HK1246241A1 - 用於多階梯通道乳化的儀器和方法 - Google Patents

用於多階梯通道乳化的儀器和方法

Info

Publication number
HK1246241A1
HK1246241A1 HK18105701.9A HK18105701A HK1246241A1 HK 1246241 A1 HK1246241 A1 HK 1246241A1 HK 18105701 A HK18105701 A HK 18105701A HK 1246241 A1 HK1246241 A1 HK 1246241A1
Authority
HK
Hong Kong
Prior art keywords
methods
step channel
emulsification
channel emulsification
channel
Prior art date
Application number
HK18105701.9A
Other languages
English (en)
Inventor
尼古拉斯．阿拉貝
阿諾爾德．埃斯特拉達
丹尼爾．菲納
羅斯．約翰遜
Original Assignee
盧米耐克斯公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 盧米耐克斯公司 filed Critical 盧米耐克斯公司
Publication of HK1246241A1 publication Critical patent/HK1246241A1/zh

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/45—Mixing liquids with liquids; Emulsifying using flow mixing
    • B01F23/451—Mixing liquids with liquids; Emulsifying using flow mixing by injecting one liquid into another
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3017—Mixing chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663—Stretching or orienting elongated molecules or particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Colloid Chemistry (AREA)
HK18105701.9A 2015-03-16 2018-05-03 用於多階梯通道乳化的儀器和方法 HK1246241A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562133621P 2015-03-16 2015-03-16
US201562269289P 2015-12-18 2015-12-18
PCT/US2016/022418 WO2016149241A1 (en) 2015-03-16 2016-03-15 Apparatus and methods for multi-step channel emulsification

Publications (1)

Publication Number Publication Date
HK1246241A1 true HK1246241A1 (zh) 2018-09-07

Family

ID=56919341

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18105701.9A HK1246241A1 (zh) 2015-03-16 2018-05-03 用於多階梯通道乳化的儀器和方法

Country Status (8)

Country Link
US (2) US10662470B2 (zh)
EP (1) EP3271058B1 (zh)
JP (1) JP6726680B2 (zh)
KR (1) KR102528348B1 (zh)
CN (1) CN107427788B (zh)
CA (1) CA2979415C (zh)
HK (1) HK1246241A1 (zh)
WO (1) WO2016149241A1 (zh)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10632479B2 (en) * 2015-05-22 2020-04-28 The Hong Kong University Of Science And Technology Droplet generator based on high aspect ratio induced droplet self-breakup
EP3520766A4 (en) * 2016-09-30 2020-10-28 Amorepacific Corporation DEVICE FOR PRODUCING A COSMETIC COMPOSITION WITH IMMEDIATELY EMULSIFIED EMULSION MATERIAL ON THE BASIS OF A MICROFLUIDIC CHANNEL
CN106492716B (zh) * 2016-12-20 2024-01-30 中国工程物理研究院激光聚变研究中心 一体式双重乳粒发生装置及其加工方法
JP7071056B2 (ja) * 2017-02-27 2022-05-18 シスメックス株式会社 液体送液方法および液体送液装置
US10544413B2 (en) 2017-05-18 2020-01-28 10X Genomics, Inc. Methods and systems for sorting droplets and beads
WO2018213643A1 (en) 2017-05-18 2018-11-22 10X Genomics, Inc. Methods and systems for sorting droplets and beads
US20190064173A1 (en) * 2017-08-22 2019-02-28 10X Genomics, Inc. Methods of producing droplets including a particle and an analyte
WO2019083852A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. MICROFLUIDIC CHANNEL NETWORKS FOR PARTITIONING
CN112399882B (zh) 2018-04-16 2023-08-01 派特恩生物技术有限公司 用于形成二维微滴阵列的方法和设备
US11130120B2 (en) * 2018-10-01 2021-09-28 Lifeng XIAO Micro-pipette tip for forming micro-droplets
US10486155B1 (en) 2018-10-22 2019-11-26 Klaris Corporation Vacuum-loaded, droplet-generating microfluidic chips and related methods
CN113747974A (zh) * 2019-02-28 2021-12-03 10X基因组学有限公司 用于提高液滴形成效率的装置、系统和方法
CN110075934B (zh) * 2019-03-25 2021-06-01 绍兴钠钇光电有限公司 一种3d打印微流控器件及其大通量制备单分散乳液的方法
PL3721980T3 (pl) * 2019-04-12 2023-04-17 Paris Sciences Et Lettres Mikroprzepływowe urządzenie do wytwarzania emulsji
KR102474965B1 (ko) * 2019-07-01 2022-12-07 오크우드 레버러토리즈, 엘엘씨 마이크로스피어 및 에멀션 제조하기 위한 시스템 및 방법
US11919002B2 (en) 2019-08-20 2024-03-05 10X Genomics, Inc. Devices and methods for generating and recovering droplets
WO2021035009A1 (en) * 2019-08-20 2021-02-25 Pattern Bioscience, Inc. Methods for screening and subsequent processing of samples taken from non-sterile sites
EP4017638A4 (en) * 2019-08-20 2023-08-16 Pattern Bioscience, Inc. MICROFLUIDIC CHIPS WITH A GUTTER TO FACILITATE THEIR LOADING AND RELATED PROCEDURES
US10953404B1 (en) 2020-04-24 2021-03-23 Pattern Bioscience, Inc. Apparatuses for contactless loading and imaging of microfluidic chips and related methods
WO2022086972A1 (en) * 2020-10-19 2022-04-28 Pattern Bioscience, Inc. Microfluidic chips including a gutter having a trough and a ridge to facilitate loading thereof and related methods
US20220126295A1 (en) * 2020-10-27 2022-04-28 Shenzhen Biorain Biotechnology Co.,Ltd. Microfluidic device for digital droplet pcr
GB2625341A (en) * 2022-12-14 2024-06-19 Lightcast Discovery Ltd Improvements in or relating to a cartridge

