for the maturation of cardiomyocytes on amniotic fluid cell-derived ecm, cellular constructs, and uses for cardiotoxicity and proarrhythmic screening of drug compounds
US20220331371A1 (en) * 2019-09-09 2022-10-20 The Regents Of The University Of Michigan Development of embryonic-like tissue from stem cells
CN113249325B (zh) * 2020-02-11 2023-02-17 合肥中科普瑞昇生物医药科技有限公司 食管鳞癌原代细胞的培养基及培养方法
US20230189794A1 (en) * 2020-04-09 2023-06-22 Qingdao Baheal Wizart Technology Co., Ltd. Composition for cryopreservation of myocardial cells
US20230390339A1 (en) * 2020-10-19 2023-12-07 Tel Hashomer Medical Research Infrastructure And Services Ltd. Urine-derived epithelial cell cultures, nephrospheroids derived therefrom and methods of producing and using same
US20220135949A1 (en) * 2020-11-03 2022-05-05 Korea Research Institute Of Bioscience And Biotechnology Human intestinal epithelium model and method for preparing same
CN115873797B (zh) * 2021-09-29 2024-08-13 北京干细胞与再生医学研究院 一种视网膜色素上皮细胞的扩增培养基及培养方法
CN114181889B (zh) * 2021-11-24 2023-10-10 中国人民解放军总医院 一种原代汗腺细胞条件培养基及原代汗腺细胞培养方法
WO2023217134A1 (zh) * 2022-05-10 2023-11-16 上海赛立维生物科技有限公司 包含心肌前体样细胞的生物制剂及其制备方法和应用
CN117503800B (zh) * 2024-01-04 2024-04-05 北京益华生物科技有限公司 一种胃黏膜上皮细胞提取液及其制备方法与应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3716907A1 (de) 1987-05-20 1988-12-01 Battelle Institut E V Verfahren zur vermehrung von epithelialzellen
AU3760489A (en) 1988-05-23 1989-12-12 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Derivatives of cyclic amp as treatment for cancer
US6692961B1 (en) * 1996-10-11 2004-02-17 Invitrogen Corporation Defined systems for epithelial cell culture and use thereof
US7217722B2 (en) 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
US7326570B2 (en) 2000-06-16 2008-02-05 The Regents Of The University Of California Induction of tubular morphogenesis using pleiotrophin
US7199147B2 (en) 2001-06-12 2007-04-03 Dainippon Sumitomo Pharma Co., Ltd. Rho kinase inhibitors
AU2003202263A1 (en) 2002-01-10 2003-07-30 Bayer Healthcare Ag Roh-kinase inhibitors
JP4469179B2 (ja) 2002-01-23 2010-05-26 バイエル ファーマセチカル コーポレーション Ｒｈｏキナーゼ阻害剤としてのピリミジン誘導体
CA2473910C (en) 2002-01-23 2011-03-15 Bayer Pharmaceuticals Corporation Pyrimidine derivatives as rho-kinase inhibitors
TW200306819A (en) 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
CA2476214A1 (en) 2002-02-08 2003-08-14 University Of South Florida Proliferated cell lines and uses thereof
US7645878B2 (en) 2002-03-22 2010-01-12 Bayer Healthcare Llc Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
GB0206860D0 (en) 2002-03-22 2002-05-01 Glaxo Group Ltd Compounds
US20050182040A1 (en) 2002-04-03 2005-08-18 Naonori Imazaki Benzamide derivatives
EP1400807A3 (en) 2002-09-17 2005-01-12 Kylix B.V. Use of novel stem cell markers for isolation of intestinal stem cells, and use of the intestinal stem cells thus obtained for the preparation of a therapeutical composition
CA2503646C (en) 2002-10-28 2011-09-27 Bayer Healthcare Ag Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors
US20070010008A1 (en) * 2005-06-29 2007-01-11 Tissuetech, Inc. Ex vivo expansion of primary animal cells
JP4869068B2 (ja) 2003-06-19 2012-02-01 スミスクライン ビーチャム コーポレーション 化合物
BRPI0411856A (pt) 2003-06-23 2006-08-29 Geron Corp composições e métodos para o aumento da atividade de telomerase
WO2005003101A2 (en) 2003-07-02 2005-01-13 Biofocus Discovery Limited Pyrazine and pyridine derivatives as rho kinase inhibitors
US8252591B2 (en) 2004-05-07 2012-08-28 Whitehead Institute For Biomedical Research Hormone responsive tissue culture system and uses thereof
US8492148B2 (en) 2005-02-23 2013-07-23 Foundation For Biomedical Research & Innovation Method for amplification of endothelial progenitor cell in vitro
CN103356708B (zh) 2005-03-31 2016-01-20 斯丹姆涅恩有限公司 制备用以预防手术后疝形成的药物的方法
