HK1247812A1 - 用於荧光成像的ir染料 - Google Patents

用於荧光成像的ir染料 Download PDF

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Publication number
HK1247812A1
HK1247812A1 HK18103207.3A HK18103207A HK1247812A1 HK 1247812 A1 HK1247812 A1 HK 1247812A1 HK 18103207 A HK18103207 A HK 18103207A HK 1247812 A1 HK1247812 A1 HK 1247812A1
Authority
HK
Hong Kong
Prior art keywords
sulfonatobutyl
dimethyl
dyes
fluorescence imaging
sulfonato
Prior art date
Application number
HK18103207.3A
Other languages
English (en)
Chinese (zh)
Inventor
Daniel R. Draney
William M. Volcheck
Katie Schaepe
Vassil Elitzin
Joy Kovar
Original Assignee
Li-Cor, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Li-Cor, Inc. filed Critical Li-Cor, Inc.
Publication of HK1247812A1 publication Critical patent/HK1247812A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4222—Evaluating particular parts, e.g. particular organs
    • A61B5/4244—Evaluating particular parts, e.g. particular organs liver
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0025—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through an oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/10—The polymethine chain containing an even number of >CH- groups
    • C09B23/107—The polymethine chain containing an even number of >CH- groups four >CH- groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Endoscopes (AREA)
  • Medicinal Preparation (AREA)
HK18103207.3A 2014-11-26 2015-11-23 用於荧光成像的ir染料 HK1247812A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462084971P 2014-11-26 2014-11-26
US62/084,971 2014-11-26
PCT/US2015/062212 WO2016085884A1 (en) 2014-11-26 2015-11-23 Ir dyes for fluorescence imaging

Publications (1)

Publication Number Publication Date
HK1247812A1 true HK1247812A1 (zh) 2018-10-05

Family

ID=54848900

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18103207.3A HK1247812A1 (zh) 2014-11-26 2015-11-23 用於荧光成像的ir染料

Country Status (10)

Country Link
US (3) US10548991B2 (enExample)
EP (1) EP3223861A1 (enExample)
JP (2) JP6673917B2 (enExample)
CN (1) CN106999609B (enExample)
AR (1) AR102743A1 (enExample)
AU (1) AU2015353700B2 (enExample)
CA (1) CA2964963A1 (enExample)
HK (1) HK1247812A1 (enExample)
TW (1) TWI737587B (enExample)
WO (1) WO2016085884A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR102743A1 (es) 2014-11-26 2017-03-22 Li Cor Inc Medios de contraste ir para imágenes por fluorescencia
WO2018191261A1 (en) * 2017-04-11 2018-10-18 Li-Cor, Inc. Solid cyanine dyes
US10758631B2 (en) 2017-04-11 2020-09-01 Li-Cor, Inc. Solid cyanine dyes
CA3091423A1 (en) 2018-02-15 2019-08-22 Children's National Medical Center Heptamethine cyanines for use as fluorescent markers of the biliary and renal systems
CN120360501A (zh) * 2018-06-14 2025-07-25 灌注科技有限公司 用于自动灌注测量的系统和方法
CN110408233B (zh) * 2019-07-17 2020-04-03 北京大学 一种对磺酸苯氧菁染料及其制备方法与用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55116259A (en) 1979-03-01 1980-09-06 Fuji Photo Film Co Ltd Microimmunoassay method
JPS5745460A (en) 1980-09-02 1982-03-15 Fuji Photo Film Co Ltd Inspection sheet for measuring trace component and inspecting method using said sheet
DE3170135D1 (en) 1980-09-02 1985-05-30 Fuji Photo Film Co Ltd Method for immunochemical measurement of trace components
US6086737A (en) 1984-03-29 2000-07-11 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
US6048982A (en) 1986-04-18 2000-04-11 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US4981977A (en) 1989-06-09 1991-01-01 Carnegie-Mellon University Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups
JPH06145539A (ja) 1992-11-04 1994-05-24 Fuji Photo Film Co Ltd シアニン化合物
US6027709A (en) 1997-01-10 2000-02-22 Li-Cor Inc. Fluorescent cyanine dyes
US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
JP2000095758A (ja) * 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
CA2424454C (en) 2000-09-19 2010-07-20 Li-Cor, Inc. Cyanine dyes
US7597878B2 (en) 2000-09-19 2009-10-06 Li-Cor, Inc. Optical fluorescent imaging
US6663847B1 (en) 2000-10-13 2003-12-16 Mallinckrodt Inc. Dynamic organ function monitoring agents
US20080154102A1 (en) 2006-07-03 2008-06-26 Frangioni John V Intraoperative imaging methods
US7993927B2 (en) 2006-07-03 2011-08-09 Beth Israel Deaconess Medical Center, Inc. Histology methods
CN102281904A (zh) 2008-11-20 2011-12-14 通用电气医疗集团股份有限公司 染料缀合物成像剂
JP5798043B2 (ja) 2009-02-06 2015-10-21 ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド 電荷均衡造影剤
EP2771333A4 (en) 2011-09-23 2015-05-20 Li Cor Inc APPLICATION OF REDUCED DYES IN IMAGING
AR102743A1 (es) 2014-11-26 2017-03-22 Li Cor Inc Medios de contraste ir para imágenes por fluorescencia
US10758631B2 (en) 2017-04-11 2020-09-01 Li-Cor, Inc. Solid cyanine dyes

Also Published As

Publication number Publication date
CN106999609A (zh) 2017-08-01
CN106999609B (zh) 2021-04-13
US20200085976A1 (en) 2020-03-19
AR102743A1 (es) 2017-03-22
US20160144058A1 (en) 2016-05-26
TW201634593A (zh) 2016-10-01
WO2016085884A1 (en) 2016-06-02
US11167046B2 (en) 2021-11-09
US10548991B2 (en) 2020-02-04
JP6673917B2 (ja) 2020-03-25
AU2015353700A1 (en) 2017-06-29
CA2964963A1 (en) 2016-06-02
JP2018502829A (ja) 2018-02-01
US20200078474A1 (en) 2020-03-12
TWI737587B (zh) 2021-09-01
JP2020109099A (ja) 2020-07-16
JP7007412B2 (ja) 2022-01-24
AU2015353700B2 (en) 2021-09-16
EP3223861A1 (en) 2017-10-04

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