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1142002A (en) * 1965-03-24 1969-02-05 Fisons Ltd Granulation
US3713780A (en) * 1971-02-01 1973-01-30 Becton Dickinson Co Apparatus for chemical testing
US5455315A (en) * 1994-06-06 1995-10-03 Xerox Corporation Emulsion polymerization processes and toners thereof
FR2747321B1 (fr) 1996-04-16 1998-07-10 Centre Nat Rech Scient Procede de preparation d'une emulsion
AU2002320576A1 (en) * 2001-07-17 2003-03-03 Paolo Gasparini Microstructure for particle and cell separation, identification, sorting, and manipulation
JP4520166B2 (ja) * 2004-02-02 2010-08-04 独立行政法人農業・食品産業技術総合研究機構 樹脂製マイクロチャネル基板及びその製造方法
CN101132853B (zh) * 2004-11-17 2012-05-09 万罗赛斯公司 使用微通道处理技术的乳化方法
DE102005037401B4 (de) 2005-08-08 2007-09-27 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Bildung einer Emulsion in einem fluidischen Mikrosystem
CA2652371A1 (en) * 2006-05-18 2007-11-29 Marilyn Rayner Manufacturing method of a membrane and a membrane thereof, for emulsification
DE102006036815B4 (de) * 2006-08-07 2010-01-14 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Emulgiereinrichtung und Verfahren zur Bildung einer Emulsion
JP5157629B2 (ja) * 2008-05-14 2013-03-06 ソニー株式会社 流路基板
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
WO2011003689A2 (en) * 2009-07-07 2011-01-13 Boehringer Ingelheim Microparts Gmbh Plasma separation reservoir
FR2950544B1 (fr) 2009-09-29 2011-12-09 Ecole Polytech Circuit microfluidique
US8399198B2 (en) 2010-03-02 2013-03-19 Bio-Rad Laboratories, Inc. Assays with droplets transformed into capsules
US20110236277A1 (en) * 2010-03-24 2011-09-29 Electronics And Telecommunications Research Institute Microfluid control device and method of manufacturing the same
FR2958186A1 (fr) 2010-03-30 2011-10-07 Ecole Polytech Dispositif de formation de gouttes dans un circuit microfluide.
EP2714254B1 (en) * 2011-05-23 2017-09-06 President and Fellows of Harvard College Control of emulsions, including multiple emulsions
US8944083B2 (en) 2011-06-15 2015-02-03 Ut-Battelle, Llc Generation of monodisperse droplets by shape-induced shear and interfacial controlled fusion of individual droplets on-demand
GB201121541D0 (en) * 2011-12-14 2012-01-25 Maelstrom Advanced Process Technologies Ltd Improved dynamic mixer
CN104203382A (zh) 2012-02-08 2014-12-10 哈佛学院院长及董事 使用流体破裂的液滴生成
WO2014018562A1 (en) * 2012-07-23 2014-01-30 Bio-Rad Laboratories, Inc. Droplet generation system with features for sample positioning
DE102013200927A1 (de) * 2013-01-22 2014-07-24 Siemens Aktiengesellschaft Verfahren zum Anreichern und Vereinzeln von Zellen mit Konzentrationen über mehrere logarithmische Stufen
US9631179B2 (en) * 2013-03-15 2017-04-25 Angle North America, Inc. Methods for segregating particles using an apparatus with a size-discriminating separation element having an elongate leading edge
US10620120B2 (en) * 2016-06-30 2020-04-14 The University Of North Carolina At Greensboro Nanoplasmonic devices and applications thereof
US20200290048A1 (en) * 2017-08-22 2020-09-17 10X Genomics, Inc. Methods and systems for generating droplets
US20190099751A1 (en) * 2017-09-29 2019-04-04 Regents Of The University Of Minnesota Compact Open-Channel Microfluidic Diodes Based On Two-Tier Capillary Junctions
WO2019118355A1 (en) * 2017-12-12 2019-06-20 10X Genomics, Inc. Systems and methods for single cell processing
CN112399882B (zh) * 2018-04-16 2023-08-01 派特恩生物技术有限公司 用于形成二维微滴阵列的方法和设备
US20210031189A1 (en) * 2018-10-22 2021-02-04 Pattern Bioscience, Inc. Droplet-Generating Microfluidic Chips and Related Methods

Also Published As

Publication number Publication date
CN107427788B (zh) 2021-03-19
CA2979415A1 (en) 2016-09-22
US11098351B2 (en) 2021-08-24
KR102528348B1 (ko) 2023-05-03
US10662470B2 (en) 2020-05-26
WO2016149241A1 (en) 2016-09-22
CA2979415C (en) 2023-08-22
JP6726680B2 (ja) 2020-07-22
US20200263237A1 (en) 2020-08-20
EP3271058A1 (en) 2018-01-24
US20160271576A1 (en) 2016-09-22
CN107427788A (zh) 2017-12-01
KR20170129199A (ko) 2017-11-24
EP3271058B1 (en) 2021-10-06
EP3271058A4 (en) 2018-11-21
JP2018511466A (ja) 2018-04-26

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