HK1245662A1 - 治療組織鈣化的方法 - Google Patents

治療組織鈣化的方法

Info

Publication number
HK1245662A1
HK1245662A1 HK18105396.9A HK18105396A HK1245662A1 HK 1245662 A1 HK1245662 A1 HK 1245662A1 HK 18105396 A HK18105396 A HK 18105396A HK 1245662 A1 HK1245662 A1 HK 1245662A1
Authority
HK
Hong Kong
Prior art keywords
methods
treating tissue
tissue calcification
calcification
treating
Prior art date
Application number
HK18105396.9A
Other languages
English (en)
Inventor
Anthony Quinn
Nelson Hsia
Tayeba Khan
Kim Lynette Askew
Gregory Grabowski
Zhiliang Cheng
W Charles O'neill
Original Assignee
Alexion Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexion Pharma Inc filed Critical Alexion Pharma Inc
Publication of HK1245662A1 publication Critical patent/HK1245662A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/04—Phosphoric diester hydrolases (3.1.4)
    • C12Y301/04001—Phosphodiesterase I (3.1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/01—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
    • C12Y306/01009—Nucleotide diphosphatase (3.6.1.9), i.e. nucleotide-pyrophosphatase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
HK18105396.9A 2014-12-19 2018-04-25 治療組織鈣化的方法 HK1245662A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462094943P 2014-12-19 2014-12-19
US201562249781P 2015-11-02 2015-11-02
PCT/US2015/066646 WO2016100803A2 (en) 2014-12-19 2015-12-18 Methods of treating tissue calcification

Publications (1)

Publication Number Publication Date
HK1245662A1 true HK1245662A1 (zh) 2018-08-31

Family

ID=56127864

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18105396.9A HK1245662A1 (zh) 2014-12-19 2018-04-25 治療組織鈣化的方法

Country Status (15)

Country Link
US (2) USRE49529E1 (zh)
EP (3) EP3967755B1 (zh)
JP (3) JP2018500315A (zh)
KR (1) KR20170095367A (zh)
CN (1) CN107109381A (zh)
AU (1) AU2015364411A1 (zh)
BR (1) BR112017012928A2 (zh)
CA (1) CA2971414A1 (zh)
CO (1) CO2017006032A2 (zh)
ES (2) ES2899895T3 (zh)
HK (1) HK1245662A1 (zh)
MX (3) MX2017007946A (zh)
PL (1) PL3967755T3 (zh)
RU (1) RU2770698C2 (zh)
WO (1) WO2016100803A2 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9744219B2 (en) * 2013-02-13 2017-08-29 Yale University Compositions and methods for treating pathological calcification and ossification
RU2770698C2 (ru) 2014-12-19 2022-04-21 Алексион Фармасьютикалз, Инк. Способы лечения кальцификации тканей
RU2757417C2 (ru) 2015-05-19 2021-10-15 Йейл Юниверсити Композиции для лечения патологических состояний кальцификации и способы их применения
EP3471747A1 (en) 2016-06-16 2019-04-24 Alexion Pharmaceuticals, Inc. Methods of treating myointimal proliferation
CA3032467A1 (en) 2016-08-05 2018-02-08 Yale University Compositions and methods for stroke prevention in pediatric sickle cell anemia patients
EP3687565A1 (en) * 2017-09-27 2020-08-05 Alexion Pharmaceuticals, Inc. Methods of improving cardiovascular function and treating cardiovascular disease using a recombinant ectonucleotide pyrophosphatase phosphodiesterase (npp1)
AU2019267545A1 (en) * 2018-05-08 2020-11-26 Yale University Compositions and methods for reducing progression of nephrolithiasis
EP3844280A4 (en) * 2018-08-31 2022-09-14 Yale University ENPP1 POLYPEPTIDES AND METHODS OF USE THEREOF
CN116157145A (zh) * 2020-06-09 2023-05-23 依诺兹梅制药公司 可溶性enpp1或enpp3蛋白及其用途
AU2021383830A1 (en) * 2020-11-19 2023-06-22 Inozyme Pharma, Inc. Treatment of enpp1 deficiency and abcc6 deficiency

Family Cites Families (23)