US20080242594A1 (en) 2005-09-08 2008-10-02 Mckay Ronald D G Methods for Promoting Stem Cell Proliferation and Survival
WO2007127454A2 (en) 2006-04-28 2007-11-08 Cythera, Inc. Hepatocyte lineage cells
WO2008009641A1 (en) 2006-07-17 2008-01-24 Novozymes A/S Cell culture media
EP2022848A1 (en) 2007-08-10 2009-02-11 Hubrecht Institut A method for identifying, expanding, and removing adult stem cells and cancer stem cells
JP5458112B2 (ja) 2009-02-03 2014-04-02 コーニンクレッカ ネザーランド アカデミー ヴァン ウェテンシャッペン 上皮幹細胞および該幹細胞を含むオルガノイドのための培養培地
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
GB201111244D0 (en) * 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
US9752124B2 (en) * 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
US8476081B2 (en) 2009-09-21 2013-07-02 Janssen Pharmaceutica Nv Assay for evaluating affinity and specificity of ligand-albumin binding
US9708582B2 (en) 2009-10-13 2017-07-18 Stemcell Technologies Inc. Method of differentiating stem cells
EP2600901B1 (en) 2010-08-06 2019-03-27 ModernaTX, Inc. A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
EP2638149B1 (en) 2010-11-12 2019-05-15 Georgetown University Immortalization of epithelial cells and methods of use
JPWO2012173207A1 (ja) 2011-06-14 2015-02-23 独立行政法人理化学研究所 網膜細胞への分化誘導方法
EP2772534B1 (en) 2011-10-27 2019-09-18 National University Corporation Tokyo Medical and Dental University Culturing colorectal epithelial stem cells and transplanting colorectal epithelium
ES2833280T3 (es) 2012-01-13 2021-06-14 Massachusetts Gen Hospital Células progenitoras pulmonares humanas aisladas y usos de las mismas
US9850463B2 (en) 2012-02-01 2017-12-26 The Regents Of The University Of California Methods of culturing retinal pigmented epithelium cells, including xeno-free production, RPE enrichment, and cryopreservation
WO2013184809A1 (en) 2012-06-05 2013-12-12 The Regents Of The University Of California Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells
WO2014078414A1 (en) 2012-11-13 2014-05-22 Joseph Wu Chemically defined production of cardiomyocytes from pluripotent stem cells
US9533013B2 (en) 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
SG10201708332WA (en) * 2013-03-15 2017-11-29 Jackson Lab Isolation of non-embryonic stem cells and uses thereof
US10266807B2 (en) * 2013-04-03 2019-04-23 FUJIFILM Cellular Dynamics, Inc. Methods and compositions for culturing endoderm progenitor cells in suspension
EP2828380B1 (en) 2013-04-03 2016-09-21 Tampereen Yliopisto Methods and media for differentiating eye cells
US10100285B2 (en) 2015-04-03 2018-10-16 Propagenix Inc. Ex vivo proliferation of epithelial cells
CN107636149A (zh) 2015-04-03 2018-01-26 普罗帕格尼克斯公司 上皮细胞的离体增殖
EP3892718A1 (en) 2015-09-11 2021-10-13 Propagenix Inc. Ex vivo proliferation of epithelial cells

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US20180002669A1 (en) 2018-01-04
US10711251B2 (en) 2020-07-14
JP6964068B2 (ja) 2021-11-10
US20180208900A1 (en) 2018-07-26
JP2018512890A (ja) 2018-05-24
WO2016161192A1 (en) 2016-10-06
KR102598772B1 (ko) 2023-11-03
EP3277799B1 (en) 2020-09-23
US20210032602A1 (en) 2021-02-04
US10711250B2 (en) 2020-07-14
AU2016243750B2 (en) 2022-02-03
AU2016243750A1 (en) 2017-10-05
CN107636149A (zh) 2018-01-26
JP2020120686A (ja) 2020-08-13
DK3277799T3 (en) 2020-12-14
US20170029779A1 (en) 2017-02-02
US9790471B2 (en) 2017-10-17
SG11201707970XA (en) 2017-10-30
IL254588A0 (en) 2017-11-30
EP3277799A1 (en) 2018-02-07
US11680246B2 (en) 2023-06-20
IL254588B (en) 2020-07-30
EP3822339A1 (en) 2021-05-19
MX2017012206A (es) 2018-01-24
US9963680B2 (en) 2018-05-08
CA2981708A1 (en) 2016-10-06
US20170029780A1 (en) 2017-02-02
KR20170134634A (ko) 2017-12-06
SG10201902872YA (en) 2019-04-29
US20230416686A1 (en) 2023-12-28
US10119121B2 (en) 2018-11-06
US20180208899A1 (en) 2018-07-26

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