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Publication number Priority date Publication date Assignee Title
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US6267964B1 (en) 1989-08-01 2001-07-31 Affibody Technology Sweden Ab Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives
SE509359C2 (sv) 1989-08-01 1999-01-18 Cemu Bioteknik Ab Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
EP1032662B1 (en) 1997-11-07 2006-03-08 Trillium Therapeutics Inc. Methods and compositions for immunomodulation
US6272859B1 (en) 1998-10-02 2001-08-14 Caterpillar Inc. Device for controlling a variable geometry turbocharger
ES2270893T3 (es) 1999-12-24 2007-04-16 Genentech, Inc. Procedimiento y composiciones para prolongar la vida media de compuestos bioactivos.
US6780587B2 (en) 2000-02-23 2004-08-24 Pxe International, Inc. Methods for diagnosing Pseudoxanthoma elasticum
EP1377306A1 (en) 2001-03-09 2004-01-07 Dyax Corp. Serum albumin binding moieties
US7858297B2 (en) 2001-12-18 2010-12-28 Centre National De La Recherche Scientifique Cnrs Chemokine-binding protein and methods of use
US7323542B2 (en) 2002-02-21 2008-01-29 University Of Virginia Patent Foundation Bone targeting peptides
US20080108560A1 (en) 2002-03-05 2008-05-08 Eli Lilly And Company Heterologous G-Csf Fusion Proteins
CA2490009A1 (en) 2002-06-21 2003-12-31 Dyax Corporation Serum protein-associated target-specific ligands and identification method therefor
ES2567634T3 (es) 2004-02-09 2016-04-25 Human Genome Sciences, Inc. Proteínas de fusión de albúmina
US20050287284A1 (en) 2004-06-28 2005-12-29 Shukla Triveni P Processed meats comprising dietary fiber gel
US20090142347A1 (en) 2004-09-29 2009-06-04 The Burnham Institute For Medical Research Tissue-Nonspecific Alkaline Phosphatase (TNAP): a Therapeutic Target for Arterial Calcification
US20100113339A1 (en) 2006-09-08 2010-05-06 Ablynx N. V. Serum albumin binding proteins with long half-lives
EP2545080B1 (en) * 2010-03-12 2017-05-10 Alexion Pharmaceuticals, Inc. Npp1 fusion proteins
SG193024A1 (en) 2011-03-11 2013-10-30 Synageva Biopharma Corp Npp1 fusion proteins
US9744219B2 (en) * 2013-02-13 2017-08-29 Yale University Compositions and methods for treating pathological calcification and ossification
RU2770698C2 (ru) * 2014-12-19 2022-04-21 Алексион Фармасьютикалз, Инк. Способы лечения кальцификации тканей
RU2757417C2 (ru) * 2015-05-19 2021-10-15 Йейл Юниверсити Композиции для лечения патологических состояний кальцификации и способы их применения
CA3005142A1 (en) 2015-11-20 2017-05-26 Yale University Compositions for treating ectopic calcification disorders, and methods using same

Also Published As

Publication number Publication date
JP2022003048A (ja) 2022-01-11
KR20170095367A (ko) 2017-08-22
EP3967755B1 (en) 2024-03-27
EP3234116A2 (en) 2017-10-25
WO2016100803A2 (en) 2016-06-23
CA2971414A1 (en) 2016-06-23
BR112017012928A2 (pt) 2018-05-15
US10493135B2 (en) 2019-12-03
JP2024010052A (ja) 2024-01-23
PL3967755T3 (pl) 2024-08-19
US20180318400A1 (en) 2018-11-08
RU2017119466A3 (zh) 2019-12-20
MX2017007946A (es) 2017-09-15
CO2017006032A2 (es) 2017-10-20
MX2023006083A (es) 2023-06-19
JP2018500315A (ja) 2018-01-11
CN107109381A (zh) 2017-08-29
ES2899895T3 (es) 2022-03-15
MX2022011281A (es) 2022-10-18
USRE49529E1 (en) 2023-05-16
EP4438118A2 (en) 2024-10-02
AU2015364411A1 (en) 2017-06-08
RU2017119466A (ru) 2019-01-21
ES2981606T3 (es) 2024-10-09
EP3234116A4 (en) 2018-08-01
EP3967755A1 (en) 2022-03-16
EP3234116B1 (en) 2021-09-08
RU2770698C2 (ru) 2022-04-21
WO2016100803A3 (en) 2016-08-04

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